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Items: 1 to 50 of 52

1.

Chromosomal Aberrations Associated with Sequential Steps of the Metastatic Cascade in Colorectal Cancer Patients.

Joosse SA, Souche FR, Babayan A, Gasch C, Kerkhoven RM, Ramos J, Fabre JM, Riethdorf S, König A, Wikman H, Alix-Panabières C, Pantel K.

Clin Chem. 2018 Oct;64(10):1505-1512. doi: 10.1373/clinchem.2018.289819. Epub 2018 Jul 20.

PMID:
30030273
2.

Defining chromosomal translocation risks in cancer.

Hogenbirk MA, Heideman MR, de Rink I, Velds A, Kerkhoven RM, Wessels LF, Jacobs H.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3649-56. doi: 10.1073/pnas.1602025113. Epub 2016 Jun 14.

3.

BRCA1-like profile predicts benefit of tandem high dose epirubicin-cyclophospamide-thiotepa in high risk breast cancer patients randomized in the WSG-AM01 trial.

Schouten PC, Gluz O, Harbeck N, Mohrmann S, Diallo-Danebrock R, Pelz E, Kruizinga J, Velds A, Nieuwland M, Kerkhoven RM, Liedtke C, Frick M, Kates R, Linn SC, Nitz U, Marme F.

Int J Cancer. 2016 Aug 15;139(4):882-9. doi: 10.1002/ijc.30078. Epub 2016 May 5.

4.

BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential.

Severson TM, Peeters J, Majewski I, Michaut M, Bosma A, Schouten PC, Chin SF, Pereira B, Goldgraben MA, Bismeijer T, Kluin RJ, Muris JJ, Jirström K, Kerkhoven RM, Wessels L, Caldas C, Bernards R, Simon IM, Linn S.

Mol Oncol. 2015 Oct;9(8):1528-38. doi: 10.1016/j.molonc.2015.04.011. Epub 2015 May 7.

5.

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.

Schouten PC, Grigoriadis A, Kuilman T, Mirza H, Watkins JA, Cooke SA, van Dyk E, Severson TM, Rueda OM, Hoogstraat M, Verhagen CV, Natrajan R, Chin SF, Lips EH, Kruizinga J, Velds A, Nieuwland M, Kerkhoven RM, Krijgsman O, Vens C, Peeper D, Nederlof PM, Caldas C, Tutt AN, Wessels LF, Linn SC.

Mol Oncol. 2015 Aug;9(7):1274-86. doi: 10.1016/j.molonc.2015.03.002. Epub 2015 Mar 20.

6.

ERBB2 Mutations Characterize a Subgroup of Muscle-invasive Bladder Cancers with Excellent Response to Neoadjuvant Chemotherapy.

Groenendijk FH, de Jong J, Fransen van de Putte EE, Michaut M, Schlicker A, Peters D, Velds A, Nieuwland M, van den Heuvel MM, Kerkhoven RM, Wessels LF, Broeks A, van Rhijn BW, Bernards R, van der Heijden MS.

Eur Urol. 2016 Mar;69(3):384-8. doi: 10.1016/j.eururo.2015.01.014. Epub 2015 Jan 27.

PMID:
25636205
7.

High-throughput identification of antigen-specific TCRs by TCR gene capture.

Linnemann C, Heemskerk B, Kvistborg P, Kluin RJ, Bolotin DA, Chen X, Bresser K, Nieuwland M, Schotte R, Michels S, Gomez-Eerland R, Jahn L, Hombrink P, Legrand N, Shu CJ, Mamedov IZ, Velds A, Blank CU, Haanen JB, Turchaninova MA, Kerkhoven RM, Spits H, Hadrup SR, Heemskerk MH, Blankenstein T, Chudakov DM, Bendle GM, Schumacher TN.

Nat Med. 2013 Nov;19(11):1534-41. doi: 10.1038/nm.3359. Epub 2013 Oct 13.

PMID:
24121928
8.

Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma.

van Rooij N, van Buuren MM, Philips D, Velds A, Toebes M, Heemskerk B, van Dijk LJ, Behjati S, Hilkmann H, El Atmioui D, Nieuwland M, Stratton MR, Kerkhoven RM, Kesmir C, Haanen JB, Kvistborg P, Schumacher TN.

J Clin Oncol. 2013 Nov 10;31(32):e439-42. doi: 10.1200/JCO.2012.47.7521. Epub 2013 Sep 16. No abstract available.

