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miRPathDB 2.0: a novel release of the miRNA Pathway Dictionary Database.

Kehl T, Kern F, Backes C, Fehlmann T, Stöckel D, Meese E, Lenhof HP, Keller A.

Nucleic Acids Res. 2019 Nov 6. pii: gkz1022. doi: 10.1093/nar/gkz1022. [Epub ahead of print]


Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients.

Keller A, Ludwig N, Fehlmann T, Kahraman M, Backes C, Kern F, Vogelmeier CF, Diener C, Fischer U, Biertz F, Herr C, Jörres RA, Lenhof HP, Bals R, Meese E.

Cells. 2019 Sep 27;8(10). pii: E1162. doi: 10.3390/cells8101162.


Systematic Assessment of Blood-Borne MicroRNAs Highlights Molecular Profiles of Endurance Sport and Carbohydrate Uptake.

Kern F, Ludwig N, Backes C, Maldener E, Fehlmann T, Suleymanov A, Meese E, Hecksteden A, Keller A, Meyer T.

Cells. 2019 Sep 6;8(9). pii: E1045. doi: 10.3390/cells8091045.


Spring is in the air: seasonal profiles indicate vernal change of miRNA activity.

Ludwig N, Hecksteden A, Kahraman M, Fehlmann T, Laufer T, Kern F, Meyer T, Meese E, Keller A, Backes C.

RNA Biol. 2019 Aug;16(8):1034-1043. doi: 10.1080/15476286.2019.1612217. Epub 2019 May 10.


CD28 null CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection.

Bano A, Pera A, Almoukayed A, Clarke THS, Kirmani S, Davies KA, Kern F.

F1000Res. 2019 Mar 25;8. pii: F1000 Faculty Rev-327. doi: 10.12688/f1000research.17119.1. eCollection 2019. Review.


The sncRNA Zoo: a repository for circulating small noncoding RNAs in animals.

Fehlmann T, Backes C, Pirritano M, Laufer T, Galata V, Kern F, Kahraman M, Gasparoni G, Ludwig N, Lenhof HP, Gregersen HA, Francke R, Meese E, Simon M, Keller A.

Nucleic Acids Res. 2019 May 21;47(9):4431-4441. doi: 10.1093/nar/gkz227.


The Dresden in-situ (S)TEM special with a continuous-flow liquid-helium cryostat.

Börrnert F, Kern F, Harder F, Riedel T, Müller H, Büchner B, Lubk A.

Ultramicroscopy. 2019 Aug;203:12-20. doi: 10.1016/j.ultramic.2019.01.005. Epub 2019 Feb 8.


Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients.

Baraniak I, Kern F, Holenya P, Griffiths P, Reeves M.

J Infect Dis. 2019 Jun 19;220(2):228-232. doi: 10.1093/infdis/jiz089.


Not Alone Here?! Scalability and User Experience of Embodied Ambient Crowds in Distributed Social Virtual Reality.

Latoschik ME, Kern F, Stauffert JP, Bartl A, Botsch M, Lugrin JL.

IEEE Trans Vis Comput Graph. 2019 May;25(5):2134-2144. doi: 10.1109/TVCG.2019.2899250. Epub 2019 Feb 18.


Large-scale validation of miRNAs by disease association, evolutionary conservation and pathway activity.

Fehlmann T, Laufer T, Backes C, Kahramann M, Alles J, Fischer U, Minet M, Ludwig N, Kern F, Kehl T, Galata V, Düsterloh A, Schrörs H, Kohlhaas J, Bals R, Huwer H, Geffers L, Krüger R, Balling R, Lenhof HP, Meese E, Keller A.

RNA Biol. 2019 Jan;16(1):93-103. doi: 10.1080/15476286.2018.1559689. Epub 2018 Dec 26.


Mechanical behaviour of extremely tough TZP bioceramics.

Kern F, Reveron H, Chevalier J, Gadow R.

J Mech Behav Biomed Mater. 2019 Feb;90:395-403. doi: 10.1016/j.jmbbm.2018.11.001. Epub 2018 Nov 3.


TEPIC 2-an extended framework for transcription factor binding prediction and integrative epigenomic analysis.

Schmidt F, Kern F, Ebert P, Baumgarten N, Schulz MH.

Bioinformatics. 2019 May 1;35(9):1608-1609. doi: 10.1093/bioinformatics/bty856.


CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death.

