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Items: 1 to 50 of 102

1.

Intracellular Staphylococcus aureus Elicits the Production of Host Very Long-Chain Saturated Fatty Acids with Antimicrobial Activity.

Bravo-Santano N, Ellis JK, Calle Y, Keun HC, Behrends V, Letek M.

Metabolites. 2019 Jul 20;9(7). pii: E148. doi: 10.3390/metabo9070148.

2.

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.

Allen SP, Hall B, Castelli LM, Francis L, Woof R, Siskos AP, Kouloura E, Gray E, Thompson AG, Talbot K, Higginbottom A, Myszczynska M, Allen CF, Stopford MJ, Hemingway J, Bauer CS, Webster CP, De Vos KJ, Turner MR, Keun HC, Hautbergue GM, Ferraiuolo L, Shaw PJ.

Brain. 2019 Mar 1;142(3):586-605. doi: 10.1093/brain/awy353.

3.

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation.

Parzych K, Saavedra-García P, Valbuena GN, Al-Sadah HA, Robinson ME, Penfold L, Kuzeva DM, Ruiz-Tellez A, Loaiza S, Holzmann V, Caputo V, Johnson DC, Kaiser MF, Karadimitris A, Lam EW, Chevet E, Feldhahn N, Keun HC, Auner HW.

Oncogene. 2019 Apr;38(17):3216-3231. doi: 10.1038/s41388-018-0651-z. Epub 2019 Jan 9.

4.

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens.

Limonciel A, van Breda SG, Jiang X, Tredwell GD, Wilmes A, Aschauer L, Siskos AP, Sachinidis A, Keun HC, Kopp-Schneider A, de Kok TM, Kleinjans JCS, Jennings P.

Front Genet. 2018 Dec 3;9:558. doi: 10.3389/fgene.2018.00558. eCollection 2018.

5.

Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism.

Behrends V, Giskeødegård GF, Bravo-Santano N, Letek M, Keun HC.

Arch Toxicol. 2019 Feb;93(2):341-353. doi: 10.1007/s00204-018-2371-0. Epub 2018 Dec 14.

6.

Determinants of the urinary and serum metabolome in children from six European populations.

Lau CE, Siskos AP, Maitre L, Robinson O, Athersuch TJ, Want EJ, Urquiza J, Casas M, Vafeiadi M, Roumeliotaki T, McEachan RRC, Azad R, Haug LS, Meltzer HM, Andrusaityte S, Petraviciene I, Grazuleviciene R, Thomsen C, Wright J, Slama R, Chatzi L, Vrijheid M, Keun HC, Coen M.

BMC Med. 2018 Nov 8;16(1):202. doi: 10.1186/s12916-018-1190-8.

7.

Urine Metabolic Signatures of Multiple Environmental Pollutants in Pregnant Women: An Exposome Approach.

Maitre L, Robinson O, Martinez D, Toledano MB, Ibarluzea J, Marina LS, Sunyer J, Villanueva CM, Keun HC, Vrijheid M, Coen M.

Environ Sci Technol. 2018 Nov 20;52(22):13469-13480. doi: 10.1021/acs.est.8b02215. Epub 2018 Oct 30.

PMID:
30285427
8.

Human Early Life Exposome (HELIX) study: a European population-based exposome cohort.

Maitre L, de Bont J, Casas M, Robinson O, Aasvang GM, Agier L, Andrušaitytė S, Ballester F, Basagaña X, Borràs E, Brochot C, Bustamante M, Carracedo A, de Castro M, Dedele A, Donaire-Gonzalez D, Estivill X, Evandt J, Fossati S, Giorgis-Allemand L, R Gonzalez J, Granum B, Grazuleviciene R, Bjerve Gützkow K, Småstuen Haug L, Hernandez-Ferrer C, Heude B, Ibarluzea J, Julvez J, Karachaliou M, Keun HC, Hjertager Krog N, Lau CE, Leventakou V, Lyon-Caen S, Manzano C, Mason D, McEachan R, Meltzer HM, Petraviciene I, Quentin J, Roumeliotaki T, Sabido E, Saulnier PJ, Siskos AP, Siroux V, Sunyer J, Tamayo I, Urquiza J, Vafeiadi M, van Gent D, Vives-Usano M, Waiblinger D, Warembourg C, Chatzi L, Coen M, van den Hazel P, Nieuwenhuijsen MJ, Slama R, Thomsen C, Wright J, Vrijheid M.

