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Contribution of specific pathogens to bloodstream infection mortality in neutropenic patients with hematologic malignancies: results from a multicentric surveillance cohort study.

Kern WV, Roth JA, Bertz H, Götting T, Dettenkofer M, Widmer AF, Theilacker C; Hospital Infection Surveillance System for Patients with Hematologic/Oncologic Malignancies Study Group (ONKO-KISS).

Transpl Infect Dis. 2019 Oct 1:e13186. doi: 10.1111/tid.13186. [Epub ahead of print]


Clinimetric properties and suitability of selected quality indicators for assessing antibiotic use in hospitalized adults: a multicentre point prevalence study in 24 hospitals in Germany.

Först G, Kern WV, Weber N, Querbach C, Kleideiter J, Knoth H, Hagel S, Ambrosch A, Löbermann M, Schröder P, Borde J, Steib-Bauert M, de With K; ABS-QI Study Group .

J Antimicrob Chemother. 2019 Aug 23. pii: dkz364. doi: 10.1093/jac/dkz364. [Epub ahead of print]


Efflux-Mediated Resistance to New Oxazolidinones and Pleuromutilin Derivatives in Escherichia coli with Class Specificities in the Resistance-Nodulation-Cell Division-Type Drug Transport Pathways.

Schuster S, Vavra M, Kern WV.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e01041-19. doi: 10.1128/AAC.01041-19. Print 2019 Sep.


Early versus late onset bloodstream infection during neutropenia after high-dose chemotherapy for hematologic malignancy.

Widmer AF, Kern WV, Roth JA, Dettenkofer M, Goetting T, Bertz H, Theilacker C; Hospital Infection Surveillance System for Patients with Hematologic/Oncologic Malignancies Study Group (ONKO-KISS).

Infection. 2019 Oct;47(5):837-845. doi: 10.1007/s15010-019-01327-0. Epub 2019 Jun 11.


Effect of Clinically Uninfected Orthopedic Implants and Pacemakers/AICDs in Low-Risk Staphylococcus aureus Bloodstream Infection on Crude Mortality Rate: A Post Hoc Analysis of a Large Cohort Study.

Kaasch AJ, Kern WV, Joost I, Hellmich M, Seifert H, Rieg S.

Open Forum Infect Dis. 2019 Apr 15;6(5):ofz170. doi: 10.1093/ofid/ofz170. eCollection 2019 May.


Proof of an Outer Membrane Target of the Efflux Inhibitor Phe-Arg-β-Naphthylamide from Random Mutagenesis.

Schuster S, Bohnert JA, Vavra M, Rossen JW, Kern WV.

Molecules. 2019 Jan 29;24(3). pii: E470. doi: 10.3390/molecules24030470.


Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals.

Rohde AM, Zweigner J, Wiese-Posselt M, Schwab F, Behnke M, Kola A, Obermann B, Knobloch JK, Feihl S, Querbach C, Gebhardt F, Mischnik A, Ihle V, Schröder W, Armean S, Peter S, Tacconelli E, Hamprecht A, Seifert H, Vehreschild MJGT, Kern WV, Gastmeier P; DZIF-ATHOS study group.

Antimicrob Resist Infect Control. 2018 Dec 27;7:159. doi: 10.1186/s13756-018-0452-8. eCollection 2018.


Investigating the impact of early valve surgery on survival in Staphylococcus aureus infective endocarditis using a marginal structural model approach - results of a large prospectively evaluated cohort.

Rieg S, von Cube M, Kaasch A, Bonaventura B, Bothe W, Wolkewitz M, Peyerl-Hoffmann G, Deppe AC, Wahlers T, Beyersdorf F, Seifert H, Kern WV.

Clin Infect Dis. 2018 Oct 22. doi: 10.1093/cid/ciy908. [Epub ahead of print]


Phylogenetics of tick-borne encephalitis virus in endemic foci in the upper Rhine region in France and Germany.

Bestehorn M, Weigold S, Kern WV, Chitimia-Dobler L, Mackenstedt U, Dobler G, Borde JP.

PLoS One. 2018 Oct 18;13(10):e0204790. doi: 10.1371/journal.pone.0204790. eCollection 2018.


Effect of schistosomiasis on the outcome of patients infected with HIV-1 starting antiretroviral therapy in rural Tanzania.

