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Items: 45


A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1.

Opalko HE, Nasa I, Kettenbach AN, Moseley JB.

Mol Biol Cell. 2019 Dec 1;30(25):3015-3023. doi: 10.1091/mbc.E19-08-0430. Epub 2019 Oct 23.


Leveraging New Definitions of the LxVP SLiM To Discover Novel Calcineurin Regulators and Substrates.

Brauer BL, Moon TM, Sheftic SR, Nasa I, Page R, Peti W, Kettenbach AN.

ACS Chem Biol. 2019 Dec 20;14(12):2672-2682. doi: 10.1021/acschembio.9b00606. Epub 2019 Nov 1.


A Consensus Binding Motif for the PP4 Protein Phosphatase.

Ueki Y, Kruse T, Weisser MB, Sundell GN, Larsen MSY, Mendez BL, Jenkins NP, Garvanska DH, Cressey L, Zhang G, Davey N, Montoya G, Ivarsson Y, Kettenbach AN, Nilsson J.

Mol Cell. 2019 Dec 19;76(6):953-964.e6. doi: 10.1016/j.molcel.2019.08.029. Epub 2019 Oct 1.


A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition.

Shee K, Wells JD, Ung M, Hampsch RA, Traphagen NA, Yang W, Liu SC, Zeldenrust MA, Wang L, Kalari KR, Yu J, Boughey JC, Demidenko E, Kettenbach AN, Cheng C, Goetz MP, Miller TW.

Clin Cancer Res. 2020 Jan 1;26(1):159-170. doi: 10.1158/1078-0432.CCR-18-2213. Epub 2019 Sep 26.


Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer.

Hosford SR, Shee K, Wells JD, Traphagen NA, Fields JL, Hampsch RA, Kettenbach AN, Demidenko E, Miller TW.

Mol Oncol. 2019 Aug;13(8):1778-1794. doi: 10.1002/1878-0261.12528. Epub 2019 Jul 9.


R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation.

Caudron-Herger M, Rusin SF, Adamo ME, Seiler J, Schmid VK, Barreau E, Kettenbach AN, Diederichs S.

Mol Cell. 2019 Jul 11;75(1):184-199.e10. doi: 10.1016/j.molcel.2019.04.018. Epub 2019 May 7.


A complex containing lysine-acetylated actin inhibits the formin INF2.

A M, Fung TS, Kettenbach AN, Chakrabarti R, Higgs HN.

Nat Cell Biol. 2019 May;21(5):592-602. doi: 10.1038/s41556-019-0307-4. Epub 2019 Apr 8.


The Phospho-Code Determining Circadian Feedback Loop Closure and Output in Neurospora.

Wang B, Kettenbach AN, Zhou X, Loros JJ, Dunlap JC.

Mol Cell. 2019 May 16;74(4):771-784.e3. doi: 10.1016/j.molcel.2019.03.003. Epub 2019 Apr 3.


Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier.

Chen Y, Wang Y, Salas LA, Miller TW, Mark K, Marotti JD, Kettenbach AN, Cheng C, Christensen BC.

Breast Cancer Res. 2019 Jan 25;21(1):14. doi: 10.1186/s13058-018-1090-z.


Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme.

Kumar GS, Choy MS, Koveal DM, Lorinsky MK, Lyons SP, Kettenbach AN, Page R, Peti W.

Sci Adv. 2018 Nov 14;4(11):eaau6044. doi: 10.1126/sciadv.aau6044. eCollection 2018 Nov.


A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans.

Lyons SP, Jenkins NP, Nasa I, Choy MS, Adamo ME, Page R, Peti W, Moorhead GB, Kettenbach AN.

Mol Cell Proteomics. 2018 Dec;17(12):2448-2461. doi: 10.1074/mcp.RA118.000822. Epub 2018 Sep 18.


Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.

Zhao Y, Zurawel AA, Jenkins NP, Duennwald ML, Cheng C, Kettenbach AN, Supattapone S.

Sci Rep. 2018 Jun 22;8(1):9554. doi: 10.1038/s41598-018-27900-5.


Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.

Nasa I, Rusin SF, Kettenbach AN, Moorhead GB.