BMJ Open. 2018 Sep 10;8(9):e021311. doi: 10.1136/bmjopen-2017-021311.

9.

Intracellular Staphylococcus aureus Modulates Host Central Carbon Metabolism To Activate Autophagy.

Bravo-Santano N, Ellis JK, Mateos LM, Calle Y, Keun HC, Behrends V, Letek M.

mSphere. 2018 Aug 8;3(4). pii: e00374-18. doi: 10.1128/mSphere.00374-18.

10.

Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses.

Vermeulen R, Saberi Hosnijeh F, Bodinier B, Portengen L, Liquet B, Garrido-Manriquez J, Lokhorst H, Bergdahl IA, Kyrtopoulos SA, Johansson AS, Georgiadis P, Melin B, Palli D, Krogh V, Panico S, Sacerdote C, Tumino R, Vineis P, Castagné R, Chadeau-Hyam M; EnviroGenoMarkers Consortium Consortium members, Botsivali M, Chatziioannou A, Valavanis I, Kleinjans JCS, de Kok TMCM, Keun HC, Athersuch TJ, Kelly R, Lenner P, Hallmans G, Stephanou EG, Myridakis A, Kogevinas M, Fazzo L, De Santis M, Comba P, Bendinelli B, Kiviranta H, Rantakokko P, Airaksinen R, Ruokojarvi P, Gilthorpe M, Fleming S, Fleming T, Tu YK, Lundh T, Chien KL, Chen WJ, Lee WC, Kate Hsiao C, Kuo PH, Hung H, Liao SF.

Int J Cancer. 2018 Sep 15;143(6):1335-1347. doi: 10.1002/ijc.31536. Epub 2018 Apr 26.

11.

T cell inhibitory mechanisms in a model of aggressive Non-Hodgkin's Lymphoma.

Hilmenyuk T, Ruckstuhl CA, Hayoz M, Berchtold C, Nuoffer JM, Solanki S, Keun HC, Beavis PA, Riether C, Ochsenbein AF.

Oncoimmunology. 2017 Sep 21;7(1):e1365997. doi: 10.1080/2162402X.2017.1365997. eCollection 2017.

12.

Assessment of metabolic phenotypic variability in children's urine using 1H NMR spectroscopy.

Maitre L, Lau CE, Vizcaino E, Robinson O, Casas M, Siskos AP, Want EJ, Athersuch T, Slama R, Vrijheid M, Keun HC, Coen M.

Sci Rep. 2017 Apr 19;7:46082. doi: 10.1038/srep46082.

13.

Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes.

Chaudhari U, Ellis JK, Wagh V, Nemade H, Hescheler J, Keun HC, Sachinidis A.

Amino Acids. 2017 Dec;49(12):1955-1963. doi: 10.1007/s00726-017-2419-0. Epub 2017 Apr 18.

14.

Lipid degradation promotes prostate cancer cell survival.

Itkonen HM, Brown M, Urbanucci A, Tredwell G, Ho Lau C, Barfeld S, Hart C, Guldvik IJ, Takhar M, Heemers HV, Erho N, Bloch K, Davicioni E, Derua R, Waelkens E, Mohler JL, Clarke N, Swinnen JV, Keun HC, Rekvig OP, Mills IG.

Oncotarget. 2017 Jun 13;8(24):38264-38275. doi: 10.18632/oncotarget.16123.

15.

Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line.

Lau CE, Tredwell GD, Ellis JK, Lam EW, Keun HC.

Sci Rep. 2017 Apr 10;7:46079. doi: 10.1038/srep46079.

16.

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.

Noble RA, Bell N, Blair H, Sikka A, Thomas H, Phillips N, Nakjang S, Miwa S, Crossland R, Rand V, Televantou D, Long A, Keun HC, Bacon CM, Bomken S, Critchlow SE, Wedge SR.

Haematologica. 2017 Jul;102(7):1247-1257. doi: 10.3324/haematol.2016.163030. Epub 2017 Apr 6.

17.

Altered Metabolic Profiles Associate with Toxicity in SOD1G93A Astrocyte-Neuron Co-Cultures.

Valbuena GN, Tortarolo M, Bendotti C, Cantoni L, Keun HC.