9.

Differential programming of B cells in AID deficient mice.

Hogenbirk MA, Heideman MR, Velds A, van den Berk PC, Kerkhoven RM, van Steensel B, Jacobs H.

PLoS One. 2013 Jul 29;8(7):e69815. doi: 10.1371/journal.pone.0069815. Print 2013.

10.

Dissecting the gray zone between follicular lymphoma and marginal zone lymphoma using morphological and genetic features.

Krijgsman O, Gonzalez P, Ponz OB, Roemer MG, Slot S, Broeks A, Braaf L, Kerkhoven RM, Bot F, van Groningen K, Beijert M, Ylstra B, de Jong D.

Haematologica. 2013 Dec;98(12):1921-9. doi: 10.3324/haematol.2013.085118. Epub 2013 Jul 12.

11.

Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

Jae LT, Raaben M, Riemersma M, van Beusekom E, Blomen VA, Velds A, Kerkhoven RM, Carette JE, Topaloglu H, Meinecke P, Wessels MW, Lefeber DJ, Whelan SP, van Bokhoven H, Brummelkamp TR.

Science. 2013 Apr 26;340(6131):479-83. doi: 10.1126/science.1233675. Epub 2013 Mar 21.

12.

Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function.

Heideman MR, Wilting RH, Yanover E, Velds A, de Jong J, Kerkhoven RM, Jacobs H, Wessels LF, Dannenberg JH.

Blood. 2013 Mar 14;121(11):2038-50. doi: 10.1182/blood-2012-08-450916. Epub 2013 Jan 17.

13.

Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

van Luenen HG, Farris C, Jan S, Genest PA, Tripathi P, Velds A, Kerkhoven RM, Nieuwland M, Haydock A, Ramasamy G, Vainio S, Heidebrecht T, Perrakis A, Pagie L, van Steensel B, Myler PJ, Borst P.

Cell. 2012 Aug 31;150(5):909-21. doi: 10.1016/j.cell.2012.07.030.

14.

Reassessing genomic targeting of AID.

Hogenbirk MA, Velds A, Kerkhoven RM, Jacobs H.

Nat Immunol. 2012 Sep;13(9):797-8; author reply 798-800. doi: 10.1038/ni.2367. No abstract available.

PMID:
22910380
15.

Search for a gene expression signature of breast cancer local recurrence in young women.

Servant N, Bollet MA, Halfwerk H, Bleakley K, Kreike B, Jacob L, Sie D, Kerkhoven RM, Hupé P, Hadhri R, Fourquet A, Bartelink H, Barillot E, Sigal-Zafrani B, van de Vijver MJ.

Clin Cancer Res. 2012 Mar 15;18(6):1704-15. doi: 10.1158/1078-0432.CCR-11-1954. Epub 2012 Jan 23.

16.

A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover.

Verzijlbergen KF, van Welsem T, Sie D, Lenstra TL, Turner DJ, Holstege FC, Kerkhoven RM, van Leeuwen F.

PLoS Genet. 2011 Oct;7(10):e1002284. doi: 10.1371/journal.pgen.1002284. Epub 2011 Oct 6.

17.

Interactions among Polycomb domains are guided by chromosome architecture.

Tolhuis B, Blom M, Kerkhoven RM, Pagie L, Teunissen H, Nieuwland M, Simonis M, de Laat W, van Lohuizen M, van Steensel B.

PLoS Genet. 2011 Mar;7(3):e1001343. doi: 10.1371/journal.pgen.1001343. Epub 2011 Mar 24.

18.

Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue.

Mittempergher L, de Ronde JJ, Nieuwland M, Kerkhoven RM, Simon I, Rutgers EJ, Wessels LF, Van't Veer LJ.

PLoS One. 2011 Feb 11;6(2):e17163. doi: 10.1371/journal.pone.0017163.

19.

The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome.

van Bemmel JG, Pagie L, Braunschweig U, Brugman W, Meuleman W, Kerkhoven RM, van Steensel B.

PLoS One. 2010 Nov 24;5(11):e15013. doi: 10.1371/journal.pone.0015013.

20.

Volatile anesthetics modulate gene expression in breast and brain tumor cells.

Huitink JM, Heimerikxs M, Nieuwland M, Loer SA, Brugman W, Velds A, Sie D, Kerkhoven RM.

