Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 98

1.

Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs.

Sperling AS, Burgess M, Keshishian H, Gasser JA, Bhatt S, Jan M, Słabicki M, Sellar RS, Fink EC, Miller PG, Liddicoat BJ, Sievers QL, Sharma R, Adams DN, Olesinski EA, Fulciniti M, Udeshi ND, Kuhn E, Letai A, Munshi NC, Carr SA, Ebert BL.

Blood. 2019 Jul 11;134(2):160-170. doi: 10.1182/blood.2019000789. Epub 2019 May 1.

PMID:
31043423
2.

A Curated Resource for Phosphosite-specific Signature Analysis.

Krug K, Mertins P, Zhang B, Hornbeck P, Raju R, Ahmad R, Szucs M, Mundt F, Forestier D, Jane-Valbuena J, Keshishian H, Gillette MA, Tamayo P, Mesirov JP, Jaffe JD, Carr SA, Mani DR.

Mol Cell Proteomics. 2019 Mar;18(3):576-593. doi: 10.1074/mcp.TIR118.000943. Epub 2018 Dec 18.

PMID:
30563849
3.

Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry.

Mertins P, Tang LC, Krug K, Clark DJ, Gritsenko MA, Chen L, Clauser KR, Clauss TR, Shah P, Gillette MA, Petyuk VA, Thomas SN, Mani DR, Mundt F, Moore RJ, Hu Y, Zhao R, Schnaubelt M, Keshishian H, Monroe ME, Zhang Z, Udeshi ND, Mani D, Davies SR, Townsend RR, Chan DW, Smith RD, Zhang H, Liu T, Carr SA.

Nat Protoc. 2018 Jul;13(7):1632-1661. doi: 10.1038/s41596-018-0006-9.

4.

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Khajuria RK, Munschauer M, Ulirsch JC, Fiorini C, Ludwig LS, McFarland SK, Abdulhay NJ, Specht H, Keshishian H, Mani DR, Jovanovic M, Ellis SR, Fulco CP, Engreitz JM, Schütz S, Lian J, Gripp KW, Weinberg OK, Pinkus GS, Gehrke L, Regev A, Lander ES, Gazda HT, Lee WY, Panse VG, Carr SA, Sankaran VG.

Cell. 2018 Mar 22;173(1):90-103.e19. doi: 10.1016/j.cell.2018.02.036. Epub 2018 Mar 15.

5.

Quantitative, multiplexed workflow for deep analysis of human blood plasma and biomarker discovery by mass spectrometry.

Keshishian H, Burgess MW, Specht H, Wallace L, Clauser KR, Gillette MA, Carr SA.

Nat Protoc. 2017 Aug;12(8):1683-1701. doi: 10.1038/nprot.2017.054. Epub 2017 Jul 27.

6.

Activity-Dependent Synaptic Refinement: New Insights from Drosophila.

Vonhoff F, Keshishian H.

Front Syst Neurosci. 2017 Apr 21;11:23. doi: 10.3389/fnsys.2017.00023. eCollection 2017. Review.

7.

In Vivo Calcium Signaling during Synaptic Refinement at the Drosophila Neuromuscular Junction.

Vonhoff F, Keshishian H.

J Neurosci. 2017 May 31;37(22):5511-5526. doi: 10.1523/JNEUROSCI.2922-16.2017. Epub 2017 May 5.

8.

New Guidelines for Publication of Manuscripts Describing Development and Application of Targeted Mass Spectrometry Measurements of Peptides and Proteins.

Abbatiello S, Ackermann BL, Borchers C, Bradshaw RA, Carr SA, Chalkley R, Choi M, Deutsch E, Domon B, Hoofnagle AN, Keshishian H, Kuhn E, Liebler DC, MacCoss M, MacLean B, Mani DR, Neubert H, Smith D, Vitek O, Zimmerman L.

Mol Cell Proteomics. 2017 Mar;16(3):327-328. doi: 10.1074/mcp.E117.067801. Epub 2017 Feb 9. No abstract available.

9.

Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease.

