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Endotracheal Tube Mucus as a Source of Airway Mucus for Rheological Study.

Markovetz MR, Subramani DB, Kissner WJ, Morrison CB, Garbarine IC, Ghio A, Ramsey KA, Arora H, Kumar PA, Nix DB, Kumagai T, Krunkosky TM, Krause DC, Radicioni G, Alexis NE, Kesimer M, Tiemeyer M, Boucher RC, Ehre C, Hill DB.

Am J Physiol Lung Cell Mol Physiol. 2019 Aug 7. doi: 10.1152/ajplung.00238.2019. [Epub ahead of print]


Another Warning Sign: High Nicotine Content in E-Cigarettes Disrupts Mucociliary Clearance, the Essential Defense Mechanism of the Lung.

Kesimer M.

Am J Respir Crit Care Med. 2019 Jun 14. doi: 10.1164/rccm.201905-1080ED. [Epub ahead of print] No abstract available.


Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.

Esther CR Jr, Muhlebach MS, Ehre C, Hill DB, Wolfgang MC, Kesimer M, Ramsey KA, Markovetz MR, Garbarine IC, Forest MG, Seim I, Zorn B, Morrison CB, Delion MF, Thelin WR, Villalon D, Sabater JR, Turkovic L, Ranganathan S, Stick SM, Boucher RC.

Sci Transl Med. 2019 Apr 3;11(486). pii: eaav3488. doi: 10.1126/scitranslmed.aav3488.


Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.

Henderson AG, Anderson WH, Ceppe A, Coakley RD, Button B, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Fuller F, Almond M, Qaqish B, Kesimer M, Boucher RC.

COPD. 2018 Dec;15(6):572-580. doi: 10.1080/15412555.2019.1566892. Epub 2019 Feb 4.


Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.

Okuda K, Chen G, Subramani DB, Wolf M, Gilmore RC, Kato T, Radicioni G, Kesimer M, Chua M, Dang H, Livraghi-Butrico A, Ehre C, Doerschuk CM, Randell SH, Matsui H, Nagase T, O'Neal WK, Boucher RC.

Am J Respir Crit Care Med. 2019 Mar 15;199(6):715-727. doi: 10.1164/rccm.201804-0734OC.


Intercellular Communication between Airway Epithelial Cells Is Mediated by Exosome-Like Vesicles.

Gupta R, Radicioni G, Abdelwahab S, Dang H, Carpenter J, Chua M, Mieczkowski PA, Sheridan JT, Randell SH, Kesimer M.

Am J Respir Cell Mol Biol. 2019 Feb;60(2):209-220. doi: 10.1165/rcmb.2018-0156OC.


SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration.

Webster MJ, Reidel B, Tan CD, Ghosh A, Alexis NE, Donaldson SH, Kesimer M, Ribeiro CMP, Tarran R.

Eur Respir J. 2018 Oct 4;52(4). pii: 1800668. doi: 10.1183/13993003.00668-2018. Print 2018 Oct.


Mucin Concentrations and Peripheral Airway Obstruction in Chronic Obstructive Pulmonary Disease.

Kesimer M, Smith BM, Ceppe A, Ford AA, Anderson WH, Barr RG, O'Neal WK, Boucher RC; SPIROMICS Investigative Group.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1453-1456. doi: 10.1164/rccm.201806-1016LE. No abstract available.


Cigarette smoke modifies and inactivates SPLUNC1, leading to airway dehydration.

Moore PJ, Reidel B, Ghosh A, Sesma J, Kesimer M, Tarran R.

FASEB J. 2018 Jun 11:fj201800345R. doi: 10.1096/fj.201800345R. [Epub ahead of print]


At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.

Martinez FJ, Han MK, Allinson JP, Barr RG, Boucher RC, Calverley PMA, Celli BR, Christenson SA, Crystal RG, Fagerås M, Freeman CM, Groenke L, Hoffman EA, Kesimer M, Kostikas K, Paine R 3rd, Rafii S, Rennard SI, Segal LN, Shaykhiev R, Stevenson C, Tal-Singer R, Vestbo J, Woodruff PG, Curtis JL, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1540-1551. doi: 10.1164/rccm.201710-2028PP. No abstract available. Erratum in: Am J Respir Crit Care Med. 2018 Dec 1;198(11):1463.