Anesth Analg. 2010 Dec;111(6):1411-5. doi: 10.1213/ANE.0b013e3181fa3533. Epub 2010 Oct 1.

PMID:
20889943
21.

Systematic protein location mapping reveals five principal chromatin types in Drosophila cells.

Filion GJ, van Bemmel JG, Braunschweig U, Talhout W, Kind J, Ward LD, Brugman W, de Castro IJ, Kerkhoven RM, Bussemaker HJ, van Steensel B.

Cell. 2010 Oct 15;143(2):212-24. doi: 10.1016/j.cell.2010.09.009. Epub 2010 Sep 30. Erratum in: Cell. 2011 Apr 1;145(1):160.

22.

Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation.

Peric-Hupkes D, Meuleman W, Pagie L, Bruggeman SW, Solovei I, Brugman W, Gräf S, Flicek P, Kerkhoven RM, van Lohuizen M, Reinders M, Wessels L, van Steensel B.

Mol Cell. 2010 May 28;38(4):603-13. doi: 10.1016/j.molcel.2010.03.016.

23.

One naive T cell, multiple fates in CD8+ T cell differentiation.

Gerlach C, van Heijst JW, Swart E, Sie D, Armstrong N, Kerkhoven RM, Zehn D, Bevan MJ, Schepers K, Schumacher TN.

J Exp Med. 2010 Jun 7;207(6):1235-46. doi: 10.1084/jem.20091175. Epub 2010 May 17.

24.

Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient.

van Heijst JW, Gerlach C, Swart E, Sie D, Nunes-Alves C, Kerkhoven RM, Arens R, Correia-Neves M, Schepers K, Schumacher TN.

Science. 2009 Sep 4;325(5945):1265-9. doi: 10.1126/science.1175455.

25.

High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model.

Vogel MJ, Pagie L, Talhout W, Nieuwland M, Kerkhoven RM, van Steensel B.

Epigenetics Chromatin. 2009 Jan 29;2(1):1. doi: 10.1186/1756-8935-2-1.

26.

Dissecting T cell lineage relationships by cellular barcoding.

Schepers K, Swart E, van Heijst JW, Gerlach C, Castrucci M, Sie D, Heimerikx M, Velds A, Kerkhoven RM, Arens R, Schumacher TN.

J Exp Med. 2008 Sep 29;205(10):2309-18. doi: 10.1084/jem.20072462. Epub 2008 Sep 22.

27.

Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.

van der Stoop P, Boutsma EA, Hulsman D, Noback S, Heimerikx M, Kerkhoven RM, Voncken JW, Wessels LF, van Lohuizen M.

PLoS One. 2008 May 21;3(5):e2235. doi: 10.1371/journal.pone.0002235.

28.

The T7-primer is a source of experimental bias and introduces variability between microarray platforms.

Kerkhoven RM, Sie D, Nieuwland M, Heimerikx M, De Ronde J, Brugman W, Velds A.

PLoS One. 2008 Apr 23;3(4):e1980. doi: 10.1371/journal.pone.0001980.

29.

Dendrimer-mediated transfer printing of DNA and RNA microarrays.

Rozkiewicz DI, Brugman W, Kerkhoven RM, Ravoo BJ, Reinhoudt DN.

J Am Chem Soc. 2007 Sep 19;129(37):11593-9. Epub 2007 Aug 29.

PMID:
17725353
30.

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.

Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers J.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6. Epub 2007 Jul 11.

31.

Reduced supportive capacity of bone marrow stroma upon chemotherapy is mediated via changes in glycosaminoglycan profile.

Zweegman S, Kessler FL, Kerkhoven RM, Heimerikx M, Celie JW, Janssen JJ, Huijgens PC, Drager AM, van den Born J.

Matrix Biol. 2007 Sep;26(7):561-71. Epub 2007 Apr 19.

PMID:
17521897
32.

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

Brummelkamp TR, Fabius AW, Mullenders J, Madiredjo M, Velds A, Kerkhoven RM, Bernards R, Beijersbergen RL.

Nat Chem Biol. 2006 Apr;2(4):202-6. Epub 2006 Feb 13.

PMID:
16474381
33.

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.

Brummelkamp TR, Berns K, Hijmans EM, Mullenders J, Fabius A, Heimerikx M, Velds A, Kerkhoven RM, Madiredjo M, Bernards R, Beijersbergen RL.

Cold Spring Harb Symp Quant Biol. 2004;69:439-45. No abstract available.

