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Items: 1 to 50 of 74

1.

An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13.

Al-Mutairy EA, Imtiaz FA, Khalid M, Al Qattan S, Saleh S, Mahmoud LM, Al-Saif MM, Al-Haj L, Al-Enazi A, AlJebreen AM, Mohammed SF, Mobeireek AF, Alkattan K, Chisti MA, Luzina IG, Al-Owain M, Weheba I, Abdelsayed AM, Ramzan K, Janssen LJ, Conca W, Alaiya A, Collison KS, Meyer BF, Atamas SP, Khabar KS, Hasday JD, Al-Mohanna F.

Eur Respir J. 2019 Jul 18;54(1). pii: 1802041. doi: 10.1183/13993003.02041-2018. Print 2019 Jul.

2.

Bi-phased regulation of the post-transcriptional inflammatory response by Tristetraprolin levels.

Mahmoud L, Moghrabi W, Khabar KSA, Hitti EG.

RNA Biol. 2019 Mar;16(3):309-319. doi: 10.1080/15476286.2019.1572437. Epub 2019 Jan 28.

3.

The intracellular pyrimidine 5'-nucleotidase NT5C3A is a negative epigenetic factor in interferon and cytokine signaling.

Al-Haj L, Khabar KSA.

Sci Signal. 2018 Feb 20;11(518). pii: eaal2434. doi: 10.1126/scisignal.aal2434.

PMID:
29463777
4.

The AU-rich element landscape across human transcriptome reveals a large proportion in introns and regulation by ELAVL1/HuR.

Bakheet T, Hitti E, Al-Saif M, Moghrabi WN, Khabar KSA.

Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):167-177. doi: 10.1016/j.bbagrm.2017.12.006. Epub 2018 Feb 2.

5.

Identification of a novel genetic locus underlying tremor and dystonia.

Monies D, Abou Al-Shaar H, Goljan EA, Al-Younes B, Al-Breacan MMA, Al-Saif MM, Wakil SM, Meyer BF, Khabar KSA, Bohlega S.

Hum Genomics. 2017 Nov 6;11(1):25. doi: 10.1186/s40246-017-0123-5.

6.

ARED-Plus: an updated and expanded database of AU-rich element-containing mRNAs and pre-mRNAs.

Bakheet T, Hitti E, Khabar KSA.

Nucleic Acids Res. 2018 Jan 4;46(D1):D218-D220. doi: 10.1093/nar/gkx975.

7.

A novel mechanism for variable phenotypic expressivity in Mendelian diseases uncovered by an AU-rich element (ARE)-creating mutation.

Patel N, Khan AO, Al-Saif M, Moghrabi WN, AlMaarik BM, Ibrahim N, Abdulwahab F, Hashem M, Alshidi T, Alobeid E, Alomar RA, Al-Harbi S, Abouelhoda M, Khabar KSA, Alkuraya FS.

Genome Biol. 2017 Jul 28;18(1):144. doi: 10.1186/s13059-017-1274-3.

8.

Sunitinib Stimulates Expression of VEGFC by Tumor Cells and Promotes Lymphangiogenesis in Clear Cell Renal Cell Carcinomas.

Dufies M, Giuliano S, Ambrosetti D, Claren A, Ndiaye PD, Mastri M, Moghrabi W, Cooley LS, Ettaiche M, Chamorey E, Parola J, Vial V, Lupu-Plesu M, Bernhard JC, Ravaud A, Borchiellini D, Ferrero JM, Bikfalvi A, Ebos JM, Khabar KS, Grépin R, Pagès G.

Cancer Res. 2017 Mar 1;77(5):1212-1226. doi: 10.1158/0008-5472.CAN-16-3088. Epub 2017 Jan 13.

9.

Hallmarks of cancer and AU-rich elements.

Khabar KS.

Wiley Interdiscip Rev RNA. 2017 Jan;8(1). doi: 10.1002/wrna.1368. Epub 2016 Jun 1. Review.

