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Best matches for Kerkelä R[au]:

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Räsänen M et al. Proc Natl Acad Sci U S A. (2016)

Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart. Perjés Á et al. Basic Res Cardiol. (2016)

Natriuretic Peptides in the Regulation of Cardiovascular Physiology and Metabolic Events. Kerkelä R et al. J Am Heart Assoc. (2015)

Search results

Items: 1 to 50 of 54

1.

Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129.

Gomes CPC, Ágg B, Andova A, Arslan S, Baker A, Barteková M, Beis D, Betsou F, Wettinger SB, Bugarski B, Condorelli G, Silva GJJD, Danilin S, de Gonzalo-Calvo D, Buil A, Carmo-Fonseca M, Enguita FJ, Felekkis K, Ferdinandy P, Gyöngyösi M, Hackl M, Karaduzovic-Hadziabdic K, Hellemans J, Heymans S, Hlavackova M, Hoydal MA, Jankovic A, Jusic A, Kardassis D, Kerkelä R, Kuster GM, Lakkisto P, Leszek P, Lustrek M, Maegdefessel L, Martelli F, Novella S, O'Brien T, Papaneophytou C, Pedrazzini T, Pinet F, Popescu O, Potočnjak I, Robinson E, Sasson S, Scholz M, Simionescu M, Stoll M, Varga ZV, Vinciguerra M, Xuereb A, Yilmaz MB, Emanueli C, Devaux Y, on behalf of the EU-CardioRNA COST Action (CA17129).

Noncoding RNA. 2019 Mar 29;5(2). pii: E31. doi: 10.3390/ncrna5020031.

2.

Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction.

Vainio LE, Szabó Z, Lin R, Ulvila J, Yrjölä R, Alakoski T, Piuhola J, Koch WJ, Ruskoaho H, Fouse SD, Seeley TW, Gao E, Signore P, Lipson KE, Magga J, Kerkelä R.

JACC Basic Transl Sci. 2019 Feb 25;4(1):83-94. doi: 10.1016/j.jacbts.2018.10.007. eCollection 2019 Feb.

3.

Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury.

Magga J, Vainio L, Kilpiö T, Hulmi JJ, Taponen S, Lin R, Räsänen M, Szabó Z, Gao E, Rahtu-Korpela L, Alakoski T, Ulvila J, Laitinen M, Pasternack A, Koch WJ, Alitalo K, Kivelä R, Ritvos O, Kerkelä R.

Mol Ther. 2019 Mar 6;27(3):600-610. doi: 10.1016/j.ymthe.2019.01.013. Epub 2019 Jan 24.

4.

Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury.

Alakoski T, Ulvila J, Yrjölä R, Vainio L, Magga J, Szabo Z, Licht JD, Kerkelä R.

Basic Res Cardiol. 2019 Jan 11;114(2):7. doi: 10.1007/s00395-018-0713-y.

5.

Primary Myocardial Fibrosis as an Alternative Phenotype Pathway of Inherited Cardiac Structural Disorders.

Junttila MJ, Holmström L, Pylkäs K, Mantere T, Kaikkonen K, Porvari K, Kortelainen ML, Pakanen L, Kerkelä R, Myerburg RJ, Huikuri HV.

Circulation. 2018 Jun 19;137(25):2716-2726. doi: 10.1161/CIRCULATIONAHA.117.032175.

PMID:
29915098
6.

USP28 Deficiency Promotes Breast and Liver Carcinogenesis as well as Tumor Angiogenesis in a HIF-independent Manner.

Richter K, Paakkola T, Mennerich D, Kubaichuk K, Konzack A, Ali-Kippari H, Kozlova N, Koivunen P, Haapasaari KM, Jukkola-Vuorinen A, Teppo HR, Dimova EY, Bloigu R, Szabo Z, Kerkelä R, Kietzmann T.

Mol Cancer Res. 2018 Jun;16(6):1000-1012. doi: 10.1158/1541-7786.MCR-17-0452. Epub 2018 Mar 15. Erratum in: Mol Cancer Res. 2018 Nov;16(11):1815. Kippari, Heidi Ali [corrected to Ali-Kippari, Heidi].

7.

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection.

Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13144-13149. Epub 2016 Oct 31.

8.

Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.

Perjés Á, Kilpiö T, Ulvila J, Magga J, Alakoski T, Szabó Z, Vainio L, Halmetoja E, Vuolteenaho O, Petäjä-Repo U, Szokodi I, Kerkelä R.

Basic Res Cardiol. 2016 Jan;111(1):2. doi: 10.1007/s00395-015-0521-6. Epub 2015 Nov 26.

PMID:
26611206
9.

Natriuretic Peptides in the Regulation of Cardiovascular Physiology and Metabolic Events.

Kerkelä R, Ulvila J, Magga J.

