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Items: 1 to 50 of 202

1.

Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness.

Ylivinkka I, Sihto H, Tynninen O, Hu Y, Laakso A, Kivisaari R, Laakkonen P, Keski-Oja J, Hyytiäinen M.

J Exp Clin Cancer Res. 2017 Jan 9;36(1):9. doi: 10.1186/s13046-016-0482-0.

2.

Netrin-1: A regulator of cancer cell motility?

Ylivinkka I, Keski-Oja J, Hyytiäinen M.

Eur J Cell Biol. 2016 Nov;95(11):513-520. doi: 10.1016/j.ejcb.2016.10.002. Epub 2016 Oct 19. Review.

PMID:
27793362
3.

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

Tatti O, Gucciardo E, Pekkonen P, Holopainen T, Louhimo R, Repo P, Maliniemi P, Lohi J, Rantanen V, Hautaniemi S, Alitalo K, Ranki A, Ojala PM, Keski-Oja J, Lehti K.

Cancer Res. 2015 May 15;75(10):2083-94. doi: 10.1158/0008-5472.CAN-14-1923. Epub 2015 Mar 25.

4.

NETRIN-4 protects glioblastoma cells FROM temozolomide induced senescence.

Li L, Hu Y, Ylivinkka I, Li H, Chen P, Keski-Oja J, Hyytiäinen M.

PLoS One. 2013 Nov 12;8(11):e80363. doi: 10.1371/journal.pone.0080363. eCollection 2013.

5.

Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment.

Loukovaara S, Lehti K, Robciuc A, Pessi T, Holopainen JM, Koli K, Immonen I, Keski-Oja J.

Graefes Arch Clin Exp Ophthalmol. 2014 Jun;252(6):881-8. doi: 10.1007/s00417-013-2508-z. Epub 2013 Nov 12.

PMID:
24218041
6.

Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.

Makarov A, Ylivinkka I, Nyman TA, Hyytiäinen M, Keski-Oja J.

Cell Biol Int. 2013 Oct;37(10):1080-8. doi: 10.1002/cbin.10134. Epub 2013 Jun 18.

PMID:
23686814
7.

Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion.

Ylivinkka I, Hu Y, Chen P, Rantanen V, Hautaniemi S, Nyman TA, Keski-Oja J, Hyytiäinen M.

J Cell Sci. 2013 Jun 1;126(Pt 11):2459-69. doi: 10.1242/jcs.120022. Epub 2013 Apr 2.

8.

Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy.

Loukovaara S, Robciuc A, Holopainen JM, Lehti K, Pessi T, Liinamaa J, Kukkonen KT, Jauhiainen M, Koli K, Keski-Oja J, Immonen I.

Acta Ophthalmol. 2013 Sep;91(6):531-9. doi: 10.1111/j.1755-3768.2012.02473.x. Epub 2012 Oct 26.

9.

LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma.

Chen H, Ko JM, Wong VC, Hyytiainen M, Keski-Oja J, Chua D, Nicholls JM, Cheung FM, Lee AW, Kwong DL, Chiu PM, Zabarovsky ER, Tsao SW, Tao Q, Kan R, Chan SH, Stanbridge EJ, Lung ML.

Cancer Lett. 2012 Dec 1;325(1):89-98. doi: 10.1016/j.canlet.2012.06.005. Epub 2012 Jun 26.

PMID:
22743615
10.

Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling.

Tamminen JA, Myllärniemi M, Hyytiäinen M, Keski-Oja J, Koli K.

J Cell Biochem. 2012 Jul;113(7):2234-47. doi: 10.1002/jcb.24094.

PMID:
22573546
11.

Netrin-4 promotes glioblastoma cell proliferation through integrin β4 signaling.

Hu Y, Ylivinkka I, Chen P, Li L, Hautaniemi S, Nyman TA, Keski-Oja J, Hyytiäinen M.

Neoplasia. 2012 Mar;14(3):219-27.

12.

Regulation of TGF-β storage and activation in the human idiopathic pulmonary fibrosis lung.

Leppäranta O, Sens C, Salmenkivi K, Kinnula VL, Keski-Oja J, Myllärniemi M, Koli K.

Cell Tissue Res. 2012 Jun;348(3):491-503. doi: 10.1007/s00441-012-1385-9. Epub 2012 Mar 22.

PMID:
22434388
13.

Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion.

Tatti O, Arjama M, Ranki A, Weiss SJ, Keski-Oja J, Lehti K.

PLoS One. 2011;6(12):e28325. doi: 10.1371/journal.pone.0028325. Epub 2011 Dec 2.

14.

Latent TGF-β binding proteins (LTBPs) 1 and 3 differentially regulate transforming growth factor-β activity in malignant mesothelioma.

