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The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial.

Lewis G, Duffy L, Ades A, Amos R, Araya R, Brabyn S, Button KS, Churchill R, Derrick C, Dowrick C, Gilbody S, Fawsitt C, Hollingworth W, Jones V, Kendrick T, Kessler D, Kounali D, Khan N, Lanham P, Pervin J, Peters TJ, Riozzie D, Salaminios G, Thomas L, Welton NJ, Wiles N, Woodhouse R, Lewis G.

Lancet Psychiatry. 2019 Sep 19. pii: S2215-0366(19)30366-9. doi: 10.1016/S2215-0366(19)30366-9. [Epub ahead of print]


Moving Beyond the Stethoscope: Diagnostic Point-of-Care Ultrasound in Pediatric Practice.

Conlon TW, Nishisaki A, Singh Y, Bhombal S, De Luca D, Kessler DO, Su ER, Chen AE, Fraga MV.

Pediatrics. 2019 Oct;144(4). pii: e20191402. doi: 10.1542/peds.2019-1402. Epub 2019 Sep 3. Review.


Acceptability of the BATHE technique amongst GPs and frequently attending patients in primary care: a nested qualitative study.

Thomas C, Cramer H, Jackson S, Kessler D, Metcalfe C, Record C, Barnes RK.

BMC Fam Pract. 2019 Sep 3;20(1):121. doi: 10.1186/s12875-019-1011-y.


An expert consensus on the most effective components of cognitive behavioural therapy for adults with depression: a modified Delphi study.

Taylor A, Tallon D, Kessler D, Peters TJ, Shafran R, Williams C, Wiles N.

Cogn Behav Ther. 2019 Aug 20:1-14. doi: 10.1080/16506073.2019.1641146. [Epub ahead of print]


Protocol for a feasibility randomised trial of low-intensity interventions for antenatal depression: ADAGIO trial comparing interpersonal counselling with cognitive behavioural therapy.

Ingram J, Johnson D, Johnson S, O'Mahen HA, Kessler D, Taylor H, Law R, Round J, Ford J, Hopley R, Glynn J, Culpin I, Evans J.

BMJ Open. 2019 Aug 18;9(8):e032649. doi: 10.1136/bmjopen-2019-032649.


Donor Iron Deficiency Study (DIDS): protocol of a study to test whether iron deficiency in blood donors affects red blood cell recovery after transfusion.

Bitan ZC, Zhou A, McMahon DJ, Kessler D, Shaz BH, Caccappolo E, Schwartz J, Francis RO, Brittenham GM, Spitalnik SL, Hod EA.

Blood Transfus. 2019 Jul;17(4):274-280. doi: 10.2450/2019.0066-19.


Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis.

Weinstabl H, Treu M, Rinnenthal J, Zahn SK, Ettmayer P, Bader G, Dahmann G, Kessler D, Rumpel K, Mischerikow N, Savarese F, Gerstberger T, Mayer M, Zoephel A, Schnitzer R, Sommergruber W, Martinelli P, Arnhof H, Peric-Simov B, Hofbauer KS, Garavel G, Scherbantin Y, Mitzner S, Fett TN, Scholz G, Bruchhaus J, Burkard M, Kousek R, Ciftci T, Sharps B, Schrenk A, Harrer C, Haering D, Wolkerstorfer B, Zhang X, Lv X, Du A, Li D, Li Y, Quant J, Pearson M, McConnell DB.

J Med Chem. 2019 Sep 12;62(17):7976-7997. doi: 10.1021/acs.jmedchem.9b00718. Epub 2019 Aug 14.


Consensus Core Point-of-care Ultrasound Applications for Pediatric Emergency Medicine Training.

Shefrin AE, Warkentine F, Constantine E, Toney A, Uya A, Doniger SJ, Sivitz AB, Horowitz R, Kessler D.

AEM Educ Train. 2019 Mar 14;3(3):251-258. doi: 10.1002/aet2.10332. eCollection 2019 Jul.


