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The impact of first untreated subclinical minimal acute rejection on risk for chronic lung allograft dysfunction or death after lung transplantation.

Levy L, Huszti E, Tikkanen J, Ghany R, Klement W, Ahmed M, Husain S, Fiset PO, Hwang D, Keshavjee S, Singer LG, Juvet S, Martinu T.

Am J Transplant. 2019 Aug 9. doi: 10.1111/ajt.15561. [Epub ahead of print]


A B Cell-Dependent Pathway Drives Chronic Lung Allograft Rejection After Ischemia-Reperfusion Injury in Mice.

Watanabe T, Martinu T, Chruscinski A, Boonstra K, Joe B, Horie M, Guan Z, Bei KF, Hwang DM, Liu M, Keshavjee S, Juvet SC.

Am J Transplant. 2019 Jul 31. doi: 10.1111/ajt.15550. [Epub ahead of print]


Lung Density Analysis Using Quantitative Chest CT for Early Prediction of Chronic Lung Allograft Dysfunction.

Horie M, Levy L, Houbois C, Salazar P, Saito T, Pakkal M, Obrien C, Sajja S, Brock K, Yasufuku K, Keshavjee S, Paul N, Martinu T.

Transplantation. 2019 May 7. doi: 10.1097/TP.0000000000002771. [Epub ahead of print]


Lung cancer photothermal ablation by low-power near-infrared laser and topical injection of indocyanine green.

Hirohashi K, Anayama T, Wada H, Nakajima T, Kato T, Keshavjee S, Orihashi K, Yasufuku K.

Interact Cardiovasc Thorac Surg. 2019 Jul 6. pii: ivz158. doi: 10.1093/icvts/ivz158. [Epub ahead of print]


Cost-effectiveness of scaling up of hepatitis C screening and treatment: a modelling study in South Korea.

Kim J, Haacker M, Keshavjee S, Atun R.

BMJ Glob Health. 2019 Jun 4;4(3):e001441. doi: 10.1136/bmjgh-2019-001441. eCollection 2019.


TB Preventive Therapy for individuals exposed to drug-resistant tuberculosis: feasibility and safety of a community-based delivery of fluoroquinolone-containing preventive regimen.

Malik AA, Fuad J, Siddiqui S, Amanullah F, Jaswal M, Pmdcp ZB, Jabeen F, Fatima R, Yuen CM, Salahuddin N, Khan AJ, Keshavjee S, Becerra MC, Hussain H.

Clin Infect Dis. 2019 Jun 12. pii: ciz502. doi: 10.1093/cid/ciz502. [Epub ahead of print]


Donor human leukocyte antigen-G single nucleotide polymorphisms are associated with post-lung transplant mortality.

Lazarte J, Ma J, Martinu T, Levy L, Klement W, White M, Pelling J, Guan Z, Azad S, Tikkanen J, Rao V, Tomlinson G, Delgado D, Keshavjee S, Juvet SC.

Eur Respir J. 2019 Aug 15;54(2). pii: 1802126. doi: 10.1183/13993003.02126-2018. Print 2019 Aug.


A successful lung transplant from a 3-year-old donor after controlled cardiac death followed by ex vivo lung perfusion: A case report.

Galasso M, Vanderlaan RD, Solomon M, Caldarone C, Keshavjee S, Cypel M, de Perrot M.

J Thorac Cardiovasc Surg. 2019 Apr 23. pii: S0022-5223(19)30877-3. doi: 10.1016/j.jtcvs.2019.02.131. [Epub ahead of print] No abstract available.


Tuberculosis household accompaniment to improve the contact management cascade: A prospective cohort study.

Yuen CM, Millones AK, Contreras CC, Lecca L, Becerra MC, Keshavjee S.

PLoS One. 2019 May 17;14(5):e0217104. doi: 10.1371/journal.pone.0217104. eCollection 2019.


Veno-venous extracorporeal life support for blastomycosis-associated acute respiratory distress syndrome.