Vehviläinen P, Koli K, Myllärniemi M, Lindholm P, Soini Y, Salmenkivi K, Kinnula VL, Keski-Oja J.

Hum Pathol. 2011 Feb;42(2):269-78. doi: 10.1016/j.humpath.2010.07.005. Epub 2010 Nov 24.

PMID:
21106222
15.

The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome.

Chan SH, Yee Ko JM, Chan KW, Chan YP, Tao Q, Hyytiainen M, Keski-Oja J, Law S, Srivastava G, Tang J, Tsao SW, Chen H, Stanbridge EJ, Lung ML.

Int J Cancer. 2011 Aug 1;129(3):565-73. doi: 10.1002/ijc.25698. Epub 2010 Nov 9.

16.

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.

Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Kallioniemi O, Ingvarsen S, Engelholm LH, Taipale J, Alitalo K, Keski-Oja J, Lehti K.

Cancer Res. 2010 Oct 15;70(20):7851-61. doi: 10.1158/0008-5472.CAN-10-1223. Epub 2010 Sep 28.

17.

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.

Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15786-91. doi: 10.1073/pnas.0914459107. Epub 2010 Aug 23.

18.

Independent regulation of short and long forms of latent TGF-beta binding protein (LTBP)-4 in cultured fibroblasts and human tissues.

Kantola AK, Ryynänen MJ, Lhota F, Keski-Oja J, Koli K.

J Cell Physiol. 2010 Jun;223(3):727-36. doi: 10.1002/jcp.22082.

PMID:
20175115
19.

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

Wempe F, De-Zolt S, Koli K, Bangsow T, Parajuli N, Dumitrascu R, Sterner-Kock A, Weissmann N, Keski-Oja J, von Melchner H.

Dis Model Mech. 2010 Mar-Apr;3(3-4):246-53. doi: 10.1242/dmm.004234. Epub 2010 Jan 27.

20.

Reduced phosphorylation of the TGF-Beta signal transducer Smad2 in emphysematous human lung.

Leppäranta O, Myllärniemi M, Salmenkivi K, Kinnula VL, Keski-Oja J, Koli K.

COPD. 2009 Aug;6(4):234-41.

PMID:
19811381
21.

Matrix association of latent TGF-beta binding protein-2 (LTBP-2) is dependent on fibrillin-1.

Vehviläinen P, Hyytiäinen M, Keski-Oja J.

J Cell Physiol. 2009 Dec;221(3):586-93. doi: 10.1002/jcp.21888.

PMID:
19681046
22.

Modulation of TGF-beta activity by latent TGF-beta-binding protein 1 in human malignant glioma cells.

Tritschler I, Gramatzki D, Capper D, Mittelbronn M, Meyermann R, Saharinen J, Wick W, Keski-Oja J, Weller M.

Int J Cancer. 2009 Aug 1;125(3):530-40. doi: 10.1002/ijc.24443.

23.

Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells.

Heiskanen TJ, Illman SA, Lohi J, Keski-Oja J.

Matrix Biol. 2009 Mar;28(2):74-83. doi: 10.1016/j.matbio.2008.12.004. Epub 2009 Jan 20.

PMID:
19379669
24.

Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia.

Manicone AM, Birkland TP, Lin M, Betsuyaku T, van Rooijen N, Lohi J, Keski-Oja J, Wang Y, Skerrett SJ, Parks WC.

J Immunol. 2009 Mar 15;182(6):3866-76. doi: 10.4049/jimmunol.0713949.

25.

MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing.

Lehti K, Rose NF, Valavaara S, Weiss SJ, Keski-Oja J.

J Cell Sci. 2009 Jan 1;122(Pt 1):126-35. doi: 10.1242/jcs.035279. Epub 2008 Dec 9.

26.

Epilysin (MMP-28)--structure, expression and potential functions.

Illman SA, Lohi J, Keski-Oja J.

Exp Dermatol. 2008 Nov;17(11):897-907. doi: 10.1111/j.1600-0625.2008.00782.x. Epub 2008 Sep 18. Review.

PMID:
18803661
27.

Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes.

Hakulinen J, Sankkila L, Sugiyama N, Lehti K, Keski-Oja J.

J Cell Biochem. 2008 Dec 1;105(5):1211-8. doi: 10.1002/jcb.21923.

PMID:
18802920
28.

Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells.

Koli K, Ryynänen MJ, Keski-Oja J.

Bone. 2008 Oct;43(4):679-88. doi: 10.1016/j.bone.2008.06.016. Epub 2008 Jul 11.

PMID:
18672106
29.

MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1.

Tatti O, Vehviläinen P, Lehti K, Keski-Oja J.

