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Items: 1 to 50 of 210

1.

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.

Bailey JD, Diotallevi M, Nicol T, McNeill E, Shaw A, Chuaiphichai S, Hale A, Starr A, Nandi M, Stylianou E, McShane H, Davis S, Fischer R, Kessler BM, McCullagh J, Channon KM, Crabtree MJ.

Cell Rep. 2019 Jul 2;28(1):218-230.e7. doi: 10.1016/j.celrep.2019.06.018.

2.

Molecular insights into an ancient form of Paget's disease of bone.

Shaw B, Burrell CL, Green D, Navarro-Martinez A, Scott D, Daroszewska A, van 't Hof R, Smith L, Hargrave F, Mistry S, Bottrill A, Kessler BM, Fischer R, Singh A, Dalmay T, Fraser WD, Henneberger K, King T, Gonzalez S, Layfield R.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10463-10472. doi: 10.1073/pnas.1820556116. Epub 2019 Apr 29.

3.

Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads.

Müller CA, Boemo MA, Spingardi P, Kessler BM, Kriaucionis S, Simpson JT, Nieduszynski CA.

Nat Methods. 2019 May;16(5):429-436. doi: 10.1038/s41592-019-0394-y. Epub 2019 Apr 22.

PMID:
31011185
4.

Improved profiling of polyamines using two-dimensional gas chromatography mass spectrometry.

Yu Z, Huang H, Zhang H, Kessler BM.

Talanta. 2019 Jul 1;199:184-188. doi: 10.1016/j.talanta.2019.02.062. Epub 2019 Feb 18.

PMID:
30952244
5.

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7.

Sapmaz A, Berlin I, Bos E, Wijdeven RH, Janssen H, Konietzny R, Akkermans JJ, Erson-Bensan AE, Koning RI, Kessler BM, Neefjes J, Ovaa H.

Nat Commun. 2019 Mar 29;10(1):1454. doi: 10.1038/s41467-019-09437-x.

6.

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.

Leimbacher PA, Jones SE, Shorrocks AK, de Marco Zompit M, Day M, Blaauwendraad J, Bundschuh D, Bonham S, Fischer R, Fink D, Kessler BM, Oliver AW, Pearl LH, Blackford AN, Stucki M.

Mol Cell. 2019 May 2;74(3):571-583.e8. doi: 10.1016/j.molcel.2019.02.014. Epub 2019 Mar 18.

7.

Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism.

Valli A, Morotti M, Zois CE, Albers PK, Soga T, Feldinger K, Fischer R, Frejno M, McIntyre A, Bridges E, Haider S, Buffa FM, Baban D, Rodriguez M, Yanes O, Whittington HJ, Lake HA, Zervou S, Lygate CA, Kessler BM, Harris AL.

Mol Cancer Res. 2019 Jul;17(7):1531-1544. doi: 10.1158/1541-7786.MCR-18-0315. Epub 2019 Mar 18.

PMID:
30885992
8.

From herbal small RNAs to one medicine.

Ji C, Kriaucionis S, Kessler BM, Jiang C.

Sci China Life Sci. 2019 Mar;62(3):285-287. doi: 10.1007/s11427-019-9513-y. Epub 2019 Mar 1. No abstract available.

PMID:
30863963
9.

Colonic epithelial cell diversity in health and inflammatory bowel disease.

Parikh K, Antanaviciute A, Fawkner-Corbett D, Jagielowicz M, Aulicino A, Lagerholm C, Davis S, Kinchen J, Chen HH, Alham NK, Ashley N, Johnson E, Hublitz P, Bao L, Lukomska J, Andev RS, Björklund E, Kessler BM, Fischer R, Goldin R, Koohy H, Simmons A.

Nature. 2019 Mar;567(7746):49-55. doi: 10.1038/s41586-019-0992-y. Epub 2019 Feb 27.

PMID:
30814735
10.

Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting.

Olie CS, Riaz M, Konietzny R, Charles PD, Pinto-Fernandez A, Kiełbasa SM, Aartsma-Rus A, Goeman JJ, Kessler BM, Raz V.

iScience. 2019 Feb 22;12:318-332. doi: 10.1016/j.isci.2019.01.024. Epub 2019 Jan 22.

11.

Human Platelet Protein Ubiquitylation and Changes following GPVI Activation.

Unsworth AJ, Bombik I, Pinto-Fernandez A, McGouran JF, Konietzny R, Zahedi RP, Watson SP, Kessler BM, Pears CJ.

Thromb Haemost. 2019 Jan;119(1):104-116. doi: 10.1055/s-0038-1676344. Epub 2018 Dec 31.

12.