Al-Fares A, Fan E, Husain S, Di Nardo M, Cypel M, Keshavjee S, Herridge MS, Del Sorbo L.

Perfusion. 2019 Apr 26:267659119844391. doi: 10.1177/0267659119844391. [Epub ahead of print]


Epithelial cell death markers in bronchoalveolar lavage correlate with chronic lung allograft dysfunction subtypes and survival in lung transplant recipients-a single-center retrospective cohort study.

Levy L, Tigert A, Huszti E, Saito T, Mitsakakis N, Moshkelgosha S, Joe B, Boonstra KM, Tikkanen JM, Keshavjee S, Juvet SC, Martinu T.

Transpl Int. 2019 Apr 19. doi: 10.1111/tri.13444. [Epub ahead of print]


Chronic Candida dubliniensis meningitis in a lung transplant recipient.

Herrera S, Pavone P, Kumar D, Singer L, Humar A, Chaparro C, Keshavjee S, Husain S, Rotstein C.

Med Mycol Case Rep. 2019 Mar 25;24:41-43. doi: 10.1016/j.mmcr.2019.03.004. eCollection 2019 Jun.


Endobronchial ultrasound-guided transbronchial needle aspiration mediastinal lymph node staging in malignant pleural mesothelioma.

Czarnecka-Kujawa K, de Perrot M, Keshavjee S, Yasufuku K.

J Thorac Dis. 2019 Feb;11(2):602-612. doi: 10.21037/jtd.2019.01.01.


Uniportal Video-Assisted Transcervical Thymectomy.

Lemaître PH, Keshavjee S.

Thorac Surg Clin. 2019 May;29(2):187-194. doi: 10.1016/j.thorsurg.2018.12.009. Review.


Donor prone positioning protects lungs from injury during warm ischemia.

Watanabe Y, Galasso M, Watanabe T, Ali A, Qaqish R, Nakajima D, Taniguchi Y, Pipkin M, Caldarone L, Chen M, Kanou T, Summers C, Ramadan K, Zhang Y, Chan H, Waddell TK, Liu M, Keshavjee S, Del Sorbo L, Cypel M.

Am J Transplant. 2019 Mar 19. doi: 10.1111/ajt.15363. [Epub ahead of print]


3D Models in the Diagnosis of Subglottic Airway Stenosis.

Hoetzenecker K, Chan HHL, Frommlet F, Schweiger T, Keshavjee S, Waddell TK, Klepetko W, Irish JC, Yasufuku K.

Ann Thorac Surg. 2019 Jun;107(6):1860-1865. doi: 10.1016/j.athoracsur.2019.01.045. Epub 2019 Feb 27.


Video-observed therapy for tuberculosis: strengthening care.

Fraser H, Keshavjee S.

Lancet. 2019 Mar 23;393(10177):1180-1181. doi: 10.1016/S0140-6736(19)30293-4. Epub 2019 Feb 21. No abstract available.


Molecular assessment of rejection and injury in lung transplant biopsies.

Halloran KM, Parkes MD, Chang J, Timofte IL, Snell GI, Westall GP, Hachem R, Kreisel D, Trulock E, Roux A, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Halloran PF.

J Heart Lung Transplant. 2019 May;38(5):504-513. doi: 10.1016/j.healun.2019.01.1317. Epub 2019 Feb 6.


Cytokine profile in lung transplant recipients with Aspergillus spp colonization.

Herrera S, Gohir W, Foroutan F, Aguilar C, Juvet S, Martinu T, Kumar D, Humar A, Rotstein C, Keshavjee S, Singer LG, Husain S.

Transpl Infect Dis. 2019 Jun;21(3):e13060. doi: 10.1111/tid.13060. Epub 2019 Mar 21.


CT-guided Microcoil Pulmonary Nodule Localization prior to Video-assisted Thoracoscopic Surgery: Diagnostic Utility and Recurrence-Free Survival.

Rodrigues JCL, Pierre AF, Hanneman K, Cabanero M, Kavanagh J, Waddell TK, Chung TB, Pakkal M, Keshavjee S, Cypel M, Yasufuku K, Nguyen ET.