Stete K, Glass TR, van Dam GJ, Ntamatungiro A, Letang E, de Dood CJ, Corstjens PLAM, Ndege R, Mapesi H, Kern WV, Hatz C, Weisser M, Utzinger J, Müller MC.

PLoS Negl Trop Dis. 2018 Oct 17;12(10):e0006844. doi: 10.1371/journal.pntd.0006844. eCollection 2018 Oct.


[Shortened duration of antibiotic therapy in bacterial infections].

Aurnhammer F, Först G, Kern WV.

Dtsch Med Wochenschr. 2018 Oct;143(20):1445-1449. doi: 10.1055/a-0651-4759. Epub 2018 Oct 4. German.


Prioritizing research areas for antibiotic stewardship programmes in hospitals: a behavioural perspective consensus paper.

Rzewuska M, Charani E, Clarkson JE, Davey PG, Duncan EM, Francis JJ, Gillies K, Kern WV, Lorencatto F, Marwick CA, McEwen J, Möhler R, Morris AM, Ramsay CR, Rogers Van Katwyk S, Skodvin B, Smith I, Suh KN, Grimshaw JM; Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) Working Group on Behavioural Approaches to Antibiotic Stewardship Programs.

Clin Microbiol Infect. 2019 Feb;25(2):163-168. doi: 10.1016/j.cmi.2018.08.020. Epub 2018 Sep 7.


Survival following Staphylococcus aureus bloodstream infection: A prospective multinational cohort study assessing the impact of place of care.

Nambiar K, Seifert H, Rieg S, Kern WV, Scarborough M, Gordon NC, Kim HB, Song KH, Tilley R, Gott H, Liao CH, Edgeworth J, Nsutebu E, López-Cortés LE, Morata L, Walker AS, Thwaites G, Llewelyn MJ, Kaasch AJ; International Staphylococcus aureus collaboration (ISAC) study group (with linked authorship to members in the Acknowledgements) and the ESCMID Study Group for Bloodstream Infections and Sepsis (ESGBIS).

J Infect. 2018 Dec;77(6):516-525. doi: 10.1016/j.jinf.2018.08.015. Epub 2018 Sep 1.


Rifampicin in treating S aureus bacteraemia.

Rieg S, Kern WV, Soriano A.

Lancet. 2018 Aug 18;392(10147):554-555. doi: 10.1016/S0140-6736(18)31555-1. Epub 2018 Aug 16. No abstract available.


Case Report and Genetic Sequence Analysis of Candidatus Borrelia kalaharica, Southern Africa.

Stete K, Rieg S, Margos G, Häcker G, Wagner D, Kern WV, Fingerle V.

Emerg Infect Dis. 2018 Sep;24(9):1659-1664. doi: 10.3201/eid2409.171381.


Infectious disease services: a survey from four university hospitals in Germany.

Rieg S, Hitzenbichler F, Hagel S, Suarez I, Kron F, Salzberger B, Pletz M, Kern WV, Fätkenheuer G, Jung N.

Infection. 2019 Feb;47(1):27-33. doi: 10.1007/s15010-018-1191-8. Epub 2018 Aug 17.


Onset of symptoms, diagnostic confirmation, and occurrence of multiple infective foci in patients with Staphylococcus aureus bloodstream infection: a look into the order of events and potential clinical implications.

Smit J, Rieg SR, Wendel AF, Kern WV, Seifert H, Schønheyder HC, Kaasch AJ.

Infection. 2018 Oct;46(5):651-658. doi: 10.1007/s15010-018-1165-x. Epub 2018 Jun 14.


Impact of fluoroquinolone prophylaxis during neutropenia on bloodstream infection: Data from a surveillance program in 8755 patients receiving high-dose chemotherapy for haematologic malignancies between 2009 and 2014.

Kern WV, Weber S, Dettenkofer M, Kaier K, Bertz H, Behnke M, Weisser M, Götting T, Widmer AF, Theilacker C; Hospital Infection Surveillance System for Patients with Haematologic/Oncologic Malignancies Study Group (ONKO-KISS).

J Infect. 2018 Jul;77(1):68-74. doi: 10.1016/j.jinf.2018.05.004. Epub 2018 Jun 6.


Staphylococcus aureus bloodstream infection in patients with ventricular assist devices-Management and outcome in a prospective bicenter cohort.

