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Items: 38

1.

Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22.

Hyvärinen K, Holopainen M, Skirdenko V, Ruhanen H, Lehenkari P, Korhonen M, Käkelä R, Laitinen S, Kerkelä E.

Front Immunol. 2018 Apr 12;9:771. doi: 10.3389/fimmu.2018.00771. eCollection 2018.

2.

Phospholipid composition of packed red blood cells and that of extracellular vesicles show a high resemblance and stability during storage.

Laurén E, Tigistu-Sahle F, Valkonen S, Westberg M, Valkeajärvi A, Eronen J, Siljander P, Pettilä V, Käkelä R, Laitinen S, Kerkelä E.

Biochim Biophys Acta. 2018 Jan;1863(1):1-8. doi: 10.1016/j.bbalip.2017.09.012. Epub 2017 Sep 28.

PMID:
28965917
3.

Reply: Adenosine Producing Mesenchymal Stromal Cells.

Kerkelä E.

Stem Cells. 2017 Jun;35(6):1649-1650. doi: 10.1002/stem.2531. Epub 2016 Nov 15.

4.

Real-Time Label-Free Monitoring of Nanoparticle Cell Uptake.

Suutari T, Silen T, S En Karaman D, Saari H, Desai D, Kerkelä E, Laitinen S, Hanzlikova M, Rosenholm JM, Yliperttula M, Viitala T.

Small. 2016 Dec;12(45):6289-6300. doi: 10.1002/smll.201601815. Epub 2016 Sep 30.

PMID:
27690329
5.

The effects of culture conditions on the functionality of efficiently obtained mesenchymal stromal cells from human cord blood.

Laitinen A, Lampinen M, Liedtke S, Kilpinen L, Kerkelä E, Sarkanen JR, Heinonen T, Kogler G, Laitinen S.

Cytotherapy. 2016 Mar;18(3):423-37. doi: 10.1016/j.jcyt.2015.11.014.

PMID:
26857232
6.

Adenosinergic Immunosuppression by Human Mesenchymal Stromal Cells Requires Co-Operation with T cells.

Kerkelä E, Laitinen A, Räbinä J, Valkonen S, Takatalo M, Larjo A, Veijola J, Lampinen M, Siljander P, Lehenkari P, Alfthan K, Laitinen S.

Stem Cells. 2016 Mar;34(3):781-90. doi: 10.1002/stem.2280. Epub 2016 Jan 26.

7.

Individual experiences following a 6-month exercise intervention: A qualitative study.

Kerkelä ES, Jonsson L, Lindwall M, Strand J.

Int J Qual Stud Health Well-being. 2015 Aug 14;10:26376. doi: 10.3402/qhw.v10.26376. eCollection 2015.

8.

The cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats is related to cell dose and infusion velocity.

Cui LL, Kerkelä E, Bakreen A, Nitzsche F, Andrzejewska A, Nowakowski A, Janowski M, Walczak P, Boltze J, Lukomska B, Jolkkonen J.

Stem Cell Res Ther. 2015 Jan 27;6:11. doi: 10.1186/scrt544.

9.

Safety and biodistribution study of bone marrow-derived mesenchymal stromal cells and mononuclear cells and the impact of the administration route in an intact porcine model.

Mäkelä T, Takalo R, Arvola O, Haapanen H, Yannopoulos F, Blanco R, Ahvenjärvi L, Kiviluoma K, Kerkelä E, Nystedt J, Juvonen T, Lehenkari P.

Cytotherapy. 2015 Apr;17(4):392-402. doi: 10.1016/j.jcyt.2014.12.004. Epub 2015 Jan 15.

PMID:
25601140
10.

Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells.

Mitkari B, Kerkelä E, Nystedt J, Korhonen M, Jolkkonen J.

J Cereb Blood Flow Metab. 2015 Mar;35(3):363-6. doi: 10.1038/jcbfm.2014.235. Epub 2015 Jan 7.

11.

Human umbilical cord blood-derived mesenchymal stromal cells display a novel interaction between P-selectin and galectin-1.

Suila H, Hirvonen T, Kotovuori A, Ritamo I, Kerkelä E, Anderson H, Natunen S, Tuimala J, Laitinen S, Nystedt J, Räbinä J, Valmu L.

Scand J Immunol. 2014 Jul;80(1):12-21. doi: 10.1111/sji.12179.

12.

Differential Clearance of Rat and Human Bone Marrow-Derived Mesenchymal Stem Cells From the Brain After Intra-arterial Infusion in Rats.

