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Description of a Mass Poisoning in a Rural District in Mozambique: The First Documented Bongkrekic Acid Poisoning in Africa.

Gudo ES, Cook K, Kasper AM, Vergara A, Salomão C, Oliveira F, Ismael H, Saeze C, Mosse C, Fernandes Q, Viegas SO, Baltazar CS, Doyle TJ, Yard E, Steck A, Serret M, Falconer TM, Kern SE, Brzezinski JL, Turner JA, Boyd BL, Jani IV; Chitima Investigation Group.

Clin Infect Dis. 2018 Apr 17;66(9):1400-1406. doi: 10.1093/cid/cix1005.


Forensic Analysis of Stains on Fabric Using Direct Analysis in Real-time Ionization with High-Resolution Accurate Mass-Mass Spectrometry.

Kern SE, Crowe JB, Litzau JJ, Heitkemper DT.

J Forensic Sci. 2018 Mar;63(2):592-597. doi: 10.1111/1556-4029.13565. Epub 2017 Jun 12.


Identification of the potent toxin bongkrekic acid in a traditional African beverage linked to a fatal outbreak.

Falconer TM, Kern SE, Brzezinski JL, Turner JA, Boyd BL, Litzau JJ.

Forensic Sci Int. 2017 Jan;270:e5-e11. doi: 10.1016/j.forsciint.2016.10.015. Epub 2016 Oct 23.


Isolation and structural characterization of a new tadalafil analog (chloropropanoylpretadalafil) found in a dietary supplement.

Kern SE, Lorenz LM, Lanzarotta A, Nickum EA, Litzau JJ.

J Pharm Biomed Anal. 2016 Sep 5;128:360-366. doi: 10.1016/j.jpba.2016.05.038. Epub 2016 May 27.


Isolation and structural characterization of a new tadalafil analog (2-hydroxyethylnortadalafil) found in a dietary supplement.

Kern SE, Nickum EA, Flurer RA, Toomey VM, Litzau JJ.

J Pharm Biomed Anal. 2015 Jan 25;103:99-103. doi: 10.1016/j.jpba.2014.10.021. Epub 2014 Nov 5.


Genome annotation by shotgun inactivation of a native gene in hemizygous cells: application to BRCA2 with implication of hypomorphic variants.

Ghosh S, Bhunia AK, Paun BC, Gilbert SF, Dhru U, Patel K, Kern SE.

Hum Mutat. 2015 Feb;36(2):260-9. doi: 10.1002/humu.22736.


Effect of a Pluronic(®) P123 formulation on the nitric oxide-generating drug JS-K.

Kaur I, Kosak KM, Terrazas M, Herron JN, Kern SE, Boucher KM, Shami PJ.

Pharm Res. 2015 Apr;32(4):1395-406. doi: 10.1007/s11095-014-1542-9. Epub 2014 Oct 18.


Accurate mass fragment library for rapid analysis of pesticides on produce using ambient pressure desorption ionization with high-resolution mass spectrometry.

Kern SE, Lin LA, Fricke FL.

J Am Soc Mass Spectrom. 2014 Aug;25(8):1482-8. doi: 10.1007/s13361-014-0912-1. Epub 2014 May 21.


Salivary α-amylase, serum albumin, and myoglobin protect against DNA-damaging activities of ingested dietary agents in vitro.

Hossain MZ, Patel K, Kern SE.

Food Chem Toxicol. 2014 Aug;70:114-9. doi: 10.1016/j.fct.2014.05.002. Epub 2014 May 16.


Extraction and measurement of NAD(P)(+) and NAD(P)H.

Kern SE, Price-Whelan A, Newman DK.

Methods Mol Biol. 2014;1149:311-23. doi: 10.1007/978-1-4939-0473-0_26.


Measurement of phenazines in bacterial cultures.

Kern SE, Newman DK.

Methods Mol Biol. 2014;1149:303-10. doi: 10.1007/978-1-4939-0473-0_25.


Are we systematically under-dosing patients with fluorouracil?

Patel K, Iacobuzio-Donahue CA, Gormley PE, Kern SE, Cunningham SC.

J Clin Oncol. 2015 Mar 1;33(7):e36-7. doi: 10.1200/JCO.2013.49.5044. Epub 2014 Mar 10. No abstract available.


Phenazine redox cycling enhances anaerobic survival in Pseudomonas aeruginosa by facilitating generation of ATP and a proton-motive force.

Glasser NR, Kern SE, Newman DK.

Mol Microbiol. 2014 Apr;92(2):399-412. doi: 10.1111/mmi.12566. Epub 2014 Mar 19.


Microvascular architecture in a case of gastric antral vascular ectasia (watermelon stomach).

Kern SE, Sitzmann JV.

Am J Gastroenterol. 2014 Mar;109(3):449-51. doi: 10.1038/ajg.2013.449. No abstract available.


Hypersensitivities for acetaldehyde and other agents among cancer cells null for clinically relevant Fanconi anemia genes.

Ghosh S, Sur S, Yerram SR, Rago C, Bhunia AK, Hossain MZ, Paun BC, Ren YR, Iacobuzio-Donahue CA, Azad NA, Kern SE.

