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Items: 1 to 50 of 333

1.

Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology.

Gutmann DH, Kettenmann H.

Neuron. 2019 Nov 6;104(3):442-449. doi: 10.1016/j.neuron.2019.08.028. Review.

PMID:
31697921
2.

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors.

Kaffes I, Szulzewsky F, Chen Z, Herting CJ, Gabanic B, Velázquez Vega JE, Shelton J, Switchenko JM, Ross JL, McSwain LF, Huse JT, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L, Maturi NP, Cimino PJ, Holland EC, Kettenmann H, Brennan CW, Brat DJ, Hambardzumyan D.

Oncoimmunology. 2019 Aug 22;8(11):e1655360. doi: 10.1080/2162402X.2019.1655360. eCollection 2019.

3.

Cien Años de Microglía: Milestones in a Century of Microglial Research.

Sierra A, Paolicelli RC, Kettenmann H.

Trends Neurosci. 2019 Nov;42(11):778-792. doi: 10.1016/j.tins.2019.09.004. Epub 2019 Oct 18. Review.

PMID:
31635851
4.

Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1.

Haage V, Elmadany N, Roll L, Faissner A, Gutmann DH, Semtner M, Kettenmann H.

Brain Behav Immun. 2019 Oct;81:470-483. doi: 10.1016/j.bbi.2019.06.047. Epub 2019 Jul 2.

5.

Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma.

Haage V, Semtner M, Vidal RO, Hernandez DP, Pong WW, Chen Z, Hambardzumyan D, Magrini V, Ly A, Walker J, Mardis E, Mertins P, Sauer S, Kettenmann H, Gutmann DH.

Acta Neuropathol Commun. 2019 Feb 14;7(1):20. doi: 10.1186/s40478-019-0665-y.

6.

Transcriptional and Translational Differences of Microglia from Male and Female Brains.

Guneykaya D, Ivanov A, Hernandez DP, Haage V, Wojtas B, Meyer N, Maricos M, Jordan P, Buonfiglioli A, Gielniewski B, Ochocka N, Cömert C, Friedrich C, Artiles LS, Kaminska B, Mertins P, Beule D, Kettenmann H, Wolf SA.

Cell Rep. 2018 Sep 4;24(10):2773-2783.e6. doi: 10.1016/j.celrep.2018.08.001.

7.

Oligodendrocytes in the Mouse Corpus Callosum Maintain Axonal Function by Delivery of Glucose.

Meyer N, Richter N, Fan Z, Siemonsmeier G, Pivneva T, Jordan P, Steinhäuser C, Semtner M, Nolte C, Kettenmann H.

Cell Rep. 2018 Feb 27;22(9):2383-2394. doi: 10.1016/j.celrep.2018.02.022.

8.

Distinguishing features of microglia- and monocyte-derived macrophages after stroke.

Kronenberg G, Uhlemann R, Richter N, Klempin F, Wegner S, Staerck L, Wolf S, Uckert W, Kettenmann H, Endres M, Gertz K.

Acta Neuropathol. 2018 Apr;135(4):551-568. doi: 10.1007/s00401-017-1795-6. Epub 2017 Dec 16.

PMID:
29249001
9.

Introduction: Special Issue in Honor of Bruce Ransom.

Kettenmann H.

Neurochem Res. 2017 Sep;42(9):2437-2441. doi: 10.1007/s11064-017-2299-4. No abstract available.

PMID:
29149436
10.

Building Bridges through Science.

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.

Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.

11.

Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment.

Szulzewsky F, Schwendinger N, Güneykaya D, Cimino PJ, Hambardzumyan D, Synowitz M, Holland EC, Kettenmann H.

Neuro Oncol. 2018 Feb 19;20(3):355-366. doi: 10.1093/neuonc/nox165.

12.

Changes in phagocytosis and potassium channel activity in microglia of 5xFAD mice indicate alterations in purinergic signaling in a mouse model of Alzheimer's disease.

Wendt S, Maricos M, Vana N, Meyer N, Guneykaya D, Semtner M, Kettenmann H.

Neurobiol Aging. 2017 Oct;58:41-53. doi: 10.1016/j.neurobiolaging.2017.05.027. Epub 2017 Jun 8.

PMID:
28697378
13.

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment.

Mattei D, Ivanov A, Ferrai C, Jordan P, Guneykaya D, Buonfiglioli A, Schaafsma W, Przanowski P, Deuther-Conrad W, Brust P, Hesse S, Patt M, Sabri O, Ross TL, Eggen BJL, Boddeke EWGM, Kaminska B, Beule D, Pombo A, Kettenmann H, Wolf SA.