Sci Rep. 2017 Mar 3;7(1):50. doi: 10.1038/s41598-017-00072-4.

18.

Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother-child cohort in Crete, Greece.

Perng W, Oken E, Roumeliotaki T, Sood D, Siskos AP, Chalkiadaki G, Dermitzaki E, Vafeiadi M, Kyrtopoulos S, Kogevinas M, Keun HC, Chatzi L.

Obes Sci Pract. 2016 Dec;2(4):471-476. doi: 10.1002/osp4.65. Epub 2016 Oct 21.

19.

CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.

Sood D, Johnson N, Jain P, Siskos AP, Bennett M, Gilham C, Busana MC, Peto J, Dos-Santos-Silva I, Keun HC, Fletcher O.

Br J Cancer. 2017 Jan;116(3):382-388. doi: 10.1038/bjc.2016.432. Epub 2017 Jan 10.

20.

Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma.

Siskos AP, Jain P, Römisch-Margl W, Bennett M, Achaintre D, Asad Y, Marney L, Richardson L, Koulman A, Griffin JL, Raynaud F, Scalbert A, Adamski J, Prehn C, Keun HC.

Anal Chem. 2017 Jan 3;89(1):656-665. doi: 10.1021/acs.analchem.6b02930. Epub 2016 Dec 13.

21.

Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion.

Koufaris C, Gallage S, Yang T, Lau CH, Valbuena GN, Keun HC.

J Proteome Res. 2016 Aug 5;15(8):2618-25. doi: 10.1021/acs.jproteome.6b00188. Epub 2016 Jul 22.

22.

p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance.

Yogev O, Barker K, Sikka A, Almeida GS, Hallsworth A, Smith LM, Jamin Y, Ruddle R, Koers A, Webber HT, Raynaud FI, Popov S, Jones C, Petrie K, Robinson SP, Keun HC, Chesler L.

Cancer Res. 2016 May 15;76(10):3025-35. doi: 10.1158/0008-5472.CAN-15-1939. Epub 2016 Mar 29.

23.

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

Fernando RN, Chaudhari U, Escher SE, Hengstler JG, Hescheler J, Jennings P, Keun HC, Kleinjans JCS, Kolde R, Kollipara L, Kopp-Schneider A, Limonciel A, Nemade H, Nguemo F, Peterson H, Prieto P, Rodrigues RM, Sachinidis A, Schäfer C, Sickmann A, Spitkovsky D, Stöber R, van Breda SGJ, van de Water B, Vivier M, Zahedi RP, Vinken M, Rogiers V.

Arch Toxicol. 2016 Jun;90(6):1529-1539. doi: 10.1007/s00204-016-1719-6. Epub 2016 Apr 29.

24.

Child development accounts (CDAs): An asset-building strategy to empower girls in Uganda.

Curley J, Ssewamala FM, Nabunya P, Ilic V, Keun HC.

Int Soc Work. 2016 Jan 1;59(1):18-31. Epub 2014 Mar 17.

25.

Metabonomic analysis of ovarian tumour cyst fluid by proton nuclear magnetic resonance spectroscopy.

Kyriakides M, Rama N, Sidhu J, Gabra H, Keun HC, El-Bahrawy M.

Oncotarget. 2016 Feb 9;7(6):7216-26. doi: 10.18632/oncotarget.6891.

26.

Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97.

Parzych K, Chinn TM, Chen Z, Loaiza S, Porsch F, Valbuena GN, Kleijnen MF, Karadimitris A, Gentleman E, Keun HC, Auner HW.

Cell Death Dis. 2015 Dec 31;6:e2031. doi: 10.1038/cddis.2015.373.

27.

A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity.

Nevedomskaya E, Perryman R, Solanki S, Syed N, Mayboroda OA, Keun HC.

J Proteome Res. 2016 Jan 4;15(1):280-90. doi: 10.1021/acs.jproteome.5b00793. Epub 2015 Dec 17.

28.

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment.

Chaudhari U, Nemade H, Wagh V, Gaspar JA, Ellis JK, Srinivasan SP, Spitkovski D, Nguemo F, Louisse J, Bremer S, Hescheler J, Keun HC, Hengstler JG, Sachinidis A.

Arch Toxicol. 2016 Nov;90(11):2763-2777. Epub 2015 Nov 4.

29.

Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells.

