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Negative Carotid Artery Remodeling in Early Type 2 Diabetes Mellitus and Increased Carotid Plaque Vulnerability in Obesity as Assessed by Magnetic Resonance Imaging.

Laugesen E, Høyem P, Thrysoe S, Hansen ESS, Mikkelsen AFS, Kerwin WS, Poulsen PL, Hansen TK, Kim WY.

J Am Heart Assoc. 2018 Aug 21;7(16):e008677. doi: 10.1161/JAHA.118.008677.


Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition.

Dey J, Deckwerth TL, Kerwin WS, Casalini JR, Merrell AJ, Grenley MO, Burns C, Ditzler SH, Dixon CP, Beirne E, Gillespie KC, Kleinman EF, Klinghoffer RA.

Sci Rep. 2017 Dec 21;7(1):18007. doi: 10.1038/s41598-017-18368-w.


Imaging of the high-risk carotid plaque: magnetic resonance imaging.

Kerwin WS, Miller Z, Yuan C.

Semin Vasc Surg. 2017 Mar;30(1):54-61. doi: 10.1053/j.semvascsurg.2017.04.009. Epub 2017 Apr 27. Review.


Multidrug Analyses in Patients Distinguish Efficacious Cancer Agents Based on Both Tumor Cell Killing and Immunomodulation.

Frazier JP, Bertout JA, Kerwin WS, Moreno-Gonzalez A, Casalini JR, Grenley MO, Beirne E, Watts KL, Keener A, Thirstrup DJ, Tretyak I, Ditzler SH, Tripp CD, Choy K, Gillings S, Breit MN, Meleo KA, Rizzo V, Herrera CL, Perry JA, Amaravadi RK, Olson JM, Klinghoffer RA.

Cancer Res. 2017 Jun 1;77(11):2869-2880. doi: 10.1158/0008-5472.CAN-17-0084. Epub 2017 Mar 31.


Semi-automatic carotid intraplaque hemorrhage detection and quantification on Magnetization-Prepared Rapid Acquisition Gradient-Echo (MP-RAGE) with optimized threshold selection.

Liu J, Balu N, Hippe DS, Ferguson MS, Martinez-Malo V, DeMarco JK, Zhu DC, Ota H, Sun J, Xu D, Kerwin WS, Hatsukami TS, Yuan C.

J Cardiovasc Magn Reson. 2016 Jul 16;18(1):41. doi: 10.1186/s12968-016-0260-3.


A Platform for Rapid, Quantitative Assessment of Multiple Drug Combinations Simultaneously in Solid Tumors In Vivo.

Dey J, Kerwin WS, Grenley MO, Casalini JR, Tretyak I, Ditzler SH, Thirstrup DJ, Frazier JP, Pierce DW, Carleton M, Klinghoffer RA.

PLoS One. 2016 Jun 30;11(6):e0158617. doi: 10.1371/journal.pone.0158617. eCollection 2016.


Summary of clinical and laboratory data of study subjects with and without DCE-MRI plaque measurements in the AIM-HIGH clinical trial.

O'Brien KD, Hippe DS, Chen H, Neradilek MB, Probstfield JL, Peck S, Isquith DA, Canton G, Yuan C, Polissar NL, Zhao XQ, Kerwin WS.

Data Brief. 2016 Jan 2;6:476-81. doi: 10.1016/j.dib.2015.12.030. eCollection 2016 Mar.


In Vivo Validation of Simultaneous Non-Contrast Angiography and intraPlaque Hemorrhage (SNAP) Magnetic Resonance Angiography: An Intracranial Artery Study.

Wang J, Guan M, Yamada K, Hippe DS, Kerwin WS, Yuan C, Börnert P, Zhao X.

PLoS One. 2016 Feb 10;11(2):e0149130. doi: 10.1371/journal.pone.0149130. eCollection 2016.


Longer duration of statin therapy is associated with decreased carotid plaque vascularity by magnetic resonance imaging.

O'Brien KD, Hippe DS, Chen H, Neradilek MB, Probstfield JL, Peck S, Isquith DA, Canton G, Yuan C, Polissar NL, Zhao XQ, Kerwin WS.

Atherosclerosis. 2016 Feb;245:74-81. doi: 10.1016/j.atherosclerosis.2015.11.032. Epub 2015 Dec 1.


Modeling hemodynamic forces in carotid artery based on local geometric features.

Chen Y, Canton G, Kerwin WS, Chiu B.

Med Biol Eng Comput. 2016 Sep;54(9):1437-52. doi: 10.1007/s11517-015-1417-1. Epub 2015 Nov 17.


Minimally invasive in tumor multidrug comparative analysis with contrast-enhanced MRI in mice.

