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Molecular characterization of acute myeloid leukemia patients who relapse more than 3 years after diagnosis: an exome sequencing study of 31 patients.

Hartmann L, Haferlach C, Meggendorfer M, Nadarajah N, Kern W, Haferlach T, Stengel A.

Haematologica. 2019 Aug 1. pii: haematol.2019.227702. doi: 10.3324/haematol.2019.227702. [Epub ahead of print]


Stress relaxation and thermally adaptable properties in vitrimer-like elastomers from HXNBR rubber with covalent bonds.

Kaiser S, Wurzer S, Pilz G, Kern W, Schlögl S.

Soft Matter. 2019 Aug 14;15(30):6062-6072. doi: 10.1039/c9sm00856j. Epub 2019 Jul 12.


"Somatic" and "pathogenic" - is the classification strategy applicable in times of large-scale sequencing?

Baer C, Walter W, Hutter S, Twardziok S, Meggendorfer M, Kern W, Haferlach T, Haferlach C.

Haematologica. 2019 Aug;104(8):1515-1520. doi: 10.3324/haematol.2019.218917. Epub 2019 Jul 4. No abstract available.


DNMT3A mutations are over-represented in young adults with NPM1 mutated AML and prompt a distinct co-mutational pattern.

Cappelli LV, Meggendorfer M, Dicker F, Jeromin S, Hutter S, Kern W, Haferlach T, Haferlach C, Höllein A.

Leukemia. 2019 Jun 17. doi: 10.1038/s41375-019-0502-0. [Epub ahead of print] No abstract available.


Efflux-mediated resistance to new oxazolidinones and pleuromutilin derivatives in Escherichia coli with class specificities in the RND-type drug transport pathways.

Schuster S, Vavra M, Kern WV.

Antimicrob Agents Chemother. 2019 Jun 17. pii: AAC.01041-19. doi: 10.1128/AAC.01041-19. [Epub ahead of print]


Data on production and characterization of melamine-furan-formaldehyde particles and reversible reactions thereof.

Urdl K, Weiss S, Hesser G, Kandelbauer A, Zikulnig-Rusch E, Müller U, Kern W.

Data Brief. 2019 May 25;25:104056. doi: 10.1016/j.dib.2019.104056. eCollection 2019 Aug.


Early versus late onset bloodstream infection during neutropenia after high-dose chemotherapy for hematologic malignancy.

Widmer AF, Kern WV, Roth JA, Dettenkofer M, Goetting T, Bertz H, Theilacker C; Hospital Infection Surveillance System for Patients with Hematologic/Oncologic Malignancies Study Group (ONKO-KISS).

Infection. 2019 Jun 11. doi: 10.1007/s15010-019-01327-0. [Epub ahead of print]


Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study.

Albasanz-Puig A, Gudiol C, Parody R, Tebe C, Akova M, Araos R, Bote A, Brunel AS, Calik S, Drgona L, García E, Hemmati P, Herrera F, Ibrahim KY, Isler B, Kanj S, Kern W, Maestro de la Calle G, Manzur A, Marin JI, Márquez-Gómez I, Martín-Dávila P, Mikulska M, Montejo JM, Montero M, Morales HMP, Morales I, Novo A, Oltolini C, Peghin M, Del Pozo JL, Puerta-Alcalde P, Ruiz-Camps I, Sipahi OR, Tilley R, Yáñez L, Gomes MZR, Carratalà J; IRONIC study group.

BMJ Open. 2019 May 24;9(5):e025744. doi: 10.1136/bmjopen-2018-025744.


Effect of Clinically Uninfected Orthopedic Implants and Pacemakers/AICDs in Low-Risk Staphylococcus aureus Bloodstream Infection on Crude Mortality Rate: A Post Hoc Analysis of a Large Cohort Study.

Kaasch AJ, Kern WV, Joost I, Hellmich M, Seifert H, Rieg S.

Open Forum Infect Dis. 2019 Apr 15;6(5):ofz170. doi: 10.1093/ofid/ofz170. eCollection 2019 May.


Proposed diagnostic criteria for classical CMML, CMML variants and pre-CMML conditions.

Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lubbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstocker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM.