Transl Psychiatry. 2017 May 9;7(5):e1120. doi: 10.1038/tp.2017.80.

14.

The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain.

Matyash M, Zabiegalov O, Wendt S, Matyash V, Kettenmann H.

PLoS One. 2017 Apr 4;12(4):e0175012. doi: 10.1371/journal.pone.0175012. eCollection 2017.

15.

Astrocytic Calcium Waves Signal Brain Injury to Neural Stem and Progenitor Cells.

Kraft A, Jubal ER, von Laer R, Döring C, Rocha A, Grebbin M, Zenke M, Kettenmann H, Stroh A, Momma S.

Stem Cell Reports. 2017 Mar 14;8(3):701-714. doi: 10.1016/j.stemcr.2017.01.009. Epub 2017 Feb 16.

16.

Barreloid Borders and Neuronal Activity Shape Panglial Gap Junction-Coupled Networks in the Mouse Thalamus.

Claus L, Philippot C, Griemsmann S, Timmermann A, Jabs R, Henneberger C, Kettenmann H, Steinhäuser C.

Cereb Cortex. 2018 Jan 1;28(1):213-222. doi: 10.1093/cercor/bhw368.

PMID:
28095365
17.

Microglia in Physiology and Disease.

Wolf SA, Boddeke HW, Kettenmann H.

Annu Rev Physiol. 2017 Feb 10;79:619-643. doi: 10.1146/annurev-physiol-022516-034406. Epub 2016 Dec 7. Review.

PMID:
27959620
18.

Deep brain stimulation during early adolescence prevents microglial alterations in a model of maternal immune activation.

Hadar R, Dong L, Del-Valle-Anton L, Guneykaya D, Voget M, Edemann-Callesen H, Schweibold R, Djodari-Irani A, Goetz T, Ewing S, Kettenmann H, Wolf SA, Winter C.

Brain Behav Immun. 2017 Jul;63:71-80. doi: 10.1016/j.bbi.2016.12.003. Epub 2016 Dec 7.

PMID:
27939248
19.

Spontaneous Ca2+ transients in mouse microglia.

Korvers L, de Andrade Costa A, Mersch M, Matyash V, Kettenmann H, Semtner M.

Cell Calcium. 2016 Dec;60(6):396-406. doi: 10.1016/j.ceca.2016.09.004. Epub 2016 Sep 22.

PMID:
27697289
20.

The "Big-Bang" for modern glial biology: Translation and comments on Pío del Río-Hortega 1919 series of papers on microglia.

Sierra A, de Castro F, Del Río-Hortega J, Rafael Iglesias-Rozas J, Garrosa M, Kettenmann H.

Glia. 2016 Nov;64(11):1801-40. doi: 10.1002/glia.23046.

PMID:
27634048
21.

Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream.

Langenfurth A, Gu S, Bautze V, Zhang C, Neumann JE, Schüller U, Stock K, Wolf SA, Maier AM, Mastrella G, Pak A, Cheng H, Kälin RE, Holmbeck K, Strotmann J, Kettenmann H, Glass R.

Sci Rep. 2016 Aug 30;6:32203. doi: 10.1038/srep32203.

22.

TLR2 controls random motility, while TLR7 regulates chemotaxis of microglial cells via distinct pathways.

Ifuku M, Buonfiglioli A, Jordan P, Lehnardt S, Kettenmann H.

Brain Behav Immun. 2016 Nov;58:338-347. doi: 10.1016/j.bbi.2016.08.003. Epub 2016 Aug 21.

PMID:
27554518
23.

Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples.

Szulzewsky F, Arora S, de Witte L, Ulas T, Markovic D, Schultze JL, Holland EC, Synowitz M, Wolf SA, Kettenmann H.

Glia. 2016 Aug;64(8):1416-36. doi: 10.1002/glia.23014.

PMID:
27312099
24.

Experimental Cortical Spreading Depression Induces NMDA Receptor Dependent Potassium Currents in Microglia.

Wendt S, Wogram E, Korvers L, Kettenmann H.

J Neurosci. 2016 Jun 8;36(23):6165-74. doi: 10.1523/JNEUROSCI.4498-15.2016.

25.

ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas.

Ku MC, Edes I, Bendix I, Pohlmann A, Waiczies H, Prozorovski T, Günther M, Martin C, Pagès G, Wolf SA, Kettenmann H, Uckert W, Niendorf T, Waiczies S.

Mol Cancer Ther. 2016 Aug;15(8):1975-87. doi: 10.1158/1535-7163.MCT-15-0850. Epub 2016 Jun 2.

26.

Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuron.