Pera A, Caserta S, Albanese F, Blowers P, Morrow G, Terrazzini N, Smith HE, Rajkumar C, Reus B, Msonda JR, Verboom M, Hallensleben M, Blasczyk R, Davies KA, Kern F.

Theranostics. 2018 Aug 7;8(16):4509-4519. doi: 10.7150/thno.27428. eCollection 2018.


Baseline Cytokine Profiles of Tuberculin-Specific CD4+ T Cells in Non-Muscle-Invasive Bladder Cancer May Predict Outcomes of BCG Immunotherapy.

Jallad S, Thomas P, Newport MJ, Kern F.

Cancer Immunol Res. 2018 Oct;6(10):1212-1219. doi: 10.1158/2326-6066.CIR-18-0046. Epub 2018 Aug 17.


MicroRNA in diagnosis and therapy monitoring of early-stage triple-negative breast cancer.

Kahraman M, Röske A, Laufer T, Fehlmann T, Backes C, Kern F, Kohlhaas J, Schrörs H, Saiz A, Zabler C, Ludwig N, Fasching PA, Strick R, Rübner M, Beckmann MW, Meese E, Keller A, Schrauder MG.

Sci Rep. 2018 Aug 2;8(1):11584. doi: 10.1038/s41598-018-29917-2.


The deterministic role of 5-mers in microRNA-gene targeting.

Hart M, Kern F, Backes C, Rheinheimer S, Fehlmann T, Keller A, Meese E.

RNA Biol. 2018;15(6):819-825. doi: 10.1080/15476286.2018.1462652. Epub 2018 May 11.


Interleukin-7 Unveils Pathogen-Specific T Cells by Enhancing Antigen-Recall Responses.

Terrazzini N, Mantegani P, Kern F, Fortis C, Mondino A, Caserta S.

J Infect Dis. 2018 May 25;217(12):1997-2007. doi: 10.1093/infdis/jiy096.


Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs.

Caserta S, Mengozzi M, Kern F, Newbury SF, Ghezzi P, Llewelyn MJ.

Front Immunol. 2018 Feb 5;8:1977. doi: 10.3389/fimmu.2017.01977. eCollection 2017.


About miRNAs, miRNA seeds, target genes and target pathways.

Kehl T, Backes C, Kern F, Fehlmann T, Ludwig N, Meese E, Lenhof HP, Keller A.

Oncotarget. 2017 Nov 9;8(63):107167-107175. doi: 10.18632/oncotarget.22363. eCollection 2017 Dec 5.


A high-resolution map of the human small non-coding transcriptome.

Fehlmann T, Backes C, Alles J, Fischer U, Hart M, Kern F, Langseth H, Rounge T, Umu SU, Kahraman M, Laufer T, Haas J, Staehler C, Ludwig N, Hübenthal M, Meder B, Franke A, Lenhof HP, Meese E, Keller A.

Bioinformatics. 2018 May 15;34(10):1621-1628. doi: 10.1093/bioinformatics/btx814.


miRCarta: a central repository for collecting miRNA candidates.

Backes C, Fehlmann T, Kern F, Kehl T, Lenhof HP, Meese E, Keller A.

Nucleic Acids Res. 2018 Jan 4;46(D1):D160-D167. doi: 10.1093/nar/gkx851.


IMOTA: an interactive multi-omics tissue atlas for the analysis of human miRNA-target interactions.

Palmieri V, Backes C, Ludwig N, Fehlmann T, Kern F, Meese E, Keller A.

Nucleic Acids Res. 2018 Jan 4;46(D1):D770-D775. doi: 10.1093/nar/gkx701.


FABP1 and Hepar expression levels in Barrett's esophagus and associated neoplasia in an Asian population.

Srivastava S, Kern F, Sharma N, McKeon F, Xian W, Yeoh KG, Ho KY, Teh M.

Dig Liver Dis. 2017 Oct;49(10):1104-1109. doi: 10.1016/j.dld.2017.06.014. Epub 2017 Jul 27.


CEACAM 6, a novel marker for the diagnosis of Barrett's esophagus.

Sharma N, Srivastava S, Kern F, Xian W, Yeoh KG, Ming T, McKeon F, Ho KY.

Dis Esophagus. 2017 Jul 1;30(7):1-5. doi: 10.1093/dote/dox026.


Endoscopic modalities for the diagnosis of Barrett's oesophagus.

Sharma N, Srivastava S, Kern F, Xian W, Ming T, McKeon F, Ho KY.

