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Items: 1 to 50 of 116

1.

Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells.

Jang HS, Pearce M, O'Donnell EF, Nguyen BD, Truong L, Mueller MJ, Bisson WH, Kerkvliet NI, Tanguay RL, Kolluri SK.

Biology (Basel). 2017 Dec 1;6(4). pii: E41. doi: 10.3390/biology6040041.

2.

TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation.

Ehrlich AK, Pennington JM, Bisson WH, Kolluri SK, Kerkvliet NI.

Toxicol Sci. 2018 Feb 1;161(2):310-320. doi: 10.1093/toxsci/kfx215.

3.

Is chronic AhR activation by rapidly metabolized ligands safe for the treatment of immune-mediated diseases?

Ehrlich AK, Kerkvliet NI.

Curr Opin Toxicol. 2017 Feb;2:72-78. doi: 10.1016/j.cotox.2017.01.007. Epub 2017 Feb 1.

4.

AhR activation increases IL-2 production by alloreactive CD4+ T cells initiating the differentiation of mucosal-homing Tim3+ Lag3+ Tr1 cells.

Ehrlich AK, Pennington JM, Tilton S, Wang X, Marshall NB, Rohlman D, Funatake C, Punj S, O'Donnell E, Yu Z, Kolluri SK, Kerkvliet NI.

Eur J Immunol. 2017 Nov;47(11):1989-2001. doi: 10.1002/eji.201747121. Epub 2017 Sep 15.

5.

The aryl hydrocarbon receptor is required for induction of p21cip1/waf1 expression and growth inhibition by SU5416 in hepatoma cells.

O'Donnell EF, Jang HS, Pearce M, Kerkvliet NI, Kolluri SK.

Oncotarget. 2017 Apr 11;8(15):25211-25225. doi: 10.18632/oncotarget.16056.

6.

Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice.

Ehrlich AK, Pennington JM, Wang X, Rohlman D, Punj S, Löhr CV, Newman MT, Kolluri SK, Kerkvliet NI.

J Immunol. 2016 Jan 1;196(1):264-73. doi: 10.4049/jimmunol.1501789. Epub 2015 Nov 16.

7.

Immune Cell Phenotyping Using Flow Cytometry.

Pockley AG, Foulds GA, Oughton JA, Kerkvliet NI, Multhoff G.

Curr Protoc Toxicol. 2015 Nov 2;66:18.8.1-34. doi: 10.1002/0471140856.tx1808s66.

PMID:
26523471
8.

In vivo contaminant partitioning to silicone implants: Implications for use in biomonitoring and body burden.

O'Connell SG, Kerkvliet NI, Carozza S, Rohlman D, Pennington J, Anderson KA.

Environ Int. 2015 Dec;85:182-8. doi: 10.1016/j.envint.2015.09.016. Epub 2015 Sep 25.

9.

Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1.

Koch DC, Jang HS, O'Donnell EF, Punj S, Kopparapu PR, Bisson WH, Kerkvliet NI, Kolluri SK.

Oncogene. 2015 Dec 10;34(50):6092-104. doi: 10.1038/onc.2015.55. Epub 2015 Apr 13.

PMID:
25867062
10.

Arsenic exposure and prevalence of the varicella zoster virus in the United States: NHANES (2003-2004 and 2009-2010).

Cardenas A, Smit E, Houseman EA, Kerkvliet NI, Bethel JW, Kile ML.

Environ Health Perspect. 2015 Jun;123(6):590-6. doi: 10.1289/ehp.1408731. Epub 2015 Jan 30.

11.

A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain.

Perkins A, Phillips JL, Kerkvliet NI, Tanguay RL, Perdew GH, Kolluri SK, Bisson WH.

Biology (Basel). 2014 Oct 17;3(4):645-69. doi: 10.3390/biology3040645.

12.

Response to comment on "Silicone wristbands as personal passive samplers".

O'Connell SG, Carozza SE, Kerkvliet NI, Anderson KA.