Haematologica. 2019 May 2. pii: haematol.2019.222059. doi: 10.3324/haematol.2019.222059. [Epub ahead of print]


RUNX1 mutations in MDS, s-AML, and de novo AML: differences in accompanying genetic alterations and outcome.

Stengel A, Kern W, Meggendorfer M, Haferlach T, Haferlach C.

Leuk Lymphoma. 2019 May;60(5):1334-1336. doi: 10.1080/10428194.2018.1522439. No abstract available.


Myeloid malignancies with isolated 7q deletion can be further characterized by their accompanying molecular mutations.

Hartmann L, Haferlach C, Meggendorfer M, Kern W, Haferlach T, Stengel A.

Genes Chromosomes Cancer. 2019 Oct;58(10):698-704. doi: 10.1002/gcc.22761. Epub 2019 May 1.


Preparation of a Water-Based Photoreactive Azosulphonate-Doped Poly(Vinyl Alcohol) and the Investigation of Its UV Response.

Nothdurft P, Schauberger JG, Riess G, Kern W.

Polymers (Basel). 2019 Jan 18;11(1). pii: E169. doi: 10.3390/polym11010169.


Impact of 9q deletions on the classification of patients with acute myeloid leukemia.

Balk B, Haferlach T, Meggendorfer M, Kern W, Haferlach C, Stengel A.

J Cancer Res Clin Oncol. 2019 Mar 29. doi: 10.1007/s00432-019-02908-0. [Epub ahead of print] No abstract available.


Impact of assay procedures on detection of MR4.5 status in chronic myeloid leukemia: Optimization of cDNA synthesis.

Jeromin S, Eder C, Haferlach C, Haferlach T, Kern W.

Int J Lab Hematol. 2019 Mar 12. doi: 10.1111/ijlh.13004. [Epub ahead of print] No abstract available.


Comprehensive molecular characterization of myeloid malignancies with 9q deletion.

Hartmann L, Haferlach T, Meggendorfer M, Kern W, Haferlach C, Stengel A.

Leuk Lymphoma. 2019 Mar 7:1-3. doi: 10.1080/10428194.2019.1585840. [Epub ahead of print] No abstract available.


Copper/Epoxy Joints in Printed Circuit Boards: Manufacturing and Interfacial Failure Mechanisms.

Nothdurft P, Riess G, Kern W.

Materials (Basel). 2019 Feb 12;12(3). pii: E550. doi: 10.3390/ma12030550. Review.


Clonal Hematopoiesis with Oncogenic Potential (CHOP): Separation from CHIP and Roads to AML.

Valent P, Kern W, Hoermann G, Milosevic Feenstra JD, Sotlar K, Pfeilstöcker M, Germing U, Sperr WR, Reiter A, Wolf D, Arock M, Haferlach T, Horny HP.

Int J Mol Sci. 2019 Feb 12;20(3). pii: E789. doi: 10.3390/ijms20030789. Review.



Efstathion CA, Burkett-Cadena ND, Kern WH Jr.

J Wildl Dis. 2019 Jul;55(3):597-607. doi: 10.7589/2017-12-307. Epub 2019 Jan 31.


Proof of an Outer Membrane Target of the Efflux Inhibitor Phe-Arg-β-Naphthylamide from Random Mutagenesis.

Schuster S, Bohnert JA, Vavra M, Rossen JW, Kern WV.

Molecules. 2019 Jan 29;24(3). pii: E470. doi: 10.3390/molecules24030470.


Evidence of clonality in cases of hypereosinophilia of undetermined significance.

Pohlkamp C, Vetro C, Dicker F, Meggendorfer M, Kern W, Haferlach C, Haferlach T.

Leuk Lymphoma. 2019 Aug;60(8):2071-2074. doi: 10.1080/10428194.2018.1564825. Epub 2019 Jan 18. No abstract available.


TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.