10.

Systematic Analysis of AU-Rich Element Expression in Cancer Reveals Common Functional Clusters Regulated by Key RNA-Binding Proteins.

Hitti E, Bakheet T, Al-Souhibani N, Moghrabi W, Al-Yahya S, Al-Ghamdi M, Al-Saif M, Shoukri MM, Lánczky A, Grépin R, Győrffy B, Pagès G, Khabar KS.

Cancer Res. 2016 Jul 15;76(14):4068-80. doi: 10.1158/0008-5472.CAN-15-3110. Epub 2016 May 17.

11.

Retraction: The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling.

Gherzi R, Trabucchi M, Ponassi M, Ruggiero T, Corte G, Moroni C, Chen CY, Khabar KS, Andersen JS, Briata P.

PLoS Biol. 2015 Nov 16;13(11):e1002314. doi: 10.1371/journal.pbio.1002314. eCollection 2015. No abstract available.

12.

Human Cytokinome Analysis for Interferon Response.

Al-Yahya S, Mahmoud L, Al-Zoghaibi F, Al-Tuhami A, Amer H, Almajhdi FN, Polyak SJ, Khabar KS.

J Virol. 2015 Jul;89(14):7108-19. doi: 10.1128/JVI.03729-14. Epub 2015 Apr 29.

13.

Posttranscriptional control of the chemokine receptor CXCR4 expression in cancer cells.

Al-Souhibani N, Al-Ghamdi M, Al-Ahmadi W, Khabar KS.

Carcinogenesis. 2014 Sep;35(9):1983-92. doi: 10.1093/carcin/bgu080. Epub 2014 Apr 1.

14.

Post-transcriptional control of cytokine gene expression in health and disease.

Khabar KS.

J Interferon Cytokine Res. 2014 Apr;34(4):215-9. doi: 10.1089/jir.2013.0151. Epub 2014 Feb 19.

15.

Sustained stabilization of Interleukin-8 mRNA in human macrophages.

Mahmoud L, Al-Enezi F, Al-Saif M, Warsy A, Khabar KS, Hitti EG.

RNA Biol. 2014;11(2):124-33. doi: 10.4161/rna.27863. Epub 2014 Feb 5.

16.

Identification of the tetraspanin CD82 as a new barrier to xenotransplantation.

Saleh SM, Parhar RS, Al-Hejailan RS, Bakheet RH, Khaleel HS, Khalak HG, Halees AS, Zaidi MZ, Meyer BF, Yung GP, Seebach JD, Conca W, Khabar KS, Collison KS, Al-Mohanna FA.

J Immunol. 2013 Sep 1;191(5):2796-805. doi: 10.4049/jimmunol.1300601. Epub 2013 Jul 19.

17.

miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer.

Al-Ahmadi W, Al-Ghamdi M, Al-Souhibani N, Khabar KS.

J Pathol. 2013 May;230(1):28-38. doi: 10.1002/path.4178. Epub 2013 Mar 21.

18.

Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements.

Al-Haj L, Blackshear PJ, Khabar KS.

Nucleic Acids Res. 2012 Sep;40(16):7739-52. doi: 10.1093/nar/gks545. Epub 2012 Jun 19.

19.

UU/UA dinucleotide frequency reduction in coding regions results in increased mRNA stability and protein expression.

Al-Saif M, Khabar KS.

Mol Ther. 2012 May;20(5):954-9. doi: 10.1038/mt.2012.29. Epub 2012 Mar 20.

20.

Sequence variations affecting AU-rich element function and disease.

Hitti E, Khabar KS.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1846-60. Review.

PMID:
22201840
21.

Cloning of cytokine 3' untranslated regions and posttranscriptional assessment using cell-based GFP assay.

Al-Haj L, Khabar KS.

Methods Mol Biol. 2012;820:91-104. doi: 10.1007/978-1-61779-439-1_6.

PMID:
22131027
22.

p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.

