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Items: 1 to 50 of 64

1.

Slowing ribosome velocity restores folding and function of mutant CFTR.

Oliver KE, Rauscher R, Mijnders M, Wang W, Wolpert MJ, Maya J, Sabusap CM, Kesterson RA, Kirk KL, Rab A, Braakman I, Hong JS, Hartman JL 4th, Ignatova Z, Sorscher EJ.

J Clin Invest. 2019 Dec 2;129(12):5236-5253. doi: 10.1172/JCI124282.

2.

Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands.

Wu L, Belyaeva OV, Adams MK, Klyuyeva AV, Lee SA, Goggans KR, Kesterson RA, Popov KM, Kedishvili NY.

J Biol Chem. 2019 Nov 8;294(45):17060-17074. doi: 10.1074/jbc.RA119.010835. Epub 2019 Sep 27.

PMID:
31562240
3.

Affinity Purification of NF1 Protein-Protein Interactors Identifies Keratins and Neurofibromin Itself as Binding Partners.

Carnes RM, Kesterson RA, Korf BR, Mobley JA, Wallis D.

Genes (Basel). 2019 Aug 28;10(9). pii: E650. doi: 10.3390/genes10090650.

4.

Specific RANK Cytoplasmic Motifs Drive Osteoclastogenesis.

Li Y, Shi Z, Jules J, Chen S, Kesterson RA, Zhao D, Zhang P, Feng X.

J Bone Miner Res. 2019 Oct;34(10):1938-1951. doi: 10.1002/jbmr.3810. Epub 2019 Aug 2.

PMID:
31173390
5.

Multi-Omics Profiling for NF1 Target Discovery in Neurofibromin (NF1) Deficient Cells.

Carnes RM, Mobley JA, Crossman DK, Liu H, Korf BR, Kesterson RA, Wallis D.

Proteomics. 2019 Jun;19(11):e1800334. doi: 10.1002/pmic.201800334.

PMID:
30908848
6.

Heterozygous Pkhd1C642* mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidney.

Shan D, Rezonzew G, Mullen S, Roye R, Zhou J, Chumley P, Revell DZ, Challa A, Kim H, Lockhart ME, Schoeb TR, Croyle MJ, Kesterson RA, Yoder BK, Guay-Woodford LM, Mrug M.

Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F463-F472. doi: 10.1152/ajprenal.00181.2018. Epub 2019 Jan 2.

7.

Truncating PKHD1 and PKD2 mutations alter energy metabolism.

Chumley P, Zhou J, Mrug S, Chacko B, Parant JM, Challa AK, Wilson LS, Berryhill TF, Barnes S, Kesterson RA, Bell PD, Darley-Usmar VM, Yoder BK, Mrug M.

Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F414-F425. doi: 10.1152/ajprenal.00167.2018. Epub 2018 Dec 19.

8.

NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer.

Dischinger PS, Tovar EA, Essenburg CJ, Madaj ZB, Gardner EE, Callaghan ME, Turner AN, Challa AK, Kempston T, Eagleson B, Kesterson RA, Bronson RT, Bowman MJ, Graveel CR, Steensma MR.

NPJ Breast Cancer. 2018 Aug 30;4:29. doi: 10.1038/s41523-018-0080-8. eCollection 2018.

9.

Mks6 mutations reveal tissue- and cell type-specific roles for the cilia transition zone.

Lewis WR, Bales KL, Revell DZ, Croyle MJ, Engle SE, Song CJ, Malarkey EB, Uytingco CR, Shan D, Antonellis PJ, Nagy TR, Kesterson RA, Mrug MM, Martens JR, Berbari NF, Gross AK, Yoder BK.

FASEB J. 2019 Jan;33(1):1440-1455. doi: 10.1096/fj.201801149R. Epub 2018 Aug 22.

10.

A CreER mouse to study melanin concentrating hormone signaling in the developing brain.

Engle SE, Antonellis PJ, Whitehouse LS, Bansal R, Emond MR, Jontes JD, Kesterson RA, Mykytyn K, Berbari NF.

Genesis. 2018 Aug;56(8):e23217. doi: 10.1002/dvg.23217.

11.

Improved Oviduct Transfer Surgery for Genetically Modified Rat Production.