Joost I, Bothe W, Pausch C, Kaasch A, Lange B, Peyerl-Hoffmann G, Flüh G, Müller M, Schneider C, Seifert H, Kern WV, Beyersdorf F, Rieg S.

J Infect. 2018 Jul;77(1):30-37. doi: 10.1016/j.jinf.2018.05.002. Epub 2018 May 17.


[Multiresistant Bacteria - Antibiotic Prescription and Antibiotics of Last Resort].

Kern WV.

Dtsch Med Wochenschr. 2018 May;143(9):643-650. doi: 10.1055/s-0043-119958. Epub 2018 Apr 23. German.


Management of superficial and deep-seated Staphylococcus aureus skin and soft tissue infections in sub-Saharan Africa: a post hoc analysis of the StaphNet cohort.

Alabi A, Kazimoto T, Lebughe M, Vubil D, Phaku P, Mandomando I, Kern WV, Abdulla S, Mellmann A, Peitzmann L, Bischoff M, Peters G, Herrmann M, Grobusch MP, Schaumburg F, Rieg S.

Infection. 2018 Jun;46(3):395-404. doi: 10.1007/s15010-018-1140-6. Epub 2018 Apr 17.


[Rational prescription of antibiotics in human medicine].

Kern WV.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 May;61(5):580-588. doi: 10.1007/s00103-018-2727-x. Review. German.


Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases.

Rello J, van Engelen TSR, Alp E, Calandra T, Cattoir V, Kern WV, Netea MG, Nseir S, Opal SM, van de Veerdonk FL, Wilcox MH, Wiersinga WJ.

Clin Microbiol Infect. 2018 Dec;24(12):1264-1272. doi: 10.1016/j.cmi.2018.03.011. Epub 2018 Mar 24.


High admission prevalence of fluoroquinolone resistance in third-generation cephalosporin-resistant Enterobacteriaceae in German university hospitals.

Rohde AM, Wiese-Posselt M, Zweigner J, Schwab F, Mischnik A, Seifert H, Gastmeier P, Kern WV; DZIF-ATHOS Study Group.

J Antimicrob Chemother. 2018 Jun 1;73(6):1688-1691. doi: 10.1093/jac/dky040.


[Infectious diseases - a specialty of internal medicine].

Fätkenheuer G, Jung N, Kern WV, Fölsch UR, Salzberger B.

Internist (Berl). 2018 Apr;59(4):334-340. doi: 10.1007/s00108-018-0387-4. Review. German.


Re: "Comparison of antipseudomonal betalactams for febrile neutropenia empiric therapy: systematic review and network metaanalysis" by Horita et al.

Averbuch D, Orasch C, Mikulska M, Livermore DM, Viscoli C, Gyssens IC, Kern WV, Klyasova G, Marchetti O, Engelhard D, Akova M, Calandra T, Cordonnier C; ECIL4 antibacterial group, a joint venture of EBMT, EORTC, ICHS, ESGICH/ESCMID and ELN.

Clin Microbiol Infect. 2018 Jun;24(6):662-663. doi: 10.1016/j.cmi.2018.01.012. Epub 2018 Feb 2. No abstract available.


Management of bloodstream infections by infection specialists in France and Germany: a cross-sectional survey.

Diallo K, Kern WV, de With K, Luc A, Thilly N, Pulcini C; ESGAP and ESGBIS.

Infection. 2018 Jun;46(3):333-339. doi: 10.1007/s15010-018-1122-8. Epub 2018 Feb 3.


Answer to February 2018 Photo Quiz.

Held J, Schweizer H, Zange S, Panning M, Kern WV, Wagner D.

J Clin Microbiol. 2018 Jan 24;56(2). pii: e03353-15. doi: 10.1128/JCM.03353-15. Print 2018 Feb. No abstract available.


Photo Quiz: Pneumonia and Pyogenic Skin Abscesses in a 79-Year-Old Man.

Held J, Schweizer H, Zange S, Panning M, Kern WV, Wagner D.

J Clin Microbiol. 2018 Jan 24;56(2). pii: e03352-15. doi: 10.1128/JCM.03352-15. Print 2018 Feb. No abstract available.


[From Molecuar to Natural Medicine].

Allgaier HP, Arnold C, Baumert TF, Becker G, Geißler M, Hafkemeyer P, Harder J, Heim MH, Huber R, Kern WV, Mohr L, Moradpour D, Offensperger S, Offensperger WB, Spangenberg HC, Thimme R, Walter E, von Weizsäcker F.