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains.

D'Ascenzio M, Pugh KM, Konietzny R, Berridge G, Tallant C, Hashem S, Monteiro O, Thomas JR, Schirle M, Knapp S, Marsden B, Fedorov O, Bountra C, Kessler BM, Brennan PE.

Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1007-1012. doi: 10.1002/anie.201807825. Epub 2018 Dec 27.

13.

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.

Volkmar N, Thezenas ML, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC.

J Cell Sci. 2019 Jan 16;132(2). pii: jcs223453. doi: 10.1242/jcs.223453.

14.

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.

Nishi R, Wijnhoven PWG, Kimura Y, Matsui M, Konietzny R, Wu Q, Nakamura K, Blundell TL, Kessler BM.

Sci Rep. 2018 Dec 17;8(1):17891. doi: 10.1038/s41598-018-36235-0.

15.

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.

Yuzhalin AE, Gordon-Weeks AN, Tognoli ML, Jones K, Markelc B, Konietzny R, Fischer R, Muth A, O'Neill E, Thompson PR, Venables PJ, Kessler BM, Lim SY, Muschel RJ.

Nat Commun. 2018 Nov 14;9(1):4783. doi: 10.1038/s41467-018-07306-7.

16.

UFLC-Derived CSF Extracellular Vesicle Origin and Proteome.

Thompson AG, Gray E, Mager I, Fischer R, Thézénas ML, Charles PD, Talbot K, El Andaloussi S, Kessler BM, Wood M, Turner MR.

Proteomics. 2018 Dec;18(24):e1800257. doi: 10.1002/pmic.201800257. Epub 2018 Dec 10.

PMID:
30411858
17.

Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.

Motnenko A, Liang CC, Yang D, Lopez-Martinez D, Yoshikawa Y, Zhan B, Ward KE, Tian J, Haas W, Spingardi P, Kessler BM, Kriaucionis S, Gygi SP, Cohn MA.

PLoS Genet. 2018 Oct 18;14(10):e1007643. doi: 10.1371/journal.pgen.1007643. eCollection 2018 Oct.

18.

Quantitative Proteomics Identification of Seminal Fluid Proteins in Male Drosophila melanogaster.

Sepil I, Hopkins BR, Dean R, Thézénas ML, Charles PD, Konietzny R, Fischer R, Kessler BM, Wigby S.

Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S46-S58. doi: 10.1074/mcp.RA118.000831. Epub 2018 Oct 4.

19.

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression.

Mavrommati I, Faedda R, Galasso G, Li J, Burdova K, Fischer R, Kessler BM, Carrero ZI, Guardavaccaro D, Pagano M, D'Angiolella V.

Cell Rep. 2018 Sep 25;24(13):3404-3412. doi: 10.1016/j.celrep.2018.08.076.

20.

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation.

Bailey J, Davis S, Shaw A, Diotallevi M, Fischer R, Benson MA, Zhu H, Brown J, Bhattacharya S, Kessler BM, Channon KM, Crabtree MJ.

Sci Rep. 2018 Sep 25;8(1):14310. doi: 10.1038/s41598-018-32481-4.

21.

Proteomic profiling of the plasma of Gambian children with cerebral malaria.

Moussa EM, Huang H, Thézénas ML, Fischer R, Ramaprasad A, Sisay-Joof F, Jallow M, Pain A, Kwiatkowski D, Kessler BM, Casals-Pascual C.

Malar J. 2018 Sep 24;17(1):337. doi: 10.1186/s12936-018-2487-y.

22.

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

Zhang T, Wei G, Millard CJ, Fischer R, Konietzny R, Kessler BM, Schwabe JWR, Brockdorff N.

Nat Commun. 2018 Sep 18;9(1):3798. doi: 10.1038/s41467-018-06235-9.

23.

53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.

Ghezraoui H, Oliveira C, Becker JR, Bilham K, Moralli D, Anzilotti C, Fischer R, Deobagkar-Lele M, Sanchiz-Calvo M, Fueyo-Marcos E, Bonham S, Kessler BM, Rottenberg S, Cornall RJ, Green CM, Chapman JR.

Nature. 2018 Aug;560(7716):122-127. doi: 10.1038/s41586-018-0362-1. Epub 2018 Jul 25.

PMID:
30046110
24.

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ.

Nat Chem Biol. 2018 Oct;14(10):988. doi: 10.1038/s41589-018-0104-6.

PMID:
29950663
25.

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ.

Nat Chem Biol. 2018 Jul;14(7):688-695. doi: 10.1038/s41589-018-0071-y. Epub 2018 Jun 18. Erratum in: Nat Chem Biol. 2018 Jun 27;:.