Radiology. 2019 Apr;291(1):214-222. doi: 10.1148/radiol.2019181674. Epub 2019 Feb 5.


Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion.

Galasso M, Feld JJ, Watanabe Y, Pipkin M, Summers C, Ali A, Qaqish R, Chen M, Ribeiro RVP, Ramadan K, Pires L, Bagnato VS, Kurachi C, Cherepanov V, Moonen G, Gazzalle A, Waddell TK, Liu M, Keshavjee S, Wilson BC, Humar A, Cypel M.

Nat Commun. 2019 Jan 29;10(1):481. doi: 10.1038/s41467-018-08261-z.


Lentiviral interleukin-10 gene therapy: Safety and questions.

Liu M, Juvet SC, Medin JA, Martinu T, Oishi H, Keshavjee S.

J Thorac Cardiovasc Surg. 2019 Feb;157(2):818-819. doi: 10.1016/j.jtcvs.2018.10.082. No abstract available.


Neutrophil extracellular traps in ex vivo lung perfusion perfusate predict the clinical outcome of lung transplant recipients.

Caldarone L, Mariscal A, Sage A, Khan M, Juvet S, Martinu T, Zamel R, Cypel M, Liu M, Palaniyar N, Keshavjee S.

Eur Respir J. 2019 Apr 4;53(4). pii: 1801736. doi: 10.1183/13993003.01736-2018. Print 2019 Apr. No abstract available.


Simultaneous multiplexed amplicon sequencing and transcriptome profiling in single cells.

Saikia M, Burnham P, Keshavjee SH, Wang MFZ, Heyang M, Moral-Lopez P, Hinchman MM, Danko CG, Parker JSL, De Vlaminck I.

Nat Methods. 2019 Jan;16(1):59-62. doi: 10.1038/s41592-018-0259-9. Epub 2018 Dec 17.


Use of predicted vital status to improve survival analysis of multidrug-resistant tuberculosis cohorts.

Brooks MB, Keshavjee S, Gelmanova I, Zemlyanaya NA, Mitnick CD, Manjourides J.

BMC Med Res Methodol. 2018 Dec 11;18(1):166. doi: 10.1186/s12874-018-0637-0.


Frailty assessment prior to thoracic surgery for lung or esophageal cancer: a feasibility study.

Hirpara DH, Kidane B, Rogalla P, Cypel M, de Perrot M, Keshavjee S, Pierre A, Waddell T, Yasufuku K, Darling GE.

Support Care Cancer. 2019 Apr;27(4):1535-1540. doi: 10.1007/s00520-018-4547-9. Epub 2018 Nov 14.


Metachronous or synchronous primary lung cancer in the era of computed tomography surveillance.

Wang Y, Yeung JC, Hanna WC, Allison F, Paul NS, Waddell TK, Cypel M, de Perrot ME, Yasufuku K, Keshavjee S, Pierre AF, Darling GE.

J Thorac Cardiovasc Surg. 2018 Oct 6. pii: S0022-5223(18)32556-X. doi: 10.1016/j.jtcvs.2018.09.052. [Epub ahead of print]


Spectrum of chronic lung allograft pathology in a mouse minor-mismatched orthotopic lung transplant model.

Martinu T, Oishi H, Juvet SC, Cypel M, Liu M, Berry GJ, Hwang DM, Keshavjee S.

Am J Transplant. 2019 Jan;19(1):247-258. doi: 10.1111/ajt.15167. Epub 2018 Nov 29.


Echinocandin use in lung transplant recipients.

Al Jishi Y, Rotstein C, Kumar D, Humar A, Singer LG, Keshavjee S, Husain S.

Clin Transplant. 2018 Dec;32(12):e13437. doi: 10.1111/ctr.13437. Epub 2018 Dec 9.


Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.

Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Le Van H, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P.

Am J Respir Crit Care Med. 2019 Mar 1;199(5):564-571. doi: 10.1164/rccm.201806-1053PP. No abstract available.