Dtsch Med Wochenschr. 2018 Jan;143(1):40-45. doi: 10.1055/s-0043-123263. Epub 2018 Jan 9. German. No abstract available.


Human resources estimates for antibiotic stewardship teams: evidence-based approaches for recommendations are needed.

Harder T, Eckmanns T, Schmidt N, Kern WV, Sin MA.

Clin Microbiol Infect. 2018 May;24(5):554-556. doi: 10.1016/j.cmi.2017.12.020. Epub 2018 Jan 6. No abstract available.


Validation of adapted daily dose definitions for hospital antibacterial drug use evaluation: a multicentre study.

Först G, de With K, Weber N, Borde J, Querbach C, Kleideiter J, Seifert C, Hagel S, Ambrosch A, Löbermann M, Schröder P, Steib-Bauert M, Kern WV; ABS-QI Study Group.

J Antimicrob Chemother. 2017 Oct 1;72(10):2931-2937. doi: 10.1093/jac/dkx244.


[Pyogenic liver abscess: Changes of Organisms and Consequences for Diagnosis and Therapy].

Mischnik A, Kern WV, Thimme R.

Dtsch Med Wochenschr. 2017 Jul;142(14):1067-1074. doi: 10.1055/s-0043-100540. Epub 2017 Jul 20. Review. German.


Antimicrobial resistance rates in gram-positive bacteria do not drive glycopeptides use.

Gladstone BP, Cona A, Shamsrizi P, Vilken T, Kern WV, Malek N, Tacconelli E.

PLoS One. 2017 Jul 20;12(7):e0181358. doi: 10.1371/journal.pone.0181358. eCollection 2017.


Contribution of AcrAB-TolC to multidrug resistance in an Escherichia coli sequence type 131 isolate.

Schuster S, Vavra M, Schweigger TM, Rossen JWA, Matsumura Y, Kern WV.

Int J Antimicrob Agents. 2017 Sep;50(3):477-481. doi: 10.1016/j.ijantimicag.2017.03.023. Epub 2017 Jul 6.


Five cases of vector-borne Francisella tularensis holarctica infections in south-western Germany and genetic diversity.

Borde JP, Zange S, Antwerpen MH, Georgi E, von Buttlar H, Kern WV, Rieg S.

Ticks Tick Borne Dis. 2017 Aug;8(5):808-812. doi: 10.1016/j.ttbdis.2017.06.009. Epub 2017 Jul 1.


First report of invasive liver abscess syndrome with endophthalmitis caused by a K2 serotype ST2398 hypervirulent Klebsiella pneumoniae in Germany, 2016.

Pichler C, Büchsel M, Rossen JW, Vavra M, Reuter S, Kern WV, Thimme R, Mischnik A.

New Microbes New Infect. 2017 Mar 3;17:77-80. doi: 10.1016/j.nmni.2017.02.006. eCollection 2017 May.


Secular trends of bloodstream infections during neutropenia in 15 181 haematopoietic stem cell transplants: 13-year results from a European multicentre surveillance study (ONKO-KISS).

Weisser M, Theilacker C, Tschudin Sutter S, Babikir R, Bertz H, Götting T, Dettenkofer M, Kern WV, Widmer AF; Hospital Infection Surveillance System for Patients With Haematologic/Oncologic Malignancies Study Group (ONKO-KISS).

Clin Microbiol Infect. 2017 Nov;23(11):854-859. doi: 10.1016/j.cmi.2017.03.020. Epub 2017 Mar 31.


Staphylococcus aureus bacteremia in patients with rheumatoid arthritis - Data from the prospective INSTINCT cohort.

Joost I, Kaasch A, Pausch C, Peyerl-Hoffmann G, Schneider C, Voll RE, Seifert H, Kern WV, Rieg S.

J Infect. 2017 Jun;74(6):575-584. doi: 10.1016/j.jinf.2017.03.003. Epub 2017 Mar 18.


The "Choosing Wisely" initiative in infectious diseases.

Lehmann C, Berner R, Bogner JR, Cornely OA, de With K, Herold S, Kern WV, Lemmen S, Pletz MW, Ruf B, Salzberger B, Stellbrink HJ, Suttorp N, Ullmann AJ, Fätkenheuer G, Jung N.