Kerwin WS, Tretyak I, Grenley MO, You S, Hatton BA, Moreno-Gonzalez A, Thirstrup DJ, Klinghoffer RA.

Magn Reson Med. 2016 Sep;76(3):946-52. doi: 10.1002/mrm.25978. Epub 2015 Sep 12.


High resolution FDG-microPET of carotid atherosclerosis: plaque components underlying enhanced FDG uptake.

Liu J, Kerwin WS, Caldwell JH, Ferguson MS, Hippe DS, Alessio AM, Martinez-Malo V, Pimentel K, Miyaoka RS, Kohler TR, Hatsukami TS, Yuan C.

Int J Cardiovasc Imaging. 2016 Jan;32(1):145-52. doi: 10.1007/s10554-015-0739-2. Epub 2015 Aug 18.


Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration.

Chen N, Brachmann C, Liu X, Pierce DW, Dey J, Kerwin WS, Li Y, Zhou S, Hou S, Carleton M, Klinghoffer RA, Palmisano M, Chopra R.

Cancer Chemother Pharmacol. 2015 Oct;76(4):699-712. doi: 10.1007/s00280-015-2833-5. Epub 2015 Aug 1.


In vivo semi-automatic segmentation of multicontrast cardiovascular magnetic resonance for prospective cohort studies on plaque tissue composition: initial experience.

Yoneyama T, Sun J, Hippe DS, Balu N, Xu D, Kerwin WS, Hatsukami TS, Yuan C.

Int J Cardiovasc Imaging. 2016 Jan;32(1):73-81. doi: 10.1007/s10554-015-0704-0. Epub 2015 Jul 14.


A technology platform to assess multiple cancer agents simultaneously within a patient's tumor.

Klinghoffer RA, Bahrami SB, Hatton BA, Frazier JP, Moreno-Gonzalez A, Strand AD, Kerwin WS, Casalini JR, Thirstrup DJ, You S, Morris SM, Watts KL, Veiseh M, Grenley MO, Tretyak I, Dey J, Carleton M, Beirne E, Pedro KD, Ditzler SH, Girard EJ, Deckwerth TL, Bertout JA, Meleo KA, Filvaroff EH, Chopra R, Press OW, Olson JM.

Sci Transl Med. 2015 Apr 22;7(284):284ra58. doi: 10.1126/scitranslmed.aaa7489.


Scan-rescan reproducibility of quantitative assessment of inflammatory carotid atherosclerotic plaque using dynamic contrast-enhanced 3T CMR in a multi-center study.

Chen H, Sun J, Kerwin WS, Balu N, Neradilek MB, Hippe DS, Isquith D, Xue Y, Yamada K, Peck S, Yuan C, O'Brien KD, Zhao XQ.

J Cardiovasc Magn Reson. 2014 Aug 1;16:51. doi: 10.1186/s12968-014-0051-7.


Atherosclerotic plaque inflammation quantification using dynamic contrast-enhanced (DCE) MRI.

Chen H, Wu T, Kerwin WS, Yuan C.

Quant Imaging Med Surg. 2013 Dec;3(6):298-301. doi: 10.3978/j.issn.2223-4292.2013.12.01.


Relationships between local geometrical features and hemodynamic flow properties.

Chiu B, Chen Y, Canton G, Kerwin WS.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:723-6. doi: 10.1109/EMBC.2013.6609602.


A framework for the co-registration of hemodynamic forces and atherosclerotic plaque components.

Canton G, Chiu B, Chen H, Chen Y, Hatsukami TS, Kerwin WS, Yuan C.

Physiol Meas. 2013 Sep;34(9):977-90. doi: 10.1088/0967-3334/34/9/977. Epub 2013 Aug 14.


Adventitial perfusion and intraplaque hemorrhage: a dynamic contrast-enhanced MRI study in the carotid artery.

Sun J, Song Y, Chen H, Kerwin WS, Hippe DS, Dong L, Chen M, Zhou C, Hatsukami TS, Yuan C.

Stroke. 2013 Apr;44(4):1031-6. doi: 10.1161/STROKEAHA.111.000435. Epub 2013 Mar 7.


MRI of carotid atherosclerosis.

Kerwin WS, Hatsukami T, Yuan C, Zhao XQ.

AJR Am J Roentgenol. 2013 Mar;200(3):W304-13. doi: 10.2214/AJR.12.8665. Review.


Carotid artery disease and stroke: assessing risk with vessel wall MRI.

Kerwin WS.

ISRN Cardiol. 2012;2012:180710. doi: 10.5402/2012/180710. Epub 2012 Nov 14.