Porphyrin-High-Density Lipoprotein: A Novel Photosensitizing Nanoparticle for Lung Cancer Therapy.

Ujiie H, Ding L, Fan R, Kato T, Lee D, Fujino K, Kinoshita T, Lee CY, Waddell TK, Keshavjee S, Wilson BC, Zheng G, Chen J, Yasufuku K.

Ann Thorac Surg. 2019 Feb;107(2):369-377. doi: 10.1016/j.athoracsur.2018.08.053. Epub 2018 Oct 11.


Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation.

Cunningham PS, Maidstone R, Durrington HJ, Venkateswaran RV, Cypel M, Keshavjee S, Gibbs JE, Loudon AS, Chow CW, Ray DW, Blaikley JF.

Thorax. 2019 Apr;74(4):413-416. doi: 10.1136/thoraxjnl-2018-212021. Epub 2018 Oct 9.


Influence of lung donor agonal and warm ischemic times on early mortality: Analyses from the ISHLT DCD Lung Transplant Registry.

Levvey B, Keshavjee S, Cypel M, Robinson A, Erasmus M, Glanville A, Hopkins P, Musk M, Hertz M, McCurry K, Van Raemdonck D, Snell G.

J Heart Lung Transplant. 2019 Jan;38(1):26-34. doi: 10.1016/j.healun.2018.08.006. Epub 2018 Aug 11.


Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.

Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017, Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fréchet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Laborín R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, Palmero D, Pape JW, Podewils LJ, Reynolds I, Riekstina V, Robert J, Rodriguez M, Seaworth B, Seung KJ, Schnippel K, Shim TS, Singla R, Smith SE, Sotgiu G, Sukhbaatar G, Tabarsi P, Tiberi S, Trajman A, Trieu L, Udwadia ZF, van der Werf TS, Veziris N, Viiklepp P, Vilbrun SC, Walsh K, Westenhouse J, Yew WW, Yim JJ, Zetola NM, Zignol M, Menzies D.

Lancet. 2018 Sep 8;392(10150):821-834. doi: 10.1016/S0140-6736(18)31644-1. Review.


Intraoperative extracorporeal support during lung transplantation in patients bridged with venovenous extracorporeal membrane oxygenation.

Hashimoto K, Hoetzenecker K, Yeung JC, Jeagal L, Donahoe L, Pierre A, de Perrot M, Yasufuku K, Waddell TK, Keshavjee S, Cypel M.

J Heart Lung Transplant. 2018 Dec;37(12):1418-1424. doi: 10.1016/j.healun.2018.07.003. Epub 2018 Sep 5.


Adjuvant lung resection in the management of nontuberculous mycobacterial lung infection: A retrospective matched cohort study.

Aznar ML, Zubrinic M, Siemienowicz M, Hashimoto K, Brode SK, Mehrabi M, Patsios D, Keshavjee S, Marras TK.

Respir Med. 2018 Sep;142:1-6. doi: 10.1016/j.rmed.2018.07.003. Epub 2018 Jul 9.


The role of endobronchial ultrasound-guided transbronchial needle aspiration in stereotactic body radiation therapy for non-small cell lung cancer.

Hashimoto K, Daddi N, Giuliani M, Hope A, Le LW, Czarnecka K, Cypel M, Pierre A, de Perrot M, Darling G, Waddell TK, Keshavjee S, Yasufuku K.

Lung Cancer. 2018 Sep;123:1-6. doi: 10.1016/j.lungcan.2018.06.011. Epub 2018 Jun 11.


Favourable health-related quality of life reported in survivors of thymic malignancies.

Soldera SV, Shakik S, Naik H, Moskovitz M, Chen J, Mittmann N, Xu W, Hope A, Bezjak A, Parajian A, Keshavjee S, Liu G.

Eur J Cardiothorac Surg. 2019 Feb 1;55(2):292-299. doi: 10.1093/ejcts/ezy259.


Pig lung transplant survival model.