Haase D, Stevenson KE, Neuberg D, Maciejewski JP, Nazha A, Sekeres MA, Ebert BL, Garcia-Manero G, Haferlach C, Haferlach T, Kern W, Ogawa S, Nagata Y, Yoshida K, Graubert TA, Walter MJ, List AF, Komrokji RS, Padron E, Sallman D, Papaemmanuil E, Campbell PJ, Savona MR, Seegmiller A, Adès L, Fenaux P, Shih LY, Bowen D, Groves MJ, Tauro S, Fontenay M, Kosmider O, Bar-Natan M, Steensma D, Stone R, Heuser M, Thol F, Cazzola M, Malcovati L, Karsan A, Ganster C, Hellström-Lindberg E, Boultwood J, Pellagatti A, Santini V, Quek L, Vyas P, Tüchler H, Greenberg PL, Bejar R; International Working Group for MDS Molecular Prognostic Committee.

Leukemia. 2019 Jul;33(7):1747-1758. doi: 10.1038/s41375-018-0351-2. Epub 2019 Jan 11.


Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals.

Rohde AM, Zweigner J, Wiese-Posselt M, Schwab F, Behnke M, Kola A, Obermann B, Knobloch JK, Feihl S, Querbach C, Gebhardt F, Mischnik A, Ihle V, Schröder W, Armean S, Peter S, Tacconelli E, Hamprecht A, Seifert H, Vehreschild MJGT, Kern WV, Gastmeier P; DZIF-ATHOS study group.

Antimicrob Resist Infect Control. 2018 Dec 27;7:159. doi: 10.1186/s13756-018-0452-8. eCollection 2018.


Metabolic and Cognitive Outcomes of Subchronic Once-Daily Intranasal Insulin Administration in Healthy Men.

Ritze Y, Kern W, Ebner EM, Jahn S, Benedict C, Hallschmid M.

Front Endocrinol (Lausanne). 2018 Nov 13;9:663. doi: 10.3389/fendo.2018.00663. eCollection 2018.


Detailed molecular analysis and evaluation of prognosis in cases with high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.

Stengel A, Kern W, Meggendorfer M, Haferlach T, Haferlach C.

Br J Haematol. 2019 Jun;185(5):951-954. doi: 10.1111/bjh.15653. Epub 2018 Nov 20. No abstract available.


NPM1 mutated AML can relapse with wild-type NPM1: persistent clonal hematopoiesis can drive relapse.

Höllein A, Meggendorfer M, Dicker F, Jeromin S, Nadarajah N, Kern W, Haferlach C, Haferlach T.

Blood Adv. 2018 Nov 27;2(22):3118-3125. doi: 10.1182/bloodadvances.2018023432.


Detection and characterization of homozygosity of mutated CALR by copy neutral loss of heterozygosity in myeloproliferative neoplasms among cases with high CALR mutation loads or with progressive disease.

Stengel A, Jeromin S, Haferlach T, Meggendorfer M, Kern W, Haferlach C.

Haematologica. 2019 May;104(5):e187-e190. doi: 10.3324/haematol.2018.202952. Epub 2018 Nov 8. No abstract available.


Investigating the impact of early valve surgery on survival in Staphylococcus aureus infective endocarditis using a marginal structural model approach - results of a large prospectively evaluated cohort.

Rieg S, von Cube M, Kaasch A, Bonaventura B, Bothe W, Wolkewitz M, Peyerl-Hoffmann G, Deppe AC, Wahlers T, Beyersdorf F, Seifert H, Kern WV.

Clin Infect Dis. 2018 Oct 22. doi: 10.1093/cid/ciy908. [Epub ahead of print]


Phylogenetics of tick-borne encephalitis virus in endemic foci in the upper Rhine region in France and Germany.

Bestehorn M, Weigold S, Kern WV, Chitimia-Dobler L, Mackenstedt U, Dobler G, Borde JP.

PLoS One. 2018 Oct 18;13(10):e0204790. doi: 10.1371/journal.pone.0204790. eCollection 2018.


Effect of schistosomiasis on the outcome of patients infected with HIV-1 starting antiretroviral therapy in rural Tanzania.

Stete K, Glass TR, van Dam GJ, Ntamatungiro A, Letang E, de Dood CJ, Corstjens PLAM, Ndege R, Mapesi H, Kern WV, Hatz C, Weisser M, Utzinger J, Müller MC.

PLoS Negl Trop Dis. 2018 Oct 17;12(10):e0006844. doi: 10.1371/journal.pntd.0006844. eCollection 2018 Oct.


[Shortened duration of antibiotic therapy in bacterial infections].

