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Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2.

Horsey AJ, Briggs DA, Holliday ND, Briddon SJ, Kerr ID.

Biochim Biophys Acta Biomembr. 2020 Feb 11;1862(6):183218. doi: 10.1016/j.bbamem.2020.183218. [Epub ahead of print]


Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis.

Kapoor P, Briggs DA, Cox MH, Kerr ID.

Int J Mol Sci. 2020 Jan 23;21(3). pii: E759. doi: 10.3390/ijms21030759.


A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma.

Sabnis DH, Storer LCD, Liu JF, Jackson HK, Kilday JP, Grundy RG, Kerr ID, Coyle B.

Sci Rep. 2019 Jul 16;9(1):10290. doi: 10.1038/s41598-019-46700-z.


ABCG2: does resolving its structure elucidate the mechanism?

Kapoor P, Horsey AJ, Cox MH, Kerr ID.

Biochem Soc Trans. 2018 Dec 17;46(6):1485-1494. doi: 10.1042/BST20180145. Epub 2018 Nov 21. Review.


Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics.

Heyes N, Kapoor P, Kerr ID.

Drug Metab Dispos. 2018 Dec;46(12):1886-1899. doi: 10.1124/dmd.118.083030. Epub 2018 Sep 28.


Cellular Patterning of Arabidopsis Roots Under Low Phosphate Conditions.

Janes G, von Wangenheim D, Cowling S, Kerr I, Band L, French AP, Bishopp A.

Front Plant Sci. 2018 Jun 5;9:735. doi: 10.3389/fpls.2018.00735. eCollection 2018.


Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets.

Cox MH, Kapoor P, Briggs DA, Kerr ID.

Biochem J. 2018 May 4;475(9):1553-1567. doi: 10.1042/BCJ20170923.


Fiber-reinforced composites in fixed prosthodontics-Quo vadis?

Vallittu PK, Shinya A, Baraba A, Kerr I, Keulemans F, Kreulen C, Lassila L, Malmstrom H, Novotny R, Peumans M, Van Rensburg J, Wolff D, Özcan M.

Dent Mater. 2017 Aug;33(8):877-879. doi: 10.1016/ Epub 2017 May 25. No abstract available.


Assessment of in silico protein sequence analysis in the clinical classification of variants in cancer risk genes.

Kerr ID, Cox HC, Moyes K, Evans B, Burdett BC, van Kan A, McElroy H, Vail PJ, Brown KL, Sumampong DB, Monteferrante NJ, Hardman KL, Theisen A, Mundt E, Wenstrup RJ, Eggington JM.

J Community Genet. 2017 Apr;8(2):87-95. doi: 10.1007/s12687-016-0289-x. Epub 2017 Jan 3.


Phase II trial of capecitabine plus erlotinib versus capecitabine alone in patients with advanced colorectal cancer.

Vincent MD, Breadner D, Soulieres D, Kerr IG, Sanatani M, Kocha W, Klimo P, MacKenzie MJ, O'Connell A, Whiston F, Malpage AS, Stitt L, Welch SA.

Future Oncol. 2017 Apr;13(9):777-786. doi: 10.2217/fon-2016-0444. Epub 2017 Jan 3.


Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein.

Mittra R, Pavy M, Subramanian N, George AM, O'Mara ML, Kerr ID, Callaghan R.

Biochem Pharmacol. 2017 Jan 1;123:19-28. doi: 10.1016/j.bcp.2016.10.002. Epub 2016 Oct 8.


The multidrug transporter ABCG2: still more questions than answers.

Horsey AJ, Cox MH, Sarwat S, Kerr ID.

Biochem Soc Trans. 2016 Jun 15;44(3):824-30. doi: 10.1042/BST20160014. Review.


What influences the worldwide genetic structure of sperm whales (Physeter macrocephalus)?

Alexander A, Steel D, Hoekzema K, Mesnick SL, Engelhaupt D, Kerr I, Payne R, Baker CS.

Mol Ecol. 2016 Jun;25(12):2754-72. doi: 10.1111/mec.13638. Epub 2016 May 2.


Long-term exposure to irinotecan reduces cell migration in glioma cells.

Al-Ghafari AB, Punjaruk W, Storer LC, Carrier DJ, Hussein D, Coyle B, Kerr ID.

J Neurooncol. 2016 May;127(3):455-62. doi: 10.1007/s11060-016-2058-4. Epub 2016 Jan 30.


ABC transporter research: going strong 40 years on.

Theodoulou FL, Kerr ID.

Biochem Soc Trans. 2015 Oct;43(5):1033-40. doi: 10.1042/BST20150139. Epub 2015 Oct 9. Review.


ABCB1 in children's brain tumours.

Coyle B, Kessler M, Sabnis DH, Kerr ID.

Biochem Soc Trans. 2015 Oct;43(5):1018-22. doi: 10.1042/BST20150137. Review.


Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques.

Wong K, Briddon SJ, Holliday ND, Kerr ID.

Biochim Biophys Acta. 2016 Jan;1863(1):19-29. doi: 10.1016/j.bbamcr.2015.10.002. Epub 2015 Oct 8.


Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors.

Darby RA, Unsworth A, Knapp S, Kerr ID, Callaghan R.

Cancer Chemother Pharmacol. 2015 Oct;76(4):853-64. doi: 10.1007/s00280-015-2858-9. Epub 2015 Sep 9.


The 'Self' and Borderline Personality Disorder: Conceptual and Clinical Considerations.

Kerr IB, Finlayson-Short L, McCutcheon LK, Beard H, Chanen AM.

Psychopathology. 2015;48(5):339-48. doi: 10.1159/000438827. Epub 2015 Sep 9. Review.


Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.

Haider AJ, Cox MH, Jones N, Goode AJ, Bridge KS, Wong K, Briggs D, Kerr ID.

Biosci Rep. 2015 Jul 17;35(4). pii: e00241. doi: 10.1042/BSR20150150.


Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.

Wu H, Zeng H, Lam R, Tempel W, Kerr ID, Min J.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):981-5. doi: 10.1107/S2053230X15010183. Epub 2015 Jul 28.


A pilot study of healthcare professionals' perspective towards conducting medical research in Saudi Arabia.

Rehman JU, Zekri J, Kerr I.

J Coll Physicians Surg Pak. 2015 Apr;25(4):308-9. doi: 04.2015/JCPSP.308309. No abstract available.


Comparison of locus-specific databases for BRCA1 and BRCA2 variants reveals disparity in variant classification within and among databases.

Vail PJ, Morris B, van Kan A, Burdett BC, Moyes K, Theisen A, Kerr ID, Wenstrup RJ, Eggington JM.

J Community Genet. 2015 Oct;6(4):351-9. doi: 10.1007/s12687-015-0220-x. Epub 2015 Mar 18.


Response to Cragun et al.

Kerr ID, Nix P, Wenstrup RJ.

Clin Genet. 2015 Aug;88(2):200. doi: 10.1111/cge.12510. Epub 2014 Oct 28. No abstract available.


Overcoming multiple drug resistance mechanisms in medulloblastoma.

Othman RT, Kimishi I, Bradshaw TD, Storer LC, Korshunov A, Pfister SM, Grundy RG, Kerr ID, Coyle B.

Acta Neuropathol Commun. 2014 May 30;2:57. doi: 10.1186/2051-5960-2-57.


Detergent-free purification of ABC (ATP-binding-cassette) transporters.

Gulati S, Jamshad M, Knowles TJ, Morrison KA, Downing R, Cant N, Collins R, Koenderink JB, Ford RC, Overduin M, Kerr ID, Dafforn TR, Rothnie AJ.

Biochem J. 2014 Jul 15;461(2):269-78. doi: 10.1042/BJ20131477.


The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis.

van Wonderen JH, McMahon RM, O'Mara ML, McDevitt CA, Thomson AJ, Kerr ID, MacMillan F, Callaghan R.

FEBS J. 2014 May;281(9):2190-2201. doi: 10.1111/febs.12773. Epub 2014 Apr 1.


The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.


Policy recommendations for addressing privacy challenges associated with cell-based research and interventions.

Ogbogu U, Burningham S, Ollenberger A, Calder K, Du L, El Emam K, Hyde-Lay R, Isasi R, Joly Y, Kerr I, Malin B, McDonald M, Penney S, Piat G, Roy DC, Sugarman J, Vercauteren S, Verhenneman G, West L, Caulfield T.

BMC Med Ethics. 2014 Feb 3;15:7. doi: 10.1186/1472-6939-15-7.


Novel simple and practical nutritional screening tool for cancer inpatients: a pilot study.

Zekri J, Morganti J, Rizvi A, Sadiq BB, Kerr I, Aslam M.

Support Care Cancer. 2014 May;22(5):1401-8. doi: 10.1007/s00520-013-2100-4. Epub 2014 Jan 4.


Towards understanding promiscuity in multidrug efflux pumps.

Wong K, Ma J, Rothnie A, Biggin PC, Kerr ID.

Trends Biochem Sci. 2014 Jan;39(1):8-16. doi: 10.1016/j.tibs.2013.11.002. Epub 2013 Dec 6. Review.


Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event.

Kay CJ, Lawler K, Kerr ID.

Biosci Rep. 2013 Dec 3;33(6). pii: e00084. doi: 10.1042/BSR20130049.


Improving the stability and function of purified ABCB1 and ABCA4: the influence of membrane lipids.

Pollock NL, McDevitt CA, Collins R, Niesten PH, Prince S, Kerr ID, Ford RC, Callaghan R.

Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):134-47. doi: 10.1016/j.bbamem.2013.09.001. Epub 2013 Sep 12.


Grade 3 trastuzumab-induced neutropenia in breast cancer patient.

Ghani EA, Kerr I, Dada R.

J Oncol Pharm Pract. 2014 Apr;20(2):154-7. doi: 10.1177/1078155213487394. Epub 2013 Jun 26. Review.


Global mercury and selenium concentrations in skin from free-ranging sperm whales (Physeter macrocephalus).