Prioritising physical and psychological symptoms: what are the barriers and facilitators to the discussion of anxiety in the primary care consultation?

Barnes MC, Kessler D, Archer C, Wiles N.

BMC Fam Pract. 2019 Jul 27;20(1):106. doi: 10.1186/s12875-019-0996-6.


Drugging an undruggable pocket on KRAS.

Kessler D, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, Mayer M, Gollner A, Covini D, Fischer S, Gerstberger T, Gmaschitz T, Goodwin C, Greb P, Häring D, Hela W, Hoffmann J, Karolyi-Oezguer J, Knesl P, Kornigg S, Koegl M, Kousek R, Lamarre L, Moser F, Munico-Martinez S, Peinsipp C, Phan J, Rinnenthal J, Sai J, Salamon C, Scherbantin Y, Schipany K, Schnitzer R, Schrenk A, Sharps B, Siszler G, Sun Q, Waterson A, Wolkerstorfer B, Zeeb M, Pearson M, Fesik SW, McConnell DB.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15823-15829. doi: 10.1073/pnas.1904529116. Epub 2019 Jul 22.


KRAS Binders Hidden in Nature.

Bergner A, Cockcroft X, Fischer G, Gollner A, Hela W, Kousek R, Mantoulidis A, Martin LJ, Mayer M, Müllauer B, Siszler G, Wolkerstorfer B, Kessler D, McConnell DB.

Chemistry. 2019 Sep 18;25(52):12037-12041. doi: 10.1002/chem.201902810. Epub 2019 Jul 25.


An automated motivational interview promotes donation intention and self-efficacy among experienced whole blood donors.

Livitz IE, France CR, France JL, Fox KR, Ankawi B, Slepian PM, Kessler DA, Rebosa M, Shaz BH.

Transfusion. 2019 Sep;59(9):2876-2884. doi: 10.1111/trf.15402. Epub 2019 Jun 14.


Time-Gated Word Recognition in Children: Effects of Auditory Access, Age, and Semantic Context.

Walker EA, Kessler D, Klein K, Spratford M, Oleson JJ, Welhaven A, McCreery RW.

J Speech Lang Hear Res. 2019 Jul 15;62(7):2519-2534. doi: 10.1044/2019_JSLHR-H-18-0407. Epub 2019 Jun 13.


The process and delivery of CBT for depression in adults: a systematic review and network meta-analysis.

López-López JA, Davies SR, Caldwell DM, Churchill R, Peters TJ, Tallon D, Dawson S, Wu Q, Li J, Taylor A, Lewis G, Kessler DS, Wiles N, Welton NJ.

Psychol Med. 2019 Sep;49(12):1937-1947. doi: 10.1017/S003329171900120X. Epub 2019 Jun 10.


A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER: ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial.

Duffy L, Bacon F, Clarke CS, Donkor Y, Freemantle N, Gilbody S, Hunter R, Kendrick T, Kessler D, King M, Lanham P, Lewis G, Mangin D, Marston L, Moore M, Nazareth I, Wiles N, Lewis G.

Trials. 2019 Jun 3;20(1):319. doi: 10.1186/s13063-019-3390-8.


Implementation of a responsible conduct of research education program at Duke University School of Medicine.

Simon C, Beerman RW, Ariansen JL, Kessler D, Sanchez AM, King K, Sarzotti-Kelsoe M, Samsa G, Bradley A, Torres L, Califf R, Swamy GK.

Account Res. 2019 Jul;26(5):288-310. doi: 10.1080/08989621.2019.1621755. Epub 2019 Jun 2.


Ten years of TRALI mitigation: measuring our progress.

Vossoughi S, Gorlin J, Kessler DA, Hillyer CD, Van Buren NL, Jimenez A, Shaz BH.

Transfusion. 2019 Aug;59(8):2567-2574. doi: 10.1111/trf.15387. Epub 2019 May 30.


A consultation-level intervention to improve care of frequently attending patients: a cluster randomised controlled feasibility trial.

