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Multiple kinases in the interferon-gamma response.

Watling D, Carmo CR, Kerr IM, Costa-Pereira AP.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6051-6. doi: 10.1073/pnas.0710814105. Epub 2008 Apr 15.


P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNgamma.

Christova R, Jones T, Wu PJ, Bolzer A, Costa-Pereira AP, Watling D, Kerr IM, Sheer D.

J Cell Sci. 2007 Sep 15;120(Pt 18):3262-70. Epub 2007 Aug 28.


Signaling through a mutant IFN-gamma receptor.

Costa-Pereira AP, Hermanns HM, Is'harc H, Williams TM, Watling D, Arulampalam V, Newman SJ, Heinrich PC, Kerr IM.

J Immunol. 2005 Nov 1;175(9):5958-65.


Differential responses to IFN-alpha subtypes in human T cells and dendritic cells.

Hilkens CM, Schlaak JF, Kerr IM.

J Immunol. 2003 Nov 15;171(10):5255-63.


Of JAKs, STATs, blind watchmakers, jeeps and trains.

Kerr IM, Costa-Pereira AP, Lillemeier BF, Strobl B.

FEBS Lett. 2003 Jul 3;546(1):1-5. Review.


The JAK/STAT pathway is not sufficient to sustain the antiproliferative response in an interferon-resistant human melanoma cell line.

Jackson DP, Watling D, Rogers NC, Banks RE, Kerr IM, Selby PJ, Patel PM.

Melanoma Res. 2003 Jun;13(3):219-29.


Cell-type and donor-specific transcriptional responses to interferon-alpha. Use of customized gene arrays.

Schlaak JF, Hilkens CM, Costa-Pereira AP, Strobl B, Aberger F, Frischauf AM, Kerr IM.

J Biol Chem. 2002 Dec 20;277(51):49428-37. Epub 2002 Oct 16.


The antiviral response to gamma interferon.

Costa-Pereira AP, Williams TM, Strobl B, Watling D, Briscoe J, Kerr IM.

J Virol. 2002 Sep;76(18):9060-8.


Mutational switch of an IL-6 response to an interferon-gamma-like response.

Costa-Pereira AP, Tininini S, Strobl B, Alonzi T, Schlaak JF, Is'harc H, Gesualdo I, Newman SJ, Kerr IM, Poli V.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8043-7.


A completely foreign receptor can mediate an interferon-gamma-like response.

Strobl B, Arulampalam V, Is'harc H, Newman SJ, Schlaak JF, Watling D, Costa-Pereira AP, Schaper F, Behrmann I, Sheehan KC, Schreiber RD, Horn F, Heinrich PC, Kerr IM.

EMBO J. 2001 Oct 1;20(19):5431-42.


A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130.

Hilkens CM, Is'harc H, Lillemeier BF, Strobl B, Bates PA, Behrmann I, Kerr IM.

FEBS Lett. 2001 Sep 7;505(1):87-91.


Analysis of gene expression using high-density and IFN-gamma-specific low-density cDNA arrays.

Aberger F, Costa-Pereira AP, Schlaak JF, Williams TM, O'Shaughnessy RF, Hollaus G, Kerr IM, Frischauf AM.

Genomics. 2001 Sep;77(1-2):50-7.


Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction.

Haan C, Is'harc H, Hermanns HM, Schmitz-Van De Leur H, Kerr IM, Heinrich PC, Grötzinger J, Behrmann I.

J Biol Chem. 2001 Oct 5;276(40):37451-8. Epub 2001 Jul 23.


STAT1 from the cell membrane to the DNA.

Lillemeier BF, Köster M, Kerr IM.

EMBO J. 2001 May 15;20(10):2508-17.


Biomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: prevalence of latent STAT1 in high-molecular weight complexes.

Lackmann M, Harpur AG, Oates AC, Mann RJ, Gabriel A, Meutermans W, Alewood PF, Kerr IM, Stark GR, Wilks AF.

Growth Factors. 1998;16(1):39-51.


How cells respond to interferons.

Stark GR, Kerr IM, Williams BR, Silverman RH, Schreiber RD.

Annu Rev Biochem. 1998;67:227-64. Review.


Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock.

Gatsios P, Terstegen L, Schliess F, Häussinger D, Kerr IM, Heinrich PC, Graeve L.

J Biol Chem. 1998 Sep 4;273(36):22962-8.


Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.

Yamauchi T, Kaburagi Y, Ueki K, Tsuji Y, Stark GR, Kerr IM, Tsushima T, Akanuma Y, Komuro I, Tobe K, Yazaki Y, Kadowaki T.

J Biol Chem. 1998 Jun 19;273(25):15719-26.


Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions.

Dahmen H, Horsten U, Küster A, Jacques Y, Minvielle S, Kerr IM, Ciliberto G, Paonessa G, Heinrich PC, Müller-Newen G.

Biochem J. 1998 May 1;331 ( Pt 3):695-702.


Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons.

Burfoot MS, Rogers NC, Watling D, Smith JM, Pons S, Paonessaw G, Pellegrini S, White MF, Kerr IM.

