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Items: 1 to 50 of 136

1.

Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients.

Carr AC, Spencer E, Hoskin TS, Rosengrave P, Kettle AJ, Shaw G.

Free Radic Biol Med. 2019 Nov 4. pii: S0891-5849(19)31559-X. doi: 10.1016/j.freeradbiomed.2019.11.004. [Epub ahead of print]

PMID:
31698081
2.

Exposure of Pseudomonas aeruginosa to bactericidal hypochlorous acid during neutrophil phagocytosis is compromised in cystic fibrosis.

Dickerhof N, Isles V, Pattemore P, Hampton MB, Kettle AJ.

J Biol Chem. 2019 Sep 6;294(36):13502-13514. doi: 10.1074/jbc.RA119.009934. Epub 2019 Jul 24.

PMID:
31341024
3.

Measurements for Sulfide-Mediated Inhibition of Myeloperoxidase Activity.

Garai D, Pálinkás Z, Balla J, Kettle AJ, Nagy P.

Methods Mol Biol. 2019;2007:179-203. doi: 10.1007/978-1-4939-9528-8_14.

PMID:
31148115
4.

Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis.

Cheng D, Talib J, Stanley CP, Rashid I, Michaëlsson E, Lindstedt EL, Croft KD, Kettle AJ, Maghzal GJ, Stocker R.

Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1448-1457. doi: 10.1161/ATVBAHA.119.312725. Epub 2019 May 2.

PMID:
31043077
5.

Oxidative cross-linking of calprotectin occurs in vivo, altering its structure and susceptibility to proteolysis.

Hoskin TS, Crowther JM, Cheung J, Epton MJ, Sly PD, Elder PA, Dobson RCJ, Kettle AJ, Dickerhof N.

Redox Biol. 2019 Jun;24:101202. doi: 10.1016/j.redox.2019.101202. Epub 2019 Apr 13.

6.

Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites.

Filbey KJ, Camberis M, Chandler J, Turner R, Kettle AJ, Eichenberger RM, Giacomin P, Le Gros G.

Mucosal Immunol. 2019 Mar;12(2):352-362. doi: 10.1038/s41385-018-0102-8. Epub 2018 Nov 6.

PMID:
30401814
7.

Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation.

Turner R, Brennan SO, Ashby LV, Dickerhof N, Hamzah MR, Pearson JF, Stamp LK, Kettle AJ.

J Biol Chem. 2018 Dec 21;293(51):19886-19898. doi: 10.1074/jbc.RA118.005237. Epub 2018 Nov 1.

PMID:
30385504
8.

Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque.

Rashid I, Maghzal GJ, Chen YC, Cheng D, Talib J, Newington D, Ren M, Vajandar SK, Searle A, Maluenda A, Lindstedt EL, Jabbour A, Kettle AJ, Bongers A, Power C, Michaëlsson E, Peter K, Stocker R.

Eur Heart J. 2018 Sep 14;39(35):3301-3310. doi: 10.1093/eurheartj/ehy419.

PMID:
30219874
9.

Heterogeneity of hypochlorous acid production in individual neutrophil phagosomes revealed by a rhodamine-based probe.

Albrett AM, Ashby LV, Dickerhof N, Kettle AJ, Winterbourn CC.

J Biol Chem. 2018 Oct 5;293(40):15715-15724. doi: 10.1074/jbc.RA118.004789. Epub 2018 Aug 22.

10.

Rust never sleeps: The continuing story of the Iron Bolt.

van der Vliet A, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J Jr, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW.

Free Radic Biol Med. 2018 Aug 20;124:353-357. doi: 10.1016/j.freeradbiomed.2018.06.017. Epub 2018 Jun 18. Review.

PMID:
29913216
11.

Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation.

Bathish B, Turner R, Paumann-Page M, Kettle AJ, Winterbourn CC.

Arch Biochem Biophys. 2018 May 15;646:120-127. doi: 10.1016/j.abb.2018.03.038. Epub 2018 Apr 4.

PMID:
29626421
12.

Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species.

Coker MS, Forbes LV, Plowman-Holmes M, Murdoch DR, Winterbourn CC, Kettle AJ.

Arch Biochem Biophys. 2018 May 15;646:80-89. doi: 10.1016/j.abb.2018.03.039. Epub 2018 Mar 31.

PMID:
29614256
13.

A myeloperoxidase precursor, pro-myeloperoxidase, is present in human plasma and elevated in cardiovascular disease patients.