PMID:
16117679
34.

Induction of p53 up-regulated modulator of apoptosis messenger RNA by chemotherapeutic treatment of locally advanced breast cancer.

Middelburg R, de Haas RR, Dekker H, Kerkhoven RM, Pohlmann PR, Fuentes-Alburo A, Mohar A, Pinedo HM, Lankelma J.

Clin Cancer Res. 2005 Mar 1;11(5):1863-9.

35.

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R.

Mol Cell. 2005 Feb 4;17(3):331-9.

36.

FoxM1 is required for execution of the mitotic programme and chromosome stability.

Laoukili J, Kooistra MR, Brás A, Kauw J, Kerkhoven RM, Morrison A, Clevers H, Medema RH.

Nat Cell Biol. 2005 Feb;7(2):126-36. Epub 2005 Jan 16.

PMID:
15654331
37.

Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment.

Glas AM, Kersten MJ, Delahaye LJ, Witteveen AT, Kibbelaar RE, Velds A, Wessels LF, Joosten P, Kerkhoven RM, Bernards R, van Krieken JH, Kluin PM, van't Veer LJ, de Jong D.

Blood. 2005 Jan 1;105(1):301-7. Epub 2004 Sep 2.

38.

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

Berns K, Hijmans EM, Mullenders J, Brummelkamp TR, Velds A, Heimerikx M, Kerkhoven RM, Madiredjo M, Nijkamp W, Weigelt B, Agami R, Ge W, Cavet G, Linsley PS, Beijersbergen RL, Bernards R.

Nature. 2004 Mar 25;428(6981):431-7.

PMID:
15042092
39.

Identification of differentially expressed genes in mouse kidney after irradiation using microarray analysis.

Kruse JJ, te Poele JA, Velds A, Kerkhoven RM, Boersma LJ, Russell NS, Stewart FA.

Radiat Res. 2004 Jan;161(1):28-38.

PMID:
14680399
40.

Platinum(II)-based coordination compounds as nucleic acid labeling reagents: synthesis, reactivity, and applications in hybridization assays.

Heetebrij RJ, Talman EG, v Velzen MA, van Gijlswijk RP, Snoeijers SS, Schalk M, Wiegant J, v d Rijke F, Kerkhoven RM, Raap AK, Tanke HJ, Reedijk J, Houthoff HJ.

Chembiochem. 2003 Jul 7;4(7):573-83.

PMID:
12851925
41.

Gene expression profiling predicts clinical outcome of breast cancer.

van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH.

Nature. 2002 Jan 31;415(6871):530-6.

PMID:
11823860
42.

Two E2F sites control growth-regulated and cell cycle-regulated transcription of the Htf9-a/RanBP1 gene through functionally distinct mechanisms.

Di Fiore B, Guarguaglini G, Palena A, Kerkhoven RM, Bernards R, Lavia P.

J Biol Chem. 1999 Apr 9;274(15):10339-48.

43.

Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors.

Allen KE, de la Luna S, Kerkhoven RM, Bernards R, La Thangue NB.

J Cell Sci. 1997 Nov;110 ( Pt 22):2819-31.

44.

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

Hateboer G, Kerkhoven RM, Shvarts A, Bernards R, Beijersbergen RL.

Genes Dev. 1996 Dec 1;10(23):2960-70.

45.

BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation.

Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, Bernards R.

EMBO J. 1995 Jul 3;14(13):3159-69.

46.

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

Beijersbergen RL, Carlée L, Kerkhoven RM, Bernards R.

Genes Dev. 1995 Jun 1;9(11):1340-53.

47.

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R.

Genes Dev. 1994 Nov 15;8(22):2680-90.

48.

Neurons in a variety of molluscs react to antibodies raised against the VD1/RPD2 alpha-neuropeptide of the pond snail Lymnaea stagnalis.

Kerkhoven RM, Ramkema MD, Van Minnen J, Croll RP, Pin T, Boer HH.

Cell Tissue Res. 1993 Aug;273(2):371-9.

PMID:
8364974
49.

The VD1/RPD2 neuronal system in the central nervous system of the pond snail Lymnaea stagnalis studied by in situ hybridization and immunocytochemistry.

Kerkhoven RM, Croll RP, Ramkema MD, Van Minnen J, Bogerd J, Boer HH.

Cell Tissue Res. 1992 Mar;267(3):551-9.

PMID:
1315219
50.

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