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Items: 48


Early Host Interactions That Drive the Dysregulated Response in Sepsis.

Kerrigan SW, Devine T, Fitzpatrick G, Thachil J, Cox D.

Front Immunol. 2019 Aug 6;10:1748. doi: 10.3389/fimmu.2019.01748. eCollection 2019. Review.


Public awareness of sepsis is still poor: we need to do more.

Kerrigan SW, Martin-Loeches I.

Intensive Care Med. 2018 Oct;44(10):1771-1773. doi: 10.1007/s00134-018-5307-5. Epub 2018 Jul 19. No abstract available.


Staphylococcus aureus protein A causes osteoblasts to hyper-mineralise in a 3D extra-cellular matrix environment.

Kavanagh N, O'Brien FJ, Kerrigan SW.

PLoS One. 2018 Jun 21;13(6):e0198837. doi: 10.1371/journal.pone.0198837. eCollection 2018.


Inhibition of Vascular Endothelial Cell Leak Following Escherichia coli Attachment in an Experimental Model of Sepsis.

McHale TM, Garciarena CD, Fagan RP, Smith SGJ, Martin-Loches I, Curley GF, Fitzpatrick F, Kerrigan SW.

Crit Care Med. 2018 Aug;46(8):e805-e810. doi: 10.1097/CCM.0000000000003219.


Electroconductive Biohybrid Collagen/Pristine Graphene Composite Biomaterials with Enhanced Biological Activity.

Ryan AJ, Kearney CJ, Shen N, Khan U, Kelly AG, Probst C, Brauchle E, Biccai S, Garciarena CD, Vega-Mayoral V, Loskill P, Kerrigan SW, Kelly DJ, Schenke-Layland K, Coleman JN, O'Brien FJ.

Adv Mater. 2018 Apr;30(15):e1706442. doi: 10.1002/adma.201706442. Epub 2018 Mar 5.


Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions.

Kavanagh N, Ryan EJ, Widaa A, Sexton G, Fennell J, O'Rourke S, Cahill KC, Kearney CJ, O'Brien FJ, Kerrigan SW.

Clin Microbiol Rev. 2018 Feb 14;31(2). pii: e00084-17. doi: 10.1128/CMR.00084-17. Print 2018 Apr. Review.


The Evolving Role of MicroRNAs in Endothelial Cell Dysfunction in Response to Infection.

Watkin RL, Fitzpatrick GG, Kerrigan SW.

Semin Thromb Hemost. 2018 Apr;44(3):216-223. doi: 10.1055/s-0037-1612623. Epub 2018 Jan 2. Review.


Pre-emptive and therapeutic value of blocking bacterial attachment to the endothelial alphaVbeta3 integrin with cilengitide in sepsis.

Garciarena CD, McHale TM, Martin-Loeches I, Kerrigan SW.

Crit Care. 2017 Sep 26;21(1):246. doi: 10.1186/s13054-017-1838-3. No abstract available.


Inhibition of major integrin αV β3 reduces Staphylococcus aureus attachment to sheared human endothelial cells.

McDonnell CJ, Garciarena CD, Watkin RL, McHale TM, McLoughlin A, Claes J, Verhamme P, Cummins PM, Kerrigan SW.

J Thromb Haemost. 2016 Dec;14(12):2536-2547. doi: 10.1111/jth.13501. Epub 2016 Oct 28.


Staphylococcus aureus-mediated blood-brain barrier injury: an in vitro human brain microvascular endothelial cell model.

McLoughlin A, Rochfort KD, McDonnell CJ, Kerrigan SW, Cummins PM.

Cell Microbiol. 2017 Mar;19(3). doi: 10.1111/cmi.12664. Epub 2016 Oct 21.


Concerted functions of Streptococcus gordonii surface proteins PadA and Hsa mediate activation of human platelets and interactions with extracellular matrix.

Haworth JA, Jenkinson HF, Petersen HJ, Back CR, Brittan JL, Kerrigan SW, Nobbs AH.

Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12667. Epub 2016 Oct 11.


Towards 3D in vitro models for the study of cardiovascular tissues and disease.

Ryan AJ, Brougham CM, Garciarena CD, Kerrigan SW, O'Brien FJ.

Drug Discov Today. 2016 Sep;21(9):1437-1445. doi: 10.1016/j.drudis.2016.04.014. Epub 2016 Apr 23. Review.


Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3.

Watson CN, Kerrigan SW, Cox D, Henderson IR, Watson SP, Arman M.

Platelets. 2016 Sep;27(6):535-40. doi: 10.3109/09537104.2016.1148129. Epub 2016 Mar 30.


Coordinated Molecular Cross-Talk between Staphylococcus aureus, Endothelial Cells and Platelets in Bloodstream Infection.

