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Items: 1 to 50 of 111

1.

Polymorphisms of the multidrug pump ABCG2: a systematic review of their effect on protein expression, function and drug pharmacokinetics.

Heyes N, Kapoor P, Kerr ID.

Drug Metab Dispos. 2018 Sep 28. pii: dmd.118.083030. doi: 10.1124/dmd.118.083030. [Epub ahead of print]

PMID:
30266733
2.

Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets.

Cox MH, Kapoor P, Briggs DA, Kerr ID.

Biochem J. 2018 May 4;475(9):1553-1567. doi: 10.1042/BCJ20170923.

3.

Assessment of in silico protein sequence analysis in the clinical classification of variants in cancer risk genes.

Kerr ID, Cox HC, Moyes K, Evans B, Burdett BC, van Kan A, McElroy H, Vail PJ, Brown KL, Sumampong DB, Monteferrante NJ, Hardman KL, Theisen A, Mundt E, Wenstrup RJ, Eggington JM.

J Community Genet. 2017 Apr;8(2):87-95. doi: 10.1007/s12687-016-0289-x. Epub 2017 Jan 3.

4.

Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein.

Mittra R, Pavy M, Subramanian N, George AM, O'Mara ML, Kerr ID, Callaghan R.

Biochem Pharmacol. 2017 Jan 1;123:19-28. doi: 10.1016/j.bcp.2016.10.002. Epub 2016 Oct 8.

PMID:
27729218
5.

The multidrug transporter ABCG2: still more questions than answers.

Horsey AJ, Cox MH, Sarwat S, Kerr ID.

Biochem Soc Trans. 2016 Jun 15;44(3):824-30. doi: 10.1042/BST20160014. Review.

6.

Long-term exposure to irinotecan reduces cell migration in glioma cells.

Al-Ghafari AB, Punjaruk W, Storer LC, Carrier DJ, Hussein D, Coyle B, Kerr ID.

J Neurooncol. 2016 May;127(3):455-62. doi: 10.1007/s11060-016-2058-4. Epub 2016 Jan 30.

PMID:
26830091
7.

ABC transporter research: going strong 40 years on.

Theodoulou FL, Kerr ID.

Biochem Soc Trans. 2015 Oct;43(5):1033-40. doi: 10.1042/BST20150139. Epub 2015 Oct 9. Review.

8.

ABCB1 in children's brain tumours.

Coyle B, Kessler M, Sabnis DH, Kerr ID.

Biochem Soc Trans. 2015 Oct;43(5):1018-22. doi: 10.1042/BST20150137. Review.

PMID:
26517917
9.

Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques.

Wong K, Briddon SJ, Holliday ND, Kerr ID.

Biochim Biophys Acta. 2016 Jan;1863(1):19-29. doi: 10.1016/j.bbamcr.2015.10.002. Epub 2015 Oct 8.

10.

Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors.

Darby RA, Unsworth A, Knapp S, Kerr ID, Callaghan R.

Cancer Chemother Pharmacol. 2015 Oct;76(4):853-64. doi: 10.1007/s00280-015-2858-9. Epub 2015 Sep 9.

PMID:
26351135
11.

Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.

Haider AJ, Cox MH, Jones N, Goode AJ, Bridge KS, Wong K, Briggs D, Kerr ID.

Biosci Rep. 2015 Jul 17;35(4). pii: e00241. doi: 10.1042/BSR20150150.

12.

Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.

Wu H, Zeng H, Lam R, Tempel W, Kerr ID, Min J.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):981-5. doi: 10.1107/S2053230X15010183. Epub 2015 Jul 28.

13.

Comparison of locus-specific databases for BRCA1 and BRCA2 variants reveals disparity in variant classification within and among databases.

Vail PJ, Morris B, van Kan A, Burdett BC, Moyes K, Theisen A, Kerr ID, Wenstrup RJ, Eggington JM.

J Community Genet. 2015 Oct;6(4):351-9. doi: 10.1007/s12687-015-0220-x. Epub 2015 Mar 18.

14.

Response to Cragun et al.

Kerr ID, Nix P, Wenstrup RJ.

Clin Genet. 2015 Aug;88(2):200. doi: 10.1111/cge.12510. Epub 2014 Oct 28. No abstract available.

PMID:
25256678
15.

Overcoming multiple drug resistance mechanisms in medulloblastoma.

Othman RT, Kimishi I, Bradshaw TD, Storer LC, Korshunov A, Pfister SM, Grundy RG, Kerr ID, Coyle B.

Acta Neuropathol Commun. 2014 May 30;2:57. doi: 10.1186/2051-5960-2-57.