Khabbal J, Kerkelä E, Mitkari B, Raki M, Nystedt J, Mikkonen V, Bergström K, Laitinen S, Korhonen M, Jolkkonen J.

Cell Transplant. 2015;24(5):819-28. doi: 10.3727/096368914X679336. Epub 2014 Mar 3.

PMID:
24593908
13.

Human bone marrow mesenchymal stem/stromal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery.

Mitkari B, Nitzsche F, Kerkelä E, Kuptsova K, Huttunen J, Nystedt J, Korhonen M, Jolkkonen J.

Behav Brain Res. 2014 Feb 1;259:50-9. doi: 10.1016/j.bbr.2013.10.030. Epub 2013 Oct 29.

PMID:
24177208
14.

Transient proteolytic modification of mesenchymal stromal cells increases lung clearance rate and targeting to injured tissue.

Kerkelä E, Hakkarainen T, Mäkelä T, Raki M, Kambur O, Kilpinen L, Nikkilä J, Lehtonen S, Ritamo I, Pernu R, Pietilä M, Takalo R, Juvonen T, Bergström K, Kalso E, Valmu L, Laitinen S, Lehenkari P, Nystedt J.

Stem Cells Transl Med. 2013 Jul;2(7):510-20. doi: 10.5966/sctm.2012-0187. Epub 2013 Jun 3.

15.

Electrical Field Stimulation with a Novel Platform: Effect on Cardiomyocyte Gene Expression but not on Orientation.

Kujala K, Ahola A, Pekkanen-Mattila M, Ikonen L, Kerkelä E, Hyttinen J, Aalto-Setälä K.

Int J Biomed Sci. 2012 Jun;8(2):109-20.

16.

2D and 3D self-assembling nanofiber hydrogels for cardiomyocyte culture.

Ikonen L, Kerkelä E, Metselaar G, Stuart MC, de Jong MR, Aalto-Setälä K.

Biomed Res Int. 2013;2013:285678. doi: 10.1155/2013/285678. Epub 2012 Dec 31.

17.

Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats.

Mitkari B, Kerkelä E, Nystedt J, Korhonen M, Mikkonen V, Huhtala T, Jolkkonen J.

Exp Neurol. 2013 Jan;239:158-62. doi: 10.1016/j.expneurol.2012.09.018. Epub 2012 Oct 8.

PMID:
23059455
18.

The effect of human and mouse fibroblast feeder cells on cardiac differentiation of human pluripotent stem cells.

Pekkanen-Mattila M, Ojala M, Kerkelä E, Rajala K, Skottman H, Aalto-Setälä K.

Stem Cells Int. 2012;2012:875059. doi: 10.1155/2012/875059. Epub 2012 Jan 19.

19.

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K.

Dis Model Mech. 2012 Mar;5(2):220-30. doi: 10.1242/dmm.008409. Epub 2011 Nov 3.

20.

Averaging in vitro cardiac field potential recordings obtained with microelectrode arrays.

Kujala VJ, Jimenez ZC, Väisänen J, Tanskanen JM, Kerkelä E, Hyttinen J, Aalto-Setälä K.

Comput Methods Programs Biomed. 2011 Nov;104(2):199-205. doi: 10.1016/j.cmpb.2011.04.001. Epub 2011 Jun 8.

PMID:
21645941
21.

Stimulation of human embryonic stem cell-derived cardiomyocytes on thin-film microelectrodes.

Viitanen J, Heimala P, Hokkanen A, Iljin K, Kerkelä E, Kolari K, Kattelus H.

Biotechnol J. 2011 May;6(5):600-3. doi: 10.1002/biot.201000355. Epub 2011 Mar 18.

PMID:
21416608
22.

A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells.

Rajala K, Lindroos B, Hussein SM, Lappalainen RS, Pekkanen-Mattila M, Inzunza J, Rozell B, Miettinen S, Narkilahti S, Kerkelä E, Aalto-Setälä K, Otonkoski T, Suuronen R, Hovatta O, Skottman H.

PLoS One. 2010 Apr 19;5(4):e10246. doi: 10.1371/journal.pone.0010246.

23.

Human embryonic stem cell-derived cardiomyocytes: demonstration of a portion of cardiac cells with fairly mature electrical phenotype.

Pekkanen-Mattila M, Chapman H, Kerkelä E, Suuronen R, Skottman H, Koivisto AP, Aalto-Setälä K.

Exp Biol Med (Maywood). 2010 Apr;235(4):522-30. doi: 10.1258/ebm.2010.009345.

PMID:
20407085
24.

Spatial and temporal expression pattern of germ layer markers during human embryonic stem cell differentiation in embryoid bodies.

