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Items: 13


Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice.

Liang HP, Kerschen EJ, Basu S, Hernandez I, Zogg M, Jia S, Hessner MJ, Toso R, Rezaie AR, Fernández JA, Camire RM, Ruf W, Griffin JH, Weiler H.

Blood. 2015 Nov 19;126(21):2415-23. doi: 10.1182/blood-2015-05-644401. Epub 2015 Sep 4. Erratum in: Blood. 2018 May 31;131(22):2509.


EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice.

Liang HP, Kerschen EJ, Hernandez I, Basu S, Zogg M, Botros F, Jia S, Hessner MJ, Griffin JH, Ruf W, Weiler H.

Blood. 2015 Apr 30;125(18):2845-54. doi: 10.1182/blood-2014-11-610717. Epub 2015 Mar 2. Erratum in: Blood. 2018 May 31;131(22):2508.


Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.

Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernández JÁ, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin JH, Baum C, Weiler H, Hauer-Jensen M.

Nat Med. 2012 Jul;18(7):1123-9. doi: 10.1038/nm.2813.


Gr1+ cells control growth of YopM-negative yersinia pestis during systemic plague.

Ye Z, Kerschen EJ, Cohen DA, Kaplan AM, van Rooijen N, Straley SC.

Infect Immun. 2009 Sep;77(9):3791-806. doi: 10.1128/IAI.00284-09. Epub 2009 Jul 6.


Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.

Mosnier LO, Zampolli A, Kerschen EJ, Schuepbach RA, Banerjee Y, Fernández JA, Yang XV, Riewald M, Weiler H, Ruggeri ZM, Griffin JH.

Blood. 2009 Jun 4;113(23):5970-8. doi: 10.1182/blood-2008-10-183327. Epub 2009 Feb 24.


Caveolin-1-dependent apoptosis induced by fibrin degradation products.

Guo YH, Hernandez I, Isermann B, Kang TB, Medved L, Sood R, Kerschen EJ, Holyst T, Mosesson MW, Weiler H.

Blood. 2009 Apr 30;113(18):4431-9. doi: 10.1182/blood-2008-07-169433. Epub 2008 Dec 12.


Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5.

Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, Kwitek AE, Lernmark A, Gorski J, Weiler H.

Blood. 2008 Dec 15;112(13):4905-14. doi: 10.1182/blood-2008-03-146555. Epub 2008 Sep 16.


Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H.

J Exp Med. 2007 Oct 1;204(10):2439-48. Epub 2007 Sep 24.


Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.

Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, Salmon JE, Coughlin SR, Weiler H.

J Exp Med. 2007 May 14;204(5):1049-56. Epub 2007 Apr 16.


Mice naturally resistant to Yersinia pestis Delta pgm strains commonly used in pathogenicity studies.

Congleton YH, Wulff CR, Kerschen EJ, Straley SC.

Infect Immun. 2006 Nov;74(11):6501-4. Epub 2006 Sep 5.


Antibody against V antigen prevents Yop-dependent growth of Yersinia pestis.

Philipovskiy AV, Cowan C, Wulff-Strobel CR, Burnett SH, Kerschen EJ, Cohen DA, Kaplan AM, Straley SC.

Infect Immun. 2005 Mar;73(3):1532-42.


The plague virulence protein YopM targets the innate immune response by causing a global depletion of NK cells.

Kerschen EJ, Cohen DA, Kaplan AM, Straley SC.

Infect Immun. 2004 Aug;72(8):4589-602.


snr-1 gene is required for nitrate reduction in Pseudomonas aeruginosa PAO1.

Kerschen EJ, Irani VR, Hassett DJ, Rowe JJ.

J Bacteriol. 2001 Mar;183(6):2125-31.

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