Environ Sci Technol. 2014;48(15):8927. doi: 10.1021/es503177x. Epub 2014 Jul 10. No abstract available.

PMID:
25010428
13.

Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease.

Punj S, Kopparapu P, Jang HS, Phillips JL, Pennington J, Rohlman D, O'Donnell E, Iversen PL, Kolluri SK, Kerkvliet NI.

PLoS One. 2014 Feb 19;9(2):e88726. doi: 10.1371/journal.pone.0088726. eCollection 2014.

14.

Suppression of acute graft-versus-host response by TCDD is independent of the CTLA-4-IFN-γ-IDO pathway.

Rohlman D, Punj S, Pennington J, Bradford S, Kerkvliet NI.

Toxicol Sci. 2013 Sep;135(1):81-90. doi: 10.1093/toxsci/kft140. Epub 2013 Jun 23.

15.

Immunotoxicology: fifty years of global scientific progress.

McKarns SC, Kerkvliet NI, Dean JH, Bonn MB, Cohen MD, Franko J, Laiosa MD, Lawrence BP, Luebke RW, Luster MI, Miller PG, Palmer RK, Pfau JC, Raman P, Regal JF, Rodgers KE, Schondelmeyer RS, Zhang X, Burns-Naas LA.

J Immunotoxicol. 2012 Oct-Dec;9(4):339-40. doi: 10.3109/1547691X.2012.658530. Epub 2012 Oct 19.

PMID:
23078377
16.

Aryl Hydrocarbon Receptor-Mediated Perturbations in Gene Expression during Early Stages of CD4(+) T-cell Differentiation.

Rohlman D, Pham D, Yu Z, Steppan LB, Kerkvliet NI.

Front Immunol. 2012 Aug 6;3:223. doi: 10.3389/fimmu.2012.00223. eCollection 2012.

17.

The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells.

O'Donnell EF, Kopparapu PR, Koch DC, Jang HS, Phillips JL, Tanguay RL, Kerkvliet NI, Kolluri SK.

PLoS One. 2012;7(7):e40926. doi: 10.1371/journal.pone.0040926. Epub 2012 Jul 17.

18.

TCDD: an environmental immunotoxicant reveals a novel pathway of immunoregulation--a 30-year odyssey.

Kerkvliet NI.

Toxicol Pathol. 2012;40(2):138-42. doi: 10.1177/0192623311427710. Epub 2011 Nov 16.

PMID:
22089840
19.

Alterations in regulatory T-cells: rediscovered pathways in immunotoxicology.

Corsini E, Oukka M, Pieters R, Kerkvliet NI, Ponce R, Germolec DR.

J Immunotoxicol. 2011 Oct-Dec;8(4):251-7. doi: 10.3109/1547691X.2011.598885. Epub 2011 Aug 17. Review.

20.

The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor.

O'Donnell EF, Saili KS, Koch DC, Kopparapu PR, Farrer D, Bisson WH, Mathew LK, Sengupta S, Kerkvliet NI, Tanguay RL, Kolluri SK.

PLoS One. 2010 Oct 1;5(10). pii: e13128. doi: 10.1371/journal.pone.0013128.

21.

Toxicity testing in the 21st century: a vision and a strategy.

Krewski D, Acosta D Jr, Andersen M, Anderson H, Bailar JC 3rd, Boekelheide K, Brent R, Charnley G, Cheung VG, Green S Jr, Kelsey KT, Kerkvliet NI, Li AA, McCray L, Meyer O, Patterson RD, Pennie W, Scala RA, Solomon GM, Stephens M, Yager J, Zeise L.

J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):51-138. doi: 10.1080/10937404.2010.483176.

22.

Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes.

Kerkvliet NI, Steppan LB, Vorachek W, Oda S, Farrer D, Wong CP, Pham D, Mourich DV.

Immunotherapy. 2009 Jul;1(4):539-47.

23.

Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells.

Marshall NB, Kerkvliet NI.

Ann N Y Acad Sci. 2010 Jan;1183:25-37. doi: 10.1111/j.1749-6632.2009.05125.x. Review.