Pekkanen-Mattila M, Pelto-Huikko M, Kujala V, Suuronen R, Skottman H, Aalto-Setälä K, Kerkelä E.

Histochem Cell Biol. 2010 May;133(5):595-606. doi: 10.1007/s00418-010-0689-7. Epub 2010 Apr 6.

PMID:
20369364
25.

Transcriptome profiling of human pre-implantation development.

Zhang P, Zucchelli M, Bruce S, Hambiliki F, Stavreus-Evers A, Levkov L, Skottman H, Kerkelä E, Kere J, Hovatta O.

PLoS One. 2009 Nov 16;4(11):e7844. doi: 10.1371/journal.pone.0007844.

26.

ROCK2 allelic variants are not associated with pre-eclampsia susceptibility in the Finnish population.

Peterson H, Laivuori H, Kerkelä E, Jiao H, Hiltunen L, Heino S, Tiala I, Knuutila S, Rasi V, Kere J, Kivinen K.

Mol Hum Reprod. 2009 Jul;15(7):443-9. doi: 10.1093/molehr/gap032. Epub 2009 May 12.

PMID:
19435756
27.

Substantial variation in the cardiac differentiation of human embryonic stem cell lines derived and propagated under the same conditions--a comparison of multiple cell lines.

Pekkanen-Mattila M, Kerkelä E, Tanskanen JM, Pietilä M, Pelto-Huikko M, Hyttinen J, Skottman H, Suuronen R, Aalto-Setälä K.

Ann Med. 2009;41(5):360-70. doi: 10.1080/07853890802609542.

PMID:
19165643
28.

Distinct sets of developmentally regulated genes that are expressed by human oocytes and human embryonic stem cells.

Zhang P, Kerkelä E, Skottman H, Levkov L, Kivinen K, Lahesmaa R, Hovatta O, Kere J.

Fertil Steril. 2007 Mar;87(3):677-90. Epub 2006 Nov 27.

PMID:
17126334
29.

Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome.

Kerkelä E, Skottman H, Friden B, Bjuresten K, Kere J, Hovatta O.

Fertil Steril. 2007 Mar;87(3):603-6. Epub 2006 Oct 30.

PMID:
17074323
30.

Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer.

Kerkelä E, Saarialho-Kere U.

Exp Dermatol. 2003 Apr;12(2):109-25. Review.

PMID:
12702139
31.

Metalloelastase (MMP-12) expression by tumour cells in squamous cell carcinoma of the vulva correlates with invasiveness, while that by macrophages predicts better outcome.

Kerkelä E, Ala-aho R, Klemi P, Grénman S, Shapiro SD, Kähäri VM, Saarialho-Kere U.

J Pathol. 2002 Oct;198(2):258-69.

PMID:
12237887
32.

Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair.

Saarialho-Kere U, Kerkelä E, Jahkola T, Suomela S, Keski-Oja J, Lohi J.

J Invest Dermatol. 2002 Jul;119(1):14-21.

33.

Human macrophage metalloelastase (MMP-12) expression is induced in chondrocytes during fetal development and malignant transformation.

Kerkelä E, Böhling T, Herva R, Uria JA, Saarialho-Kere U.

Bone. 2001 Nov;29(5):487-93.

PMID:
11704502
34.

Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers.

Kerkelä E, Ala-aho R, Lohi J, Grénman R, M-Kähäri V, Saarialho-Kere U.

Br J Cancer. 2001 Mar 2;84(5):659-69.

35.

Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger.

Lohi H, Kujala M, Kerkelä E, Saarialho-Kere U, Kestilä M, Kere J.

Genomics. 2000 Nov 15;70(1):102-12.

PMID:
11087667
36.

Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer.

Kerkelä E, Ala-Aho R, Jeskanen L, Rechardt O, Grénman R, Shapiro SD, Kähäri VM, Saarialho-Kere U.

J Invest Dermatol. 2000 Jun;114(6):1113-9.

37.

Accumulation of matrilysin (MMP-7) and macrophage metalloelastase (MMP-12) in actinic damage.

Saarialho-Kere U, Kerkelä E, Jeskanen L, Hasan T, Pierce R, Starcher B, Raudasoja R, Ranki A, Oikarinen A, Vaalamo M.

J Invest Dermatol. 1999 Oct;113(4):664-72.

38.

Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their phylogenetic analysis and tissue-specific expression in the mouse.

Ruotsalainen H, Sipilä L, Kerkelä E, Pospiech H, Myllylä R.

Matrix Biol. 1999 Jun;18(3):325-9.

PMID:
10429951

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