J Am Heart Assoc. 2015 Oct 27;4(10):e002423. doi: 10.1161/JAHA.115.002423. Review. No abstract available.

10.

[Adverse cardiac effects associated with anticancer drugs].

Piuhola J, Tenhunen O, Kerkelä R.

Duodecim. 2015;131(5):441-7. Review. Finnish.

PMID:
26237906
11.

The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression.

Kelloniemi A, Szabo Z, Serpi R, Näpänkangas J, Ohukainen P, Tenhunen O, Kaikkonen L, Koivisto E, Bagyura Z, Kerkelä R, Leosdottir M, Hedner T, Melander O, Ruskoaho H, Rysä J.

PLoS One. 2015 Jun 22;10(6):e0130502. doi: 10.1371/journal.pone.0130502. eCollection 2015.

12.

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.

Moilanen AM, Rysä J, Kaikkonen L, Karvonen T, Mustonen E, Serpi R, Szabó Z, Tenhunen O, Bagyura Z, Näpänkangas J, Ohukainen P, Tavi P, Kerkelä R, Leósdóttir M, Wahlstrand B, Hedner T, Melander O, Ruskoaho H.

PLoS One. 2015 Apr 27;10(4):e0124907. doi: 10.1371/journal.pone.0124907. eCollection 2015.

13.

Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice.

Tolonen AM, Magga J, Szabó Z, Viitala P, Gao E, Moilanen AM, Ohukainen P, Vainio L, Koch WJ, Kerkelä R, Ruskoaho H, Serpi R.

Pharmacol Res Perspect. 2014 Aug;2(4):e00056. doi: 10.1002/prp2.56. Epub 2014 Jun 12.

14.

Bone morphogenetic protein-2--a potential autocrine/paracrine factor in mediating the stretch activated B-type and atrial natriuretic peptide expression in cardiac myocytes.

Tokola H, Rysä J, Pikkarainen S, Hautala N, Leskinen H, Kerkelä R, Ilves M, Aro J, Vuolteenaho O, Ritvos O, Ruskoaho H.

Mol Cell Endocrinol. 2015 Jan 5;399:9-21. doi: 10.1016/j.mce.2014.09.003. Epub 2014 Sep 10.

PMID:
25218476
15.

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms.

Perjés Á, Skoumal R, Tenhunen O, Kónyi A, Simon M, Horváth IG, Kerkelä R, Ruskoaho H, Szokodi I.

PLoS One. 2014 Apr 2;9(4):e93473. doi: 10.1371/journal.pone.0093473. eCollection 2014.

16.

Connective tissue growth factor inhibition attenuates left ventricular remodeling and dysfunction in pressure overload-induced heart failure.

Szabó Z, Magga J, Alakoski T, Ulvila J, Piuhola J, Vainio L, Kivirikko KI, Vuolteenaho O, Ruskoaho H, Lipson KE, Signore P, Kerkelä R.

Hypertension. 2014 Jun;63(6):1235-40. doi: 10.1161/HYPERTENSIONAHA.114.03279. Epub 2014 Mar 31.

PMID:
24688123
17.

p38α regulates SERCA2a function.

Kaikkonen L, Magga J, Ronkainen VP, Koivisto E, Perjes Á, Chuprun JK, Vinge LE, Kilpiö T, Aro J, Ulvila J, Alakoski T, Bibb JA, Szokodi I, Koch WJ, Ruskoaho H, Kerkelä R.

J Mol Cell Cardiol. 2014 Feb;67:86-93. doi: 10.1016/j.yjmcc.2013.12.005. Epub 2013 Dec 17.

18.

Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection.

Kerkelä R, Karsikas S, Szabo Z, Serpi R, Magga J, Gao E, Alitalo K, Anisimov A, Sormunen R, Pietilä I, Vainio L, Koch WJ, Kivirikko KI, Myllyharju J, Koivunen P.

Mol Cell Biol. 2013 Aug;33(16):3321-9. doi: 10.1128/MCB.00432-13. Epub 2013 Jun 17.

19.

β-Adrenergic agonists mediate enhancement of β1-adrenergic receptor N-terminal cleavage and stabilization in vivo and in vitro.

Hakalahti AE, Khan H, Vierimaa MM, Pekkala EH, Lackman JJ, Ulvila J, Kerkelä R, Petäjä-Repo UE.

Mol Pharmacol. 2013 Jan;83(1):129-41. doi: 10.1124/mol.112.080440. Epub 2012 Oct 11.

PMID:
23066091
20.

Neuronostatin, a novel peptide encoded by somatostatin gene, regulates cardiac contractile function and cardiomyocyte survival.

Vainio L, Perjes A, Ryti N, Magga J, Alakoski T, Serpi R, Kaikkonen L, Piuhola J, Szokodi I, Ruskoaho H, Kerkelä R.