Am J Pathol. 2014 Jan;184(1):260-70. doi: 10.1016/j.ajpath.2013.09.023. Epub 2013 Nov 6.


Cellular distribution studies of the nitric oxide-generating antineoplastic prodrug O(2) -(2,4-dinitrophenyl)1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate formulated in Pluronic P123 micelles.

Kaur I, Terrazas M, Kosak KM, Kern SE, Boucher KM, Shami PJ.

J Pharm Pharmacol. 2013 Sep;65(9):1329-36. doi: 10.1111/jphp.12100. Epub 2013 Jul 10.


"Selective cell death mediated by small conditional RNAs" is not selective.

Patel K, Kern SE.

Cancer Biol Ther. 2013 Aug;14(8):693-6. doi: 10.4161/cbt.25093. Epub 2013 May 31.


FAM190A deficiency creates a cell division defect.

Patel K, Scrimieri F, Ghosh S, Zhong J, Kim MS, Ren YR, Morgan RA, Iacobuzio-Donahue CA, Pandey A, Kern SE.

Am J Pathol. 2013 Jul;183(1):296-303. doi: 10.1016/j.ajpath.2013.03.020. Epub 2013 May 10.


DNA-intercalators causing rapid re-expression of methylated and silenced genes in cancer cells.

Hossain MZ, Healey MA, Lee C, Poh W, Yerram SR, Patel K, Azad NS, Herman JG, Kern SE.

Oncotarget. 2013 Feb;4(2):298-309.


Biological clues to potent DNA-damaging activities in food and flavoring.

Hossain MZ, Gilbert SF, Patel K, Ghosh S, Bhunia AK, Kern SE.

Food Chem Toxicol. 2013 May;55:557-67. doi: 10.1016/j.fct.2013.01.058. Epub 2013 Feb 8.


Why your new cancer biomarker may never work: recurrent patterns and remarkable diversity in biomarker failures.

Kern SE.

Cancer Res. 2012 Dec 1;72(23):6097-101. doi: 10.1158/0008-5472.CAN-12-3232. Epub 2012 Nov 19. Review.


Unbiased discovery of interactions at a control locus driving expression of the cancer-specific therapeutic and diagnostic target, mesothelin.

Ren YR, Chaerkady R, Hu S, Wan J, Qian J, Zhu H, Pandey A, Kern SE.

J Proteome Res. 2012 Nov 2;11(11):5301-10. doi: 10.1021/pr300797v. Epub 2012 Oct 12.


Ecology of uncultured Prochlorococcus clades revealed through single-cell genomics and biogeographic analysis.

Malmstrom RR, Rodrigue S, Huang KH, Kelly L, Kern SE, Thompson A, Roggensack S, Berube PM, Henn MR, Chisholm SW.

ISME J. 2013 Jan;7(1):184-98. doi: 10.1038/ismej.2012.89. Epub 2012 Aug 16.


Analysis of polymorphisms and haplotype structure of the human thymidylate synthase genetic region: a tool for pharmacogenetic studies.

Ghosh S, Hossain MZ, Borges M, Goggins MG, Ingersoll RG, Eshleman JR, Klein AP, Kern SE.

PLoS One. 2012;7(4):e34426. doi: 10.1371/journal.pone.0034426. Epub 2012 Apr 5.


Comparison between cerebral state index and bispectral index as measures of electroencephalographic effects of sevoflurane using combined sigmoidal E(max) model.

Han DW, Linares-Perdomo OJ, Lee JS, Kim JH, Kern SE.

Acta Pharmacol Sin. 2011 Oct;32(10):1208-14. doi: 10.1038/aps.2011.99. Epub 2011 Sep 5.


Reexamining a proposal: thymidylate synthase 5'-untranslated region as a regulator of translation efficiency.

Ghosh S, Winter JM, Patel K, Kern SE.

Cancer Biol Ther. 2011 Oct 15;12(8):750-5. doi: 10.4161/cbt.12.8.16867. Epub 2011 Oct 15.


Community screening and treatment of asymptomatic carriers of Plasmodium falciparum with artemether-lumefantrine to reduce malaria disease burden: a modelling and simulation analysis.

Kern SE, Tiono AB, Makanga M, Gbadoé AD, Premji Z, Gaye O, Sagara I, Ubben D, Cousin M, Oladiran F, Sander O, Ogutu B.

Malar J. 2011 Jul 29;10:210. doi: 10.1186/1475-2875-10-210.


Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.

DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA.

Nature. 2011 Jul 6;475(7354):106-9. doi: 10.1038/nature10189.


FAM190A rearrangements provide a multitude of individualized tumor signatures and neo-antigens in cancer.

Scrimieri F, Calhoun ES, Patel K, Gupta R, Huso DL, Hruban RH, Kern SE.

Oncotarget. 2011 Jan-Feb;2(1-2):69-75.


Structural analysis of the cancer-specific promoter in mesothelin and in other genes overexpressed in cancers.

Ren YR, Patel K, Paun BC, Kern SE.