Lambert LJ, Johnson LW, Kennedy D, Cadillac J, Kesterson RA.

Bio Protoc. 2017 Aug 20;7(16). pii: e2503. doi: 10.21769/BioProtoc.2503.

12.

Neurofibromin (NF1) genetic variant structure-function analyses using a full-length mouse cDNA.

Wallis D, Li K, Lui H, Hu K, Chen MJ, Li J, Kang J, Das S, Korf BR, Kesterson RA.

Hum Mutat. 2018 Jun;39(6):816-821. doi: 10.1002/humu.23421. Epub 2018 Apr 10.

PMID:
29522274
13.

Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.

Pruitt HC, Metge BJ, Weeks SE, Chen D, Wei S, Kesterson RA, Shevde LA, Samant RS.

Oncogene. 2018 Mar;37(12):1610-1623. doi: 10.1038/s41388-017-0037-7. Epub 2018 Jan 12.

14.

Updated nomenclature for human and mouse neurofibromatosis type 1 genes.

Anastasaki C, Le LQ, Kesterson RA, Gutmann DH.

Neurol Genet. 2017 Jul 26;3(4):e169. doi: 10.1212/NXG.0000000000000169. eCollection 2017 Aug. No abstract available.

15.

Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer.

Kesterson RA, Johnson LW, Lambert LJ, Vivian JL, Welch DR, Ballinger SW.

Bio Protoc. 2016 Oct 20;6(20). pii: e1976.

16.

Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology.

Lambert LJ, Challa AK, Niu A, Zhou L, Tucholski J, Johnson MS, Nagy TR, Eberhardt AW, Estep PN, Kesterson RA, Grams JM.

Dis Model Mech. 2016 Oct 1;9(10):1169-1179. Epub 2016 Jul 28.

17.

Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I.

Li K, Turner AN, Chen M, Brosius SN, Schoeb TR, Messiaen LM, Bedwell DM, Zinn KR, Anastasaki C, Gutmann DH, Korf BR, Kesterson RA.

Dis Model Mech. 2016 Jul 1;9(7):759-67. doi: 10.1242/dmm.025783. Epub 2016 Jun 2.

18.

Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease.

Lewis WR, Malarkey EB, Tritschler D, Bower R, Pasek RC, Porath JD, Birket SE, Saunier S, Antignac C, Knowles MR, Leigh MW, Zariwala MA, Challa AK, Kesterson RA, Rowe SM, Drummond IA, Parant JM, Hildebrandt F, Porter ME, Yoder BK, Berbari NF.

PLoS Genet. 2016 Jul 29;12(7):e1006220. doi: 10.1371/journal.pgen.1006220. eCollection 2016 Jul.

19.

Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes.

Challa AK, Boitet ER, Turner AN, Johnson LW, Kennedy D, Downs ER, Hymel KM, Gross AK, Kesterson RA.

PLoS One. 2016 May 25;11(5):e0155812. doi: 10.1371/journal.pone.0155812. eCollection 2016.

20.

The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype.

Schultz MJ, Holdbrooks AT, Chakraborty A, Grizzle WE, Landen CN, Buchsbaum DJ, Conner MG, Arend RC, Yoon KJ, Klug CA, Bullard DC, Kesterson RA, Oliver PG, O'Connor AK, Yoder BK, Bellis SL.

Cancer Res. 2016 Jul 1;76(13):3978-88. doi: 10.1158/0008-5472.CAN-15-2834. Epub 2016 May 23.

21.

Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouse.

Pasek RC, Malarkey E, Berbari NF, Sharma N, Kesterson RA, Tres LL, Kierszenbaum AL, Yoder BK.

Dev Biol. 2016 Apr 15;412(2):208-18. doi: 10.1016/j.ydbio.2016.01.042. Epub 2016 Mar 3.

22.

NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.

Toonen JA, Anastasaki C, Smithson LJ, Gianino SM, Li K, Kesterson RA, Gutmann DH.

Hum Mol Genet. 2016 May 1;25(9):1703-13. doi: 10.1093/hmg/ddw039. Epub 2016 Feb 16.

23.

CRYβA3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation.

Hegde S, Kesterson RA, Srivastava OP.

PLoS One. 2016 Feb 10;11(2):e0149027. doi: 10.1371/journal.pone.0149027. eCollection 2016.