24.

Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands.

Bisson WH, Koch DC, O'Donnell EF, Khalil SM, Kerkvliet NI, Tanguay RL, Abagyan R, Kolluri SK.

J Med Chem. 2009 Sep 24;52(18):5635-41. doi: 10.1021/jm900199u.

25.

Expression of constitutively-active aryl hydrocarbon receptor in T-cells enhances the down-regulation of CD62L, but does not alter expression of CD25 or suppress the allogeneic CTL response.

Funatake CJ, Ao K, Suzuki T, Murai H, Yamamoto M, Fujii-Kuriyama Y, Kerkvliet NI, Nohara K.

J Immunotoxicol. 2009 Sep;6(3):194-203. doi: 10.1080/15476910903124454.

PMID:
19635034
26.

AHR-mediated immunomodulation: the role of altered gene transcription.

Kerkvliet NI.

Biochem Pharmacol. 2009 Feb 15;77(4):746-60. doi: 10.1016/j.bcp.2008.11.021. Epub 2008 Nov 27. Review.

27.

2,3,7,8 Tetrachlorodibenzo-p-Dioxin (TCDD) Directly Enhances the Maturation and Apoptosis of Dendritic Cells In Vitro.

Ruby CE, Funatake CJ, Kerkvliet NI.

J Immunotoxicol. 2005 Jul 1;1(3):159-66. doi: 10.1080/15476910490920968.

PMID:
18958649
28.
30.

Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing.

Marshall NB, Oda SK, London CA, Moulton HM, Iversen PL, Kerkvliet NI, Mourich DV.

J Immunol Methods. 2007 Aug 31;325(1-2):114-26. Epub 2007 Jul 27.

PMID:
17673254
31.
32.

In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor.

Yu Z, Loehr CV, Fischer KA, Louderback MA, Krueger SK, Dashwood RH, Kerkvliet NI, Pereira CB, Jennings-Gee JE, Dance ST, Miller MS, Bailey GS, Williams DE.

Cancer Res. 2006 Jan 15;66(2):755-62.

34.

Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo.

Mahadevan B, Luch A, Bravo CF, Atkin J, Steppan LB, Pereira C, Kerkvliet NI, Baird WM.

Cancer Lett. 2005 Sep 8;227(1):25-32. Epub 2005 Jan 7.

PMID:
16051029
35.

Immune cell phenotyping using flow cytometry.

Oughton JA, Kerkvliet NI.

Curr Protoc Toxicol. 2005;Chapter 18:Unit18.8. doi: 10.1002/0471140856.tx1808s23.

PMID:
23045120
36.

Early consequences of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on the activation and survival of antigen-specific T cells.

Funatake CJ, Dearstyne EA, Steppan LB, Shepherd DM, Spanjaard ES, Marshak-Rothstein A, Kerkvliet NI.

Toxicol Sci. 2004 Nov;82(1):129-42. Epub 2004 Aug 13.

PMID:
15310856
37.
38.

Influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antigen-presenting activity of dendritic cells.

Vorderstrasse BA, Dearstyne EA, Kerkvliet NI.

Toxicol Sci. 2003 Mar;72(1):103-12.

PMID:
12604839
41.
42.

Recent advances in understanding the mechanisms of TCDD immunotoxicity.

Kerkvliet NI.

Int Immunopharmacol. 2002 Feb;2(2-3):277-91. Review.

PMID:
11811931
44.

Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression.

Vorderstrasse BA, Steppan LB, Silverstone AE, Kerkvliet NI.

Toxicol Appl Pharmacol. 2001 Mar 15;171(3):157-64.

PMID:
11243915
45.
47.
48.
49.

CTL hyporesponsiveness induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin: role of cytokines and apoptosis.

Prell RA, Dearstyne E, Steppan LG, Vella AT, Kerkvliet NI.

Toxicol Appl Pharmacol. 2000 Aug 1;166(3):214-21.

PMID:
10906285
50.

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