Al-Khalaf HH, Colak D, Al-Saif M, Al-Bakheet A, Hendrayani SF, Al-Yousef N, Kaya N, Khabar KS, Aboussekhra A.

PLoS One. 2011;6(7):e21111. doi: 10.1371/journal.pone.0021111. Epub 2011 Jul 20.

23.

Green fluorescent protein reporter system with transcriptional sequence heterogeneity for monitoring the interferon response.

Mahmoud L, Al-Saif M, Amer HM, Sheikh M, Almajhdi FN, Khabar KS.

J Virol. 2011 Sep;85(18):9268-75. doi: 10.1128/JVI.00772-11. Epub 2011 Jul 13.

24.

Global assessment of GU-rich regulatory content and function in the human transcriptome.

Halees AS, Hitti E, Al-Saif M, Mahmoud L, Vlasova-St Louis IA, Beisang DJ, Bohjanen PR, Khabar K.

RNA Biol. 2011 Jul-Aug;8(4):681-91. doi: 10.4161/rna.8.4.16283. Epub 2011 Jul 1.

25.

The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes.

Al-Souhibani N, Al-Ahmadi W, Hesketh JE, Blackshear PJ, Khabar KS.

Oncogene. 2010 Jul 22;29(29):4205-15. doi: 10.1038/onc.2010.168. Epub 2010 May 24.

26.

Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements.

Khabar KS.

Cell Mol Life Sci. 2010 Sep;67(17):2937-55. doi: 10.1007/s00018-010-0383-x. Epub 2010 May 22. Review.

27.

A versatile ribosomal protein promoter-based reporter system for selective assessment of RNA stability and post-transcriptional control.

Hitti E, Al-Yahya S, Al-Saif M, Mohideen P, Mahmoud L, Polyak SJ, Khabar KS.

RNA. 2010 Jun;16(6):1245-55. doi: 10.1261/rna.2026310. Epub 2010 Apr 23.

28.

Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation.

Al-Ahmadi W, Al-Ghamdi M, Al-Haj L, Al-Saif M, Khabar KS.

Nucleic Acids Res. 2009 Jun;37(11):3612-24. doi: 10.1093/nar/gkp223. Epub 2009 Apr 9.

29.

Temporally regulated traffic of HuR and its associated ARE-containing mRNAs from the chromatoid body to polysomes during mouse spermatogenesis.

Nguyen Chi M, Chalmel F, Agius E, Vanzo N, Khabar KS, Jégou B, Morello D.

PLoS One. 2009;4(3):e4900. doi: 10.1371/journal.pone.0004900. Epub 2009 Mar 31.

30.

AU-rich elements regulate Drosophila gene expression.

Cairrao F, Halees AS, Khabar KS, Morello D, Vanzo N.

Mol Cell Biol. 2009 May;29(10):2636-43. doi: 10.1128/MCB.01506-08. Epub 2009 Mar 9.

31.

Cloning-free regulated monitoring of reporter and gene expression.

al-Haj L, Al-Ahmadi W, Al-Saif M, Demirkaya O, Khabar KS.

BMC Mol Biol. 2009 Mar 8;10:20. doi: 10.1186/1471-2199-10-20.

32.

RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth.

Al-Ahmadi W, Al-Haj L, Al-Mohanna FA, Silverman RH, Khabar KS.

Oncogene. 2009 Apr 16;28(15):1782-91. doi: 10.1038/onc.2009.16. Epub 2009 Mar 2.

33.

Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition.

Kanies CL, Smith JJ, Kis C, Schmidt C, Levy S, Khabar KS, Morrow J, Deane N, Dixon DA, Beauchamp RD.

Mol Cancer Res. 2008 Jul;6(7):1124-36. doi: 10.1158/1541-7786.MCR-07-2095.

34.

Impact of targeting the adenine- and uracil-rich element of bcl-2 mRNA with oligoribonucleotides on apoptosis, cell cycle, and neuronal differentiation in SHSY-5Y cells.