Khalilova IS, Dickerhof N, Mocatta TJ, Bhagra CJ, McClean DR, Obinger C, Kettle AJ.

PLoS One. 2018 Mar 28;13(3):e0192952. doi: 10.1371/journal.pone.0192952. eCollection 2018.

14.

Superoxide dismutase protects ribonucleotide reductase from inactivation in yeast.

Das AB, Sadowska-Bartosz I, Königstorfer A, Kettle AJ, Winterbourn CC.

Free Radic Biol Med. 2018 Feb 20;116:114-122. doi: 10.1016/j.freeradbiomed.2018.01.001. Epub 2018 Jan 4.

PMID:
29305896
15.

A multi-substrate assay for finding physiologically effective inhibitors of myeloperoxidase.

Forbes LV, Kettle AJ.

Anal Biochem. 2018 Mar 1;544:13-21. doi: 10.1016/j.ab.2017.12.022. Epub 2017 Dec 16.

PMID:
29258826
16.

Neutrophil granule proteins generate bactericidal ammonia chloramine on reaction with hydrogen peroxide.

Green JN, Chapman ALP, Bishop CJ, Winterbourn CC, Kettle AJ.

Free Radic Biol Med. 2017 Dec;113:363-371. doi: 10.1016/j.freeradbiomed.2017.10.343. Epub 2017 Oct 18.

PMID:
29055823
17.

Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency.

Dickerhof N, Pearson JF, Hoskin TS, Berry LJ, Turner R, Sly PD, Kettle AJ; AREST CF.

Free Radic Biol Med. 2017 Dec;113:236-243. doi: 10.1016/j.freeradbiomed.2017.09.028. Epub 2017 Oct 2.

PMID:
28982600
18.

Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men.

Pullar JM, Carr AC, Bozonet SM, Rosengrave P, Kettle AJ, Vissers MC.

Andrology. 2017 May;5(3):431-438. doi: 10.1111/andr.12327. Epub 2017 Mar 10.

19.

Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease.

Dickerhof N, Turner R, Khalilova I, Fantino E, Sly PD, Kettle AJ; AREST CF.

J Cyst Fibros. 2017 Mar;16(2):214-221. doi: 10.1016/j.jcf.2016.10.012. Epub 2016 Nov 24.

20.

A novel quinone derived from 5-hydroxyindoleacetic acid reacts with protein: Possible participation of oxidation of serotonin and its metabolite in the development of atherosclerosis.

Kato Y, Oki K, Suga N, Ono S, Ishisaka A, Miura Y, Kanazawa S, Naito M, Kitamoto N, Kettle AJ.

Free Radic Biol Med. 2016 Dec;101:500-510. doi: 10.1016/j.freeradbiomed.2016.11.023. Epub 2016 Nov 14.

PMID:
27856348
21.

Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy.

Terrill JR, Duong MN, Turner R, Le Guiner C, Boyatzis A, Kettle AJ, Grounds MD, Arthur PG.

Redox Biol. 2016 Oct;9:276-286. doi: 10.1016/j.redox.2016.08.016. Epub 2016 Aug 30.

22.

Reactive Oxygen Species and Neutrophil Function.

Winterbourn CC, Kettle AJ, Hampton MB.

Annu Rev Biochem. 2016 Jun 2;85:765-92. doi: 10.1146/annurev-biochem-060815-014442. Epub 2016 Apr 6. Review.

PMID:
27050287
23.

The Fdb3 transcription factor of the Fusarium Detoxification of Benzoxazolinone gene cluster is required for MBOA but not BOA degradation in Fusarium pseudograminearum.

Kettle AJ, Carere J, Batley J, Manners JM, Kazan K, Gardiner DM.

Fungal Genet Biol. 2016 Mar;88:44-53. doi: 10.1016/j.fgb.2016.01.015. Epub 2016 Jan 29.

PMID:
26828593
24.

Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function.

Dickerhof N, Schindler L, Bernhagen J, Kettle AJ, Hampton MB.

Free Radic Biol Med. 2015 Dec;89:498-511. doi: 10.1016/j.freeradbiomed.2015.09.009. Epub 2015 Oct 8.

PMID:
26453918
25.

A γ-lactamase from cereal infecting Fusarium spp. catalyses the first step in the degradation of the benzoxazolinone class of phytoalexins.

Kettle AJ, Carere J, Batley J, Benfield AH, Manners JM, Kazan K, Gardiner DM.

