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Items: 1 to 50 of 61

1.

RNase H-dependent PCR-enabled T-cell receptor sequencing for highly specific and efficient targeted sequencing of T-cell receptor mRNA for single-cell and repertoire analysis.

Li S, Sun J, Allesøe R, Datta K, Bao Y, Oliveira G, Forman J, Jin R, Olsen LR, Keskin DB, Shukla SA, Wu CJ, Livak KJ.

Nat Protoc. 2019 Aug;14(8):2571-2594. doi: 10.1038/s41596-019-0195-x. Epub 2019 Jul 24.

PMID:
31341290
2.

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial.

Keskin DB, Anandappa AJ, Sun J, Tirosh I, Mathewson ND, Li S, Oliveira G, Giobbie-Hurder A, Felt K, Gjini E, Shukla SA, Hu Z, Li L, Le PM, Allesøe RL, Richman AR, Kowalczyk MS, Abdelrahman S, Geduldig JE, Charbonneau S, Pelton K, Iorgulescu JB, Elagina L, Zhang W, Olive O, McCluskey C, Olsen LR, Stevens J, Lane WJ, Salazar AM, Daley H, Wen PY, Chiocca EA, Harden M, Lennon NJ, Gabriel S, Getz G, Lander ES, Regev A, Ritz J, Neuberg D, Rodig SJ, Ligon KL, Suvà ML, Wucherpfennig KW, Hacohen N, Fritsch EF, Livak KJ, Ott PA, Wu CJ, Reardon DA.

Nature. 2019 Jan;565(7738):234-239. doi: 10.1038/s41586-018-0792-9. Epub 2018 Dec 19.

3.

Acquired mechanisms of immune escape in cancer following immunotherapy.

Iorgulescu JB, Braun D, Oliveira G, Keskin DB, Wu CJ.

Genome Med. 2018 Nov 22;10(1):87. doi: 10.1186/s13073-018-0598-2.

4.

A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens.

Hu Z, Anandappa AJ, Sun J, Kim J, Leet DE, Bozym DJ, Chen C, Williams L, Shukla SA, Zhang W, Tabbaa D, Steelman S, Olive O, Livak KJ, Kishi H, Muraguchi A, Guleria I, Stevens J, Lane WJ, Burkhardt UE, Fritsch EF, Neuberg D, Ott PA, Keskin DB, Hacohen N, Wu CJ.

Blood. 2018 Nov 1;132(18):1911-1921. doi: 10.1182/blood-2018-04-843763. Epub 2018 Aug 27.

PMID:
30150207
5.

Targeting DEC-205-DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis.

Tabansky I, Keskin DB, Watts D, Petzold C, Funaro M, Sands W, Wright P, Yunis EJ, Najjar S, Diamond B, Cao Y, Mooney D, Kretschmer K, Stern JNH.

Mol Med. 2018 May 3;24(1):17. doi: 10.1186/s10020-018-0017-6.

6.

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.

Shukla SA, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, Langer R, Lee PC, Gusenleitner D, Keskin DB, Babadi M, Mohammad A, Gnirke A, Clement K, Cartun ZJ, Van Allen EM, Miao D, Huang Y, Snyder A, Merghoub T, Wolchok JD, Garraway LA, Meissner A, Weber JS, Hacohen N, Neuberg D, Potts PR, Murphy GF, Lian CG, Schadendorf D, Hodi FS, Wu CJ.

Cell. 2018 Apr 19;173(3):624-633.e8. doi: 10.1016/j.cell.2018.03.026. Epub 2018 Apr 12.

7.

Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma.

Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ.

Nature. 2018 Mar 14;555(7696):402. doi: 10.1038/nature25145.

8.

Identification and characterization of HLA-A24-specific XBP1, CD138 (Syndecan-1) and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma.

Bae J, Hideshima T, Zhang GL, Zhou J, Keskin DB, Munshi NC, Anderson KC.

Leukemia. 2018 Mar;32(3):752-764. doi: 10.1038/leu.2017.316. Epub 2017 Nov 1.

9.

TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells.