Papucci L, Witort E, Bevilacqua AM, Donnini M, Lulli M, Borchi E, Khabar KS, Tempestini A, Lapucci A, Schiavone N, Nicolin A, Capaccioli S.

Mol Pharmacol. 2008 Feb;73(2):498-508. Epub 2007 Nov 7.

PMID:
17989353
35.

ARED Organism: expansion of ARED reveals AU-rich element cluster variations between human and mouse.

Halees AS, El-Badrawi R, Khabar KS.

Nucleic Acids Res. 2008 Jan;36(Database issue):D137-40. Epub 2007 Nov 4.

36.

Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling.

Ruggiero T, Trabucchi M, Ponassi M, Corte G, Chen CY, al-Haj L, Khabar KS, Briata P, Gherzi R.

BMC Mol Biol. 2007 Apr 16;8:28.

37.

Post-transcriptional control of the interferon system.

Khabar KS, Young HA.

Biochimie. 2007 Jun-Jul;89(6-7):761-9. Epub 2007 Feb 24. Review.

38.

Rapid transit in the immune cells: the role of mRNA turnover regulation.

Khabar KS.

J Leukoc Biol. 2007 Jun;81(6):1335-44. Epub 2007 Mar 30. Review.

PMID:
17400611
39.

Bioinformatics and experimental derivation of an efficient hybrid 3' untranslated region and use in expression active linear DNA with minimum poly(A) region.

Al-Zoghaibi F, Ashour T, Al-Ahmadi W, Abulleef H, Demirkaya O, Khabar KS.

Gene. 2007 Apr 15;391(1-2):130-9. Epub 2006 Dec 30.

PMID:
17258873
40.
41.

Regulation of CXCL-8 (interleukin-8) induction by double-stranded RNA signaling pathways during hepatitis C virus infection.

Wagoner J, Austin M, Green J, Imaizumi T, Casola A, Brasier A, Khabar KS, Wakita T, Gale M Jr, Polyak SJ.

J Virol. 2007 Jan;81(1):309-18. Epub 2006 Oct 11.

42.

Stability of CXCL-8 and related AU-rich mRNAs in the context of hepatitis C virus replication in vitro.

Green J, Khabar KS, Koo BC, Williams BR, Polyak SJ.

J Infect Dis. 2006 Mar 15;193(6):802-11. Epub 2006 Feb 13.

PMID:
16479515
43.

ARED 3.0: the large and diverse AU-rich transcriptome.

Bakheet T, Williams BR, Khabar KS.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D111-4.

44.
45.

The AU-rich transcriptome: more than interferons and cytokines, and its role in disease.

Khabar KS.

J Interferon Cytokine Res. 2005 Jan;25(1):1-10. Review.

PMID:
15684617
46.
47.

Patterns of coordinate down-regulation of ARE-containing transcripts following immune cell activation.

Raghavan A, Dhalla M, Bakheet T, Ogilvie RL, Vlasova IA, Khabar KS, Williams BR, Bohjanen PR.

Genomics. 2004 Dec;84(6):1002-13.

PMID:
15533717
48.

Expressed gene clusters associated with cellular sensitivity and resistance towards anti-viral and anti-proliferative actions of interferon.

Khabar KS, Al-Haj L, Al-Zoghaibi F, Marie M, Dhalla M, Polyak SJ, Williams BR.

J Mol Biol. 2004 Sep 17;342(3):833-46.

PMID:
15342240
49.

Assessment of reliability of microarray data and estimation of signal thresholds using mixture modeling.

Asyali MH, Shoukri MM, Demirkaya O, Khabar KS.

Nucleic Acids Res. 2004 Apr 27;32(8):2323-35. Print 2004.

50.

Selection of AU-rich transiently expressed sequences: reversal of cDNA abundance.

Khabar KS, Dhalla M, Al-Haj L, Bakheet T, Sy C, Naemmuddin M.

RNA. 2004 Apr;10(4):747-53.

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