Garciarena CD, McHale TM, Watkin RL, Kerrigan SW.

Pathogens. 2015 Dec 5;4(4):869-82. doi: 10.3390/pathogens4040869. Review.


Dysregulation of the endothelium following Staphylococcus aureus infection.

Kerrigan SW, McDonnell C.

Biochem Soc Trans. 2015 Aug;43(4):715-9. doi: 10.1042/BST20140309. Epub 2015 Aug 3. Review.


Focusing on the role of platelets in immune defence against invading pathogens.

Kerrigan SW, Poole A.

Platelets. 2015;26(4):285. doi: 10.3109/09537104.2015.1038230. Epub 2015 Apr 24. No abstract available.


Staphylococcus epidermidis serine--aspartate repeat protein G (SdrG) binds to osteoblast integrin alpha V beta 3.

Claro T, Kavanagh N, Foster TJ, O'Brien FJ, Kerrigan SW.

Microbes Infect. 2015 Jun;17(6):395-401. doi: 10.1016/j.micinf.2015.02.003. Epub 2015 Mar 5.


The expanding field of platelet-bacterial interconnections.

Kerrigan SW.

Platelets. 2015;26(4):293-301. doi: 10.3109/09537104.2014.997690. Epub 2015 Mar 3. Review.


A novel role for the fibrinogen Asn-Gly-Arg (NGR) motif in platelet function.

Moriarty R, McManus CA, Lambert M, Tilley T, Devocelle M, Brennan M, Kerrigan SW, Cox D.

Thromb Haemost. 2015 Feb;113(2):290-304. doi: 10.1160/TH14-04-0366. Epub 2014 Nov 20.


Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4.

Arman M, Krauel K, Tilley DO, Weber C, Cox D, Greinacher A, Kerrigan SW, Watson SP.

Blood. 2014 May 15;123(20):3166-74. doi: 10.1182/blood-2013-11-540526. Epub 2014 Mar 18.


A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.

Mitrugno A, Williams D, Kerrigan SW, Moran N.

Blood. 2014 Jan 9;123(2):249-60. doi: 10.1182/blood-2013-03-492447. Epub 2013 Nov 20.


Multiple sites on Streptococcus gordonii surface protein PadA bind to platelet GPIIbIIIa.

Keane C, Petersen HJ, Tilley D, Haworth J, Cox D, Jenkinson HF, Kerrigan SW.

Thromb Haemost. 2013 Dec;110(6):1278-1287. doi: 10.1160/TH13-07-0580. Epub 2013 Oct 17.


A platelet dense-granule secretion defect may lead to a muted inflammatory cell mobilization response in cystic fibrosis patients.

McGivern TJ, Molloy K, Bahar M, McElvaney NG, Moran N, Kerrigan SW.

J Thromb Haemost. 2013 Oct;11(10):1939-42. doi: 10.1111/jth.12377. No abstract available.


Glycoprotein Ibα and FcγRIIa play key roles in platelet activation by the colonizing bacterium, Streptococcus oralis.

Tilley DO, Arman M, Smolenski A, Cox D, O'Donnell JS, Douglas CW, Watson SP, Kerrigan SW.

J Thromb Haemost. 2013 May;11(5):941-50. doi: 10.1111/jth.12175.


Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection.

Claro T, Widaa A, McDonnell C, Foster TJ, O'Brien FJ, Kerrigan SW.

Microbiology. 2013 Jan;159(Pt 1):147-54. doi: 10.1099/mic.0.063016-0. Epub 2012 Nov 15.


Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis.

Widaa A, Claro T, Foster TJ, O'Brien FJ, Kerrigan SW.

PLoS One. 2012;7(7):e40586. doi: 10.1371/journal.pone.0040586. Epub 2012 Jul 11.


The Sbi protein is a multifunctional immune evasion factor of Staphylococcus aureus.

Smith EJ, Visai L, Kerrigan SW, Speziale P, Foster TJ.

Infect Immun. 2011 Sep;79(9):3801-9. doi: 10.1128/IAI.05075-11. Epub 2011 Jun 27.


Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis.

Claro T, Widaa A, O'Seaghdha M, Miajlovic H, Foster TJ, O'Brien FJ, Kerrigan SW.

PLoS One. 2011 Apr 15;6(4):e18748. doi: 10.1371/journal.pone.0018748.


Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation.

Cox D, Kerrigan SW, Watson SP.

J Thromb Haemost. 2011 Jun;9(6):1097-107. doi: 10.1111/j.1538-7836.2011.04264.x. Review.


Investigation of the interaction of biodegradable micro- and nanoparticulate drug delivery systems with platelets.

Ramtoola Z, Lyons P, Keohane K, Kerrigan SW, Kirby BP, Kelly JG.