United European Gastroenterol J. 2016 Dec;4(6):733-740. doi: 10.1177/2050640615619281. Epub 2015 Dec 15. Review.


Expansions of Cytotoxic CD4+CD28- T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection.

Broadley I, Pera A, Morrow G, Davies KA, Kern F.

Front Immunol. 2017 Mar 2;8:195. doi: 10.3389/fimmu.2017.00195. eCollection 2017. Review.


CMV-Specific T-cell Responses at Older Ages: Broad Responses With a Large Central Memory Component May Be Key to Long-term Survival.

Bajwa M, Vita S, Vescovini R, Larsen M, Sansoni P, Terrazzini N, Caserta S, Thomas D, Davies KA, Smith H, Kern F.

J Infect Dis. 2017 Apr 15;215(8):1212-1220. doi: 10.1093/infdis/jix080.


Cytomegalovirus as a Driver of Excess Cardiovascular Mortality in Rheumatoid Arthritis: A Red Herring or a Smoking Gun?

Pera A, Broadley I, Davies KA, Kern F.

Circ Res. 2017 Jan 20;120(2):274-277. doi: 10.1161/CIRCRESAHA.116.309982. Review. No abstract available.


Identification of a new plasmid-encoded cytochrome P450 CYP107DY1 from Bacillus megaterium with a catalytic activity towards mevastatin.

Milhim M, Putkaradze N, Abdulmughni A, Kern F, Hartz P, Bernhardt R.

J Biotechnol. 2016 Dec 20;240:68-75. doi: 10.1016/j.jbiotec.2016.11.002. Epub 2016 Nov 2.


Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties.

Sałat K, Podkowa A, Malikowska N, Kern F, Pabel J, Wojcieszak E, Kulig K, Wanner KT, Strach B, Wyska E.

Neuropharmacology. 2017 Feb;113(Pt A):331-342. doi: 10.1016/j.neuropharm.2016.10.019. Epub 2016 Oct 19.


Quantitative determination of elastic and inelastic attenuation coefficients by off-axis electron holography.

Kern F, Wolf D, Pschera P, Lubk A.

Ultramicroscopy. 2016 Dec;171:26-33. doi: 10.1016/j.ultramic.2016.08.011. Epub 2016 Aug 23.


Functional Diversity of Cytomegalovirus-Specific T Cells Is Maintained in Older People and Significantly Associated With Protein Specificity and Response Size.

Bajwa M, Vita S, Vescovini R, Larsen M, Sansoni P, Terrazzini N, Caserta S, Thomas D, Davies KA, Smith H, Kern F.

J Infect Dis. 2016 Nov 1;214(9):1430-1437. Epub 2016 Aug 11.


Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS).

Caserta S, Kern F, Cohen J, Drage S, Newbury SF, Llewelyn MJ.

Sci Rep. 2016 Jun 20;6:28006. doi: 10.1038/srep28006.


Identification of Plant-derived Alkaloids with Therapeutic Potential for Myotonic Dystrophy Type I.

Herrendorff R, Faleschini MT, Stiefvater A, Erne B, Wiktorowicz T, Kern F, Hamburger M, Potterat O, Kinter J, Sinnreich M.

J Biol Chem. 2016 Aug 12;291(33):17165-77. doi: 10.1074/jbc.M115.710616. Epub 2016 Jun 13.


A new perspective of the structural complexity of HCMV-specific T-cell responses.

Sylwester A, Nambiar KZ, Caserta S, Klenerman P, Picker LJ, Kern F.

Mech Ageing Dev. 2016 Sep;158:14-22. doi: 10.1016/j.mad.2016.03.002. Epub 2016 Mar 5.


Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium.

Finak G, Langweiler M, Jaimes M, Malek M, Taghiyar J, Korin Y, Raddassi K, Devine L, Obermoser G, Pekalski ML, Pontikos N, Diaz A, Heck S, Villanova F, Terrazzini N, Kern F, Qian Y, Stanton R, Wang K, Brandes A, Ramey J, Aghaeepour N, Mosmann T, Scheuermann RH, Reed E, Palucka K, Pascual V, Blomberg BB, Nestle F, Nussenblatt RB, Brinkman RR, Gottardo R, Maecker H, McCoy JP.

Sci Rep. 2016 Feb 10;6:20686. doi: 10.1038/srep20686.


CYP267A1 and CYP267B1 from Sorangium cellulosum So ce56 are Highly Versatile Drug Metabolizers.