Exp Cell Res. 2008 Aug 1;314(13):2501-14. doi: 10.1016/j.yexcr.2008.05.018. Epub 2008 Jun 6.

PMID:
18602101
30.

Fibronectin and heparin binding domains of latent TGF-beta binding protein (LTBP)-4 mediate matrix targeting and cell adhesion.

Kantola AK, Keski-Oja J, Koli K.

Exp Cell Res. 2008 Aug 1;314(13):2488-500. doi: 10.1016/j.yexcr.2008.05.010. Epub 2008 May 29.

PMID:
18585707
31.

Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype.

Myllärniemi M, Vuorinen K, Pulkkinen V, Kankaanranta H, Aine T, Salmenkivi K, Keski-Oja J, Koli K, Kinnula V.

J Pathol. 2008 Mar;214(4):456-63.

PMID:
18072275
32.

Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis.

Myllärniemi M, Lindholm P, Ryynänen MJ, Kliment CR, Salmenkivi K, Keski-Oja J, Kinnula VL, Oury TD, Koli K.

Am J Respir Crit Care Med. 2008 Feb 1;177(3):321-9. Epub 2007 Nov 1.

33.

Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species.

Koli K, Myllärniemi M, Keski-Oja J, Kinnula VL.

Antioxid Redox Signal. 2008 Feb;10(2):333-42. Review.

PMID:
17961070
34.

Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells.

Illman SA, Lehti K, Keski-Oja J, Lohi J.

J Cell Sci. 2006 Sep 15;119(Pt 18):3856-65. Epub 2006 Aug 29.

35.

Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis.

Koli K, Myllärniemi M, Vuorinen K, Salmenkivi K, Ryynänen MJ, Kinnula VL, Keski-Oja J.

Am J Pathol. 2006 Jul;169(1):61-71.

36.

ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells.

Hakulinen J, Keski-Oja J.

J Biol Chem. 2006 Jul 28;281(30):21369-76. Epub 2006 May 30.

37.

[Year 2005 Anders Jahre Young Scientist Award goes to Olli Ritvos].

Keski-Oja J.

Duodecim. 2005;121(21):2263-4. Finnish. No abstract available.

PMID:
16457106
38.
39.

[Degradation products of endothelial basement membranes: their role as tumor suppressor].

Wickström SA, Keski-Oja J.

Duodecim. 2005;121(17):1829-37. Review. Finnish. No abstract available.

PMID:
16262120
40.

Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements.

Kantola AK, Keski-Oja J, Koli K.

Gene. 2005 Dec 19;363:142-50. Epub 2005 Oct 11.

PMID:
16223572
41.

Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts.

Koli K, Hyytiäinen M, Ryynänen MJ, Keski-Oja J.

Exp Cell Res. 2005 Nov 1;310(2):370-82. Epub 2005 Sep 12.

PMID:
16157329
42.

Endostatin signaling and regulation of endothelial cell-matrix interactions.

Wickström SA, Alitalo K, Keski-Oja J.

Adv Cancer Res. 2005;94:197-229. Review.

PMID:
16096002
44.

Cutis laxa in hereditary gelsolin amyloidosis.

Kiuru-Enari S, Keski-Oja J, Haltia M.

Br J Dermatol. 2005 Feb;152(2):250-7.

PMID:
15727635
45.

Binding of endostatin to phosphatidylserine-containing membranes and formation of amyloid-like fibers.

Zhao H, Jutila A, Nurminen T, Wickström SA, Keski-Oja J, Kinnunen PK.

Biochemistry. 2005 Mar 1;44(8):2857-63.

PMID:
15723529
46.

TGF-beta activation by traction?

Keski-Oja J, Koli K, von Melchner H.

Trends Cell Biol. 2004 Dec;14(12):657-9. Review.

PMID:
15564041
47.

Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.

Koli K, Wempe F, Sterner-Kock A, Kantola A, Komor M, Hofmann WK, von Melchner H, Keski-Oja J.

J Cell Biol. 2004 Oct 11;167(1):123-33. Epub 2004 Oct 4.

48.

Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation.

Hyytiäinen M, Penttinen C, Keski-Oja J.

Crit Rev Clin Lab Sci. 2004;41(3):233-64. Review.

PMID:
15307633
49.

An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells.

Wickström SA, Alitalo K, Keski-Oja J.

J Biol Chem. 2004 May 7;279(19):20178-85. Epub 2004 Feb 18.

50.

PDGF-BB induces expression of LTBP-1 but not TGF-beta1 in a rat cirrhotic fat storing cell line.

Westhoff JH, Sawitza I, Keski-Oja J, Gressner AM, Breitkopf K.

Growth Factors. 2003 Sep-Dec;21(3-4):121-30.

PMID:
14708940

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