Aurnhammer F, Först G, Kern WV.

Dtsch Med Wochenschr. 2018 Oct;143(20):1445-1449. doi: 10.1055/a-0651-4759. Epub 2018 Oct 4. German.


Prioritizing research areas for antibiotic stewardship programmes in hospitals: a behavioural perspective consensus paper.

Rzewuska M, Charani E, Clarkson JE, Davey PG, Duncan EM, Francis JJ, Gillies K, Kern WV, Lorencatto F, Marwick CA, McEwen J, Möhler R, Morris AM, Ramsay CR, Rogers Van Katwyk S, Skodvin B, Smith I, Suh KN, Grimshaw JM; Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) Working Group on Behavioural Approaches to Antibiotic Stewardship Programs.

Clin Microbiol Infect. 2019 Feb;25(2):163-168. doi: 10.1016/j.cmi.2018.08.020. Epub 2018 Sep 7.


Survival following Staphylococcus aureus bloodstream infection: A prospective multinational cohort study assessing the impact of place of care.

Nambiar K, Seifert H, Rieg S, Kern WV, Scarborough M, Gordon NC, Kim HB, Song KH, Tilley R, Gott H, Liao CH, Edgeworth J, Nsutebu E, López-Cortés LE, Morata L, Walker AS, Thwaites G, Llewelyn MJ, Kaasch AJ; International Staphylococcus aureus collaboration (ISAC) study group (with linked authorship to members in the Acknowledgements) and the ESCMID Study Group for Bloodstream Infections and Sepsis (ESGBIS).

J Infect. 2018 Dec;77(6):516-525. doi: 10.1016/j.jinf.2018.08.015. Epub 2018 Sep 1.


Rifampicin in treating S aureus bacteraemia.

Rieg S, Kern WV, Soriano A.

Lancet. 2018 Aug 18;392(10147):554-555. doi: 10.1016/S0140-6736(18)31555-1. Epub 2018 Aug 16. No abstract available.


Case Report and Genetic Sequence Analysis of Candidatus Borrelia kalaharica, Southern Africa.

Stete K, Rieg S, Margos G, Häcker G, Wagner D, Kern WV, Fingerle V.

Emerg Infect Dis. 2018 Sep;24(9):1659-1664. doi: 10.3201/eid2409.171381.


Infectious disease services: a survey from four university hospitals in Germany.

Rieg S, Hitzenbichler F, Hagel S, Suarez I, Kron F, Salzberger B, Pletz M, Kern WV, Fätkenheuer G, Jung N.

Infection. 2019 Feb;47(1):27-33. doi: 10.1007/s15010-018-1191-8. Epub 2018 Aug 17.


Identification of prognostic parameters in CLL with no abnormalities detected by chromosome banding and FISH analyses.

Vetro C, Haferlach T, Jeromin S, Stengel A, Zenger M, Nadarajah N, Baer C, Weissmann S, Kern W, Meggendorfer M, Haferlach C.

Br J Haematol. 2018 Oct;183(1):47-59. doi: 10.1111/bjh.15498. Epub 2018 Jul 18.


Onset of symptoms, diagnostic confirmation, and occurrence of multiple infective foci in patients with Staphylococcus aureus bloodstream infection: a look into the order of events and potential clinical implications.

Smit J, Rieg SR, Wendel AF, Kern WV, Seifert H, Schønheyder HC, Kaasch AJ.

Infection. 2018 Oct;46(5):651-658. doi: 10.1007/s15010-018-1165-x. Epub 2018 Jun 14.


Impact of fluoroquinolone prophylaxis during neutropenia on bloodstream infection: Data from a surveillance program in 8755 patients receiving high-dose chemotherapy for haematologic malignancies between 2009 and 2014.

Kern WV, Weber S, Dettenkofer M, Kaier K, Bertz H, Behnke M, Weisser M, Götting T, Widmer AF, Theilacker C; Hospital Infection Surveillance System for Patients with Haematologic/Oncologic Malignancies Study Group (ONKO-KISS).

J Infect. 2018 Jul;77(1):68-74. doi: 10.1016/j.jinf.2018.05.004. Epub 2018 Jun 6.