Ngo D, Sinha S, Shen D, Kuhn EW, Keyes MJ, Shi X, Benson MD, O'Sullivan JF, Keshishian H, Farrell LA, Fifer MA, Vasan RS, Sabatine MS, Larson MG, Carr SA, Wang TJ, Gerszten RE.

Circulation. 2016 Jul 26;134(4):270-85. doi: 10.1161/CIRCULATIONAHA.116.021803.

10.

Automated Microchromatography Enables Multiplexing of Immunoaffinity Enrichment of Peptides to Greater than 150 for Targeted MS-Based Assays.

Ippoliti PJ, Kuhn E, Mani DR, Fagbami L, Keshishian H, Burgess MW, Jaffe JD, Carr SA.

Anal Chem. 2016 Aug 2;88(15):7548-55. doi: 10.1021/acs.analchem.6b00946. Epub 2016 Jul 12.

PMID:
27321643
11.

Cyclic nucleotide signaling is required during synaptic refinement at the Drosophila neuromuscular junction.

Vonhoff F, Keshishian H.

Dev Neurobiol. 2017 Jan;77(1):39-60. doi: 10.1002/dneu.22407. Epub 2016 Jun 20.

12.

Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.

Kroksveen AC, Jaffe JD, Aasebø E, Barsnes H, Bjørlykke Y, Franciotta D, Keshishian H, Myhr KM, Opsahl JA, van Pesch V, Teunissen CE, Torkildsen Ø, Ulvik RJ, Vethe H, Carr SA, Berven FS.

Proteomics. 2015 Oct;15(19):3361-9. doi: 10.1002/pmic.201400142. Epub 2015 Sep 8.

PMID:
26152395
13.

Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.

Keshishian H, Burgess MW, Gillette MA, Mertins P, Clauser KR, Mani DR, Kuhn EW, Farrell LA, Gerszten RE, Carr SA.

Mol Cell Proteomics. 2015 Sep;14(9):2375-93. doi: 10.1074/mcp.M114.046813. Epub 2015 Feb 27.

14.

Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.

Abbatiello SE, Schilling B, Mani DR, Zimmerman LJ, Hall SC, MacLean B, Albertolle M, Allen S, Burgess M, Cusack MP, Gosh M, Hedrick V, Held JM, Inerowicz HD, Jackson A, Keshishian H, Kinsinger CR, Lyssand J, Makowski L, Mesri M, Rodriguez H, Rudnick P, Sadowski P, Sedransk N, Shaddox K, Skates SJ, Kuhn E, Smith D, Whiteaker JR, Whitwell C, Zhang S, Borchers CH, Fisher SJ, Gibson BW, Liebler DC, MacCoss MJ, Neubert TA, Paulovich AG, Regnier FE, Tempst P, Carr SA.

Mol Cell Proteomics. 2015 Sep;14(9):2357-74. doi: 10.1074/mcp.M114.047050. Epub 2015 Feb 18.

15.

Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors.

Mishra-Gorur K, Çağlayan AO, Schaffer AE, Chabu C, Henegariu O, Vonhoff F, Akgümüş GT, Nishimura S, Han W, Tu S, Baran B, Gümüş H, Dilber C, Zaki MS, Hossni HAA, Rivière JB, Kayserili H, Spencer EG, Rosti RÖ, Schroth J, Per H, Çağlar C, Çağlar Ç, Dölen D, Baranoski JF, Kumandaş S, Minja FJ, Erson-Omay EZ, Mane SM, Lifton RP, Xu T, Keshishian H, Dobyns WB, Chi NC, Šestan N, Louvi A, Bilgüvar K, Yasuno K, Gleeson JG, Günel M.

Neuron. 2015 Jan 7;85(1):228. doi: 10.1016/j.neuron.2014.12.046. Epub 2015 Jan 7. No abstract available.

16.

Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors.

Mishra-Gorur K, Çağlayan AO, Schaffer AE, Chabu C, Henegariu O, Vonhoff F, Akgümüş GT, Nishimura S, Han W, Tu S, Baran B, Gümüş H, Dilber C, Zaki MS, Hossni HA, Rivière JB, Kayserili H, Spencer EG, Rosti RÖ, Schroth J, Per H, Çağlar C, Çağlar Ç, Dölen D, Baranoski JF, Kumandaş S, Minja FJ, Erson-Omay EZ, Mane SM, Lifton RP, Xu T, Keshishian H, Dobyns WB, Chi NC, Šestan N, Louvi A, Bilgüvar K, Yasuno K, Gleeson JG, Günel M.