Koufaris C, Valbuena GN, Pomyen Y, Tredwell GD, Nevedomskaya E, Lau CH, Yang T, Benito A, Ellis JK, Keun HC.

Oncogene. 2016 May;35(21):2766-76. doi: 10.1038/onc.2015.333. Epub 2015 Oct 19.

30.

convISA: A simple, convoluted method for isotopomer spectral analysis of fatty acids and cholesterol.

Tredwell GD, Keun HC.

Metab Eng. 2015 Nov;32:125-132. doi: 10.1016/j.ymben.2015.09.008. Epub 2015 Oct 9.

31.

Metabolic profiling in human exposome studies.

Athersuch TJ, Keun HC.

Mutagenesis. 2015 Nov;30(6):755-62. doi: 10.1093/mutage/gev060. Epub 2015 Aug 18. Review.

PMID:
26290610
32.

Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism.

Fletcher ME, Boshier PR, Wakabayashi K, Keun HC, Smolenski RT, Kirkham PA, Adcock IM, Barton PJ, Takata M, Marczin N.

Am J Physiol Lung Cell Mol Physiol. 2015 Jun 15;308(12):L1274-85. doi: 10.1152/ajplung.00220.2014. Epub 2015 Apr 10.

33.

Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.

Valbuena GN, Rizzardini M, Cimini S, Siskos AP, Bendotti C, Cantoni L, Keun HC.

Mol Neurobiol. 2016 May;53(4):2222-40. doi: 10.1007/s12035-015-9165-7. Epub 2015 May 12.

34.

diXa: a data infrastructure for chemical safety assessment.

Hendrickx DM, Aerts HJ, Caiment F, Clark D, Ebbels TM, Evelo CT, Gmuender H, Hebels DG, Herwig R, Hescheler J, Jennen DG, Jetten MJ, Kanterakis S, Keun HC, Matser V, Overington JP, Pilicheva E, Sarkans U, Segura-Lepe MP, Sotiriadou I, Wittenberger T, Wittwehr C, Zanzi A, Kleinjans JC.

Bioinformatics. 2015 May 1;31(9):1505-7. doi: 10.1093/bioinformatics/btu827. Epub 2014 Dec 12.

35.

Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention.

Miller JA, Pappan K, Thompson PA, Want EJ, Siskos AP, Keun HC, Wulff J, Hu C, Lang JE, Chow HH.

Cancer Prev Res (Phila). 2015 Jan;8(1):86-93. doi: 10.1158/1940-6207.CAPR-14-0100. Epub 2014 Nov 11.

36.

Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway.

Trousil S, Lee P, Pinato DJ, Ellis JK, Dina R, Aboagye EO, Keun HC, Sharma R.

Cancer Res. 2014 Dec 1;74(23):6867-77. doi: 10.1158/0008-5472.CAN-13-2409. Epub 2014 Sep 29.

37.

Over-representation of correlation analysis (ORCA): a method for identifying associations between variable sets.

Pomyen Y, Segura M, Ebbels TM, Keun HC.

Bioinformatics. 2015 Jan 1;31(1):102-8. doi: 10.1093/bioinformatics/btu589. Epub 2014 Sep 2.

PMID:
25183485
38.

Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study.

Maitre L, Fthenou E, Athersuch T, Coen M, Toledano MB, Holmes E, Kogevinas M, Chatzi L, Keun HC.

BMC Med. 2014 Jul 11;12:110. doi: 10.1186/1741-7015-12-110.

39.

Metabonomic analysis of water extracts from different angelica roots by ¹H-nuclear magnetic resonance spectroscopy.

Chan PH, Zhang WL, Lau CH, Cheung CY, Keun HC, Tsim KW, Lam H.

Molecules. 2014 Mar 20;19(3):3460-70. doi: 10.3390/molecules19033460.

40.

The human early-life exposome (HELIX): project rationale and design.

Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, Thomsen C, Wright J, Athersuch TJ, Avellana N, Basagaña X, Brochot C, Bucchini L, Bustamante M, Carracedo A, Casas M, Estivill X, Fairley L, van Gent D, Gonzalez JR, Granum B, Gražulevičienė R, Gutzkow KB, Julvez J, Keun HC, Kogevinas M, McEachan RR, Meltzer HM, Sabidó E, Schwarze PE, Siroux V, Sunyer J, Want EJ, Zeman F, Nieuwenhuijsen MJ.