Wogram E, Wendt S, Matyash M, Pivneva T, Draguhn A, Kettenmann H.

Eur J Neurosci. 2016 Jun;43(11):1523-34. doi: 10.1111/ejn.13256. Epub 2016 May 21.

PMID:
27060918
27.

Glioma Stem Cells but Not Bulk Glioma Cells Upregulate IL-6 Secretion in Microglia/Brain Macrophages via Toll-like Receptor 4 Signaling.

Dzaye O, Hu F, Derkow K, Haage V, Euskirchen P, Harms C, Lehnardt S, Synowitz M, Wolf SA, Kettenmann H.

J Neuropathol Exp Neurol. 2016 May;75(5):429-40. doi: 10.1093/jnen/nlw016. Epub 2016 Mar 30.

28.

The role of microglia and macrophages in glioma maintenance and progression.

Hambardzumyan D, Gutmann DH, Kettenmann H.

Nat Neurosci. 2016 Jan;19(1):20-7. doi: 10.1038/nn.4185. Review.

29.

In memoriam: Uwe-Karsten Hanisch (May 6, 1961 to April 18, 2015).

Kettenmann H, Prinz M.

Glia. 2015 Aug;63(8):1285-7. doi: 10.1002/glia.22864. Epub 2015 May 25. No abstract available.

PMID:
26013361
30.

Actin dynamics shape microglia effector functions.

Uhlemann R, Gertz K, Boehmerle W, Schwarz T, Nolte C, Freyer D, Kettenmann H, Endres M, Kronenberg G.

Brain Struct Funct. 2016 Jun;221(5):2717-34. doi: 10.1007/s00429-015-1067-y. Epub 2015 May 20.

PMID:
25989853
31.

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis.

Feng X, Szulzewsky F, Yerevanian A, Chen Z, Heinzmann D, Rasmussen RD, Alvarez-Garcia V, Kim Y, Wang B, Tamagno I, Zhou H, Li X, Kettenmann H, Ransohoff RM, Hambardzumyan D.

Oncotarget. 2015 Jun 20;6(17):15077-94.

32.

Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway.

Rosenberger K, Dembny P, Derkow K, Engel O, Krüger C, Wolf SA, Kettenmann H, Schott E, Meisel A, Lehnardt S.

Mol Neurodegener. 2015 Feb 26;10:5. doi: 10.1186/s13024-015-0003-1.

33.

Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing.

Schaafsma W, Zhang X, van Zomeren KC, Jacobs S, Georgieva PB, Wolf SA, Kettenmann H, Janova H, Saiepour N, Hanisch UK, Meerlo P, van den Elsen PJ, Brouwer N, Boddeke HW, Eggen BJ.

Brain Behav Immun. 2015 Aug;48:205-21. doi: 10.1016/j.bbi.2015.03.013. Epub 2015 Apr 2.

PMID:
25843371
34.

Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.

Hoffmann CJ, Harms U, Rex A, Szulzewsky F, Wolf SA, Grittner U, Lättig-Tünnemann G, Sendtner M, Kettenmann H, Dirnagl U, Endres M, Harms C.

Circulation. 2015 May 19;131(20):1772-82. doi: 10.1161/CIRCULATIONAHA.114.013003. Epub 2015 Mar 20.

PMID:
25794850
35.

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.

Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK.

Glia. 2015 Jun;63(6):1083-99. doi: 10.1002/glia.22803. Epub 2015 Mar 2.

PMID:
25731696
36.

Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.

Szulzewsky F, Pelz A, Feng X, Synowitz M, Markovic D, Langmann T, Holtman IR, Wang X, Eggen BJ, Boddeke HW, Hambardzumyan D, Wolf SA, Kettenmann H.

PLoS One. 2015 Feb 6;10(2):e0116644. doi: 10.1371/journal.pone.0116644. eCollection 2015.

37.

The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer's disease.

Pannell M, Meier MA, Szulzewsky F, Matyash V, Endres M, Kronenberg G, Prinz V, Waiczies S, Wolf SA, Kettenmann H.

Brain Struct Funct. 2016 Mar;221(2):1157-72. doi: 10.1007/s00429-014-0962-y. Epub 2014 Dec 19.

PMID:
25523105
38.

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling.

Hu F, Dzaye O, Hahn A, Yu Y, Scavetta RJ, Dittmar G, Kaczmarek AK, Dunning KR, Ricciardelli C, Rinnenthal JL, Heppner FL, Lehnardt S, Synowitz M, Wolf SA, Kettenmann H.

Neuro Oncol. 2015 Feb;17(2):200-10. doi: 10.1093/neuonc/nou324. Epub 2014 Dec 1.