J Pharm Pharmacol. 2011 Jan;63(1):26-32. doi: 10.1111/j.2042-7158.2010.01174.x. Epub 2010 Nov 16.


Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii.

Keane C, Petersen H, Reynolds K, Newman DK, Cox D, Jenkinson HF, Newman PJ, Kerrigan SW.

Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2408-15. doi: 10.1161/ATVBAHA.110.216515. Epub 2010 Nov 11.


Invasive Streptococcus pneumoniae trigger platelet activation via Toll-like receptor 2.

Keane C, Tilley D, Cunningham A, Smolenski A, Kadioglu A, Cox D, Jenkinson HF, Kerrigan SW.

J Thromb Haemost. 2010 Dec;8(12):2757-65. doi: 10.1111/j.1538-7836.2010.04093.x.


Platelet-bacterial interactions.

Kerrigan SW, Cox D.

Cell Mol Life Sci. 2010 Feb;67(4):513-23. doi: 10.1007/s00018-009-0207-z. Epub 2009 Nov 29. Review.


Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets.

Miajlovic H, Zapotoczna M, Geoghegan JA, Kerrigan SW, Speziale P, Foster TJ.

Microbiology. 2010 Mar;156(Pt 3):920-8. doi: 10.1099/mic.0.036673-0. Epub 2009 Dec 10.


Human platelets recognize a novel surface protein, PadA, on Streptococcus gordonii through a unique interaction involving fibrinogen receptor GPIIbIIIa.

Petersen HJ, Keane C, Jenkinson HF, Vickerman MM, Jesionowski A, Waterhouse JC, Cox D, Kerrigan SW.

Infect Immun. 2010 Jan;78(1):413-22. doi: 10.1128/IAI.00664-09. Epub 2009 Nov 2.


The thrombotic potential of oral pathogens.

Kerrigan SW, Cox D.

J Oral Microbiol. 2009 Aug 26;1. doi: 10.3402/jom.v1i0.1999.


Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction.

Tobin NP, Henehan GT, Murphy RP, Atherton JC, Guinan AF, Kerrigan SW, Cox D, Cahill PA, Cummins PM.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1403-13. doi: 10.1152/ajpheart.00240.2008. Epub 2008 Jul 25.


Molecular basis for Staphylococcus aureus-mediated platelet aggregate formation under arterial shear in vitro.

Kerrigan SW, Clarke N, Loughman A, Meade G, Foster TJ, Cox D.

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):335-40. Epub 2007 Dec 6.


Role of Streptococcus gordonii surface proteins SspA/SspB and Hsa in platelet function.

Kerrigan SW, Jakubovics NS, Keane C, Maguire P, Wynne K, Jenkinson HF, Cox D.

Infect Immun. 2007 Dec;75(12):5740-7. Epub 2007 Sep 24.


The effect of different strains of Helicobacter pylori on platelet aggregation.

Corcoran PA, Atherton JC, Kerrigan SW, Wadstrom T, Murray FE, Peek RM, Fitzgerald DJ, Cox DM, Byrne MF.

Can J Gastroenterol. 2007 Jun;21(6):367-70.


Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions.

O'Seaghdha M, van Schooten CJ, Kerrigan SW, Emsley J, Silverman GJ, Cox D, Lenting PJ, Foster TJ.

FEBS J. 2006 Nov;273(21):4831-41. Epub 2006 Sep 25.


Functions of cell surface-anchored antigen I/II family and Hsa polypeptides in interactions of Streptococcus gordonii with host receptors.

Jakubovics NS, Kerrigan SW, Nobbs AH, Strömberg N, van Dolleweerd CJ, Cox DM, Kelly CG, Jenkinson HF.

Infect Immun. 2005 Oct;73(10):6629-38.


A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb.

Plummer C, Wu H, Kerrigan SW, Meade G, Cox D, Ian Douglas CW.

Br J Haematol. 2005 Apr;129(1):101-9.


Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation.

Kerrigan SW, Gaur M, Murphy RP, Shattil SJ, Leavitt AD.

Blood. 2004 Sep 1;104(5):1327-34. Epub 2004 Apr 1.


Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation.

Byrne MF, Kerrigan SW, Corcoran PA, Atherton JC, Murray FE, Fitzgerald DJ, Cox DM.

Gastroenterology. 2003 Jun;124(7):1846-54.


Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.

Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt AD, Shattil SJ.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12819-24. Epub 2002 Sep 18.


A role for glycoprotein Ib in Streptococcus sanguis-induced platelet aggregation.

Kerrigan SW, Douglas I, Wray A, Heath J, Byrne MF, Fitzgerald D, Cox D.

Blood. 2002 Jul 15;100(2):509-16.


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