J Biol Chem. 2011 Apr 8;286(14):11960-9. doi: 10.1074/jbc.M110.193458. Epub 2011 Feb 2.


The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting.

Kern SE, Shi C, Hruban RH.

J Pathol. 2011 Jan;223(2):295-306. doi: 10.1002/path.2813. Epub 2010 Nov 16. Review.


MKK4 as oncogene or tumor suppressor: in cancer and senescence, the story's getting old.

Cunningham SC, Gallmeier E, Kern SE.

Aging (Albany NY). 2010 Nov;2(11):752-3. No abstract available.


The need for modeling and simulation to design clinical investigations in children.

Jadhav PR, Kern SE.

J Clin Pharmacol. 2010 Sep;50(9 Suppl):121S-129S. doi: 10.1177/0091270010376968.


Modeling the effect of sevoflurane on corrected QT prolongation: a pharmacodynamic analysis.

Han DW, Park K, Jang SB, Kern SE.

Anesthesiology. 2010 Oct;113(4):806-11. doi: 10.1097/ALN.0b013e3181f26d34.


Where's the passion?

Kern SE.

Cancer Biol Ther. 2010 Oct 1;10(7):655-7. doi: 10.4161/cbt.10.7.12994. Epub 2010 Oct 1.


Genomic analysis of oceanic cyanobacterial myoviruses compared with T4-like myoviruses from diverse hosts and environments.

Sullivan MB, Huang KH, Ignacio-Espinoza JC, Berlin AM, Kelly L, Weigele PR, DeFrancesco AS, Kern SE, Thompson LR, Young S, Yandava C, Fu R, Krastins B, Chase M, Sarracino D, Osburne MS, Henn MR, Chisholm SW.

Environ Microbiol. 2010 Nov;12(11):3035-56. doi: 10.1111/j.1462-2920.2010.02280.x.


Improved DNA electrophoresis in conditions favoring polyborates and lewis acid complexation.

Singhal H, Ren YR, Kern SE.

PLoS One. 2010 Jun 25;5(6):e11318. doi: 10.1371/journal.pone.0011318.


The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria.

Borrmann S, Sallas WM, Machevo S, González R, Björkman A, Mårtensson A, Hamel M, Juma E, Peshu J, Ogutu B, Djimdé A, D'Alessandro U, Marrast AC, Lefèvre G, Kern SE.

Trop Med Int Health. 2010 Apr;15(4):434-41. doi: 10.1111/j.1365-3156.2010.02477.x. Epub 2010 Feb 17.


Modelling the genesis and treatment of cancer: the potential role of physiologically based pharmacodynamics.

Steimer JL, Dahl SG, De Alwis DP, Gundert-Remy U, Karlsson MO, Martinkova J, Aarons L, Ahr HJ, Clairambault J, Freyer G, Friberg LE, Kern SE, Kopp-Schneider A, Ludwig WD, De Nicolao G, Rocchetti M, Troconiz IF.

Eur J Cancer. 2010 Jan;46(1):21-32. doi: 10.1016/j.ejca.2009.10.011.


Clinical trials in neonates: a therapeutic imperative.

Ward RM, Kern SE.

Clin Pharmacol Ther. 2009 Dec;86(6):585-7. doi: 10.1038/clpt.2009.207.


Endogenous phenazine antibiotics promote anaerobic survival of Pseudomonas aeruginosa via extracellular electron transfer.

Wang Y, Kern SE, Newman DK.

J Bacteriol. 2010 Jan;192(1):365-9. doi: 10.1128/JB.01188-09.


Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents.

Goteti K, Garner CE, Utley L, Dai J, Ashwell S, Moustakas DT, Gönen M, Schwartz GK, Kern SE, Zabludoff S, Brassil PJ.

Cancer Chemother Pharmacol. 2010 Jul;66(2):245-54. doi: 10.1007/s00280-009-1153-z. Epub 2009 Oct 16.


Re: Tandem vs single autologous hematopoietic cell transplantation for the treatment of multiple myeloma: a systematic review and meta-analysis.

Tricot G, Kern SE, Barlogie B.

J Natl Cancer Inst. 2009 Jul 1;101(13):964-6; author reply 966-7. doi: 10.1093/jnci/djp127. Epub 2009 Jun 17. No abstract available.


Emerging molecular biology of pancreatic cancer.

Hruban RH, Maitra A, Schulick R, Laheru D, Herman J, Kern SE, Goggins M.

Gastrointest Cancer Res. 2008 Jul;2(4 Suppl):S10-5.


Hybrids of aneuploid human cancer cells permit complementation of simple and complex cancer defects.

Dezentje DA, Arking DE, Kortenhorst MS, West K, Chakravarti A, Kern SE.

Cancer Biol Ther. 2009 Feb;8(4):347-55. Epub 2009 Feb 4.


Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.

Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW, Lin JC, Palmisano E, Brune K, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Parmigiani G, Kern SE, Velculescu VE, Kinzler KW, Vogelstein B, Eshleman JR, Goggins M, Klein AP.

Science. 2009 Apr 10;324(5924):217. doi: 10.1126/science.1171202. Epub 2009 Mar 5.

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