Neuron. 2014 Dec 17;84(6):1226-39. doi: 10.1016/j.neuron.2014.12.014. Erratum in: Neuron. 2015 Jan 7;85(1):228. Neuron. 2015 Jan 7;85(1):228.

17.

A systematic nomenclature for the insect brain.

Ito K, Shinomiya K, Ito M, Armstrong JD, Boyan G, Hartenstein V, Harzsch S, Heisenberg M, Homberg U, Jenett A, Keshishian H, Restifo LL, Rössler W, Simpson JH, Strausfeld NJ, Strauss R, Vosshall LB; Insect Brain Name Working Group.

Neuron. 2014 Feb 19;81(4):755-65. doi: 10.1016/j.neuron.2013.12.017.

18.

Simplified and efficient quantification of low-abundance proteins at very high multiplex via targeted mass spectrometry.

Burgess MW, Keshishian H, Mani DR, Gillette MA, Carr SA.

Mol Cell Proteomics. 2014 Apr;13(4):1137-49. doi: 10.1074/mcp.M113.034660. Epub 2014 Feb 11.

19.

Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach.

Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S.

Mol Cell Proteomics. 2014 Mar;13(3):907-17. doi: 10.1074/mcp.M113.036095. Epub 2014 Jan 17.

20.

Retrograde BMP signaling at the synapse: a permissive signal for synapse maturation and activity-dependent plasticity.

Berke B, Wittnam J, McNeill E, Van Vactor DL, Keshishian H.

J Neurosci. 2013 Nov 6;33(45):17937-50. doi: 10.1523/JNEUROSCI.6075-11.2013.

21.

Design, implementation and multisite evaluation of a system suitability protocol for the quantitative assessment of instrument performance in liquid chromatography-multiple reaction monitoring-MS (LC-MRM-MS).

Abbatiello SE, Mani DR, Schilling B, Maclean B, Zimmerman LJ, Feng X, Cusack MP, Sedransk N, Hall SC, Addona T, Allen S, Dodder NG, Ghosh M, Held JM, Hedrick V, Inerowicz HD, Jackson A, Keshishian H, Kim JW, Lyssand JS, Riley CP, Rudnick P, Sadowski P, Shaddox K, Smith D, Tomazela D, Wahlander A, Waldemarson S, Whitwell CA, You J, Zhang S, Kinsinger CR, Mesri M, Rodriguez H, Borchers CH, Buck C, Fisher SJ, Gibson BW, Liebler D, Maccoss M, Neubert TA, Paulovich A, Regnier F, Skates SJ, Tempst P, Wang M, Carr SA.

Mol Cell Proteomics. 2013 Sep;12(9):2623-39. doi: 10.1074/mcp.M112.027078. Epub 2013 May 20.

22.

TUNEL-antibody double-labeling method for Drosophila embryos.

Sweeney ST, Hidalgo A, de Belle JS, Keshishian H.

Cold Spring Harb Protoc. 2012 Sep 1;2012(9):1013-6. doi: 10.1101/pdb.prot068379.

PMID:
22949709
23.

Genetic systems for functional cell ablation in Drosophila.

Sweeney ST, Hidalgo A, de Belle JS, Keshishian H.

Cold Spring Harb Protoc. 2012 Sep 1;2012(9):950-6. doi: 10.1101/pdb.top068361.

PMID:
22949708
24.

Embryonic cell ablation in Drosophila using lasers.

Sweeney ST, Hidalgo A, de Belle JS, Keshishian H.

Cold Spring Harb Protoc. 2012 Jun 1;2012(6):691-3. doi: 10.1101/pdb.prot068395.

PMID:
22661443
25.

Setup for functional cell ablation with lasers: coupling of a laser to a microscope.

Sweeney ST, Hidalgo A, de Belle JS, Keshishian H.

Cold Spring Harb Protoc. 2012 Jun 1;2012(6):726-32. doi: 10.1101/pdb.ip068387.