39.

Glioma-associated microglia and macrophages/monocytes display distinct electrophysiological properties and do not communicate via gap junctions.

Richter N, Wendt S, Georgieva PB, Hambardzumyan D, Nolte C, Kettenmann H.

Neurosci Lett. 2014 Nov 7;583:130-5. doi: 10.1016/j.neulet.2014.09.035. Epub 2014 Sep 27.

40.

Altered microglial phagocytosis in GPR34-deficient mice.

Preissler J, Grosche A, Lede V, Le Duc D, Krügel K, Matyash V, Szulzewsky F, Kallendrusch S, Immig K, Kettenmann H, Bechmann I, Schöneberg T, Schulz A.

Glia. 2015 Feb;63(2):206-15. doi: 10.1002/glia.22744. Epub 2014 Aug 20.

PMID:
25142016
41.

The capsaicin receptor TRPV1 as a novel modulator of neural precursor cell proliferation.

Stock K, Garthe A, de Almeida Sassi F, Glass R, Wolf SA, Kettenmann H.

Stem Cells. 2014 Dec;32(12):3183-95. doi: 10.1002/stem.1805.

42.

Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells.

Griemsmann S, Höft SP, Bedner P, Zhang J, von Staden E, Beinhauer A, Degen J, Dublin P, Cope DW, Richter N, Crunelli V, Jabs R, Willecke K, Theis M, Seifert G, Kettenmann H, Steinhäuser C.

Cereb Cortex. 2015 Oct;25(10):3420-33. doi: 10.1093/cercor/bhu157. Epub 2014 Jul 17.

43.

Intracellular glycine receptor function facilitates glioma formation in vivo.

Förstera B, Dzaye O, Winkelmann A, Semtner M, Benedetti B, Markovic DS, Synowitz M, Wend P, Fähling M, Junier MP, Glass R, Kettenmann H, Meier JC.

J Cell Sci. 2014 Sep 1;127(Pt 17):3687-98. doi: 10.1242/jcs.146662. Epub 2014 Jul 2.

44.

Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline.

Hu F, Ku MC, Markovic D, Dzaye O, Lehnardt S, Synowitz M, Wolf SA, Kettenmann H.

Int J Cancer. 2014 Dec 1;135(11):2569-78. doi: 10.1002/ijc.28908. Epub 2014 May 9.

45.

Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia.

Mattei D, Djodari-Irani A, Hadar R, Pelz A, de Cossío LF, Goetz T, Matyash M, Kettenmann H, Winter C, Wolf SA.

Brain Behav Immun. 2014 May;38:175-84. doi: 10.1016/j.bbi.2014.01.019. Epub 2014 Feb 7. Erratum in: Brain Behav Immun. 2015 May;46:328-9.

PMID:
24509090
46.

The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ, and IL-4.

Pannell M, Szulzewsky F, Matyash V, Wolf SA, Kettenmann H.

Glia. 2014 May;62(5):667-79. doi: 10.1002/glia.22633. Epub 2014 Feb 7.

PMID:
24504982
47.

Minocycline protects the immature white matter against hyperoxia.

Schmitz T, Krabbe G, Weikert G, Scheuer T, Matheus F, Wang Y, Mueller S, Kettenmann H, Matyash V, Bührer C, Endesfelder S.

Exp Neurol. 2014 Apr;254:153-65. doi: 10.1016/j.expneurol.2014.01.017. Epub 2014 Jan 31.

PMID:
24491957
48.

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.

Langenfurth A, Rinnenthal JL, Vinnakota K, Prinz V, Carlo AS, Stadelmann C, Siffrin V, Peaschke S, Endres M, Heppner F, Glass R, Wolf SA, Kettenmann H.

J Neurosci Res. 2014 Mar;92(3):275-86. doi: 10.1002/jnr.23288. Epub 2013 Dec 9.

PMID:
24323769
49.

Generation of neuronal progenitor cells in response to tumors in the human brain.

Macas J, Ku MC, Nern C, Xu Y, Bühler H, Remke M, Synowitz M, Franz K, Seifert V, Plate KH, Kettenmann H, Glass R, Momma S.

Stem Cells. 2014 Jan;32(1):244-57. doi: 10.1002/stem.1581.

50.

The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia.

Przanowski P, Dabrowski M, Ellert-Miklaszewska A, Kloss M, Mieczkowski J, Kaza B, Ronowicz A, Hu F, Piotrowski A, Kettenmann H, Komorowski J, Kaminska B.

J Mol Med (Berl). 2014 Mar;92(3):239-54. doi: 10.1007/s00109-013-1090-5. Epub 2013 Oct 6.

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