J Biol Chem. 1997 Sep 26;272(39):24183-90.


Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1.

Haque SJ, Wu Q, Kammer W, Friedrich K, Smith JM, Kerr IM, Stark GR, Williams BR.

Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8563-8.


Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor.

Shimoda K, Feng J, Murakami H, Nagata S, Watling D, Rogers NC, Stark GR, Kerr IM, Ihle JN.

Blood. 1997 Jul 15;90(2):597-604.


Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.

Feng J, Witthuhn BA, Matsuda T, Kohlhuber F, Kerr IM, Ihle JN.

Mol Cell Biol. 1997 May;17(5):2497-501.


A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

Kohlhuber F, Rogers NC, Watling D, Feng J, Guschin D, Briscoe J, Witthuhn BA, Kotenko SV, Pestka S, Stark GR, Ihle JN, Kerr IM.

Mol Cell Biol. 1997 Feb;17(2):695-706.


Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.

Horvath CM, Stark GR, Kerr IM, Darnell JE Jr.

Mol Cell Biol. 1996 Dec;16(12):6957-64.


Participation of JAK and STAT proteins in growth hormone-induced signaling.

Han Y, Leaman DW, Watling D, Rogers NC, Groner B, Kerr IM, Wood WI, Stark GR.

J Biol Chem. 1996 Mar 8;271(10):5947-52.


JAKs, STATs and signal transduction in response to the interferons and other cytokines.

Briscoe J, Guschin D, Rogers NC, Watling D, Müller M, Horn F, Heinrich P, Stark GR, Kerr IM.

Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29;351(1336):167-71. Review.


Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

Briscoe J, Rogers NC, Witthuhn BA, Watling D, Harpur AG, Wilks AF, Stark GR, Ihle JN, Kerr IM.

EMBO J. 1996 Feb 15;15(4):799-809.


Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor.

Leaman DW, Pisharody S, Flickinger TW, Commane MA, Schlessinger J, Kerr IM, Levy DE, Stark GR.

Mol Cell Biol. 1996 Jan;16(1):369-75.


Function of Stat2 protein in transcriptional activation by alpha interferon.

Qureshi SA, Leung S, Kerr IM, Stark GR, Darnell JE Jr.

Mol Cell Biol. 1996 Jan;16(1):288-93.


Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

Bluyssen HA, Muzaffar R, Vlieststra RJ, van der Made AC, Leung S, Stark GR, Kerr IM, Trapman J, Levy DE.

Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5645-9.


Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway.

Heim MH, Kerr IM, Stark GR, Darnell JE Jr.

Science. 1995 Mar 3;267(5202):1347-9.


Role of STAT2 in the alpha interferon signaling pathway.

Leung S, Qureshi SA, Kerr IM, Darnell JE Jr, Stark GR.

Mol Cell Biol. 1995 Mar;15(3):1312-7.


Jaks and Stats in signaling by the cytokine receptor superfamily.

Ihle JN, Kerr IM.

Trends Genet. 1995 Feb;11(2):69-74. Review.


Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, Cantrell DA.

EMBO J. 1994 Dec 1;13(23):5605-15.


Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.

Darnell JE Jr, Kerr IM, Stark GR.

Science. 1994 Jun 3;264(5164):1415-21. Review.


Constitutive production of alpha and beta interferons in mutant human cell lines.

McKendry R, Pellegrini S, Kerr IM, Stark GR.

J Virol. 1994 Jun;68(6):4057-62.


Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.

Improta T, Schindler C, Horvath CM, Kerr IM, Stark GR, Darnell JE Jr.

Proc Natl Acad Sci U S A. 1994 May 24;91(11):4776-80.


Interferon response pathways--a paradigm for cytokine signalling?

Müller M, Ibelgaufts H, Kerr IM.

J Viral Hepat. 1994;1(2):87-103. Review.


Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

Müller M, Laxton C, Briscoe J, Schindler C, Improta T, Darnell JE Jr, Stark GR, Kerr IM.

EMBO J. 1993 Nov;12(11):4221-8.


A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.

Shuai K, Stark GR, Kerr IM, Darnell JE Jr.

Science. 1993 Sep 24;261(5129):1744-6.


The interferon-stimulable response elements of two human genes detect overlapping sets of transcription factors.

Parrington J, Rogers NC, Gewert DR, Pine R, Veals SA, Levy DE, Stark GR, Kerr IM.

Eur J Biochem. 1993 Jun 15;214(3):617-26.


Mutant human cells defective in induction of major histocompatibility complex class II genes by interferon gamma.

Mao C, Davies D, Kerr IM, Stark GR.

Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2880-4.


The antiviral effects of the interferons and their inhibition.

Kerr IM, Stark GR.

J Interferon Res. 1992 Aug;12(4):237-40. Review. No abstract available.


Interferon-dependent signaling pathways: DNA elements, transcription factors, mutations, and effects of viral proteins.

Stark GR, Kerr IM.

J Interferon Res. 1992 Jun;12(3):147-51. Review. No abstract available.


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