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Items: 1 to 50 of 76

1.

Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2.

Perander M, Al-Mahdi R, Jensen TC, Nunn JA, Kildalsen H, Johansen B, Gabrielsen M, Keyse SM, Seternes OM.

Sci Rep. 2017 Mar 2;7:43471. doi: 10.1038/srep43471.

2.

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling.

Kidger AM, Rushworth LK, Stellzig J, Davidson J, Bryant CJ, Bayley C, Caddye E, Rogers T, Keyse SM, Caunt CJ.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E317-E326. doi: 10.1073/pnas.1614684114. Epub 2017 Jan 4. Erratum in: Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7651.

3.

Visualizing and Quantitating the Spatiotemporal Regulation of Ras/ERK Signaling by Dual-Specificity Mitogen-Activated Protein Phosphatases (MKPs).

Caunt CJ, Kidger AM, Keyse SM.

Methods Mol Biol. 2016;1447:197-215. doi: 10.1007/978-1-4939-3746-2_12.

PMID:
27514808
4.

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.

Dayalan Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt CJ, Hastie CJ, Lamont DJ, Torrente L, Chowdhry S, Benjamin IJ, Keyse SM, Cuenda A, Dinkova-Kostova AT.

Mol Cell Biol. 2016 Aug 26;36(18):2403-17. doi: 10.1128/MCB.00292-16. Print 2016 Sep 15.

5.

The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs).

Kidger AM, Keyse SM.

Semin Cell Dev Biol. 2016 Feb;50:125-32. doi: 10.1016/j.semcdb.2016.01.009. Epub 2016 Jan 11. Review.

6.

New insights into the activation, interaction partners and possible functions of MK5/PRAK.

Perander M, Keyse SM, Seternes OM.

Front Biosci (Landmark Ed). 2016 Jan 1;21:374-84. Review.

PMID:
26709779
7.

Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production.

Niedzielska M, Raffi FA, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt UK, Wirtz S, Sparwasser T, Hochrein H, Figdor CG, Keyse SM, Lang R.

J Immunol. 2015 Aug 15;195(4):1753-62. doi: 10.4049/jimmunol.1400658. Epub 2015 Jul 13.

8.

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.

Rushworth LK, Kidger AM, Delavaine L, Stewart G, van Schelven S, Davidson J, Bryant CJ, Caddye E, East P, Caunt CJ, Keyse SM.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18267-72. doi: 10.1073/pnas.1420159112. Epub 2014 Dec 8.

9.

BRAF inhibitor resistance: are holidays and cocktails the answer?

Bryant CJ, Keyse SM, Caunt CJ.

Pigment Cell Melanoma Res. 2014 Sep;27(5):693-5. doi: 10.1111/pcmr.12291. Epub 2014 Jul 21. No abstract available.

PMID:
24995574
10.

Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production.

Niedzielska M, Bodendorfer B, Münch S, Eichner A, Derigs M, da Costa O, Schweizer A, Neff F, Nitschke L, Sparwasser T, Keyse SM, Lang R.

J Biol Chem. 2014 Jan 24;289(4):2112-26. doi: 10.1074/jbc.M113.535245. Epub 2013 Dec 5.

11.

Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling.

Caunt CJ, Keyse SM.

FEBS J. 2013 Jan;280(2):489-504. doi: 10.1111/j.1742-4658.2012.08716.x. Epub 2012 Aug 28. Review.

12.

Distinct docking mechanisms mediate interactions between the Msg5 phosphatase and mating or cell integrity mitogen-activated protein kinases (MAPKs) in Saccharomyces cerevisiae.

Palacios L, Dickinson RJ, Sacristán-Reviriego A, Didmon MP, Marín MJ, Martín H, Keyse SM, Molina M.

J Biol Chem. 2011 Dec 9;286(49):42037-50. doi: 10.1074/jbc.M111.286948. Epub 2011 Oct 17.

13.

Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.

Dickinson RJ, Delavaine L, Cejudo-Marín R, Stewart G, Staples CJ, Didmon MP, Trinidad AG, Alonso A, Pulido R, Keyse SM.

J Biol Chem. 2011 Nov 4;286(44):38018-26. doi: 10.1074/jbc.M111.255844. Epub 2011 Sep 9.

14.

Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling.

Rutkowski R, Dickinson R, Stewart G, Craig A, Schimpl M, Keyse SM, Gartner A.

PLoS Genet. 2011 Aug;7(8):e1002238. doi: 10.1371/journal.pgen.1002238. Epub 2011 Aug 25.

15.

Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation.

Staples CJ, Owens DM, Maier JV, Cato AC, Keyse SM.

J Biol Chem. 2010 Aug 20;285(34):25928-40. doi: 10.1074/jbc.M110.117911. Epub 2010 Jun 11. Erratum in: J Biol Chem. 2011 May 13;286(19):17398.

16.

Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK.

Kucharska A, Rushworth LK, Staples C, Morrice NA, Keyse SM.

Cell Signal. 2009 Dec;21(12):1794-805. doi: 10.1016/j.cellsig.2009.07.015. Epub 2009 Aug 7.

PMID:
19666109
17.

Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.

Aberg E, Torgersen KM, Johansen B, Keyse SM, Perander M, Seternes OM.

J Biol Chem. 2009 Jul 17;284(29):19392-401. doi: 10.1074/jbc.M109.023283. Epub 2009 May 27.

18.

Does MK5 reconcile classical and atypical MAP kinases?

Perander M, Keyse SM, Seternes OM.

Front Biosci. 2008 May 1;13:4617-24.

PMID:
18508533
19.

Dual-specificity MAP kinase phosphatases (MKPs) and cancer.

Keyse SM.