Mucin Production and Hydration Responses to Mucopurulent Materials in Normal versus Cystic Fibrosis Airway Epithelia.

Abdullah LH, Coakley R, Webster MJ, Zhu Y, Tarran R, Radicioni G, Kesimer M, Boucher RC, Davis CW, Ribeiro CMP.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):481-491. doi: 10.1164/rccm.201706-1139OC.


Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography.

Adams DC, Pahlevaninezhad H, Szabari MV, Cho JL, Hamilos DL, Kesimer M, Boucher RC, Luster AD, Medoff BD, Suter MJ.

Biomed Opt Express. 2017 Sep 26;8(10):4729-4741. doi: 10.1364/BOE.8.004729. eCollection 2017 Oct 1.


E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion.

Reidel B, Radicioni G, Clapp PW, Ford AA, Abdelwahab S, Rebuli ME, Haridass P, Alexis NE, Jaspers I, Kesimer M.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):492-501. doi: 10.1164/rccm.201708-1590OC.


Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease.

Terryah ST, Fellner RC, Ahmad S, Moore PJ, Reidel B, Sesma JI, Kim CS, Garland AL, Scott DW, Sabater JR, Carpenter J, Randell SH, Kesimer M, Abraham WM, Arendshorst WJ, Tarran R.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L192-L205. doi: 10.1152/ajplung.00546.2016. Epub 2017 Oct 5.


Airway Mucin Concentration as a Marker of Chronic Bronchitis.

Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez F, Paine R 3rd, Woodruff PG, O'Neal WK, Boucher RC.

N Engl J Med. 2017 Sep 7;377(10):911-922. doi: 10.1056/NEJMoa1701632.


Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma.

Burbank AJ, Duran CG, Pan Y, Burns P, Jones S, Jiang Q, Yang C, Jenkins S, Wells H, Alexis N, Kesimer M, Bennett WD, Zhou H, Peden DB, Hernandez ML.

J Allergy Clin Immunol. 2018 Apr;141(4):1231-1238.e1. doi: 10.1016/j.jaci.2017.06.029. Epub 2017 Jul 20.


Little Cigars are More Toxic than Cigarettes and Uniquely Change the Airway Gene and Protein Expression.

Ghosh A, Abdelwahab SH, Reeber SL, Reidel B, Marklew AJ, Garrison AJ, Lee S, Dang H, Herring AH, Glish GL, Kesimer M, Tarran R.

Sci Rep. 2017 Apr 27;7:46239. doi: 10.1038/srep46239.


Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways.

Abdullah LH, Evans JR, Wang TT, Ford AA, Makhov AM, Nguyen K, Coakley RD, Griffith JD, Davis CW, Ballard ST, Kesimer M.

JCI Insight. 2017 Mar 23;2(6):e89752. doi: 10.1172/jci.insight.89752.


Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization.

Dickey BF, Fahy JV, Kesimer M, Boucher RC, Evans CM, Thornton D.

Ann Am Thorac Soc. 2016 Nov;13(11):2103-2104. No abstract available.


Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.

Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD, Luster AD.

Sci Transl Med. 2016 Oct 5;8(359):359ra132.


The innate immune properties of airway mucosal surfaces are regulated by dynamic interactions between mucins and interacting proteins: the mucin interactome.

Radicioni G, Cao R, Carpenter J, Ford AA, Wang T, Li L, Kesimer M.

Mucosal Immunol. 2016 Nov;9(6):1442-1454. doi: 10.1038/mi.2016.27. Epub 2016 Apr 13.


Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs.

Kesimer M, Cullen J, Cao R, Radicioni G, Mathews KG, Seiler G, Gookin JL.

PLoS One. 2015 Sep 28;10(9):e0138988. doi: 10.1371/journal.pone.0138988. eCollection 2015.


