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Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia.

van der Lee DI, Reijmers RM, Honders MW, Hagedoorn RS, de Jong RC, Kester MG, van der Steen DM, de Ru AH, Kweekel C, Bijen HM, Jedema I, Veelken H, van Veelen PA, Heemskerk MH, Falkenburg JHF, Griffioen M.

J Clin Invest. 2019 Jan 14. pii: 97482. doi: 10.1172/JCI97482. [Epub ahead of print]


Remission of psoriasis during treatment with sorafenib.

van Kester MS, Luelmo SAC, Vermeer MH, Blank C, van Doorn R.

JAAD Case Rep. 2018 Nov 14;4(10):1065-1067. doi: 10.1016/j.jdcr.2018.09.009. eCollection 2018 Nov. No abstract available.


Tumor-promoting effects of pancreatic cancer cell exosomes on THP-1-derived macrophages.

Linton SS, Abraham T, Liao J, Clawson GA, Butler PJ, Fox T, Kester M, Matters GL.

PLoS One. 2018 Nov 1;13(11):e0206759. doi: 10.1371/journal.pone.0206759. eCollection 2018.


Computational and Experimental Investigation of Janus-like Monolayers on Ultrasmall Noble Metal Nanoparticles.

Merz SN, Farrell ZJ, Pearring J, Hoover E, Kester M, Egorov SA, Green DL, DuBay KH.

ACS Nano. 2018 Nov 27;12(11):11031-11040. doi: 10.1021/acsnano.8b05188. Epub 2018 Oct 26.


Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy.

Mousset CM, Hobo W, Ji Y, Fredrix H, De Giorgi V, Allison RD, Kester MGD, Falkenburg JHF, Schaap NPM, Jansen JH, Gattinoni L, Dolstra H, van der Waart AB.

Oncoimmunology. 2018 Aug 6;7(10):e1488565. doi: 10.1080/2162402X.2018.1488565. eCollection 2018.


Identification of non-mutated neoantigens presented by TAP-deficient tumors.

Marijt KA, Blijleven L, Verdegaal EME, Kester MG, Kowalewski DJ, Rammensee HG, Stevanović S, Heemskerk MHM, van der Burg SH, van Hall T.

J Exp Med. 2018 Sep 3;215(9):2325-2337. doi: 10.1084/jem.20180577. Epub 2018 Aug 16.


Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era.

Shaw J, Costa-Pinheiro P, Patterson L, Drews K, Spiegel S, Kester M.

Adv Cancer Res. 2018;140:327-366. doi: 10.1016/bs.acr.2018.04.016. Epub 2018 Jun 19.


Therapeutic Effect of Blueberry Extracts for Acute Myeloid Leukemia.

McGill CM, Brown TJ, Cheng YY, Fisher LN, Shanmugavelandy SS, Gustafson SJ, Dunlap KL, Lila MA, Kester M, Toran PT, Claxton DF, Barth BM.

Int J Biopharm Sci. 2018 Jan;1(1). pii: 102. Epub 2018 Jan 2.


A breathtaking DRESS due to amoxicillin-clavulanate presenting as polymorphic eruption of the pregnancy.

van Kester MS, Langeveld TJC, Bouwsma H, van Rees JB, Holman ER, Teng YKO, van Zuuren EJ.

J Eur Acad Dermatol Venereol. 2018 Dec;32(12):e436-e437. doi: 10.1111/jdv.14956. Epub 2018 May 3. No abstract available.


The simultaneous isolation of multiple high and low frequent T-cell populations from donor peripheral blood mononuclear cells using the major histocompatibility complex I-Streptamer isolation technology.

Roex MCJ, Hageman L, Heemskerk MT, Veld SAJ, van Liempt E, Kester MGD, Germeroth L, Stemberger C, Falkenburg JHF, Jedema I.

Cytotherapy. 2018 Apr;20(4):543-555. doi: 10.1016/j.jcyt.2018.01.008. Epub 2018 Feb 12.


Lymphangitis carcinomatosa of a cutaneous squamous cell carcinoma.

van Kester MS, Genders RE, Quint KD.

BMJ Case Rep. 2018 Feb 8;2018. pii: bcr-2017-222923. doi: 10.1136/bcr-2017-222923. No abstract available.


Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice.

Li G, Liu D, Kimchi ET, Kaifi JT, Qi X, Manjunath Y, Liu X, Deering T, Avella DM, Fox T, Rockey DC, Schell TD, Kester M, Staveley-O'Carroll KF.

Gastroenterology. 2018 Mar;154(4):1024-1036.e9. doi: 10.1053/j.gastro.2017.10.050. Epub 2018 Jan 31.


Agminated Spitz naevi or metastatic spitzoid melanoma?

van Kester MS, Eggen C, Beishuizen A, Kukutsch NA.