24.

KIAA0556 is a novel ciliary basal body component mutated in Joubert syndrome.

Sanders AA, de Vrieze E, Alazami AM, Alzahrani F, Malarkey EB, Sorusch N, Tebbe L, Kuhns S, van Dam TJ, Alhashem A, Tabarki B, Lu Q, Lambacher NJ, Kennedy JE, Bowie RV, Hetterschijt L, van Beersum S, van Reeuwijk J, Boldt K, Kremer H, Kesterson RA, Monies D, Abouelhoda M, Roepman R, Huynen MH, Ueffing M, Russell RB, Wolfrum U, Yoder BK, van Wijk E, Alkuraya FS, Blacque OE.

Genome Biol. 2015 Dec 29;16:293. doi: 10.1186/s13059-015-0858-z.

25.

Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential.

Feeley KP, Bray AW, Westbrook DG, Johnson LW, Kesterson RA, Ballinger SW, Welch DR.

Cancer Res. 2015 Oct 15;75(20):4429-36. doi: 10.1158/0008-5472.CAN-15-0074.

26.

Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload.

Fetterman JL, Zelickson BR, Johnson LW, Moellering DR, Westbrook DG, Pompilius M, Sammy MJ, Johnson M, Dunham-Snary KJ, Cao X, Bradley WE, Zhang J, Wei CC, Chacko B, Schurr TG, Kesterson RA, Dell'italia LJ, Darley-Usmar VM, Welch DR, Ballinger SW.

Biochem J. 2013 Oct 15;455(2):157-67. doi: 10.1042/BJ20130029. Erratum in: Biochem J. 2013 Oct 1;455(1):147.

27.

An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue.

O'Connor AK, Malarkey EB, Berbari NF, Croyle MJ, Haycraft CJ, Bell PD, Hohenstein P, Kesterson RA, Yoder BK.

Cilia. 2013 Jul 3;2(1):8. doi: 10.1186/2046-2530-2-8.

28.

Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice.

Berbari NF, Pasek RC, Malarkey EB, Yazdi SM, McNair AD, Lewis WR, Nagy TR, Kesterson RA, Yoder BK.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7796-801. doi: 10.1073/pnas.1210192110. Epub 2013 Apr 18.

29.

Effects of risperidone on energy balance in female C57BL/6J mice.

Li X, Johnson MS, Smith DL Jr, Li Y, Kesterson RA, Allison DB, Nagy TR.

Obesity (Silver Spring). 2013 Sep;21(9):1850-7. doi: 10.1002/oby.20350. Epub 2013 May 29.

30.

Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis.

Pasek RC, Berbari NF, Lewis WR, Kesterson RA, Yoder BK.

Cilia. 2012 Nov 1;1(1):20. doi: 10.1186/2046-2530-1-20.

31.

Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis.

Cook LM, Cao X, Dowell AE, Debies MT, Edmonds MD, Beck BH, Kesterson RA, Desmond RA, Frost AR, Hurst DR, Welch DR.

Clin Exp Metastasis. 2012 Apr;29(4):315-25. doi: 10.1007/s10585-012-9452-x. Epub 2012 Jan 13.

32.

Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.

Ashley JW, Shi Z, Zhao H, Li X, Kesterson RA, Feng X.

PLoS One. 2011;6(10):e25838. doi: 10.1371/journal.pone.0025838. Epub 2011 Oct 3.

33.

Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation.

Berbari NF, Kin NW, Sharma N, Michaud EJ, Kesterson RA, Yoder BK.

Dev Biol. 2011 Dec 1;360(1):66-76. doi: 10.1016/j.ydbio.2011.09.001. Epub 2011 Sep 16.

34.

ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptor.

Liu Z, Swindall AF, Kesterson RA, Schoeb TR, Bullard DC, Bellis SL.

J Biol Chem. 2011 Nov 11;286(45):39654-62. doi: 10.1074/jbc.M111.276063. Epub 2011 Sep 19.

35.

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome.

Morabito MV, Abbas AI, Hood JL, Kesterson RA, Jacobs MM, Kump DS, Hachey DL, Roth BL, Emeson RB.