J Biol Chem. 2012 Feb 10;287(7):4572-80. doi: 10.1074/jbc.M111.289215. Epub 2011 Dec 14.

21.

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

Buler M, Aatsinki SM, Skoumal R, Komka Z, Tóth M, Kerkelä R, Georgiadi A, Kersten S, Hakkola J.

J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23.

22.

Cytosolic phospholipase A(2)α protects against ischemia/reperfusion injury in the heart.

Kerkelä R, Boucher M, Zaka R, Gao E, Harris D, Piuhola J, Song J, Serpi R, Woulfe KC, Cheung JY, O'Leary E, Bonventre JV, Force T.

Clin Transl Sci. 2011 Aug;4(4):236-42. doi: 10.1111/j.1752-8062.2011.00294.x.

23.

M-CAT element mediates mechanical stretch-activated transcription of B-type natriuretic peptide via ERK activation.

Koivisto E, Karkkola L, Majalahti T, Aro J, Tokola H, Kerkelä R, Ruskoaho H.

Can J Physiol Pharmacol. 2011 Aug;89(8):539-50. doi: 10.1139/y11-049. Epub 2011 Aug 3.

PMID:
21812548
24.

Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms.

Koivisto E, Kaikkonen L, Tokola H, Pikkarainen S, Aro J, Pennanen H, Karvonen T, Rysä J, Kerkelä R, Ruskoaho H.

Mol Cell Endocrinol. 2011 May 16;338(1-2):18-27. doi: 10.1016/j.mce.2011.02.015. Epub 2011 Feb 24.

PMID:
21354263
25.

Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity.

Skoumal R, Tóth M, Serpi R, Rysä J, Leskinen H, Ulvila J, Saiho T, Aro J, Ruskoaho H, Szokodi I, Kerkelä R.

J Mol Cell Cardiol. 2011 Apr;50(4):634-41. doi: 10.1016/j.yjmcc.2011.01.001. Epub 2011 Jan 9.

PMID:
21223972
26.

Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response.

Kerkelä R, Ilves M, Pikkarainen S, Tokola H, Ronkainen VP, Majalahti T, Leppäluoto J, Vuolteenaho O, Ruskoaho H.

Am J Physiol Regul Integr Comp Physiol. 2011 Jan;300(1):R140-9. doi: 10.1152/ajpregu.00853.2009. Epub 2010 Nov 17.

27.

Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy.

Rasi K, Piuhola J, Czabanka M, Sormunen R, Ilves M, Leskinen H, Rysä J, Kerkelä R, Janmey P, Heljasvaara R, Peuhkurinen K, Vuolteenaho O, Ruskoaho H, Vajkoczy P, Pihlajaniemi T, Eklund L.

Circ Res. 2010 Nov 12;107(10):1241-52. doi: 10.1161/CIRCRESAHA.110.222133. Epub 2010 Sep 16.

PMID:
20847313
28.

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.

Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T.

J Clin Invest. 2010 Jul;120(7):2280-91. doi: 10.1172/JCI41407.

29.

Divergent effects of losartan and metoprolol on cardiac remodeling, c-kit+ cells, proliferation and apoptosis in the left ventricle after myocardial infarction.

Serpi R, Tolonen AM, Tenhunen O, Pieviläinen O, Kubin AM, Vaskivuo T, Soini Y, Kerkelä R, Leskinen H, Ruskoaho H.

Clin Transl Sci. 2009 Dec;2(6):422-30. doi: 10.1111/j.1752-8062.2009.00163.x.

30.

The mixed-lineage kinase 1-3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors.

Ola A, Kerkelä R, Tokola H, Pikkarainen S, Skoumal R, Vuolteenaho O, Ruskoaho H.

Br J Pharmacol. 2010 Feb 1;159(3):717-25. doi: 10.1111/j.1476-5381.2009.00567.x. Epub 2010 Jan 8.

31.

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death.

Zhou J, Shao Z, Kerkela R, Ichijo H, Muslin AJ, Pombo C, Force T.

Mol Cell Biol. 2009 Aug;29(15):4167-76. doi: 10.1128/MCB.01067-08. Epub 2009 May 18.

32.

Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase.

Kerkela R, Woulfe KC, Durand JB, Vagnozzi R, Kramer D, Chu TF, Beahm C, Chen MH, Force T.

Clin Transl Sci. 2009 Feb;2(1):15-25. doi: 10.1111/j.1752-8062.2008.00090.x.

33.

Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation.

Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS.

J Clin Invest. 2008 Nov;118(11):3609-18. doi: 10.1172/JCI36245. Epub 2008 Oct 1.

34.

Functionally opposing roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the regulation of cardiac contractility.