Environ Health Perspect. 2014 Jun;122(6):535-44. doi: 10.1289/ehp.1307204. Epub 2014 Mar 7.

41.

Metabolomic characterization of nipple aspirate fluid by (1)H NMR spectroscopy and GC-MS.

Tredwell GD, Miller JA, Chow HH, Thompson PA, Keun HC.

J Proteome Res. 2014 Feb 7;13(2):883-9. doi: 10.1021/pr400924k. Epub 2014 Jan 7.

42.

Serum metabolomic pertubations among workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Saberi Hosnijeh F, Pechlivanis A, Keun HC, Portengen L, Bueno-de-Mesquita HB, Heederik D, Vermeulen R.

Environ Mol Mutagen. 2013 Aug;54(7):558-65. doi: 10.1002/em.21802. Epub 2013 Aug 1.

PMID:
23907991
43.

Evaluation of 1H NMR metabolic profiling using biofluid mixture design.

Athersuch TJ, Malik S, Weljie A, Newton J, Keun HC.

Anal Chem. 2013 Jul 16;85(14):6674-81. doi: 10.1021/ac400449f. Epub 2013 Jun 26.

PMID:
23730812
44.

Metabolomics in toxicology and preclinical research.

Ramirez T, Daneshian M, Kamp H, Bois FY, Clench MR, Coen M, Donley B, Fischer SM, Ekman DR, Fabian E, Guillou C, Heuer J, Hogberg HT, Jungnickel H, Keun HC, Krennrich G, Krupp E, Luch A, Noor F, Peter E, Riefke B, Seymour M, Skinner N, Smirnova L, Verheij E, Wagner S, Hartung T, van Ravenzwaay B, Leist M.

ALTEX. 2013;30(2):209-25. doi: 10.14573/altex.2013.2.209.

45.

A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein β (C/EBPβ), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor (CAR).

Blazquez M, Carretero A, Ellis JK, Athersuch TJ, Cavill R, Ebbels TM, Keun HC, Castell JV, Lahoz A, Bort R.

J Proteome Res. 2013 Jun 7;12(6):2732-41. doi: 10.1021/pr400085n. Epub 2013 May 15.

PMID:
23641669
46.

Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research.

Hebels DG, Georgiadis P, Keun HC, Athersuch TJ, Vineis P, Vermeulen R, Portengen L, Bergdahl IA, Hallmans G, Palli D, Bendinelli B, Krogh V, Tumino R, Sacerdote C, Panico S, Kleinjans JC, de Kok TM, Smith MT, Kyrtopoulos SA; EnviroGenomarkers Project Consortium.

Environ Health Perspect. 2013 Apr;121(4):480-7. doi: 10.1289/ehp.1205657. Epub 2013 Feb 5.

47.

Development of quantitative structure-metabolism (QSMR) relationships for substituted anilines based on computational chemistry.

Athersuch TJ, Wilson ID, Keun HC, Lindon JC.

Xenobiotica. 2013 Sep;43(9):792-802. doi: 10.3109/00498254.2013.767953. Epub 2013 Feb 6.

PMID:
23384072
48.

1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.

Jiménez B, Mirnezami R, Kinross J, Cloarec O, Keun HC, Holmes E, Goldin RD, Ziprin P, Darzi A, Nicholson JK.

J Proteome Res. 2013 Feb 1;12(2):959-68. doi: 10.1021/pr3010106. Epub 2013 Jan 16.

PMID:
23240862
49.

Proteomic and metabolomic responses to connexin43 silencing in primary hepatocyte cultures.

Vinken M, Maes M, Cavill R, Valkenborg D, Ellis JK, Decrock E, Leybaert L, Staes A, Gevaert K, Oliveira AG, Menezes GB, Cogliati B, Dagli ML, Ebbels TM, Witters E, Keun HC, Vanhaecke T, Rogiers V.

Arch Toxicol. 2013 May;87(5):883-94. doi: 10.1007/s00204-012-0994-0. Epub 2012 Dec 7.

PMID:
23224291
50.

Metabolic characterization of Leishmania major infection in activated and nonactivated macrophages.

Lamour SD, Choi BS, Keun HC, Müller I, Saric J.

J Proteome Res. 2012 Aug 3;11(8):4211-22. doi: 10.1021/pr3003358. Epub 2012 Jul 12.

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