Australas J Dermatol. 2018 Aug;59(3):e234-e235. doi: 10.1111/ajd.12781. Epub 2018 Feb 5. No abstract available.


STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia.

Doshi UA, Shaw J, Fox TE, Claxton DF, Loughran TP, Kester M.

Signal Transduct Target Ther. 2017 Oct 27;2:17051. doi: 10.1038/sigtrans.2017.51. eCollection 2017.


Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface.

Bijen HM, Hassan C, Kester MGD, Janssen GMC, Hombrink P, de Ru AH, Drijfhout JW, Meiring HD, de Jong AP, Falkenburg JHF, Jimenez CR, Heemskerk MHM, van Veelen PA.

Proteomics. 2018 Jun;18(12):e1700250. doi: 10.1002/pmic.201700250. Epub 2018 Feb 23.


Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8+ T Cells During Relapse after Allogeneic Stem Cell Transplantation.

Hutten TJA, Norde WJ, Woestenenk R, Wang RC, Maas F, Kester M, Falkenburg JHF, Berglund S, Luznik L, Jansen JH, Schaap N, Dolstra H, Hobo W.

Biol Blood Marrow Transplant. 2018 Apr;24(4):666-677. doi: 10.1016/j.bbmt.2017.11.027. Epub 2017 Dec 26.


Ceramide Nanoliposomes as a MLKL-Dependent, Necroptosis-Inducing, Chemotherapeutic Reagent in Ovarian Cancer.

Zhang X, Kitatani K, Toyoshima M, Ishibashi M, Usui T, Minato J, Egiz M, Shigeta S, Fox T, Deering T, Kester M, Yaegashi N.

Mol Cancer Ther. 2018 Jan;17(1):50-59. doi: 10.1158/1535-7163.MCT-17-0173. Epub 2017 Oct 27.


Novel uses of bilateral advancement flaps for tip defects on the nose: Part I.

van Kester MS, Genders RE.

J Am Acad Dermatol. 2018 Apr;78(4):e91-e92. doi: 10.1016/j.jaad.2017.09.057. Epub 2017 Oct 6. No abstract available.


Novel uses of bilateral advancement flaps for tip defects on the nose: Part II.

Genders RE, van Kester MS.

J Am Acad Dermatol. 2018 Apr;78(4):e93-e94. doi: 10.1016/j.jaad.2017.09.058. Epub 2017 Oct 5. No abstract available.


Blood-based metabolic signatures in Alzheimer's disease.

de Leeuw FA, Peeters CFW, Kester MI, Harms AC, Struys EA, Hankemeier T, van Vlijmen HWT, van der Lee SJ, van Duijn CM, Scheltens P, Demirkan A, van de Wiel MA, van der Flier WM, Teunissen CE.

Alzheimers Dement (Amst). 2017 Sep 6;8:196-207. doi: 10.1016/j.dadm.2017.07.006. eCollection 2017.


Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo.

Shin M, Snyder HW, Donvito G, Schurman LD, Fox TE, Lichtman AH, Kester M, Hsu KL.

Mol Pharm. 2018 Mar 5;15(3):721-728. doi: 10.1021/acs.molpharmaceut.7b00657. Epub 2017 Sep 13.


SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models.

Hengst JA, Dick TE, Sharma A, Doi K, Hegde S, Tan SF, Geffert LM, Fox TE, Sharma AK, Desai D, Amin S, Kester M, Loughran TP, Paulson RF, Claxton DF, Wang HG, Yun JK.

Cancer Transl Med. 2017 Jul-Aug;3(4):109-121. doi: 10.4103/ctm.ctm_7_17. Epub 2017 Aug 14.


The use of nanoparticulates to treat breast cancer.

Tang X, Loc WS, Dong C, Matters GL, Butler PJ, Kester M, Meyers C, Jiang Y, Adair JH.

Nanomedicine (Lond). 2017 Oct;12(19):2367-2388. doi: 10.2217/nnm-2017-0202. Epub 2017 Sep 4. Review.


Therapeutic implications of bioactive sphingolipids: A focus on colorectal cancer.

Camp ER, Patterson LD, Kester M, Voelkel-Johnson C.

Cancer Biol Ther. 2017 Sep 2;18(9):640-650. doi: 10.1080/15384047.2017.1345396. Epub 2017 Jul 7. Review.


Effective encapsulation and biological activity of phosphorylated chemotherapeutics in calcium phosphosilicate nanoparticles for the treatment of pancreatic cancer.

Loc WS, Linton SS, Wilczynski ZR, Matters GL, McGovern CO, Abraham T, Fox T, Gigliotti CM, Tang X, Tabakovic A, Martin JA, Clawson GA, Smith JP, Butler PJ, Kester M, Adair JH.

Nanomedicine. 2017 Oct;13(7):2313-2324. doi: 10.1016/j.nano.2017.06.017. Epub 2017 Jul 1.


Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.

Vijayan M, Xia C, Song YE, Ngo H, Studstill CJ, Drews K, Fox TE, Johnson MC, Hiscott J, Kester M, Alexander S, Hahm B.

J Immunol. 2017 Jul 15;199(2):677-687. doi: 10.4049/jimmunol.1601959. Epub 2017 Jun 9.


A phase I/II minor histocompatibility antigen-loaded dendritic cell vaccination trial to safely improve the efficacy of donor lymphocyte infusions in myeloma.

Franssen LE, Roeven MWH, Hobo W, Doorn R, Oostvogels R, Falkenburg JHF, van de Donk NW, Kester MGD, Fredrix H, Westinga K, Slaper-Cortenbach I, Spierings E, Kersten MJ, Dolstra H, Mutis T, Schaap N, Lokhorst HM.

Bone Marrow Transplant. 2017 Oct;52(10):1378-1383. doi: 10.1038/bmt.2017.118. Epub 2017 Jun 5.


Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses ex vivo.

Thordardottir S, Schaap N, Louer E, Kester MG, Falkenburg JH, Jansen J, Radstake TR, Hobo W, Dolstra H.

Oncoimmunology. 2017 Feb 6;6(3):e1285991. doi: 10.1080/2162402X.2017.1285991. eCollection 2017.


Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer.

Morad SAF, Davis TS, MacDougall MR, Tan SF, Feith DJ, Desai DH, Amin SG, Kester M, Loughran TP Jr, Cabot MC.

Biochem Pharmacol. 2017 Apr 15;130:21-33. doi: 10.1016/j.bcp.2017.02.002. Epub 2017 Feb 9.


The wingman flap: Bilateral closure of a supra-tip defect of the nose.

Kouwenhoven ST, van Kester MS, Genders RE.

J Am Acad Dermatol. 2017 Feb;76(2):e57-e58. doi: 10.1016/j.jaad.2016.08.037. No abstract available.


TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1.

Jahn L, Hombrink P, Hagedoorn RS, Kester MG, van der Steen DM, Rodriguez T, Pentcheva-Hoang T, de Ru AH, Schoonakker MP, Meeuwsen MH, Griffioen M, van Veelen PA, Falkenburg JH, Heemskerk MH.

Blood. 2017 Mar 9;129(10):1284-1295. doi: 10.1182/blood-2016-09-737536. Epub 2017 Jan 4.


Apolipoprotein A1 in Cerebrospinal Fluid and Plasma and Progression to Alzheimer's Disease in Non-Demented Elderly.

Slot RE, Van Harten AC, Kester MI, Jongbloed W, Bouwman FH, Teunissen CE, Scheltens P, Veerhuis R, van der Flier WM.

J Alzheimers Dis. 2017;56(2):687-697. doi: 10.3233/JAD-151068.


Acid ceramidase is upregulated in AML and represents a novel therapeutic target.

Tan SF, Liu X, Fox TE, Barth BM, Sharma A, Turner SD, Awwad A, Dewey A, Doi K, Spitzer B, Shah MV, Morad SA, Desai D, Amin S, Zhu J, Liao J, Yun J, Kester M, Claxton DF, Wang HG, Cabot MC, Schuchman EH, Levine RL, Feith DJ, Loughran TP Jr.

Oncotarget. 2016 Dec 13;7(50):83208-83222. doi: 10.18632/oncotarget.13079.


Determinants of bird conservation-action implementation and associated population trends of threatened species.

Luther DA, Brooks TM, Butchart SH, Hayward MW, Kester ME, Lamoreux J, Upgren A.

Conserv Biol. 2016 Dec;30(6):1338-1346. doi: 10.1111/cobi.12757. Epub 2016 Aug 24.


Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking.

Young MM, Takahashi Y, Fox TE, Yun JK, Kester M, Wang HG.

Cell Rep. 2016 Nov 1;17(6):1532-1545. doi: 10.1016/j.celrep.2016.10.019.


Generation of CD20-specific TCRs for TCR gene therapy of CD20low B-cell malignancies insusceptible to CD20-targeting antibodies.

Jahn L, van der Steen DM, Hagedoorn RS, Hombrink P, Kester MG, Schoonakker MP, de Ridder D, van Veelen PA, Falkenburg JH, Heemskerk MH.

Oncotarget. 2016 Nov 22;7(47):77021-77037. doi: 10.18632/oncotarget.12778.


A Cholecystokinin B Receptor-Specific DNA Aptamer for Targeting Pancreatic Ductal Adenocarcinoma.

Clawson GA, Abraham T, Pan W, Tang X, Linton SS, McGovern CO, Loc WS, Smith JP, Butler PJ, Kester M, Adair JH, Matters GL.

Nucleic Acid Ther. 2017 Feb;27(1):23-35. doi: 10.1089/nat.2016.0621. Epub 2016 Oct 18.