Infection. 2017 Jun;45(3):263-268. doi: 10.1007/s15010-017-0997-0. Epub 2017 Mar 13. Review.


Community-Associated Staphylococcus aureus from Sub-Saharan Africa and Germany: A Cross-Sectional Geographic Correlation Study.

Ruffing U, Alabi A, Kazimoto T, Vubil DC, Akulenko R, Abdulla S, Alonso P, Bischoff M, Germann A, Grobusch MP, Helms V, Hoffmann J, Kern WV, Kremsner PG, Mandomando I, Mellmann A, Peters G, Schaumburg F, Schubert S, Strauß L, Tanner M, Briesen HV, Wende L, Müller LV, Herrmann M.

Sci Rep. 2017 Mar 13;7(1):154. doi: 10.1038/s41598-017-00214-8.


[Hospital Antibiotic Stewardship - New Guidelines and New Findings].

de With K, Wilke K, Först G, Kramme E, Kern WV.

Dtsch Med Wochenschr. 2017 Feb;142(3):177-182. doi: 10.1055/s-0042-121745. Epub 2017 Feb 10. Review. German. No abstract available.


In vitro susceptibility to 19 agents other than β-lactams among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission.

Mischnik A, Baumert P, Hamprecht A, Rohde AM, Peter S, Feihl S, Knobloch J, Gölz H, Kola A, Obermann B, Querbach C, Willmann M, Gebhardt F, Tacconelli E, Gastmeier P, Seifert H, Kern WV; DZIF-ATHOS Study Group.

J Antimicrob Chemother. 2017 May 1;72(5):1359-1363. doi: 10.1093/jac/dkw577.


Determining vancomycin Etest MICs in patients with MRSA bloodstream infection does not support switching antimicrobials.

Hos NJ, Jazmati N, Stefanik D, Hellmich M, AlSael H, Kern WV, Rieg S, Wisplinghoff H, Seifert H, Kaasch AJ.

J Infect. 2017 Mar;74(3):248-259. doi: 10.1016/j.jinf.2016.12.007. Epub 2016 Dec 22.


Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission.

Mischnik A, Baumert P, Hamprecht A, Rohde A, Peter S, Feihl S, Knobloch J, Gölz H, Kola A, Obermann B, Querbach C, Willmann M, Gebhardt F, Tacconelli E, Gastmeier P, Seifert H, Kern WV; DZIF-ATHOS Study Group.

Int J Antimicrob Agents. 2017 Feb;49(2):239-242. doi: 10.1016/j.ijantimicag.2016.10.013. Epub 2016 Nov 28.


Susceptibility to penicillin derivatives among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission.

Mischnik A, Baumert P, Hamprecht A, Rohde A, Peter S, Feihl S, Knobloch J, Gölz H, Kola A, Obermann B, Querbach C, Willmann M, Gebhardt F, Tacconelli E, Gastmeier P, Seifert H, Kern WV; DZIF-ATHOS Study Group.

Diagn Microbiol Infect Dis. 2017 Jan;87(1):71-73. doi: 10.1016/j.diagmicrobio.2016.09.012. Epub 2016 Sep 23.


Staphylococcus aureus bacteremia with iliac artery endarteritis in a patient receiving ustekinumab.

Joost I, Steinfurt J, Meyer PT, Kern WV, Rieg S.

BMC Infect Dis. 2016 Oct 20;16(1):586.


Combination antimicrobial therapy in patients with Staphylococcus aureus bacteraemia-a post hoc analysis in 964 prospectively evaluated patients.

Rieg S, Joost I, Weiß V, Peyerl-Hoffmann G, Schneider C, Hellmich M, Seifert H, Kern WV, Kaasch A.

Clin Microbiol Infect. 2017 Jun;23(6):406.e1-406.e8. doi: 10.1016/j.cmi.2016.08.026. Epub 2016 Sep 8.


[Options for the optimized therapy of Helicobacter pylori infection].

Lübbert C, Vogelmann R, Salzberger B, Kern WV.

Z Gastroenterol. 2016 Oct;54(10):1170-1171. Epub 2016 Oct 6. German. No abstract available.


Outpatient Antibiotic Prescription.

Bätzing-Feigenbaum J, Schulz M, Schulz M, Hering R, Kern WV.

Dtsch Arztebl Int. 2016 Jul 1;113(26):454-9. doi: 10.3238/arztebl.2016.0454.

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