Savery LC, Evers DC, Wise SS, Falank C, Wise J, Gianios C Jr, Kerr I, Payne R, Thompson WD, Perkins C, Zheng T, Zhu C, Benedict L, Wise JP Sr.

Sci Total Environ. 2013 Apr 15;450-451:59-71. doi: 10.1016/j.scitotenv.2013.01.070. Epub 2013 Mar 1.


Capecitabine-induced terminal ileitis.

Al-Gahmi AM, Kerr IG, Zekri JM, Zagnoon AA.

Ann Saudi Med. 2012 Nov-Dec;32(6):661-2. doi: 10.5144/0256-4947.2012.661. No abstract available.


Working with the 'difficult' patient: the use of a contextual cognitive-analytic therapy based training in improving team function in a routine psychiatry service setting.

Caruso R, Biancosino B, Borghi C, Marmai L, Kerr IB, Grassi L.

Community Ment Health J. 2013 Dec;49(6):722-7. doi: 10.1007/s10597-012-9579-x. Epub 2013 Jan 5.


Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids.

De Marcos Lousa C, van Roermund CW, Postis VL, Dietrich D, Kerr ID, Wanders RJ, Baldwin SA, Baker A, Theodoulou FL.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1279-84. doi: 10.1073/pnas.1218034110. Epub 2013 Jan 3.


Localisation of a family of complex-forming β-barrels in the T. vaginalis hydrogenosomal membrane.

Kay C, Lawler K, Self TJ, Dyall SD, Kerr ID.

FEBS Lett. 2012 Nov 16;586(22):4038-45. doi: 10.1016/j.febslet.2012.10.004. Epub 2012 Oct 13.


The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis.

Kay C, Woodward KD, Lawler K, Self TJ, Dyall SD, Kerr ID.

PLoS Negl Trop Dis. 2012;6(6):e1693. doi: 10.1371/journal.pntd.0001693. Epub 2012 Jun 19.


Dimerization of ABCG2 analysed by bimolecular fluorescence complementation.

Haider AJ, Briggs D, Self TJ, Chilvers HL, Holliday ND, Kerr ID.

PLoS One. 2011;6(10):e25818. doi: 10.1371/journal.pone.0025818. Epub 2011 Oct 3.


Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics.

Dorrian JM, Briggs DA, Ridley ML, Layfield R, Kerr ID.

FEBS J. 2011 Nov;278(21):4015-24. doi: 10.1111/j.1742-4658.2011.08305.x. Epub 2011 Sep 15.


The ABCG family of membrane-associated transporters: you don't have to be big to be mighty.

Kerr ID, Haider AJ, Gelissen IC.

Br J Pharmacol. 2011 Dec;164(7):1767-79. doi: 10.1111/j.1476-5381.2010.01177.x. Review.


Pacific Ocean-wide profile of CYP1A1 expression, stable carbon and nitrogen isotope ratios, and organic contaminant burden in sperm whale skin biopsies.

Godard-Codding CA, Clark R, Fossi MC, Marsili L, Maltese S, West AG, Valenzuela L, Rowntree V, Polyak I, Cannon JC, Pinkerton K, Rubio-Cisneros N, Mesnick SL, Cox SB, Kerr I, Payne R, Stegeman JJ.

Environ Health Perspect. 2011 Mar;119(3):337-43. doi: 10.1289/ehp.0901809. Epub 2010 Dec 6.


Unraveling the evolution of auxin signaling.

De Smet I, Voss U, Lau S, Wilson M, Shao N, Timme RE, Swarup R, Kerr I, Hodgman C, Bock R, Bennett M, Jürgens G, Beeckman T.

Plant Physiol. 2011 Jan;155(1):209-21. doi: 10.1104/pp.110.168161. Epub 2010 Nov 16.


Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion.

Hussein D, Punjaruk W, Storer LC, Shaw L, Othman R, Peet A, Miller S, Bandopadhyay G, Heath R, Kumari R, Bowman KJ, Braker P, Rahman R, Jones GD, Watson S, Lowe J, Kerr ID, Grundy RG, Coyle B.

Neuro Oncol. 2011 Jan;13(1):70-83. doi: 10.1093/neuonc/noq144. Epub 2010 Oct 25. Erratum in: Neuro Oncol. 2012 Dec;14(12):1528. Ottoman, Ramadan [corrected to Othman, Ramadhan].


In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR.

PLoS Negl Trop Dis. 2010 Sep 14;4(9). pii: e825. doi: 10.1371/journal.pntd.0000825.


Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1.

Crowley E, O'Mara ML, Kerr ID, Callaghan R.

FEBS J. 2010 Oct;277(19):3974-85. doi: 10.1111/j.1742-4658.2010.07789.x. Epub 2010 Aug 20.


Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.

Kerr ID, Wu P, Marion-Tsukamaki R, Mackey ZB, Brinen LS.

PLoS Negl Trop Dis. 2010 Jun 8;4(6):e701. doi: 10.1371/journal.pntd.0000701.


A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.

He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL.

J Biol Chem. 2010 Jun 11;285(24):18516-27. doi: 10.1074/jbc.M109.086181. Epub 2010 Apr 8.

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