Yoshizawa A, Bi K, Keskin DB, Zhang G, Reinhold B, Reinherz EL.

Eur J Immunol. 2018 Jan;48(1):128-150. doi: 10.1002/eji.201747174. Epub 2017 Sep 29.

10.

An immunogenic personal neoantigen vaccine for patients with melanoma.

Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ.

Nature. 2017 Jul 13;547(7662):217-221. doi: 10.1038/nature22991. Epub 2017 Jul 5. Erratum in: Nature. 2018 Mar 14;555(7696):402.

11.

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction.

Abelin JG, Keskin DB, Sarkizova S, Hartigan CR, Zhang W, Sidney J, Stevens J, Lane W, Zhang GL, Eisenhaure TM, Clauser KR, Hacohen N, Rooney MS, Carr SA, Wu CJ.

Immunity. 2017 Feb 21;46(2):315-326. doi: 10.1016/j.immuni.2017.02.007.

12.

Erratum to: Advancing drug delivery systems for the treatment of multiple sclerosis.

Tabansky I, Messina MD, Bangeranye C, Goldstein J, Blitz-Shabbir KM, Machado S, Jeganathan V, Wright P, Najjar S, Cao Y, Sands W, Keskin DB, Stern JN.

Immunol Res. 2016 Apr;64(2):640. doi: 10.1007/s12026-016-8791-0. No abstract available.

PMID:
26895430
13.

Advancing drug delivery systems for the treatment of multiple sclerosis.

Tabansky I, Messina MD, Bangeranye C, Goldstein J, Blitz-Shabbir KM, Machado S, Jeganathan V, Wright P, Najjar S, Cao Y, Sands W, Keskin DB, Stern JN.

Immunol Res. 2015 Dec;63(1-3):58-69. doi: 10.1007/s12026-015-8719-0. Review. Erratum in: Immunol Res. 2016 Apr;64(2):640.

PMID:
26475738
14.

Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors.

Bae J, Keskin DB, Cowens K, Lee AH, Dranoff G, Munshi NC, Anderson KC.

J Leuk (Los Angel). 2015 Jun;3(2). pii: 178. Epub 2015 Apr 21.

15.

Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity.

Keskin DB, Reinhold BR, Zhang GL, Ivanov AR, Karger BL, Reinherz EL.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2418. doi: 10.1073/pnas.1503931112. Epub 2015 Apr 6. No abstract available. Erratum in: Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2845.

16.

Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity.

Keskin DB, Reinhold BB, Zhang GL, Ivanov AR, Karger BL, Reinherz EL.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2151-6. doi: 10.1073/pnas.1423482112. Epub 2015 Feb 2.

17.

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.

Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1517-22. doi: 10.1073/pnas.1424829112. Epub 2015 Jan 20.

18.

Human leukocyte antigen typing using a knowledge base coupled with a high-throughput oligonucleotide probe array analysis.

Zhang GL, Keskin DB, Lin HN, Lin HH, DeLuca DS, Leppanen S, Milford EL, Reinherz EL, Brusic V.

Front Immunol. 2014 Nov 27;5:597. doi: 10.3389/fimmu.2014.00597. eCollection 2014.

19.

Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides.

Reinherz EL, Keskin DB, Reinhold B.

Front Immunol. 2014 Sep 4;5:418. doi: 10.3389/fimmu.2014.00418. eCollection 2014. Review.

20.

Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.

Rajasagi M, Shukla SA, Fritsch EF, Keskin DB, DeLuca D, Carmona E, Zhang W, Sougnez C, Cibulskis K, Sidney J, Stevenson K, Ritz J, Neuberg D, Brusic V, Gabriel S, Lander ES, Getz G, Hacohen N, Wu CJ.

Blood. 2014 Jul 17;124(3):453-62. doi: 10.1182/blood-2014-04-567933. Epub 2014 Jun 2.

21.

Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.

Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL.

J Biol Chem. 2014 Jul 4;289(27):18880-92. doi: 10.1074/jbc.M114.574996. Epub 2014 May 21. Erratum in: J Biol Chem. 2015 Jan 2;290(1):239.