PMID:
22661442
26.

Monitoring membrane excitability in Drosophila expressing modified shaker constructs.

Olsen DP, Keshishian H.

Cold Spring Harb Protoc. 2012 Feb 1;2012(2):226-30. doi: 10.1101/pdb.prot067801.

PMID:
22301649
27.

Experimental methods for examining synaptic plasticity in Drosophila.

Olsen DP, Keshishian H.

Cold Spring Harb Protoc. 2012 Feb 1;2012(2):162-73. doi: 10.1101/pdb.top067785. Review.

PMID:
22301648
28.

Hydroxyurea ablation of mushroom bodies in Drosophila.

Sweeney ST, Hidalgo A, de Belle JS, Keshishian H.

Cold Spring Harb Protoc. 2012 Feb 1;2012(2):231-4. doi: 10.1101/pdb.prot067777.

PMID:
22301647
29.

X-gal staining of the central nervous system in adult Drosophila.

Sweeney ST, Hidalgo A, de Belle JS, Keshishian H.

Cold Spring Harb Protoc. 2012 Feb 1;2012(2):239-41. doi: 10.1101/pdb.prot067405.

PMID:
22301646
30.

Antibody staining of the central nervous system in adult Drosophila.

Sweeney ST, Hidalgo A, de Belle JS, Keshishian H.

Cold Spring Harb Protoc. 2012 Feb 1;2012(2):235-8. doi: 10.1101/pdb.prot067397.

PMID:
22301645
31.

Dissection of adult Drosophila brains.

Sweeney ST, Hidalgo A, de Belle JS, Keshishian H.

Cold Spring Harb Protoc. 2011 Dec 1;2011(12):1472-4. doi: 10.1101/pdb.prot066878.

PMID:
22135655
32.

A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.

Addona TA, Shi X, Keshishian H, Mani DR, Burgess M, Gillette MA, Clauser KR, Shen D, Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, Carr SA.

Nat Biotechnol. 2011 Jun 19;29(7):635-43. doi: 10.1038/nbt.1899.

33.

Cracking the combinatorial semaphorin code.

Berke B, Keshishian H.

Neuron. 2011 Apr 28;70(2):175-7. doi: 10.1016/j.neuron.2011.04.010.

34.

Maintenance and regulation of extracellular volume and the ion environment in Drosophila larval nerves.

Leiserson WM, Keshishian H.

Glia. 2011 Sep;59(9):1312-21. doi: 10.1002/glia.21132. Epub 2011 Feb 8. Review.

35.

Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume.

Leiserson WM, Forbush B, Keshishian H.

Glia. 2011 Feb;59(2):320-32. doi: 10.1002/glia.21103.

36.

Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement.

Carrillo RA, Olsen DP, Yoon KS, Keshishian H.

Neuron. 2010 Oct 6;68(1):32-44. doi: 10.1016/j.neuron.2010.09.005.

37.

Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.

Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D.

Mol Cancer Res. 2010 Jun;8(6):896-906. doi: 10.1158/1541-7786.MCR-09-0409. Epub 2010 May 25.

38.

Automated detection of inaccurate and imprecise transitions in peptide quantification by multiple reaction monitoring mass spectrometry.

Abbatiello SE, Mani DR, Keshishian H, Carr SA.

Clin Chem. 2010 Feb;56(2):291-305. doi: 10.1373/clinchem.2009.138420. Epub 2009 Dec 18.

39.

Quantification of cardiovascular biomarkers in patient plasma by targeted mass spectrometry and stable isotope dilution.

Keshishian H, Addona T, Burgess M, Mani DR, Shi X, Kuhn E, Sabatine MS, Gerszten RE, Carr SA.

Mol Cell Proteomics. 2009 Oct;8(10):2339-49. doi: 10.1074/mcp.M900140-MCP200. Epub 2009 Jul 13.

40.

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma.