16.

Detergent-free purification of ABC (ATP-binding-cassette) transporters.

Gulati S, Jamshad M, Knowles TJ, Morrison KA, Downing R, Cant N, Collins R, Koenderink JB, Ford RC, Overduin M, Kerr ID, Dafforn TR, Rothnie AJ.

Biochem J. 2014 Jul 15;461(2):269-78. doi: 10.1042/BJ20131477.

PMID:
24758594
17.

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis.

van Wonderen JH, McMahon RM, O'Mara ML, McDevitt CA, Thomson AJ, Kerr ID, MacMillan F, Callaghan R.

FEBS J. 2014 May;281(9):2190-2201. doi: 10.1111/febs.12773. Epub 2014 Apr 1.

18.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

19.

Towards understanding promiscuity in multidrug efflux pumps.

Wong K, Ma J, Rothnie A, Biggin PC, Kerr ID.

Trends Biochem Sci. 2014 Jan;39(1):8-16. doi: 10.1016/j.tibs.2013.11.002. Epub 2013 Dec 6. Review.

PMID:
24316304
20.

Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event.

Kay CJ, Lawler K, Kerr ID.

Biosci Rep. 2013 Dec 3;33(6). pii: e00084. doi: 10.1042/BSR20130049.

21.

Improving the stability and function of purified ABCB1 and ABCA4: the influence of membrane lipids.

Pollock NL, McDevitt CA, Collins R, Niesten PH, Prince S, Kerr ID, Ford RC, Callaghan R.

Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):134-47. doi: 10.1016/j.bbamem.2013.09.001. Epub 2013 Sep 12.

22.

Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids.

De Marcos Lousa C, van Roermund CW, Postis VL, Dietrich D, Kerr ID, Wanders RJ, Baldwin SA, Baker A, Theodoulou FL.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1279-84. doi: 10.1073/pnas.1218034110. Epub 2013 Jan 3.

23.

Localisation of a family of complex-forming β-barrels in the T. vaginalis hydrogenosomal membrane.

Kay C, Lawler K, Self TJ, Dyall SD, Kerr ID.

FEBS Lett. 2012 Nov 16;586(22):4038-45. doi: 10.1016/j.febslet.2012.10.004. Epub 2012 Oct 13.

24.

The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis.

Kay C, Woodward KD, Lawler K, Self TJ, Dyall SD, Kerr ID.

PLoS Negl Trop Dis. 2012;6(6):e1693. doi: 10.1371/journal.pntd.0001693. Epub 2012 Jun 19.

25.

Dimerization of ABCG2 analysed by bimolecular fluorescence complementation.

Haider AJ, Briggs D, Self TJ, Chilvers HL, Holliday ND, Kerr ID.

PLoS One. 2011;6(10):e25818. doi: 10.1371/journal.pone.0025818. Epub 2011 Oct 3.

26.

Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics.

Dorrian JM, Briggs DA, Ridley ML, Layfield R, Kerr ID.

FEBS J. 2011 Nov;278(21):4015-24. doi: 10.1111/j.1742-4658.2011.08305.x. Epub 2011 Sep 15.

27.

The ABCG family of membrane-associated transporters: you don't have to be big to be mighty.

Kerr ID, Haider AJ, Gelissen IC.

Br J Pharmacol. 2011 Dec;164(7):1767-79. doi: 10.1111/j.1476-5381.2010.01177.x. Review.

28.

Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion.

Hussein D, Punjaruk W, Storer LC, Shaw L, Othman R, Peet A, Miller S, Bandopadhyay G, Heath R, Kumari R, Bowman KJ, Braker P, Rahman R, Jones GD, Watson S, Lowe J, Kerr ID, Grundy RG, Coyle B.

Neuro Oncol. 2011 Jan;13(1):70-83. doi: 10.1093/neuonc/noq144. Epub 2010 Oct 25. Erratum in: Neuro Oncol. 2012 Dec;14(12):1528. Ottoman, Ramadan [corrected to Othman, Ramadhan].

29.

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR.

PLoS Negl Trop Dis. 2010 Sep 14;4(9). pii: e825. doi: 10.1371/journal.pntd.0000825.

30.

Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1.

Crowley E, O'Mara ML, Kerr ID, Callaghan R.

FEBS J. 2010 Oct;277(19):3974-85. doi: 10.1111/j.1742-4658.2010.07789.x. Epub 2010 Aug 20.

31.

Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.

Kerr ID, Wu P, Marion-Tsukamaki R, Mackey ZB, Brinen LS.