22.

HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology.

Zhang GL, Riemer AB, Keskin DB, Chitkushev L, Reinherz EL, Brusic V.

Database (Oxford). 2014 Apr 4;2014:bau031. doi: 10.1093/database/bau031. Print 2014.

23.

Developmental bias in cleavage-stage mouse blastomeres.

Tabansky I, Lenarcic A, Draft RW, Loulier K, Keskin DB, Rosains J, Rivera-Feliciano J, Lichtman JW, Livet J, Stern JN, Sanes JR, Eggan K.

Curr Biol. 2013 Jan 7;23(1):21-31. doi: 10.1016/j.cub.2012.10.054. Epub 2012 Nov 21.

24.

Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients.

Cai A, Keskin DB, DeLuca DS, Alonso A, Zhang W, Zhang GL, Hammond NN, Nardi V, Stone RM, Neuberg D, Sidney J, Brusic V, Wu CJ.

Clin Cancer Res. 2012 Oct 15;18(20):5761-72. doi: 10.1158/1078-0432.CCR-12-1182. Epub 2012 Aug 21.

25.

Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing.

Lank SM, Golbach BA, Creager HM, Wiseman RW, Keskin DB, Reinherz EL, Brusic V, O'Connor DH.

BMC Genomics. 2012 Aug 6;13:378. doi: 10.1186/1471-2164-13-378.

27.

PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.

DeLuca DS, Keskin DB, Zhang GL, Reinherz EL, Brusic V.

BMC Bioinformatics. 2011;12 Suppl 13:S6. doi: 10.1186/1471-2105-12-S13-S6. Epub 2011 Nov 30.

28.

The role of natural killer cells in autoimmune blistering diseases.

Zakka LR, Fradkov E, Keskin DB, Tabansky I, Stern JN, Ahmed AR.

Autoimmunity. 2012 Feb;45(1):44-54. doi: 10.3109/08916934.2011.606446. Epub 2011 Sep 19. Review.

PMID:
21923616
29.

Impaired B cell development and function in the absence of IkappaBNS.

Touma M, Keskin DB, Shiroki F, Saito I, Koyasu S, Reinherz EL, Clayton LK.

J Immunol. 2011 Oct 15;187(8):3942-52. doi: 10.4049/jimmunol.1002109. Epub 2011 Sep 7.

30.

Dana-Farber repository for machine learning in immunology.

Zhang GL, Lin HH, Keskin DB, Reinherz EL, Brusic V.

J Immunol Methods. 2011 Nov 30;374(1-2):18-25. doi: 10.1016/j.jim.2011.07.007. Epub 2011 Jul 18.

31.

Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery.

Zhang Z, Tongchusak S, Mizukami Y, Kang YJ, Ioji T, Touma M, Reinhold B, Keskin DB, Reinherz EL, Sasada T.

Biomaterials. 2011 May;32(14):3666-78. doi: 10.1016/j.biomaterials.2011.01.067. Epub 2011 Feb 23.

PMID:
21345488
32.

Direct identification of an HPV-16 tumor antigen from cervical cancer biopsy specimens.

Keskin DB, Reinhold B, Lee SY, Zhang G, Lank S, O'Connor DH, Berkowitz RS, Brusic V, Kim SJ, Reinherz EL.

Front Immunol. 2011 Dec 13;2:75. doi: 10.3389/fimmu.2011.00075. eCollection 2011.

33.

Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using Peptide block entropy.

Olsen LR, Zhang GL, Keskin DB, Reinherz EL, Brusic V.

Front Immunol. 2011 Dec 20;2:69. doi: 10.3389/fimmu.2011.00069. eCollection 2011.

34.

MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles.

Zhang GL, DeLuca DS, Keskin DB, Chitkushev L, Zlateva T, Lund O, Reinherz EL, Brusic V.

J Immunol Methods. 2011 Nov 30;374(1-2):53-61. doi: 10.1016/j.jim.2010.11.009. Epub 2010 Dec 2.

36.
37.