Mariscal A, Caldarone L, Tikkanen J, Nakajima D, Chen M, Yeung J, Cypel M, Liu M, Keshavjee S.

Nat Protoc. 2018 Aug;13(8):1814-1828. doi: 10.1038/s41596-018-0019-4.


Ischemia-reperfusion induces death receptor-independent necroptosis via calpain-STAT3 activation in a lung transplant setting.

Kim H, Zamel R, Bai XH, Lu C, Keshavjee S, Keshavjee S, Liu M.

Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L595-L608. doi: 10.1152/ajplung.00069.2018. Epub 2018 Jul 19.


Experience from an American Association for Thoracic Surgery Foundation for Thoracic Surgery Training Fellowship: Lung transplantation in Toronto General Hospital.

Tian D, Keshavjee S.

J Thorac Cardiovasc Surg. 2018 Aug;156(2):929-930. doi: 10.1016/j.jtcvs.2018.04.036. No abstract available.


Introducing the concept of semielective lung transplantation through the use of ex vivo lung perfusion.

Cypel M, Yeung JC, Keshavjee S.

J Thorac Cardiovasc Surg. 2018 Dec;156(6):2350-2352. doi: 10.1016/j.jtcvs.2018.05.056. Epub 2018 Jun 4. No abstract available.


A novel combined ex vivo and in vivo lentiviral interleukin-10 gene delivery strategy at the time of transplantation decreases chronic lung allograft rejection in mice.

Oishi H, Juvet SC, Martinu T, Sato M, Medin JA, Liu M, Keshavjee S.

J Thorac Cardiovasc Surg. 2018 Sep;156(3):1305-1315. doi: 10.1016/j.jtcvs.2018.05.003. Epub 2018 May 29.


Visualizing Heterogeneous Pulmonary Ventilation. Respiratory Failure due to an Anterior Mediastinal Mass.

Desîlets A, Keshavjee S, Goligher EC.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):e88-e89. doi: 10.1164/rccm.201801-0037IM. No abstract available.


Inhibition of regulated necrosis attenuates receptor-interacting protein kinase 1-mediated ischemia-reperfusion injury after lung transplantation.

Kanou T, Ohsumi A, Kim H, Chen M, Bai X, Guan Z, Hwang D, Cypel M, Keshavjee S, Liu M.

J Heart Lung Transplant. 2018 Oct;37(10):1261-1270. doi: 10.1016/j.healun.2018.04.005. Epub 2018 Apr 26.


Identification of risk epitope mismatches associated with de novo donor-specific HLA antibody development in cardiothoracic transplantation.

McCaughan JA, Battle RK, Singh SKS, Tikkanen JM, Moayedi Y, Ross HJ, Singer LG, Keshavjee S, Tinckam KJ.

Am J Transplant. 2018 Dec;18(12):2924-2933. doi: 10.1111/ajt.14951. Epub 2018 Jun 22.


Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation.

Levy L, Juvet SC, Boonstra K, Singer LG, Azad S, Joe B, Cypel M, Keshavjee S, Martinu T.

Respir Res. 2018 May 25;19(1):102. doi: 10.1186/s12931-018-0786-z.


Comprehensive outcomes after lung retransplantation: A single-center review.

Halloran K, Aversa M, Tinckam K, Martinu T, Binnie M, Chaparro C, Chow CW, Waddell T, McRae K, Pierre A, de Perrot M, Yasufuku K, Cypel M, Keshavjee S, Singer LG.

Clin Transplant. 2018 Jun;32(6):e13281. doi: 10.1111/ctr.13281. Epub 2018 Jun 3.


Turning Off the Tap: Using the FAST Approach to Stop the Spread of Drug-Resistant Tuberculosis in the Russian Federation.

Miller AC, Livchits V, Ahmad Khan F, Atwood S, Kornienko S, Kononenko Y, Vasilyeva I, Keshavjee S.

J Infect Dis. 2018 Jul 13;218(4):654-658. doi: 10.1093/infdis/jiy190.

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