Barnes RK, Cramer H, Thomas C, Sanderson E, Hollinghurst S, Metcalfe C, Jackson S, Record C, Thorley H, Kessler D.

BJGP Open. 2019 Jan 9;3(1):bjgpopen18X101623. doi: 10.3399/bjgpopen18X101623. eCollection 2019 Apr.


Obstacles to recruitment in paediatric studies focusing on mental health in a physical health context: the experiences of clinical gatekeepers in an observational cohort study.

Loades ME, Smith L, Higson-Sweeney N, Beasant L, Stallard P, Kessler D, Crawley E.

BMC Med Res Methodol. 2019 Apr 27;19(1):89. doi: 10.1186/s12874-019-0730-z.


From Non-Normalizable Boltzmann-Gibbs Statistics to Infinite-Ergodic Theory.

Aghion E, Kessler DA, Barkai E.

Phys Rev Lett. 2019 Jan 11;122(1):010601. doi: 10.1103/PhysRevLett.122.010601.


Influence of Cardiopulmonary Resuscitation Coaching and Provider Role on Perception of Cardiopulmonary Resuscitation Quality During Simulated Pediatric Cardiac Arrest.

Cheng A, Kessler D, Lin Y, Tofil NM, Hunt EA, Davidson J, Chatfield J, Duff JP; International Network for Simulation-based Pediatric Innovation, Research and Education (INSPIRE) CPR Investigators.

Pediatr Crit Care Med. 2019 Apr;20(4):e191-e198. doi: 10.1097/PCC.0000000000001871.


The effect of an International competitive leaderboard on self-motivated simulation-based CPR practice among healthcare professionals: A randomized control trial.

Chang TP, Raymond T, Dewan M, MacKinnon R, Whitfill T, Harwayne-Gidansky I, Doughty C, Frisell K, Kessler D, Wolfe H, Auerbach M, Rutledge C, Mitchell D, Jani P, Walsh CM; INSPIRE In-Hospital QCPR Leaderboard Investigators.

Resuscitation. 2019 May;138:273-281. doi: 10.1016/j.resuscitation.2019.02.050. Epub 2019 Apr 1.


Abiotic transformation products of tetracycline and chlortetracycline in salt solutions and manure.

Keßler DN, Fokuhl VK, Petri MS, Spielmeyer A.

Chemosphere. 2019 Jun;224:487-493. doi: 10.1016/j.chemosphere.2019.02.169. Epub 2019 Feb 25.


GPs' views and experiences of managing patients with personality disorder: a qualitative interview study.

French L, Moran P, Wiles N, Kessler D, Turner KM.

BMJ Open. 2019 Feb 27;9(2):e026616. doi: 10.1136/bmjopen-2018-026616.


Basic Units of Inter-Individual Variation in Resting State Connectomes.

Sripada C, Angstadt M, Rutherford S, Kessler D, Kim Y, Yee M, Levina E.

Sci Rep. 2019 Feb 13;9(1):1900. doi: 10.1038/s41598-018-38406-5.


Transfusion-Transmitted Zika Virus Infection in Pregnant Mice Leads to Broad Tissue Tropism With Severe Placental Damage and Fetal Demise.

Tai W, Voronin D, Chen J, Bao W, Kessler DA, Shaz B, Jiang S, Yazdanbakhsh K, Du L.

Front Microbiol. 2019 Jan 23;10:29. doi: 10.3389/fmicb.2019.00029. eCollection 2019.


Hereditary elliptocytosis of donor red blood cell unit detected during Coombs crossmatch.

DeSimone RA, Ong SJ, Crowley KM, Vasovic LV, Senaldi E, Kessler DA, Goel R, Hsu YS.

Transfusion. 2019 Feb;59(2):446-447. doi: 10.1111/trf.14981. No abstract available.


Resting state network modularity along the prodromal late onset Alzheimer's disease continuum.

Contreras JA, Avena-Koenigsberger A, Risacher SL, West JD, Tallman E, McDonald BC, Farlow MR, Apostolova LG, Goñi J, Dzemidzic M, Wu YC, Kessler D, Jeub L, Fortunato S, Saykin AJ, Sporns O.

