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Items: 36


PromISR-6, a Guanabenz Analogue, Improves Cellular Survival in an Experimental Model of Huntington's Disease.

Sundaram JR, Wu Y, Lee IC, George SE, Hota M, Ghosh S, Kesavapany S, Ahmed M, Tan EK, Shenolikar S.

ACS Chem Neurosci. 2019 Aug 21;10(8):3575-3589. doi: 10.1021/acschemneuro.9b00185. Epub 2019 Jul 30.


Overexpression of the Cdk5 inhibitory peptide in motor neurons rescue of amyotrophic lateral sclerosis phenotype in a mouse model.

Binukumar BK, Skuntz S, Prochazkova M, Kesavapany S, Amin ND, Shukla V, Grant P, Kulkarni AB, Pant HC.

Hum Mol Genet. 2019 Jun 12. pii: ddz118. doi: 10.1093/hmg/ddz118. [Epub ahead of print]


Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer's Disease.

Sundaram JR, Poore CP, Sulaimee NHB, Pareek T, Cheong WF, Wenk MR, Pant HC, Frautschy SA, Low CM, Kesavapany S.

J Alzheimers Dis. 2017;60(4):1429-1442. doi: 10.3233/JAD-170093.


TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice.

Shukla V, Seo J, Binukumar BK, Amin ND, Reddy P, Grant P, Kuntz S, Kesavapany S, Steiner J, Mishra SK, Tsai LH, Pant HC.

J Alzheimers Dis. 2017;56(1):335-349. doi: 10.3233/JAD-160916.


Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.

Sundaram JR, Poore CP, Sulaimee NH, Pareek T, Asad AB, Rajkumar R, Cheong WF, Wenk MR, Dawe GS, Chuang KH, Pant HC, Kesavapany S.

J Neurosci. 2013 Jan 2;33(1):334-43. doi: 10.1523/JNEUROSCI.3593-12.2013.


A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice.

Shukla V, Zheng YL, Mishra SK, Amin ND, Steiner J, Grant P, Kesavapany S, Pant HC.

FASEB J. 2013 Jan;27(1):174-86. doi: 10.1096/fj.12-217497. Epub 2012 Oct 4.


Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.

Pareek TK, Belkadi A, Kesavapany S, Zaremba A, Loh SL, Bai L, Cohen ML, Meyer C, Liby KT, Miller RH, Sporn MB, Letterio JJ.

Sci Rep. 2011;1:201. doi: 10.1038/srep00201. Epub 2011 Dec 19.


Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.

Sundaram JR, Chan ES, Poore CP, Pareek TK, Cheong WF, Shui G, Tang N, Low CM, Wenk MR, Kesavapany S.

J Neurosci. 2012 Jan 18;32(3):1020-34. doi: 10.1523/JNEUROSCI.5177-11.2012.


Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease.

Lim L, Jackson-Lewis V, Wong LC, Shui GH, Goh AX, Kesavapany S, Jenner AM, Fivaz M, Przedborski S, Wenk MR.

Cell Death Differ. 2012 Mar;19(3):416-27. doi: 10.1038/cdd.2011.105. Epub 2011 Aug 5.


Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation.

Zheng YL, Li BS, Rudrabhatla P, Shukla V, Amin ND, Maric D, Kesavapany S, Kanungo J, Pareek TK, Takahashi S, Grant P, Kulkarni AB, Pant HC.

Mol Biol Cell. 2010 Oct 15;21(20):3601-14. doi: 10.1091/mbc.E10-01-0054. Epub 2010 Sep 1.


A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.

Zheng YL, Amin ND, Hu YF, Rudrabhatla P, Shukla V, Kanungo J, Kesavapany S, Grant P, Albers W, Pant HC.

J Biol Chem. 2010 Oct 29;285(44):34202-12. doi: 10.1074/jbc.M110.134643. Epub 2010 Aug 18.


Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.

Poore CP, Sundaram JR, Pareek TK, Fu A, Amin N, Mohamed NE, Zheng YL, Goh AX, Lai MK, Ip NY, Pant HC, Kesavapany S.

J Neurosci. 2010 Jun 23;30(25):8457-67. doi: 10.1523/JNEUROSCI.6062-09.2010.


A fluorescent glycolipid-binding peptide probe traces cholesterol dependent microdomain-derived trafficking pathways.

Steinert S, Lee E, Tresset G, Zhang D, Hortsch R, Wetzel R, Hebbar S, Sundram JR, Kesavapany S, Boschke E, Kraut R.

PLoS One. 2008 Aug 13;3(8):e2933. doi: 10.1371/journal.pone.0002933.


Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein.

Rudrabhatla P, Zheng YL, Amin ND, Kesavapany S, Albers W, Pant HC.

J Biol Chem. 2008 Sep 26;283(39):26737-47. doi: 10.1074/jbc.M801633200. Epub 2008 Jul 17.


Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis.

Amin ND, Zheng YL, Kesavapany S, Kanungo J, Guszczynski T, Sihag RK, Rudrabhatla P, Albers W, Grant P, Pant HC.

J Neurosci. 2008 Apr 2;28(14):3631-43. doi: 10.1523/JNEUROSCI.0453-08.2008.


Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons.

Kesavapany S, Patel V, Zheng YL, Pareek TK, Bjelogrlic M, Albers W, Amin N, Jaffe H, Gutkind JS, Strong MJ, Grant P, Pant HC.

Mol Biol Cell. 2007 Sep;18(9):3645-55. Epub 2007 Jul 11.


Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5.

Kesavapany S, Zheng YL, Amin N, Pant HC.

Biotechnol J. 2007 Aug;2(8):978-87. Review.


Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress.

Kino T, Ichijo T, Amin ND, Kesavapany S, Wang Y, Kim N, Rao S, Player A, Zheng YL, Garabedian MJ, Kawasaki E, Pant HC, Chrousos GP.

Mol Endocrinol. 2007 Jul;21(7):1552-68. Epub 2007 Apr 17.


Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1.

Pareek TK, Keller J, Kesavapany S, Agarwal N, Kuner R, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):660-5. Epub 2006 Dec 28.


Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival.

Zheng YL, Li BS, Kanungo J, Kesavapany S, Amin N, Grant P, Pant HC.

Mol Biol Cell. 2007 Feb;18(2):404-13. Epub 2006 Nov 15.


Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1.

Kesavapany S, Pareek TK, Zheng YL, Amin N, Gutkind JS, Ma W, Kulkarni AB, Grant P, Pant HC.

Neurosignals. 2006-2007;15(4):157-73. Epub 2006 Aug 18.


Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.

Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, Harvey RJ, Harvey K, Cookson MR.

Neurobiol Dis. 2006 Aug;23(2):329-41. Epub 2006 Jun 5.


Cyclin-dependent kinase 5 activity regulates pain signaling.

Pareek TK, Keller J, Kesavapany S, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):791-6. Epub 2006 Jan 9.


The pathobiology of amyotrophic lateral sclerosis: a proteinopathy?

Strong MJ, Kesavapany S, Pant HC.

J Neuropathol Exp Neurol. 2005 Aug;64(8):649-64. Review.


Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.

Beilina A, Van Der Brug M, Ahmad R, Kesavapany S, Miller DW, Petsko GA, Cookson MR.

Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5703-8. Epub 2005 Apr 11.


A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons.

Zheng YL, Kesavapany S, Gravell M, Hamilton RS, Schubert M, Amin N, Albers W, Grant P, Pant HC.

EMBO J. 2005 Jan 12;24(1):209-20. Epub 2004 Dec 9.


The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.

Perkinton MS, Standen CL, Lau KF, Kesavapany S, Byers HL, Ward M, McLoughlin DM, Miller CC.

J Biol Chem. 2004 May 21;279(21):22084-91. Epub 2004 Mar 18.


Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide.

Kesavapany S, Li BS, Amin N, Zheng YL, Grant P, Pant HC.

Biochim Biophys Acta. 2004 Mar 11;1697(1-2):143-53. Review.


The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

Standen CL, Perkinton MS, Byers HL, Kesavapany S, Lau KF, Ward M, McLoughlin D, Miller CC.

Mol Cell Neurosci. 2003 Dec;24(4):851-7.


Cyclin-dependent kinase 5 in neurofilament function and regulation.

Kesavapany S, Li BS, Pant HC.

Neurosignals. 2003 Sep-Oct;12(4-5):252-64. Review.


Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.

Kesavapany S, Lau KF, Ackerley S, Banner SJ, Shemilt SJ, Cooper JD, Leigh PN, Shaw CE, McLoughlin DM, Miller CC.

J Neurosci. 2003 Jun 15;23(12):4975-83.


Expression of the Fe65 adapter protein in adult and developing mouse brain.

Kesavapany S, Banner SJ, Lau KF, Shaw CE, Miller CC, Cooper JD, McLoughlin DM.

Neuroscience. 2002;115(3):951-60.


Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

Lau KF, Howlett DR, Kesavapany S, Standen CL, Dingwall C, McLoughlin DM, Miller CC.

Mol Cell Neurosci. 2002 May;20(1):13-20.


p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction.

Kesavapany S, Lau KF, McLoughlin DM, Brownlees J, Ackerley S, Leigh PN, Shaw CE, Miller CC.

Eur J Neurosci. 2001 Jan;13(2):241-7.


Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

Standen CL, Brownlees J, Grierson AJ, Kesavapany S, Lau KF, McLoughlin DM, Miller CC.

J Neurochem. 2001 Jan;76(1):316-20.

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