26.

Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis.

Psallidas I, Kanellakis NI, Gerry S, Thézénas ML, Charles PD, Samsonova A, Schiller HB, Fischer R, Asciak R, Hallifax RJ, Mercer R, Dobson M, Dong T, Pavord ID, Collins GS, Kessler BM, Pass HI, Maskell N, Stathopoulos GT, Rahman NM.

Lancet Oncol. 2018 Jul;19(7):930-939. doi: 10.1016/S1470-2045(18)30294-8. Epub 2018 Jun 13.

PMID:
29908990
27.

Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion.

Huang H, van Dullemen LFA, Akhtar MZ, Faro ML, Yu Z, Valli A, Dona A, Thézénas ML, Charles PD, Fischer R, Kaisar M, Leuvenink HGD, Ploeg RJ, Kessler BM.

Sci Rep. 2018 Jun 4;8(1):8539. doi: 10.1038/s41598-018-26804-8.

28.

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.

Dimitrova E, Kondo T, Feldmann A, Nakayama M, Koseki Y, Konietzny R, Kessler BM, Koseki H, Klose RJ.

Elife. 2018 May 29;7. pii: e37084. doi: 10.7554/eLife.37084.

29.

Immunopeptidomic Profiling of HLA-A2-Positive Triple Negative Breast Cancer Identifies Potential Immunotherapy Target Antigens.

Ternette N, Olde Nordkamp MJM, Müller J, Anderson AP, Nicastri A, Hill AVS, Kessler BM, Li D.

Proteomics. 2018 Jun;18(12):e1700465. doi: 10.1002/pmic.201700465.

30.

Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows.

Partridge T, Nicastri A, Kliszczak AE, Yindom LM, Kessler BM, Ternette N, Borrow P.

Front Immunol. 2018 Apr 27;9:912. doi: 10.3389/fimmu.2018.00912. eCollection 2018.

31.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.

Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28.

32.

A robust mass spectrometry method for rapid profiling of erythrocyte ghost membrane proteomes.

Fye HKS, Mrosso P, Bruce L, Thézénas ML, Davis S, Fischer R, Rwegasira GL, Makani J, Kessler BM.

Clin Proteomics. 2018 Mar 21;15:14. doi: 10.1186/s12014-018-9190-4. eCollection 2018.

33.

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.

Fung E, Richter C, Yang HB, Schäffer I, Fischer R, Kessler BM, Bassermann F, D'Angiolella V.

EMBO Rep. 2018 Mar;19(3). pii: e44799. doi: 10.15252/embr.201744799. Epub 2018 Jan 18.

34.

Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice.

Kanellopoulos AH, Koenig J, Huang H, Pyrski M, Millet Q, Lolignier S, Morohashi T, Gossage SJ, Jay M, Linley JE, Baskozos G, Kessler BM, Cox JJ, Dolphin AC, Zufall F, Wood JN, Zhao J.

EMBO J. 2018 Feb 1;37(3):427-445. doi: 10.15252/embj.201796692. Epub 2018 Jan 15.

35.

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis.

Thompson AG, Gray E, Thézénas ML, Charles PD, Evetts S, Hu MT, Talbot K, Fischer R, Kessler BM, Turner MR.

Ann Neurol. 2018 Feb;83(2):258-268. doi: 10.1002/ana.25143. Epub 2018 Feb 9.

PMID:
29331073
36.

Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis.

Schwenzer A, Quirke AM, Marzeda AM, Wong A, Montgomery AB, Sayles HR, Eick S, Gawron K, Chomyszyn-Gajewska M, Łazarz-Bartyzel K, Davis S, Potempa J, Kessler BM, Fischer R, Venables PJ, Payne JB, Mikuls TR, Midwood KS.

Arthritis Rheumatol. 2017 Dec;69(12):2303-2313. doi: 10.1002/art.40227. Epub 2017 Oct 30.

37.

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D.

Nature. 2017 Oct 26;550(7677):481-486. doi: 10.1038/nature24451. Epub 2017 Oct 18.

38.

Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.

Schuller M, Riedel K, Gibbs-Seymour I, Uth K, Sieg C, Gehring AP, Ahel I, Bracher F, Kessler BM, Elkins JM, Knapp S.

ACS Chem Biol. 2017 Nov 17;12(11):2866-2874. doi: 10.1021/acschembio.7b00445. Epub 2017 Oct 19.

39.

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.

Gerken PA, Wolstenhulme JR, Tumber A, Hatch SB, Zhang Y, Müller S, Chandler SA, Mair B, Li F, Nijman SMB, Konietzny R, Szommer T, Yapp C, Fedorov O, Benesch JLP, Vedadi M, Kessler BM, Kawamura A, Brennan PE, Smith MD.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15555-15559. doi: 10.1002/anie.201706788. Epub 2017 Nov 7.