Neuroimage Clin. 2019;22:101687. doi: 10.1016/j.nicl.2019.101687. Epub 2019 Jan 22.


IntEgrating Smoking Cessation treatment As part of usual Psychological care for dEpression and anxiety (ESCAPE): protocol for a randomised and controlled, multicentre, acceptability, feasibility and implementation trial.

Taylor G, Aveyard P, Bartlem K, Shaw A, Player J, Metcalfe C, Kessler D, Munafò M.

Pilot Feasibility Stud. 2019 Jan 22;5:16. doi: 10.1186/s40814-018-0385-2. eCollection 2019.


Credentialing Pediatric Emergency Medicine Faculty in Point-of-Care Ultrasound: Expert Guidelines.

Abo AM, Alade KH, Rempell RG, Kessler D, Fischer JW, Lewiss RE, Raio CC, Marin JR.

Pediatr Emerg Care. 2019 Jan 7. doi: 10.1097/PEC.0000000000001677. [Epub ahead of print]


Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole.

Osmanovic D, Kessler DA, Rabin Y, Soen Y.

Biol Direct. 2018 Oct 26;13(1):24. doi: 10.1186/s13062-018-0224-7.


Seven Former FDA Commissioners: The FDA Should Be An Independent Federal Agency.

Califf RM, Hamburg M, Henney JE, Kessler DA, McClellan M, von Eschenbach AC, Young F.

Health Aff (Millwood). 2019 Jan;38(1):84-86. doi: 10.1377/hlthaff.2018.05185.


Use of Capnography and Cardiopulmonary Resuscitation Feedback Devices Among Prehospital Advanced Life Support Providers.

Sahyoun C, Siliciano C, Kessler D.

Pediatr Emerg Care. 2018 Dec 27. doi: 10.1097/PEC.0000000000001685. [Epub ahead of print]


Development of the Integrated Parkinson's Care Network (IPCN): using co-design to plan collaborative care for people with Parkinson's disease.

Kessler D, Hauteclocque J, Grimes D, Mestre T, Côtéd D, Liddy C.

Qual Life Res. 2019 May;28(5):1355-1364. doi: 10.1007/s11136-018-2092-0. Epub 2019 Jan 2.


GPs' attitudes towards digital technologies for depression: an online survey in primary care.

Breedvelt JJ, Zamperoni V, Kessler D, Riper H, Kleiboer AM, Elliott I, Abel KM, Gilbody S, Bockting CL.

Br J Gen Pract. 2019 Mar;69(680):e164-e170. doi: 10.3399/bjgp18X700721. Epub 2018 Dec 17.


Competition in Outpatient Procedure Markets.

Baker LC, Bundorf MK, Kessler DP.

Med Care. 2019 Jan;57(1):36-41. doi: 10.1097/MLR.0000000000001003.


Materials used to support cognitive behavioural therapy for depression: a survey of therapists' clinical practice and views.

Tallon D, McClay CA, Kessler D, Lewis G, Peters TJ, Shafran R, Williams C, Wiles N.

Cogn Behav Ther. 2019 Nov;48(6):463-481. doi: 10.1080/16506073.2018.1541927. Epub 2018 Dec 3.


Combining mirtazapine with SSRIs or SNRIs for treatment-resistant depression: the MIR RCT.

Kessler D, Burns A, Tallon D, Lewis G, MacNeill S, Round J, Hollingworth W, Chew-Graham C, Anderson I, Campbell J, Dickens C, Macleod U, Gilbody S, Davies S, Peters TJ, Wiles N.

Health Technol Assess. 2018 Nov;22(63):1-136. doi: 10.3310/hta22630.


Contralateral Routing of Signal Yields Significant Speech in Noise Benefit for Unilateral Cochlear Implant Recipients.

Dwyer RT, Kessler D, Butera IM, Gifford RH.