Association between cancer and immunosuppressive therapy--analysis of selected studies in pemphigus and pemphigoid.

Mabrouk D, Gürcan HM, Keskin DB, Christen WG, Ahmed AR.

Ann Pharmacother. 2010 Nov;44(11):1770-6. doi: 10.1345/aph.1P309. Epub 2010 Oct 5. Review.

PMID:
20923942
38.

Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells.

Stern JN, Keskin DB, Kato Z, Waldner H, Schallenberg S, Anderson A, von Boehmer H, Kretschmer K, Strominger JL.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17280-5. doi: 10.1073/pnas.1010263107. Epub 2010 Sep 20.

39.

A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers.

Riemer AB, Keskin DB, Zhang G, Handley M, Anderson KS, Brusic V, Reinhold B, Reinherz EL.

J Biol Chem. 2010 Sep 17;285(38):29608-22. doi: 10.1074/jbc.M110.126722. Epub 2010 Jul 8.

40.

Bioinformatic identification and characterization of human endothelial cell-restricted genes.

Bhasin M, Yuan L, Keskin DB, Otu HH, Libermann TA, Oettgen P.

BMC Genomics. 2010 May 28;11:342. doi: 10.1186/1471-2164-11-342.

41.

Information for healthcare providers on general features of IGIV with emphasis on differences between commercially available products.

Gürcan HM, Keskin DB, Ahmed AR.

Autoimmun Rev. 2010 Jun;9(8):553-9. doi: 10.1016/j.autrev.2010.03.003. Epub 2010 Mar 24. Review.

PMID:
20346419
42.

Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes.

Ofran Y, Kim HT, Brusic V, Blake L, Mandrell M, Wu CJ, Sarantopoulos S, Bellucci R, Keskin DB, Soiffer RJ, Antin JH, Ritz J.

Clin Cancer Res. 2010 Mar 1;16(5):1642-51. doi: 10.1158/1078-0432.CCR-09-2701. Epub 2010 Feb 16.

43.

A review of the current use of rituximab in autoimmune diseases.

Gürcan HM, Keskin DB, Stern JN, Nitzberg MA, Shekhani H, Ahmed AR.

Int Immunopharmacol. 2009 Jan;9(1):10-25. doi: 10.1016/j.intimp.2008.10.004. Epub 2008 Nov 8. Review.

PMID:
19000786
44.

Rap1 activation is required for Fc gamma receptor-dependent phagocytosis.

Chung J, Serezani CH, Huang SK, Stern JN, Keskin DB, Jagirdar R, Brock TG, Aronoff DM, Peters-Golden M.

J Immunol. 2008 Oct 15;181(8):5501-9.

45.

Strategies for the identification of loci responsible for the pathogenesis of multiple sclerosis.

Stern JN, Keskin DB.

Cell Mol Biol Lett. 2008;13(4):656-66. doi: 10.2478/s11658-008-0030-9. Epub 2008 Aug 23. Review.

46.
47.

Possible role of natural killer cells in pemphigus vulgaris - preliminary observations.

Stern JN, Keskin DB, Barteneva N, Zuniga J, Yunis EJ, Ahmed AR.

Clin Exp Immunol. 2008 Jun;152(3):472-81. doi: 10.1111/j.1365-2249.2008.03638.x. Epub 2008 Mar 28.

48.

Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice.

Stern JN, Keskin DB, Zhang H, Lv H, Kato Z, Strominger JL.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5172-6. doi: 10.1073/pnas.0712131105. Epub 2008 Mar 24.

49.

Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy.

Keskin DB, Stern JN, Fridkis-Hareli M, Razzaque Ahmed A.

Cytokine. 2008 Mar;41(3):315-21. doi: 10.1016/j.cyto.2007.12.007. Erratum in: Cytokine. 2008 Aug;43(2):229.

PMID:
18289869
50.

Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.

Touma M, Antonini V, Kumar M, Osborn SL, Bobenchik AM, Keskin DB, Connolly JE, Grusby MJ, Reinherz EL, Clayton LK.

J Immunol. 2007 Aug 1;179(3):1681-92.

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