Mapping contrast agent uptake and retention in MRI studies of myocardial perfusion: case control study of dogs with Duchenne muscular dystrophy.

Kerwin WS, Naumova A, Storb R, Tapscott SJ, Wang Z.

Int J Cardiovasc Imaging. 2013 Apr;29(4):819-26. doi: 10.1007/s10554-012-0137-y. Epub 2012 Oct 17.


Characterization of distensibility, plaque burden, and composition of the atherosclerotic carotid artery using magnetic resonance imaging.

Canton G, Hippe DS, Sun J, Underhill HR, Kerwin WS, Tang D, Yuan C.

Med Phys. 2012 Oct;39(10):6247-53. doi: 10.1118/1.4754302.


Characterization of carotid plaques on 3-dimensional ultrasound imaging by registration with multicontrast magnetic resonance imaging.

Chiu B, Shamdasani V, Entrekin R, Yuan C, Kerwin WS.

J Ultrasound Med. 2012 Oct;31(10):1567-80.


Progression of experimental lesions of atherosclerosis: assessment by kinetic modeling of black-blood dynamic contrast-enhanced MRI.

Chen H, Ricks J, Rosenfeld M, Kerwin WS.

Magn Reson Med. 2013 Jun;69(6):1712-20. doi: 10.1002/mrm.24415. Epub 2012 Jul 24.


Simultaneous noncontrast angiography and intraplaque hemorrhage (SNAP) imaging for carotid atherosclerotic disease evaluation.

Wang J, Börnert P, Zhao H, Hippe DS, Zhao X, Balu N, Ferguson MS, Hatsukami TS, Xu J, Yuan C, Kerwin WS.

Magn Reson Med. 2013 Feb;69(2):337-45. doi: 10.1002/mrm.24254. Epub 2012 Mar 22.


Segmentation of carotid plaque using multicontrast 3D gradient echo MRI.

Liu W, Balu N, Sun J, Zhao X, Chen H, Yuan C, Zhao H, Xu J, Wang G, Kerwin WS.

J Magn Reson Imaging. 2012 Apr;35(4):812-9. doi: 10.1002/jmri.22886. Epub 2011 Nov 29.


Fast plaque burden assessment of the femoral artery using 3D black-blood MRI and automated segmentation.

Chiu B, Sun J, Zhao X, Wang J, Balu N, Chi J, Xu J, Yuan C, Kerwin WS.

Med Phys. 2011 Oct;38(10):5370-84. doi: 10.1118/1.3633899.


Carotid artery atherosclerosis: effect of intensive lipid therapy on the vasa vasorum--evaluation by using dynamic contrast-enhanced MR imaging.

Dong L, Kerwin WS, Chen H, Chu B, Underhill HR, Neradilek MB, Hatsukami TS, Yuan C, Zhao XQ.

Radiology. 2011 Jul;260(1):224-31. doi: 10.1148/radiol.11101264. Epub 2011 Apr 14.


Real-time co-registration using novel ultrasound technology: ex vivo validation and in vivo applications.

Yang EY, Polsani VR, Washburn MJ, Zang W, Hall AL, Virani SS, Hodge MD, Parker D, Kerwin WS, Lawrie GM, Garami Z, Ballantyne CM, Morrisett JD, Nambi V.

J Am Soc Echocardiogr. 2011 Jul;24(7):720-8. doi: 10.1016/j.echo.2011.02.003. Epub 2011 Mar 24.


Extended graphical model for analysis of dynamic contrast-enhanced MRI.

Chen H, Li F, Zhao X, Yuan C, Rutt B, Kerwin WS.

Magn Reson Med. 2011 Sep;66(3):868-78. doi: 10.1002/mrm.22819. Epub 2011 Mar 9.


Noninvasive imaging of plaque inflammation: role of contrast-enhanced MRI.

Kerwin WS.

JACC Cardiovasc Imaging. 2010 Nov;3(11):1136-8. doi: 10.1016/j.jcmg.2010.09.004. No abstract available.


Advanced techniques for MRI of atherosclerotic plaque.

Kerwin WS, Canton G.

Top Magn Reson Imaging. 2009 Aug;20(4):217-25. doi: 10.1097/RMR.0b013e3181ea2853. Review.


Localized measurement of atherosclerotic plaque inflammatory burden with dynamic contrast-enhanced MRI.

Chen H, Cai J, Zhao X, Underhill H, Ota H, Oikawa M, Dong L, Yuan C, Kerwin WS.

Magn Reson Med. 2010 Aug;64(2):567-73. doi: 10.1002/mrm.22369.


Comparison of Simpson's method and three-dimensional reconstruction for measurement of right ventricular volume in patients with complete or corrected transposition of the great arteries.