J Am Acad Audiol. 2019 Mar;30(3):235-242. doi: 10.3766/jaaa.17117. Epub 2018 Jan 30.


Donor incentives improve cardiovascular disease risk profile and donation rates.

Goel R, Kessler D, Nandi V, Ortiz C, Hillyer CD, Shaz BH.

Transfusion. 2019 Jan;59(1):250-258. doi: 10.1111/trf.14989. Epub 2018 Nov 8.


Age- and sex-dependent changes in levels of circulating brain-enriched microRNAs during normal aging.

Sheinerman K, Tsivinsky V, Mathur A, Kessler D, Shaz B, Umansky S.

Aging (Albany NY). 2018 Oct 31;10(10):3017-3041. doi: 10.18632/aging.101613.


Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR).

Kessler DS, MacNeill SJ, Tallon D, Lewis G, Peters TJ, Hollingworth W, Round J, Burns A, Chew-Graham CA, Anderson IM, Shepherd T, Campbell J, Dickens CM, Carter M, Jenkinson C, Macleod U, Gibson H, Davies S, Wiles NJ.

BMJ. 2018 Oct 31;363:k4218. doi: 10.1136/bmj.k4218. Erratum in: BMJ. 2018 Nov 15;363:k4691.


Pediatric Feeding Disorder: Consensus Definition and Conceptual Framework.

Goday PS, Huh SY, Silverman A, Lukens CT, Dodrill P, Cohen SS, Delaney AL, Feuling MB, Noel RJ, Gisel E, Kenzer A, Kessler DB, Kraus de Camargo O, Browne J, Phalen JA.

J Pediatr Gastroenterol Nutr. 2019 Jan;68(1):124-129. doi: 10.1097/MPG.0000000000002188.


Synthesizing Qualitative Data Sets to Improve the Design of Trials and Complex Health Interventions: A Worked Example.

Turner KM, Percival J, Kessler D, Donovan JL.

Qual Health Res. 2019 Apr;29(5):693-699. doi: 10.1177/1049732318803894. Epub 2018 Oct 8.


Simulation of spatial systems with demographic noise.

Weissmann H, Shnerb NM, Kessler DA.

Phys Rev E. 2018 Aug;98(2-1):022131. doi: 10.1103/PhysRevE.98.022131.


Management of treatment-resistant depression in primary care: a mixed-methods study.

Wiles N, Taylor A, Turner N, Barnes M, Campbell J, Lewis G, Morrison J, Peters TJ, Thomas L, Turner K, Kessler D.

Br J Gen Pract. 2018 Oct;68(675):e673-e681. doi: 10.3399/bjgp18X699053.


Neurophysiological monitoring during cervical spine surgeries: Longitudinal costs and outcomes.

Ney JP, Kessler DP.

Clin Neurophysiol. 2018 Nov;129(11):2245-2251. doi: 10.1016/j.clinph.2018.08.002. Epub 2018 Aug 29.


Adherence to Pediatric Cardiac Arrest Guidelines Across a Spectrum of Fifty Emergency Departments: A Prospective, In Situ, Simulation-based Study.

Auerbach M, Brown L, Whitfill T, Baird J, Abulebda K, Bhatnagar A, Lutfi R, Gawel M, Walsh B, Tay KY, Lavoie M, Nadkarni V, Dudas R, Kessler D, Katznelson J, Ganghadaran S, Hamilton MF.

Acad Emerg Med. 2018 Dec;25(12):1396-1408. doi: 10.1111/acem.13564. Epub 2018 Oct 25.


Optimizing CPR performance with CPR coaching for pediatric cardiac arrest: A randomized simulation-based clinical trial.

Cheng A, Duff JP, Kessler D, Tofil NM, Davidson J, Lin Y, Chatfield J, Brown LL, Hunt EA; International Network for Simulation-based Pediatric Innovation Research and Education (INSPIRE) CPR.

Resuscitation. 2018 Nov;132:33-40. doi: 10.1016/j.resuscitation.2018.08.021. Epub 2018 Aug 24.


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