Fungal Genet Biol. 2015 Oct;83:1-9. doi: 10.1016/j.fgb.2015.08.005. Epub 2015 Aug 18.

PMID:
26296598
26.

Chemical Characterization of Urate Hydroperoxide, A Pro-oxidant Intermediate Generated by Urate Oxidation in Inflammatory and Photoinduced Processes.

Patrício ES, Prado FM, da Silva RP, Carvalho LA, Prates MV, Dadamos T, Bertotti M, Di Mascio P, Kettle AJ, Meotti FC.

Chem Res Toxicol. 2015 Aug 17;28(8):1556-66. doi: 10.1021/acs.chemrestox.5b00132. Epub 2015 Aug 5.

PMID:
26207674
27.

Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis.

Magon NJ, Turner R, Gearry RB, Hampton MB, Sly PD, Kettle AJ.

Free Radic Biol Med. 2015 Sep;86:133-44. doi: 10.1016/j.freeradbiomed.2015.05.022. Epub 2015 May 22.

PMID:
26006104
28.

Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase.

Odobasic D, Muljadi RC, O'Sullivan KM, Kettle AJ, Dickerhof N, Summers SA, Kitching AR, Holdsworth SR.

Arthritis Rheumatol. 2015 Jul;67(7):1868-80. doi: 10.1002/art.39109.

29.

Degradation of the benzoxazolinone class of phytoalexins is important for virulence of Fusarium pseudograminearum towards wheat.

Kettle AJ, Batley J, Benfield AH, Manners JM, Kazan K, Gardiner DM.

Mol Plant Pathol. 2015 Dec;16(9):946-62. doi: 10.1111/mpp.12250. Epub 2015 Apr 15.

30.

Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils.

Wilkie-Grantham RP, Magon NJ, Harwood DT, Kettle AJ, Vissers MC, Winterbourn CC, Hampton MB.

J Biol Chem. 2015 Apr 10;290(15):9896-905. doi: 10.1074/jbc.M114.613422. Epub 2015 Feb 19.

31.

Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model.

Chandler JD, Min E, Huang J, McElroy CS, Dickerhof N, Mocatta T, Fletcher AA, Evans CM, Liang L, Patel M, Kettle AJ, Nichols DP, Day BJ.

Am J Respir Cell Mol Biol. 2015 Aug;53(2):193-205. doi: 10.1165/rcmb.2014-0208OC.

32.

Covalent modification of cytoskeletal proteins in neuronal cells by tryptamine-4,5-dione.

Kato Y, Ono S, Kitamoto N, Kettle AJ.

Redox Biol. 2014;2:983-90. doi: 10.1016/j.redox.2014.08.004. Epub 2014 Aug 22.

33.

Protein chlorination in neutrophil phagosomes and correlation with bacterial killing.

Green JN, Kettle AJ, Winterbourn CC.

Free Radic Biol Med. 2014 Dec;77:49-56. doi: 10.1016/j.freeradbiomed.2014.08.013. Epub 2014 Sep 16.

PMID:
25236747
34.

Uric acid and thiocyanate as competing substrates of lactoperoxidase.

Seidel A, Parker H, Turner R, Dickerhof N, Khalilova IS, Wilbanks SM, Kettle AJ, Jameson GN.

J Biol Chem. 2014 Aug 8;289(32):21937-49. doi: 10.1074/jbc.M113.544957. Epub 2014 Jun 13.

35.

Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins.

Dickerhof N, Magon NJ, Tyndall JD, Kettle AJ, Hampton MB.

Biochem J. 2014 Sep 1;462(2):303-14. doi: 10.1042/BJ20140612.

PMID:
24916123
36.

Myeloperoxidase and oxidation of uric acid in gout: implications for the clinical consequences of hyperuricaemia.

Stamp LK, Turner R, Khalilova IS, Zhang M, Drake J, Forbes LV, Kettle AJ.

Rheumatology (Oxford). 2014 Nov;53(11):1958-65. doi: 10.1093/rheumatology/keu218. Epub 2014 Jun 4.

PMID:
24899662
37.

Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: critical protective actions of ascorbate and thiocyanate.

Rees MD, Maiocchi SL, Kettle AJ, Thomas SR.

Free Radic Biol Med. 2014 Jul;72:91-103. doi: 10.1016/j.freeradbiomed.2014.03.037. Epub 2014 Apr 4.

PMID:
24704973
38.

Oxidation contributes to low glutathione in the airways of children with cystic fibrosis.