PLoS Negl Trop Dis. 2010 Jun 8;4(6):e701. doi: 10.1371/journal.pntd.0000701.

32.

A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.

He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL.

J Biol Chem. 2010 Jun 11;285(24):18516-27. doi: 10.1074/jbc.M109.086181. Epub 2010 Apr 8.

33.

Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.

Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA.

J Med Chem. 2010 Feb 25;53(4):1763-73. doi: 10.1021/jm901633v.

34.
35.

Structural studies of pterin-based inhibitors of dihydropteroate synthase.

Hevener KE, Yun MK, Qi J, Kerr ID, Babaoglu K, Hurdle JG, Balakrishna K, White SW, Lee RE.

J Med Chem. 2010 Jan 14;53(1):166-77. doi: 10.1021/jm900861d.

36.

Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.

Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. doi: 10.1016/j.bmcl.2009.08.098. Epub 2009 Sep 3.

37.

Two approaches to discovering and developing new drugs for Chagas disease.

McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS.

Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1:263-9.

38.

Vinyl sulfones as antiparasitic agents and a structural basis for drug design.

Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS.

J Biol Chem. 2009 Sep 18;284(38):25697-703. doi: 10.1074/jbc.M109.014340. Epub 2009 Jul 20.

39.

Heterologous expression of a membrane-spanning auxin importer: implications for functional analyses of auxin transporters.

Carrier DJ, Abu Bakar NT, Lawler K, Dorrian JM, Haider A, Bennett MJ, Kerr ID.

Int J Plant Genomics. 2009;2009:848145. Epub 2009 Jun 18.

40.

Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1.

Crowley E, O'Mara ML, Reynolds C, Tieleman DP, Storm J, Kerr ID, Callaghan R.

Biochemistry. 2009 Jul 7;48(26):6249-58. doi: 10.1021/bi900373x.

41.

Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.

Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ.

PLoS One. 2009;4(4):e5156. doi: 10.1371/journal.pone.0005156. Epub 2009 Apr 9.

42.

Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy.

Chuthapisith S, Bean BE, Cowley G, Eremin JM, Samphao S, Layfield R, Kerr ID, Wiseman J, El-Sheemy M, Sreenivasan T, Eremin O.

Eur J Cancer. 2009 May;45(7):1274-81. doi: 10.1016/j.ejca.2008.12.026. Epub 2009 Jan 24.

PMID:
19171478
43.

Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity.

Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS.

J Med Chem. 2009 Feb 12;52(3):852-7. doi: 10.1021/jm8013663.

44.

Purification and structural analyses of ABCG2.

McDevitt CA, Collins R, Kerr ID, Callaghan R.

Adv Drug Deliv Rev. 2009 Jan 31;61(1):57-65. doi: 10.1016/j.addr.2008.07.004. Epub 2008 Dec 13. Review.

PMID:
19124053
45.

Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

McDevitt CA, Crowley E, Hobbs G, Starr KJ, Kerr ID, Callaghan R.

FEBS J. 2008 Sep;275(17):4354-62. doi: 10.1111/j.1742-4658.2008.06578.x. Epub 2008 Jul 24.

46.

The binding of auxin to the Arabidopsis auxin influx transporter AUX1.

Carrier DJ, Bakar NT, Swarup R, Callaghan R, Napier RM, Bennett MJ, Kerr ID.

Plant Physiol. 2008 Sep;148(1):529-35. doi: 10.1104/pp.108.122044. Epub 2008 Jul 9.

47.

Cytosolic region of TM6 in P-glycoprotein: topographical analysis and functional perturbation by site directed labeling.

Storm J, Modok S, O'Mara ML, Tieleman DP, Kerr ID, Callaghan R.

Biochemistry. 2008 Mar 25;47(12):3615-24. doi: 10.1021/bi7023089. Epub 2008 Feb 28.

PMID:
18303860
48.

P-glycoprotein: so many ways to turn it on.

Callaghan R, Crowley E, Potter S, Kerr ID.

J Clin Pharmacol. 2008 Mar;48(3):365-78. Epub 2007 Dec 21. Review.

PMID:
18156365
49.

Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein.

Lawson J, O'Mara ML, Kerr ID.

Biochim Biophys Acta. 2008 Feb;1778(2):376-91. Epub 2007 Nov 1. Review.

50.

Crystallographic and NMR analyses of UvsW and UvsW.1 from bacteriophage T4.

Kerr ID, Sivakolundu S, Li Z, Buchsbaum JC, Knox LA, Kriwacki R, White SW.

J Biol Chem. 2007 Nov 23;282(47):34392-400. Epub 2007 Sep 17.

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