Szokodi I, Kerkelä R, Kubin AM, Sármán B, Pikkarainen S, Kónyi A, Horváth IG, Papp L, Tóth M, Skoumal R, Ruskoaho H.

Circulation. 2008 Oct 14;118(16):1651-8. doi: 10.1161/CIRCULATIONAHA.107.758623. Epub 2008 Sep 29.

PMID:
18824646
35.

Cardiotoxicity of the new cancer therapeutics--mechanisms of, and approaches to, the problem.

Force T, Kerkelä R.

Drug Discov Today. 2008 Sep;13(17-18):778-84. doi: 10.1016/j.drudis.2008.05.011. Epub 2008 Sep 2. Review.

36.

Adaptive or maladaptive response to adenoviral adrenomedullin gene transfer is context-dependent in the heart.

Leskinen H, Rauma-Pinola T, Szokodi I, Kerkelä R, Pikkarainen S, Uusimaa P, Hautala T, Vuolteenaho O, Ruskoaho H.

J Gene Med. 2008 Aug;10(8):867-77. doi: 10.1002/jgm.1219.

PMID:
18615773
37.

Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics.

Chen MH, Kerkelä R, Force T.

Circulation. 2008 Jul 1;118(1):84-95. doi: 10.1161/CIRCULATIONAHA.108.776831. Review. No abstract available.

38.

Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib.

Chu TF, Rupnick MA, Kerkela R, Dallabrida SM, Zurakowski D, Nguyen L, Woulfe K, Pravda E, Cassiola F, Desai J, George S, Morgan JA, Harris DM, Ismail NS, Chen JH, Schoen FJ, Van den Abbeele AD, Demetri GD, Force T, Chen MH.

Lancet. 2007 Dec 15;370(9604):2011-9.

39.

Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury.

Piuhola J, Kerkelä R, Keenan JI, Hampton MB, Richards AM, Pemberton CJ.

Clin Sci (Lond). 2008 Feb;114(4):293-304.

PMID:
17919123
40.

Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane-domain receptor signaling pathways.

Force T, Woulfe K, Koch WJ, Kerkelä R.

Sci STKE. 2007 Jul 31;2007(397):pe41. Review.

PMID:
17666710
41.

Glycogen synthase kinase-3beta -- actively inhibiting hypertrophy.

Kerkelä R, Woulfe K, Force T.

Trends Cardiovasc Med. 2007 Apr;17(3):91-6. Review.

PMID:
17418370
42.

p38 mitogen-activated protein kinase: a future target for heart failure therapy?

Kerkela R, Force T.

J Am Coll Cardiol. 2006 Aug 1;48(3):556-8. Epub 2006 Jul 12. Review. No abstract available.

43.

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

Kerkelä R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, Walters B, Shevtsov S, Pesant S, Clubb FJ, Rosenzweig A, Salomon RN, Van Etten RA, Alroy J, Durand JB, Force T.

Nat Med. 2006 Aug;12(8):908-16. Epub 2006 Jul 23.

44.

The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.

Chen X, Shevtsov SP, Hsich E, Cui L, Haq S, Aronovitz M, Kerkelä R, Molkentin JD, Liao R, Salomon RN, Patten R, Force T.

Mol Cell Biol. 2006 Jun;26(12):4462-73.

45.

Recent insights into cardiac hypertrophy and left ventricular remodeling.

Kerkela R, Force T.

Curr Heart Fail Rep. 2006 Apr;3(1):14-8. Review.

PMID:
16684492
46.

Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load.

Pikkarainen S, Tokola H, Kerkelä R, Ilves M, Mäkinen M, Orzechowski HD, Paul M, Vuolteenaho O, Ruskoaho H.

Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1639-45. Epub 2006 Jan 12.

47.

GATA transcription factors in the developing and adult heart.

Pikkarainen S, Tokola H, Kerkelä R, Ruskoaho H.

Cardiovasc Res. 2004 Aug 1;63(2):196-207. Review.

PMID:
15249177
48.

Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart.

Tenhunen O, Sármán B, Kerkelä R, Szokodi I, Papp L, Tóth M, Ruskoaho H.

J Biol Chem. 2004 Jun 4;279(23):24852-60. Epub 2004 Mar 29.

49.

GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program.

Pikkarainen S, Tokola H, Majalahti-Palviainen T, Kerkela R, Hautala N, Bhalla SS, Charron F, Nemer M, Vuolteenaho O, Ruskoaho H.

J Biol Chem. 2003 Jun 27;278(26):23807-16. Epub 2003 Apr 17.

50.

Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors.

Pikkarainen S, Tokola H, Kerkelä R, Majalahti-Palviainen T, Vuolteenaho O, Ruskoaho H.

J Biol Chem. 2003 Feb 7;278(6):3969-75. Epub 2002 Nov 21.

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