Kettle AJ, Turner R, Gangell CL, Harwood DT, Khalilova IS, Chapman AL, Winterbourn CC, Sly PD; AREST CF.

Eur Respir J. 2014 Jul;44(1):122-9. doi: 10.1183/09031936.00170213. Epub 2014 Mar 23.

39.

Rapid reaction of superoxide with insulin-tyrosyl radicals to generate a hydroperoxide with subsequent glutathione addition.

Das AB, Nauser T, Koppenol WH, Kettle AJ, Winterbourn CC, Nagy P.

Free Radic Biol Med. 2014 May;70:86-95. doi: 10.1016/j.freeradbiomed.2014.02.006. Epub 2014 Feb 20. Erratum in: Free Radic Biol Med. 2015 May;82:206.

PMID:
24561577
40.

Cross-linking methionine and amine residues with reactive halogen species.

Ronsein GE, Winterbourn CC, Di Mascio P, Kettle AJ.

Free Radic Biol Med. 2014 May;70:278-87. doi: 10.1016/j.freeradbiomed.2014.01.023. Epub 2014 Jan 28.

PMID:
24486343
41.

Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium.

Maghzal GJ, Cergol KM, Shengule SR, Suarna C, Newington D, Kettle AJ, Payne RJ, Stocker R.

J Biol Chem. 2014 Feb 28;289(9):5580-95. doi: 10.1074/jbc.M113.539486. Epub 2014 Jan 16.

42.

Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates.

Forbes LV, Sjögren T, Auchère F, Jenkins DW, Thong B, Laughton D, Hemsley P, Pairaudeau G, Turner R, Eriksson H, Unitt JF, Kettle AJ.

J Biol Chem. 2013 Dec 20;288(51):36636-47. doi: 10.1074/jbc.M113.507756. Epub 2013 Nov 5.

43.

Inactivation of human myeloperoxidase by hydrogen peroxide.

Paumann-Page M, Furtmüller PG, Hofbauer S, Paton LN, Obinger C, Kettle AJ.

Arch Biochem Biophys. 2013 Nov 1;539(1):51-62. doi: 10.1016/j.abb.2013.09.004. Epub 2013 Sep 11.

44.

Measuring chlorine bleach in biology and medicine.

Kettle AJ, Albrett AM, Chapman AL, Dickerhof N, Forbes LV, Khalilova I, Turner R.

Biochim Biophys Acta. 2014 Feb;1840(2):781-93. doi: 10.1016/j.bbagen.2013.07.004. Epub 2013 Jul 18. Review.

PMID:
23872351
45.

Ceruloplasmin is an endogenous inhibitor of myeloperoxidase.

Chapman AL, Mocatta TJ, Shiva S, Seidel A, Chen B, Khalilova I, Paumann-Page ME, Jameson GN, Winterbourn CC, Kettle AJ.

J Biol Chem. 2013 Mar 1;288(9):6465-77. doi: 10.1074/jbc.M112.418970. Epub 2013 Jan 10.

46.

Myeloperoxidase: a front-line defender against phagocytosed microorganisms.

Klebanoff SJ, Kettle AJ, Rosen H, Winterbourn CC, Nauseef WM.

J Leukoc Biol. 2013 Feb;93(2):185-98. doi: 10.1189/jlb.0712349. Epub 2012 Oct 11. Review.

47.

Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability.

Hock BD, Taylor KG, Cross NB, Kettle AJ, Hampton MB, McKenzie JL.

Immunology. 2012 Nov;137(3):249-58. doi: 10.1111/imm.12004.

48.

Myeloperoxidase catalyzes the conjugation of serotonin to thiols via free radicals and tryptamine-4,5-dione.

Kato Y, Peskin AV, Dickerhof N, Harwood DT, Kettle AJ.

Chem Res Toxicol. 2012 Nov 19;25(11):2322-32. doi: 10.1021/tx300218f. Epub 2012 Oct 10.

PMID:
23009681
49.

Redox reactions and microbial killing in the neutrophil phagosome.

Winterbourn CC, Kettle AJ.

Antioxid Redox Signal. 2013 Feb 20;18(6):642-60. doi: 10.1089/ars.2012.4827. Epub 2012 Oct 9. Review.

PMID:
22881869
50.

Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.

Forbes LV, Furtmüller PG, Khalilova I, Turner R, Obinger C, Kettle AJ.

Biochem Pharmacol. 2012 Oct 1;84(7):949-60. doi: 10.1016/j.bcp.2012.07.020. Epub 2012 Jul 27.

PMID:
22846601

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