Staphylococcus aureus bloodstream infection in patients with ventricular assist devices-Management and outcome in a prospective bicenter cohort.

Joost I, Bothe W, Pausch C, Kaasch A, Lange B, Peyerl-Hoffmann G, Flüh G, Müller M, Schneider C, Seifert H, Kern WV, Beyersdorf F, Rieg S.

J Infect. 2018 Jul;77(1):30-37. doi: 10.1016/j.jinf.2018.05.002. Epub 2018 May 17.


Molecular patterns in cytopenia patients with or without evidence of myeloid neoplasm-a comparison of 756 cases.

Baer C, Pohlkamp C, Haferlach C, Kern W, Haferlach T.

Leukemia. 2018 Oct;32(10):2295-2298. doi: 10.1038/s41375-018-0119-8. Epub 2018 Mar 30. No abstract available.


Selective inhibition of BCL-2 is a promising target in patients with high-risk myelodysplastic syndromes and adverse mutational profile.

Reidel V, Kauschinger J, Hauch RT, Müller-Thomas C, Nadarajah N, Burgkart R, Schmidt B, Hempel D, Jacob A, Slotta-Huspenina J, Höckendorf U, Peschel C, Kern W, Haferlach T, Götze KS, Jilg S, Jost PJ.

Oncotarget. 2018 Apr 3;9(25):17270-17281. doi: 10.18632/oncotarget.24775. eCollection 2018 Apr 3.


The mutational landscape of 18 investigated genes clearly separates four subtypes of myelodysplastic/myeloproliferative neoplasms.

Meggendorfer M, Jeromin S, Haferlach C, Kern W, Haferlach T.

Haematologica. 2018 May;103(5):e192-e195. doi: 10.3324/haematol.2017.183160. No abstract available.


[Multiresistant Bacteria - Antibiotic Prescription and Antibiotics of Last Resort].

Kern WV.

Dtsch Med Wochenschr. 2018 May;143(9):643-650. doi: 10.1055/s-0043-119958. Epub 2018 Apr 23. German.


Management of superficial and deep-seated Staphylococcus aureus skin and soft tissue infections in sub-Saharan Africa: a post hoc analysis of the StaphNet cohort.

Alabi A, Kazimoto T, Lebughe M, Vubil D, Phaku P, Mandomando I, Kern WV, Abdulla S, Mellmann A, Peitzmann L, Bischoff M, Peters G, Herrmann M, Grobusch MP, Schaumburg F, Rieg S.

Infection. 2018 Jun;46(3):395-404. doi: 10.1007/s15010-018-1140-6. Epub 2018 Apr 17.


[Rational prescription of antibiotics in human medicine].

Kern WV.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 May;61(5):580-588. doi: 10.1007/s00103-018-2727-x. Review. German.


Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases.

Rello J, van Engelen TSR, Alp E, Calandra T, Cattoir V, Kern WV, Netea MG, Nseir S, Opal SM, van de Veerdonk FL, Wilcox MH, Wiersinga WJ.

Clin Microbiol Infect. 2018 Dec;24(12):1264-1272. doi: 10.1016/j.cmi.2018.03.011. Epub 2018 Mar 24.


Minimal residual disease (MRD) monitoring and mutational landscape in AML with RUNX1-RUNX1T1: a study on 134 patients.

Höllein A, Jeromin S, Meggendorfer M, Fasan A, Nadarajah N, Kern W, Haferlach C, Haferlach T.

Leukemia. 2018 Oct;32(10):2270-2274. doi: 10.1038/s41375-018-0086-0. Epub 2018 Mar 6. No abstract available.


IDH1R132, IDH2R140 and IDH2R172 in AML: different genetic landscapes correlate with outcome and may influence targeted treatment strategies.

Meggendorfer M, Cappelli LV, Walter W, Haferlach C, Kern W, Falini B, Haferlach T.

Leukemia. 2018 May;32(5):1249-1253. doi: 10.1038/s41375-018-0026-z. Epub 2018 Jan 30. No abstract available.


Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2.

Baer C, Muehlbacher V, Kern W, Haferlach C, Haferlach T.

Haematologica. 2018 Aug;103(8):e348-e350. doi: 10.3324/haematol.2017.187302. Epub 2018 Mar 22. No abstract available.

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