Cancer Metastasis Rev. 2008 Jun;27(2):253-61. doi: 10.1007/s10555-008-9123-1. Review.

PMID:
18330678
20.

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter.

Ekerot M, Stavridis MP, Delavaine L, Mitchell MP, Staples C, Owens DM, Keenan ID, Dickinson RJ, Storey KG, Keyse SM.

Biochem J. 2008 Jun 1;412(2):287-98. doi: 10.1042/BJ20071512.

21.

DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5.

Arkell RS, Dickinson RJ, Squires M, Hayat S, Keyse SM, Cook SJ.

Cell Signal. 2008 May;20(5):836-43. doi: 10.1016/j.cellsig.2007.12.014. Epub 2007 Dec 27.

PMID:
18280112
22.

Protein phosphatases and cancer. Preface.

Keyse SM.

Cancer Metastasis Rev. 2008 Jun;27(2):121-2. doi: 10.1007/s10555-008-9122-2. No abstract available.

PMID:
18259839
23.

The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5.

Perander M, Aberg E, Johansen B, Dreyer B, Guldvik IJ, Outzen H, Keyse SM, Seternes OM.

Biochem J. 2008 May 1;411(3):613-22. doi: 10.1042/BJ20071369.

PMID:
18248330
24.

Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

Owens DM, Keyse SM.

Oncogene. 2007 May 14;26(22):3203-13. Review.

PMID:
17496916
25.

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases.

Fox GC, Shafiq M, Briggs DC, Knowles PP, Collister M, Didmon MJ, Makrantoni V, Dickinson RJ, Hanrahan S, Totty N, Stark MJ, Keyse SM, McDonald NQ.

Nature. 2007 May 24;447(7143):487-92. Epub 2007 May 9.

PMID:
17495930
26.

5 Pyst1/MKP3, a novel dual-specificity phosphatase, and FGF signalling in chick limb development.

Eblaghie M, Sanz-Ezquerro J, Dickinson R, Munsterberg A, Keyse S, Tickle C.

J Anat. 2002 Nov;201(5):418. No abstract available.

27.

Diverse physiological functions for dual-specificity MAP kinase phosphatases.

Dickinson RJ, Keyse SM.

J Cell Sci. 2006 Nov 15;119(Pt 22):4607-15. Review.

28.

Spatio-temporal regulation of mitogen-activated protein kinase (MAPK) signalling by protein phosphatases.

Karlsson M, Mandl M, Keyse SM.

Biochem Soc Trans. 2006 Nov;34(Pt 5):842-5.

PMID:
17052211
29.

Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4.

Aberg E, Perander M, Johansen B, Julien C, Meloche S, Keyse SM, Seternes OM.

J Biol Chem. 2006 Nov 17;281(46):35499-510. Epub 2006 Sep 13.

30.

Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryos.

Smith TG, Karlsson M, Lunn JS, Eblaghie MC, Keenan ID, Farrell ER, Tickle C, Storey KG, Keyse SM.

FEBS Lett. 2006 Jul 24;580(17):4242-5. Epub 2006 Jul 5.

31.

The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development.

Christie GR, Williams DJ, Macisaac F, Dickinson RJ, Rosewell I, Keyse SM.

Mol Cell Biol. 2005 Sep;25(18):8323-33.

32.

Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite.

Smith TG, Sweetman D, Patterson M, Keyse SM, Münsterberg A.

Development. 2005 Mar;132(6):1305-14. Epub 2005 Feb 16.

34.

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway.

Seternes OM, Mikalsen T, Johansen B, Michaelsen E, Armstrong CG, Morrice NA, Turgeon B, Meloche S, Moens U, Keyse SM.

EMBO J. 2004 Dec 8;23(24):4780-91. Epub 2004 Dec 2. Erratum in: EMBO J. 2005 Feb 23;24(4):873.

35.
36.

Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos.

Eblaghie MC, Lunn JS, Dickinson RJ, Münsterberg AE, Sanz-Ezquerro JJ, Farrell ER, Mathers J, Keyse SM, Storey K, Tickle C.

Curr Biol. 2003 Jun 17;13(12):1009-18.

38.
39.

Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase.

Dickinson RJ, Williams DJ, Slack DN, Williamson J, Seternes OM, Keyse SM.

Biochem J. 2002 May 15;364(Pt 1):145-55.

40.
41.

Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.

Li J, Gorospe M, Hutter D, Barnes J, Keyse SM, Liu Y.

Mol Cell Biol. 2001 Dec;21(23):8213-24.

42.

Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.

Glading A, Uberall F, Keyse SM, Lauffenburger DA, Wells A.

J Biol Chem. 2001 Jun 29;276(26):23341-8. Epub 2001 Apr 23.

43.

Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1.

Slack DN, Seternes OM, Gabrielsen M, Keyse SM.

J Biol Chem. 2001 May 11;276(19):16491-500. Epub 2001 Jan 30.

44.

CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin.

Sánchez-Pérez I, Martínez-Gomariz M, Williams D, Keyse SM, Perona R.

Oncogene. 2000 Oct 26;19(45):5142-52.

45.

Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc.

Sommer A, Burkhardt H, Keyse SM, Lüscher B.

FEBS Lett. 2000 Jun 2;474(2-3):146-50.

46.

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

Keyse SM.

Curr Opin Cell Biol. 2000 Apr;12(2):186-92. Review.

PMID:
10712927
47.
48.

Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.

Stewart AE, Dowd S, Keyse SM, McDonald NQ.

Nat Struct Biol. 1999 Feb;6(2):174-81.

PMID:
10048930
50.

Protein phosphatases and the regulation of MAP kinase activity.

Keyse SM.

Semin Cell Dev Biol. 1998 Apr;9(2):143-52. Review.

PMID:
9599409

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