Addona TA, Abbatiello SE, Schilling B, Skates SJ, Mani DR, Bunk DM, Spiegelman CH, Zimmerman LJ, Ham AJ, Keshishian H, Hall SC, Allen S, Blackman RK, Borchers CH, Buck C, Cardasis HL, Cusack MP, Dodder NG, Gibson BW, Held JM, Hiltke T, Jackson A, Johansen EB, Kinsinger CR, Li J, Mesri M, Neubert TA, Niles RK, Pulsipher TC, Ransohoff D, Rodriguez H, Rudnick PA, Smith D, Tabb DL, Tegeler TJ, Variyath AM, Vega-Montoto LJ, Wahlander A, Waldemarson S, Wang M, Whiteaker JR, Zhao L, Anderson NL, Fisher SJ, Liebler DC, Paulovich AG, Regnier FE, Tempst P, Carr SA.

Nat Biotechnol. 2009 Jul;27(7):633-41. doi: 10.1038/nbt.1546. Epub 2009 Jun 28. Erratum in: Nat Biotechnol. 2009 Sep;27(9):864.

41.

Developing multiplexed assays for troponin I and interleukin-33 in plasma by peptide immunoaffinity enrichment and targeted mass spectrometry.

Kuhn E, Addona T, Keshishian H, Burgess M, Mani DR, Lee RT, Sabatine MS, Gerszten RE, Carr SA.

Clin Chem. 2009 Jun;55(6):1108-17. doi: 10.1373/clinchem.2009.123935. Epub 2009 Apr 16.

42.

Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury.

Lewis GD, Wei R, Liu E, Yang E, Shi X, Martinovic M, Farrell L, Asnani A, Cyrille M, Ramanathan A, Shaham O, Berriz G, Lowry PA, Palacios IF, Taşan M, Roth FP, Min J, Baumgartner C, Keshishian H, Addona T, Mootha VK, Rosenzweig A, Carr SA, Fifer MA, Sabatine MS, Gerszten RE.

J Clin Invest. 2008 Oct;118(10):3503-12. doi: 10.1172/JCI35111.

43.

Accurate inclusion mass screening: a bridge from unbiased discovery to targeted assay development for biomarker verification.

Jaffe JD, Keshishian H, Chang B, Addona TA, Gillette MA, Carr SA.

Mol Cell Proteomics. 2008 Oct;7(10):1952-62. doi: 10.1074/mcp.M800218-MCP200. Epub 2008 Jun 4.

44.

Spatial and temporal control of gene expression in Drosophila using the inducible GeneSwitch GAL4 system. I. Screen for larval nervous system drivers.

Nicholson L, Singh GK, Osterwalder T, Roman GW, Davis RL, Keshishian H.

Genetics. 2008 Jan;178(1):215-34. doi: 10.1534/genetics.107.081968.

45.

Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution.

Keshishian H, Addona T, Burgess M, Kuhn E, Carr SA.

Mol Cell Proteomics. 2007 Dec;6(12):2212-29. Epub 2007 Oct 15.

46.

Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop.

Cheng H, Addona T, Keshishian H, Dahlstrand E, Lu C, Dorsch M, Li Z, Wang A, Ocain TD, Li P, Parsons TF, Jaffee B, Xu Y.

Biochem Biophys Res Commun. 2007 Jan 19;352(3):609-16. Epub 2006 Nov 21.

PMID:
17141195
47.

Lim kinase regulates the development of olfactory and neuromuscular synapses.

Ang LH, Chen W, Yao Y, Ozawa R, Tao E, Yonekura J, Uemura T, Keshishian H, Hing H.

Dev Biol. 2006 May 1;293(1):178-90. Epub 2006 Mar 10.

48.

Dissection of synaptic excitability phenotypes by using a dominant-negative Shaker K+ channel subunit.

Mosca TJ, Carrillo RA, White BH, Keshishian H.

Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3477-82. Epub 2005 Feb 22.

49.

Motoneurons regulate myoblast proliferation and patterning in Drosophila.

Fernandes JJ, Keshishian H.

Dev Biol. 2005 Jan 15;277(2):493-505.

50.

Drosophila serpin 4 functions as a neuroserpin-like inhibitor of subtilisin-like proprotein convertases.

Osterwalder T, Kuhnen A, Leiserson WM, Kim YS, Keshishian H.

J Neurosci. 2004 Jun 16;24(24):5482-91.

Supplemental Content

Loading ...
Support Center