The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.

Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, Bennett WD, Kesimer M, Boucher RC.

Am J Respir Crit Care Med. 2015 Jul 15;192(2):182-90. doi: 10.1164/rccm.201412-2230OC.


Physical characterization and profiling of airway epithelial derived exosomes using light scattering.

Kesimer M, Gupta R.

Methods. 2015 Oct 1;87:59-63. doi: 10.1016/j.ymeth.2015.03.013. Epub 2015 Mar 27.


Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure.

Henderson AG, Ehre C, Button B, Abdullah LH, Cai LH, Leigh MW, DeMaria GC, Matsui H, Donaldson SH, Davis CW, Sheehan JK, Boucher RC, Kesimer M.

J Clin Invest. 2014 Jul;124(7):3047-60. doi: 10.1172/JCI73469. Epub 2014 Jun 2.


Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.

Hobbs CA, Blanchard MG, Alijevic O, Tan CD, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Henderson AG, Redinbo MR, Stutts MJ, Tarran R.

Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L990-L1001. doi: 10.1152/ajplung.00103.2013. Epub 2013 Oct 11. Erratum in: Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L708.


The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status.

Guo X, Kesimer M, Tolun G, Zheng X, Xu Q, Lu J, Sheehan JK, Griffith JD, Li X.

Sci Rep. 2012;2:640. doi: 10.1038/srep00640. Epub 2012 Sep 7.


Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways.

Kesimer M, Ehre C, Burns KA, Davis CW, Sheehan JK, Pickles RJ.

Mucosal Immunol. 2013 Mar;6(2):379-92. doi: 10.1038/mi.2012.81. Epub 2012 Aug 29.


A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia.

Button B, Cai LH, Ehre C, Kesimer M, Hill DB, Sheehan JK, Boucher RC, Rubinstein M.

Science. 2012 Aug 24;337(6097):937-41. doi: 10.1126/science.1223012.


Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways.

Hobbs CA, Blanchard MG, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Redinbo MR, Stutts MJ, Tarran R.

FASEB J. 2012 Oct;26(10):4348-59. doi: 10.1096/fj.12-207431. Epub 2012 Jul 13. Retraction in: FASEB J. 2013 May;27(5):2081.


Nanoparticle analysis of circulating cell-derived vesicles in ovarian cancer patients.

Gercel-Taylor C, Atay S, Tullis RH, Kesimer M, Taylor DD.

Anal Biochem. 2012 Sep 1;428(1):44-53. doi: 10.1016/j.ab.2012.06.004. Epub 2012 Jun 9.


Mapping the protein domain structures of the respiratory mucins: a mucin proteome coverage study.

Cao R, Wang TT, DeMaria G, Sheehan JK, Kesimer M.

J Proteome Res. 2012 Aug 3;11(8):4013-23. doi: 10.1021/pr300058z. Epub 2012 Jun 28.


Studying mucin secretion from human bronchial epithelial cell primary cultures.

Abdullah LH, Wolber C, Kesimer M, Sheehan JK, Davis CW.

Methods Mol Biol. 2012;842:259-77. doi: 10.1007/978-1-61779-513-8_16.


Mass spectrometric analysis of mucin core proteins.

Kesimer M, Sheehan JK.

Methods Mol Biol. 2012;842:67-79. doi: 10.1007/978-1-61779-513-8_4.


Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells.

Atay S, Gercel-Taylor C, Kesimer M, Taylor DD.

Exp Cell Res. 2011 May 1;317(8):1192-202. doi: 10.1016/j.yexcr.2011.01.014. Epub 2011 Jan 26.


Hemoglobin Raleigh results in factitiously low hemoglobin A1c when evaluated via immunoassay analyzer.

Jain N, Kesimer M, Hoyer JD, Calikoglu AS.

J Diabetes Complications. 2011 Jan-Feb;25(1):14-8. doi: 10.1016/j.jdiacomp.2009.09.004. Epub 2009 Nov 6.


Unpacking a gel-forming mucin: a view of MUC5B organization after granular release.