Kern F, Khatri Y, Litzenburger M, Bernhardt R.

Drug Metab Dispos. 2016 Apr;44(4):495-504. doi: 10.1124/dmd.115.068486. Epub 2016 Feb 3.


Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion.

Yamamoto Y, Wang X, Bertrand D, Kern F, Zhang T, Duleba M, Srivastava S, Khor CC, Hu Y, Wilson LH, Blaszyk H, Rolshud D, Teh M, Liu J, Howitt BE, Vincent M, Crum CP, Nagarajan N, Ho KY, McKeon F, Xian W.

Nat Commun. 2016 Jan 19;7:10380. doi: 10.1038/ncomms10380.


Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size.

Chiu YL, Lin CH, Sung BY, Chuang YF, Schneck JP, Kern F, Pawelec G, Wang GC.

Sci Rep. 2016 Jan 18;6:19227. doi: 10.1038/srep19227.


Highly Efficient CYP167A1 (EpoK) dependent Epothilone B Formation and Production of 7-Ketone Epothilone D as a New Epothilone Derivative.

Kern F, Dier TK, Khatri Y, Ewen KM, Jacquot JP, Volmer DA, Bernhardt R.

Sci Rep. 2015 Oct 8;5:14881. doi: 10.1038/srep14881.


In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells.

Yamamoto Y, Ning G, Howitt BE, Mehra K, Wu L, Wang X, Hong Y, Kern F, Wei TS, Zhang T, Nagarajan N, Basuli D, Torti S, Brewer M, Choolani M, McKeon F, Crum CP, Xian W.

J Pathol. 2016 Mar;238(4):519-530. doi: 10.1002/path.4649. Epub 2016 Jan 9.


Cloning and variation of ground state intestinal stem cells.

Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, Hyams JS, Devers T, Bronson R, Lacy DB, Ho KY, Crum CP, McKeon F, Xian W.

Nature. 2015 Jun 11;522(7555):173-8. doi: 10.1038/nature14484. Epub 2015 Jun 3.


Neuron-specific enolase correlates to laboratory markers of haemolysis in patients on long-term circulatory support.

Geisen U, Benk C, Beyersdorf F, Klemm R, Trummer G, Özbek B, Kern F, Heilmann C.

Eur J Cardiothorac Surg. 2015 Sep;48(3):416-20; discussion 420. doi: 10.1093/ejcts/ezu513. Epub 2015 Jan 5.


Conversions of tricyclic antidepressants and antipsychotics with selected P450s from Sorangium cellulosum So ce56.

Litzenburger M, Kern F, Khatri Y, Bernhardt R.

Drug Metab Dispos. 2015 Mar;43(3):392-9. doi: 10.1124/dmd.114.061937. Epub 2014 Dec 30.


Generation and screening of oxime libraries addressing the neuronal GABA transporter GAT1.

Kern FT, Wanner KT.

ChemMedChem. 2015 Feb;10(2):396-410. doi: 10.1002/cmdc.201402376. Epub 2014 Nov 4.


Gender differences and age-specific associations between body mass index and other cardiovascular risk factors in CMV infected and uninfected people.

Terrazzini N, Bajwa M, Thomas D, Smith H, Kern F.

Immunol Lett. 2014 Nov;162(1 Pt B):316-22. doi: 10.1016/j.imlet.2014.09.011. Epub 2014 Sep 22.


WITHDRAWN: Gender differences and age-specific associations between Body Mass Index and other cardiovascular risk factors in CMV infected and uninfected people.

Terrazzini N, Bajwa M, Thomas D, Smith H, Kern F.

Immunol Lett. 2014 Sep 22. pii: S0165-2478(14)00199-0. doi: 10.1016/j.imlet.2014.09.010. [Epub ahead of print]


Cell-mediated immunity to human CMV infection: a brief overview.

Terrazzini N, Kern F.

F1000Prime Rep. 2014 May 6;6:28. doi: 10.12703/P6-28. eCollection 2014. Review.


Diagnosis of childhood tuberculosis and host RNA expression in Africa.

Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton MS, Hibberd ML, Kern F, Langford PR, Ling L, Mlotha R, Ottenhoff THM, Pienaar S, Pillay V, Scott JAG, Twahir H, Wilkinson RJ, Coin LJ, Heyderman RS, Levin M, Eley B.

N Engl J Med. 2014 May 1;370(18):1712-1723. doi: 10.1056/NEJMoa1303657.

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