Moroseos T, Mitsumori L, Kerwin WS, Sahn DJ, Helbing WA, Kilner PJ, Shurman A, Litt H, Sheehan FH.

Am J Cardiol. 2010 Jun 1;105(11):1603-9. doi: 10.1016/j.amjcard.2010.01.025. Epub 2010 Apr 21.


Cardiovascular magnetic resonance in carotid atherosclerotic disease.

Dong L, Kerwin WS, Ferguson MS, Li R, Wang J, Chen H, Canton G, Hatsukami TS, Yuan C.

J Cardiovasc Magn Reson. 2009 Dec 15;11:53. doi: 10.1186/1532-429X-11-53. Review.


Magnetic [corrected] resonance imaging [corrected] features of the disruption-prone and the disrupted carotid plaque.

Chu B, Ferguson MS, Chen H, Hippe DS, Kerwin WS, Canton G, Yuan C, Hatsukami TS.

JACC Cardiovasc Imaging. 2009 Jul;2(7):883-96. doi: 10.1016/j.jcmg.2009.03.013. Review. Erratum in: JACC Cardiovasc Imaging. 2009 Sep;2(9):1146.


Contrast-enhanced MRI of carotid atherosclerosis: dependence on contrast agent.

Kerwin WS, Zhao X, Yuan C, Hatsukami TS, Maravilla KR, Underhill HR, Zhao X.

J Magn Reson Imaging. 2009 Jul;30(1):35-40. doi: 10.1002/jmri.21826.


Signal features of the atherosclerotic plaque at 3.0 Tesla versus 1.5 Tesla: impact on automatic classification.

Kerwin WS, Liu F, Yarnykh V, Underhill H, Oikawa M, Yu W, Hatsukami TS, Yuan C.

J Magn Reson Imaging. 2008 Oct;28(4):987-95. doi: 10.1002/jmri.21529.


MR imaging of adventitial vasa vasorum in carotid atherosclerosis.

Kerwin WS, Oikawa M, Yuan C, Jarvik GP, Hatsukami TS.

Magn Reson Med. 2008 Mar;59(3):507-14. doi: 10.1002/mrm.21532.


Three-dimensional shape analysis of right ventricular remodeling in repaired tetralogy of Fallot.

Sheehan FH, Ge S, Vick GW 3rd, Urnes K, Kerwin WS, Bolson EL, Chung T, Kovalchin JP, Sahn DJ, Jerosch-Herold M, Stolpen AH.

Am J Cardiol. 2008 Jan 1;101(1):107-13.


Reader and platform reproducibility for quantitative assessment of carotid atherosclerotic plaque using 1.5T Siemens, Philips, and General Electric scanners.

Saam T, Hatsukami TS, Yarnykh VL, Hayes CE, Underhill H, Chu B, Takaya N, Cai J, Kerwin WS, Xu D, Polissar NL, Neradilek B, Hamar WK, Maki J, Shaw DW, Buck RJ, Wyman B, Yuan C.

J Magn Reson Imaging. 2007 Aug;26(2):344-52.


The vulnerable, or high-risk, atherosclerotic plaque: noninvasive MR imaging for characterization and assessment.

Saam T, Hatsukami TS, Takaya N, Chu B, Underhill H, Kerwin WS, Cai J, Ferguson MS, Yuan C.

Radiology. 2007 Jul;244(1):64-77. Review.


Serial MRI of carotid plaque burden: influence of subject repositioning on measurement precision.

Balu N, Kerwin WS, Chu B, Liu F, Yuan C.

Magn Reson Med. 2007 Mar;57(3):592-9.


MRI of atherosclerosis in clinical trials.

Yuan C, Kerwin WS, Yarnykh VL, Cai J, Saam T, Chu B, Takaya N, Ferguson MS, Underhill H, Xu D, Liu F, Hatsukami TS.

NMR Biomed. 2006 Oct;19(6):636-54. Review.


Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study.

Kerwin WS, O'Brien KD, Ferguson MS, Polissar N, Hatsukami TS, Yuan C.

Radiology. 2006 Nov;241(2):459-68. Epub 2006 Sep 11.


Automated measurement of mean wall thickness in the common carotid artery by MRI: a comparison to intima-media thickness by B-mode ultrasound.

Underhill HR, Kerwin WS, Hatsukami TS, Yuan C.

J Magn Reson Imaging. 2006 Aug;24(2):379-87.


Effect of contrast enhancement on the measurement of carotid arterial lumen and wall volume using MRI.

Phan BA, Chu B, Kerwin WS, Xu D, Yuan C, Hatsukami T, Zhao XQ.

J Magn Reson Imaging. 2006 Apr;23(4):481-5.


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