Neurobiol Dis. 2010 Aug;39(2):169-80. doi: 10.1016/j.nbd.2010.04.004. Epub 2010 Apr 13.

36.

Generating conditional mutants to analyze ciliary functions: the use of Cre-lox technology to disrupt cilia in specific organs.

O'Connor AK, Kesterson RA, Yoder BK.

Methods Cell Biol. 2009;93:305-30. doi: 10.1016/S0091-679X(08)93015-6. Epub 2009 Dec 4.

PMID:
20409823
37.

Utilization of conditional alleles to study the role of the primary cilium in obesity.

Kesterson RA, Berbari NF, Pasek RC, Yoder BK.

Methods Cell Biol. 2009;94:163-79. doi: 10.1016/S0091-679X(08)94008-5. Epub 2009 Dec 23. Review.

PMID:
20362090
38.

Risperidone alters food intake, core body temperature, and locomotor activity in mice.

Cope MB, Li X, Jumbo-Lucioni P, DiCostanzo CA, Jamison WG, Kesterson RA, Allison DB, Nagy TR.

Physiol Behav. 2009 Mar 2;96(3):457-63. doi: 10.1016/j.physbeh.2008.11.011. Epub 2008 Nov 27.

39.

Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.

Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, Kousoulas KG, Rogers PM, Kesterson RA, Thearle M, Ferrante AW Jr, Mynatt RL, Burris TP, Dong JZ, Halem HA, Culler MD, Heisler LK, Stephens JM, Butler AA.

Cell Metab. 2008 Dec;8(6):468-81. doi: 10.1016/j.cmet.2008.10.011.

40.

G2E3 is a dual function ubiquitin ligase required for early embryonic development.

Brooks WS, Helton ES, Banerjee S, Venable M, Johnson L, Schoeb TR, Kesterson RA, Crawford DF.

J Biol Chem. 2008 Aug 8;283(32):22304-15. doi: 10.1074/jbc.M803238200. Epub 2008 May 28.

41.

Noninvasive bioluminescence imaging in small animals.

Zinn KR, Chaudhuri TR, Szafran AA, O'Quinn D, Weaver C, Dugger K, Lamar D, Kesterson RA, Wang X, Frank SJ.

ILAR J. 2008;49(1):103-15.

42.

Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling.

Chen M, Aprahamian CJ, Kesterson RA, Harmon CM, Yang Y.

Biochemistry. 2007 Oct 9;46(40):11389-97. Epub 2007 Sep 18.

43.

Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease.

Davenport JR, Watts AJ, Roper VC, Croyle MJ, van Groen T, Wyss JM, Nagy TR, Kesterson RA, Yoder BK.

Curr Biol. 2007 Sep 18;17(18):1586-94. Epub 2007 Sep 6.

44.

Structural insights into the role of the ACTH receptor cysteine residues on receptor function.

Yang Y, Chen M, Kesterson RA Jr, Harmon CM.

Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1120-6. Epub 2007 Jun 27.

45.

Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2.

Singh M, Kesterson RA, Jacobs MM, Joers JM, Gore JC, Emeson RB.

J Biol Chem. 2007 Aug 3;282(31):22448-59. Epub 2007 Jun 12.

46.

No effect of dietary fat on short-term weight gain in mice treated with atypical antipsychotic drugs.

Cope MB, Jumbo-Lucioni P, Walton RG, Kesterson RA, Allison DB, Nagy TR.

Int J Obes (Lond). 2007 Jun;31(6):1014-22. Epub 2007 Jan 16.

PMID:
17224931
47.

Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice.

He X, Schoeb TR, Panoskaltsis-Mortari A, Zinn KR, Kesterson RA, Zhang J, Samuel S, Hicks MJ, Hickey MJ, Bullard DC.

J Immunol. 2006 Dec 15;177(12):8748-56.

48.

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.

Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6207-12. Epub 2005 Apr 15.

49.

HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice.

Ercil NE, Galici R, Kesterson RA.

Psychopharmacology (Berl). 2005 Jul;180(2):279-85. Epub 2005 Feb 18.

PMID:
15719225
50.

Putative targets of CNS melanocortin receptor activity.

Lamar CR, Gardner W, Brazda A, Kesterson RA.

Ann N Y Acad Sci. 2003 Jun;994:211-7. Review.

PMID:
12851318

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