Kesimer M, Makhov AM, Griffith JD, Verdugo P, Sheehan JK.

Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L15-22. doi: 10.1152/ajplung.00194.2009. Epub 2009 Sep 25.


Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii.

Kesimer M, Kiliç N, Mehrotra R, Thornton DJ, Sheehan JK.

BMC Microbiol. 2009 Aug 11;9:163. doi: 10.1186/1471-2180-9-163.


Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.

Kesimer M, Scull M, Brighton B, DeMaria G, Burns K, O'Neal W, Pickles RJ, Sheehan JK.

FASEB J. 2009 Jun;23(6):1858-68. doi: 10.1096/fj.08-119131. Epub 2009 Feb 3.


Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

Kesimer M, Kirkham S, Pickles RJ, Henderson AG, Alexis NE, Demaria G, Knight D, Thornton DJ, Sheehan JK.

Am J Physiol Lung Cell Mol Physiol. 2009 Jan;296(1):L92-L100. doi: 10.1152/ajplung.90388.2008. Epub 2008 Oct 17.


Analyzing the functions of large glycoconjugates through the dissipative properties of their absorbed layers using the gel-forming mucin MUC5B as an example.

Kesimer M, Sheehan JK.

Glycobiology. 2008 Jun;18(6):463-72. doi: 10.1093/glycob/cwn024. Epub 2008 Mar 13.


Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model.

Nguyen LP, Omoluabi O, Parra S, Frieske JM, Clement C, Ammar-Aouchiche Z, Ho SB, Ehre C, Kesimer M, Knoll BJ, Tuvim MJ, Dickey BF, Bond RA.

Am J Respir Cell Mol Biol. 2008 Mar;38(3):256-62. Epub 2007 Dec 20.


Innate immunity and mucus structure and function.

Sheehan JK, Kesimer M, Pickles R.

Novartis Found Symp. 2006;279:155-66; discussion 167-9, 216-9. Review.


Adsorption of human salivary mucin MG1 onto glow-discharge plasma treated acrylic resin surfaces.

Yildirim MS, Kesimer M, Hasirci N, Kiliç N, Hasanreisoğlu U.

J Oral Rehabil. 2006 Oct;33(10):775-83. Erratum in: J Oral Rehabil. 2006 Dec;33(12):934.


The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A.

Thelin WR, Kesimer M, Tarran R, Kreda SM, Grubb BR, Sheehan JK, Stutts MJ, Milgram SL.

J Biol Chem. 2005 Dec 16;280(50):41512-20. Epub 2005 Oct 20.


High cystine in platelets from patients with nephropathic cystinosis: a chemical, ultrastructural, and functional evaluation.

Olcay L, Erdemli E, Kesimer M, Büyükasik Y, Okur H, Kalkanoğlu HS, Coskun T, Altay C.

J Clin Pathol. 2005 Sep;58(9):939-45.


Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces.

Matsui H, Verghese MW, Kesimer M, Schwab UE, Randell SH, Sheehan JK, Grubb BR, Boucher RC.

J Immunol. 2005 Jul 15;175(2):1090-9.


Urate oxidation during percutaneous transluminal coronary angioplasty and thrombolysis in patients with coronary artery disease.

Yardim-Akaydin S, Kesimer M, Imren E, Sepici A, Simşek B, Torun M.

Clin Chim Acta. 2005 Dec;362(1-2):131-7. Epub 2005 Jul 1.


L-2-hydroxyglutaric aciduria: a report of 29 patients.

Topçu M, Aydin OF, Yalçinkaya C, Haliloğlu G, Aysun S, Anlar B, Topaloğlu H, Turanli G, Yalnizoğlu D, Kesimer M, Coşkun T.

Turk J Pediatr. 2005 Jan-Mar;47(1):1-7.


Transient nonketotic hyperglycinemia: two case reports and literature review.

Aliefendioğlu D, Tana Aslan Ay, Coşkun T, Dursun A, Cakmak FN, Kesimer M.

Pediatr Neurol. 2003 Feb;28(2):151-5. Review.


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