Sci Signal. 2018 May 15;11(530). pii: eaai8669. doi: 10.1126/scisignal.aai8669.


Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity.

Kettenbach AN, Schlosser KA, Lyons SP, Nasa I, Gui J, Adamo ME, Gerber SA.

Sci Signal. 2018 May 15;11(530). pii: eaaq1441. doi: 10.1126/scisignal.aaq1441.


Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis.

Nasa I, Kettenbach AN.

Front Cell Dev Biol. 2018 Mar 22;6:30. doi: 10.3389/fcell.2018.00030. eCollection 2018. Review.


Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.

Shee K, Yang W, Hinds JW, Hampsch RA, Varn FS, Traphagen NA, Patel K, Cheng C, Jenkins NP, Kettenbach AN, Demidenko E, Owens P, Faber AC, Golub TR, Straussman R, Miller TW.

J Exp Med. 2018 Mar 5;215(3):895-910. doi: 10.1084/jem.20171818. Epub 2018 Feb 7.


Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division.

Lee ME, Rusin SF, Jenkins N, Kettenbach AN, Moseley JB.

Curr Biol. 2018 Jan 8;28(1):84-92.e4. doi: 10.1016/j.cub.2017.11.034. Epub 2017 Dec 14.


Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics.

Rusin SF, Adamo ME, Kettenbach AN.

Front Cell Dev Biol. 2017 Nov 22;5:97. doi: 10.3389/fcell.2017.00097. eCollection 2017.


PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.

Choy MS, Swingle M, D'Arcy B, Abney K, Rusin SF, Kettenbach AN, Page R, Honkanen RE, Peti W.

J Am Chem Soc. 2017 Dec 13;139(49):17703-17706. doi: 10.1021/jacs.7b09368. Epub 2017 Nov 28.


Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.

Dumitru AMG, Rusin SF, Clark AEM, Kettenbach AN, Compton DA.

Elife. 2017 Nov 20;6. pii: e29303. doi: 10.7554/eLife.29303.


Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7348-E7357. doi: 10.1073/pnas.1707304114. Epub 2017 Aug 14.


A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.

Cullati SN, Kabeche L, Kettenbach AN, Gerber SA.

J Cell Biol. 2017 Aug 7;216(8):2339-2354. doi: 10.1083/jcb.201512055. Epub 2017 Jun 19.


HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex.

Orr A, Song H, Rusin SF, Kettenbach AN, Wickner W.

Mol Biol Cell. 2017 Apr 1;28(7):975-983. doi: 10.1091/mbc.E16-10-0743. Epub 2017 Feb 1.


Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics.

Petrone A, Adamo ME, Cheng C, Kettenbach AN.

Mol Cell Proteomics. 2016 Jul;15(7):2448-61. doi: 10.1074/mcp.M116.059394. Epub 2016 May 1.


Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells.

Sullivan JM, Havrda MC, Kettenbach AN, Paolella BR, Zhang Z, Gerber SA, Israel MA.

Stem Cells. 2016 May;34(5):1321-31. doi: 10.1002/stem.2291. Epub 2016 Feb 1.


Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells.

Rusin SF, Schlosser KA, Adamo ME, Kettenbach AN.

Sci Signal. 2015 Oct 13;8(398):rs12. doi: 10.1126/scisignal.aab3138.


Analysis of the Candida albicans Phosphoproteome.

Willger SD, Liu Z, Olarte RA, Adamo ME, Stajich JE, Myers LC, Kettenbach AN, Hogan DA.

Eukaryot Cell. 2015 May;14(5):474-85. doi: 10.1128/EC.00011-15. Epub 2015 Mar 6.


Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN, Deng L, Wu Y, Baldissard S, Adamo ME, Gerber SA, Moseley JB.

Mol Cell Proteomics. 2015 May;14(5):1275-87. doi: 10.1074/mcp.M114.045245. Epub 2015 Feb 26.


SPECHT - single-stage phosphopeptide enrichment and stable-isotope chemical tagging: quantitative phosphoproteomics of insulin action in muscle.

Kettenbach AN, Sano H, Keller SR, Lienhard GE, Gerber SA.

J Proteomics. 2015 Jan 30;114:48-60. doi: 10.1016/j.jprot.2014.11.001. Epub 2014 Nov 9.


Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion.

Orr A, Wickner W, Rusin SF, Kettenbach AN, Zick M.

Mol Biol Cell. 2015 Jan 15;26(2):305-15. doi: 10.1091/mbc.E14-08-1298. Epub 2014 Nov 19.


Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle.

Wang B, Kettenbach AN, Gerber SA, Loros JJ, Dunlap JC.

PLoS Genet. 2014 Sep 25;10(9):e1004599. doi: 10.1371/journal.pgen.1004599. eCollection 2014 Sep.


Dueling kinases regulate cell size at division through the SAD kinase Cdr2.

Deng L, Baldissard S, Kettenbach AN, Gerber SA, Moseley JB.

Curr Biol. 2014 Feb 17;24(4):428-33. doi: 10.1016/j.cub.2014.01.009. Epub 2014 Feb 6.


Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.

Soundararajan M, Roos AK, Savitsky P, Filippakopoulos P, Kettenbach AN, Olsen JV, Gerber SA, Eswaran J, Knapp S, Elkins JM.

Structure. 2013 Jun 4;21(6):986-96. doi: 10.1016/j.str.2013.03.012. Epub 2013 May 9.


Rapid determination of multiple linear kinase substrate motifs by mass spectrometry.

Kettenbach AN, Wang T, Faherty BK, Madden DR, Knapp S, Bailey-Kellogg C, Gerber SA.

Chem Biol. 2012 May 25;19(5):608-18. doi: 10.1016/j.chembiol.2012.04.011.


Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.

Hood EA, Kettenbach AN, Gerber SA, Compton DA.

Mol Biol Cell. 2012 Jun;23(12):2264-74. doi: 10.1091/mbc.E11-12-1013. Epub 2012 Apr 25.


MMFPh: a maximal motif finder for phosphoproteomics datasets.

Wang T, Kettenbach AN, Gerber SA, Bailey-Kellogg C.

Bioinformatics. 2012 Jun 15;28(12):1562-70. doi: 10.1093/bioinformatics/bts195. Epub 2012 Apr 23.


Increasing phosphoproteomic coverage through sequential digestion by complementary proteases.

Gilmore JM, Kettenbach AN, Gerber SA.

Anal Bioanal Chem. 2012 Jan;402(2):711-20. doi: 10.1007/s00216-011-5466-5. Epub 2011 Oct 15.


Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.

Yore MM, Kettenbach AN, Sporn MB, Gerber SA, Liby KT.

PLoS One. 2011;6(7):e22862. doi: 10.1371/journal.pone.0022862. Epub 2011 Jul 27.


Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells.

Kettenbach AN, Schweppe DK, Faherty BK, Pechenick D, Pletnev AA, Gerber SA.

Sci Signal. 2011 Jun 28;4(179):rs5. doi: 10.1126/scisignal.2001497.


Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.

Sano H, Peck GR, Kettenbach AN, Gerber SA, Lienhard GE.

J Biol Chem. 2011 May 13;286(19):16541-5. doi: 10.1074/jbc.C111.228908. Epub 2011 Mar 22.


Absolute quantification of protein and post-translational modification abundance with stable isotope-labeled synthetic peptides.

Kettenbach AN, Rush J, Gerber SA.

Nat Protoc. 2011 Feb;6(2):175-86. doi: 10.1038/nprot.2010.196. Epub 2011 Jan 27.


Quantitative proteomics reveals a dynamic interactome and phase-specific phosphorylation in the Neurospora circadian clock.

Baker CL, Kettenbach AN, Loros JJ, Gerber SA, Dunlap JC.

Mol Cell. 2009 May 15;34(3):354-63. doi: 10.1016/j.molcel.2009.04.023.


Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.

Lyons PD, Peck GR, Kettenbach AN, Gerber SA, Roudaia L, Lienhard GE.

Biosci Rep. 2009 Aug;29(4):229-35. doi: 10.1042/BSR20080162.


The absolute quantification strategy: application to phosphorylation profiling of human separase serine 1126.

Gerber SA, Kettenbach AN, Rush J, Gygi SP.

Methods Mol Biol. 2007;359:71-86.


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