A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer.

Jahn L, Hagedoorn RS, van der Steen DM, Hombrink P, Kester MG, Schoonakker MP, de Ridder D, van Veelen PA, Falkenburg JH, Heemskerk MH.

Oncotarget. 2016 Nov 1;7(44):71536-71547. doi: 10.18632/oncotarget.12247.


The absence of multiple atypical nevi in germline CDKN2A mutations: Comment on "Hereditary melanoma: Update on syndromes and management: Genetics of familial atypical multiple mole melanoma syndrome".

Ipenburg NA, Gruis NA, Bergman W, van Kester MS.

J Am Acad Dermatol. 2016 Oct;75(4):e157. doi: 10.1016/j.jaad.2016.04.069. No abstract available.


Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model.

Li G, Liu D, Cooper TK, Kimchi ET, Qi X, Avella DM, Li N, Yang QX, Kester M, Rountree CB, Kaifi JT, Cole DJ, Rockey DC, Schell TD, Staveley-O'Carroll KF.

J Hepatol. 2017 Jan;66(1):75-85. doi: 10.1016/j.jhep.2016.07.044. Epub 2016 Aug 9.


A Female with Hereditary Angioedema Developing Wheals: A Case Report.

van Kester MS, Bergman W, Lavrijsen AP.

Acta Derm Venereol. 2017 Feb 8;97(2):285-286. doi: 10.2340/00015555-2490. No abstract available.


Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia.

Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC.

J Lipid Res. 2016 Jul;57(7):1231-42. doi: 10.1194/jlr.M067389. Epub 2016 May 2.


Short-chain ceramides depress integrin cell surface expression and function in colorectal cancer cells.

Morad SA, Bridges LC, Almeida Larrea AD, Mayen AL, MacDougall MR, Davis TS, Kester M, Cabot MC.

Cancer Lett. 2016 Jul 1;376(2):199-204. doi: 10.1016/j.canlet.2016.03.049. Epub 2016 Apr 1.


A novel biologically active acid stable liposomal formulation of docosahexaenoic acid in human breast cancer cell lines.

Skibinski CG, Das A, Chen KM, Liao J, Manni A, Kester M, El-Bayoumy K.

Chem Biol Interact. 2016 May 25;252:1-8. doi: 10.1016/j.cbi.2016.03.035. Epub 2016 Apr 1.


Eosinophilic, Polymorphic, and Pruritic Eruption Associated With Radiotherapy on the Skin of the Right Breast.

van Kester MS, Quint KD.

JAMA Oncol. 2016 Mar 17. doi: 10.1001/jamaoncol.2015.6596. [Epub ahead of print] No abstract available.


Integrated Whole Genome and Transcriptome Analysis Identified a Therapeutic Minor Histocompatibility Antigen in a Splice Variant of ITGB2.

Pont MJ, van der Lee DI, van der Meijden ED, van Bergen CA, Kester MG, Honders MW, Vermaat M, Eefting M, Marijt EW, Kielbasa SM, Hoen PA, Falkenburg JH, Griffioen M.

Clin Cancer Res. 2016 Aug 15;22(16):4185-96. doi: 10.1158/1078-0432.CCR-15-2307. Epub 2016 Mar 10.


Addition of 10-Day Decitabine to Fludarabine/Total Body Irradiation Conditioning is Feasible and Induces Tumor-Associated Antigen-Specific T Cell Responses.

Cruijsen M, Hobo W, van der Velden WJFM, Bremmers MEJ, Woestenenk R, Bär B, Falkenburg JHF, Kester M, Schaap NPM, Jansen J, Blijlevens NNM, Dolstra H, Huls G.

Biol Blood Marrow Transplant. 2016 Jun;22(6):1000-1008. doi: 10.1016/j.bbmt.2016.02.003. Epub 2016 Feb 6.


More on PML in Patients Treated with Dimethyl Fumarate. Author reply.

van Kester MS, Bouwes Bavinck JN, Quint KD.

N Engl J Med. 2016 Jan 21;374(3):295-6. doi: 10.1056/NEJMc1512228. No abstract available.


Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells.

Rivera IG, Ordoñez M, Presa N, Gangoiti P, Gomez-Larrauri A, Trueba M, Fox T, Kester M, Gomez-Muñoz A.

Biochem Pharmacol. 2016 Feb 15;102:107-119. doi: 10.1016/j.bcp.2015.12.009. Epub 2015 Dec 18.


Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort.

Kester MI, Teunissen CE, Sutphen C, Herries EM, Ladenson JH, Xiong C, Scheltens P, van der Flier WM, Morris JC, Holtzman DM, Fagan AM.

Alzheimers Res Ther. 2015 Sep 17;7(1):59. doi: 10.1186/s13195-015-0142-1.

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