40.

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.

Adam J, Ramracheya R, Chibalina MV, Ternette N, Hamilton A, Tarasov AI, Zhang Q, Rebelato E, Rorsman NJG, Martín-Del-Río R, Lewis A, Özkan G, Do HW, Spégel P, Saitoh K, Kato K, Igarashi K, Kessler BM, Pugh CW, Tamarit-Rodriguez J, Mulder H, Clark A, Frizzell N, Soga T, Ashcroft FM, Silver A, Pollard PJ, Rorsman P.

Cell Rep. 2017 Sep 26;20(13):3135-3148. doi: 10.1016/j.celrep.2017.08.093.

41.

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

Weber A, Elliott PR, Pinto-Fernandez A, Bonham S, Kessler BM, Komander D, El Oualid F, Krappmann D.

Cell Chem Biol. 2017 Oct 19;24(10):1299-1313.e7. doi: 10.1016/j.chembiol.2017.08.006. Epub 2017 Sep 14.

42.

Mechanisms by which Porphyromonas gingivalis evades innate immunity.

Abdi K, Chen T, Klein BA, Tai AK, Coursen J, Liu X, Skinner J, Periasamy S, Choi Y, Kessler BM, Palmer RJ, Gittis A, Matzinger P, Duncan MJ, Singh NJ.

PLoS One. 2017 Aug 3;12(8):e0182164. doi: 10.1371/journal.pone.0182164. eCollection 2017.

43.

A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption.

Lee R, Fischer R, Charles PD, Adlam D, Valli A, Di Gleria K, Kharbanda RK, Choudhury RP, Antoniades C, Kessler BM, Channon KM.

Clin Proteomics. 2017 Jun 19;14:22. doi: 10.1186/s12014-017-9157-x. eCollection 2017.

44.

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.

Munro S, Hookway ES, Floderer M, Carr SM, Konietzny R, Kessler BM, Oppermann U, La Thangue NB.

Cell Rep. 2017 Jun 13;19(11):2193-2201. doi: 10.1016/j.celrep.2017.05.053.

45.

Proteomic profiling of the brain of mice with experimental cerebral malaria.

Moussa E, Huang H, Ahras M, Lall A, Thezenas ML, Fischer R, Kessler BM, Pain A, Billker O, Casals-Pascual C.

J Proteomics. 2018 May 30;180:61-69. doi: 10.1016/j.jprot.2017.06.002. Epub 2017 Jun 5.

PMID:
28602553
46.

A quantitative label-free analysis of the extracellular proteome of human supraspinatus tendon reveals damage to the pericellular and elastic fibre niches in torn and aged tissue.

Hakimi O, Ternette N, Murphy R, Kessler BM, Carr A.

PLoS One. 2017 May 18;12(5):e0177656. doi: 10.1371/journal.pone.0177656. eCollection 2017.

47.

Correction: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.

Endoh M, Endo TA, Shinga J, Hayashi K, Farcas A, Ma KW, Ito S, Sharif J, Endoh T, Onaga N, Nakayama M, Ishikura T, Masui O, Kessler BM, Suda T, Ohara O, Okuda A, Klose RJ, Koseki H.

Elife. 2017 Apr 25;6. pii: e27970. doi: 10.7554/eLife.27970. No abstract available.

48.

Phosphorylation Induces Structural Changes in the Autographa californica Nucleopolyhedrovirus P10 Protein.

Raza F, McGouran JF, Kessler BM, Possee RD, King LA.

J Virol. 2017 Jun 9;91(13). pii: e00002-17. doi: 10.1128/JVI.00002-17. Print 2017 Jul 1.

49.

Protein arginine methylation: a prominent modification and its demethylation.

Wesche J, Kühn S, Kessler BM, Salton M, Wolf A.

Cell Mol Life Sci. 2017 Sep;74(18):3305-3315. doi: 10.1007/s00018-017-2515-z. Epub 2017 Mar 31. Review.

PMID:
28364192
50.

E3 Ligase cIAP2 Mediates Downregulation of MRE11 and Radiosensitization in Response to HDAC Inhibition in Bladder Cancer.

Nicholson J, Jevons SJ, Groselj B, Ellermann S, Konietzny R, Kerr M, Kessler BM, Kiltie AE.

Cancer Res. 2017 Jun 1;77(11):3027-3039. doi: 10.1158/0008-5472.CAN-16-3232. Epub 2017 Mar 31.

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