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Items: 14

1.

Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues.

Payne RJ, Bulloch EM, Kerbarh O, Abell C.

Org Biomol Chem. 2010 Aug 7;8(15):3534-42. doi: 10.1039/c004062b. Epub 2010 Jun 9.

PMID:
20532401
2.

Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes.

Sridharan S, Howard N, Kerbarh O, Błaszczyk M, Abell C, Blundell TL.

J Mol Biol. 2010 Mar 19;397(1):290-300. doi: 10.1016/j.jmb.2010.01.019. Epub 2010 Jan 15.

PMID:
20079748
3.

Long-lasting enfuvirtide carrier pentasaccharide conjugates with potent anti-human immunodeficiency virus type 1 activity.

Huet T, Kerbarh O, Schols D, Clayette P, Gauchet C, Dubreucq G, Vincent L, Bompais H, Mazinghien R, Querolle O, Salvador A, Lemoine J, Lucidi B, Balzarini J, Petitou M.

Antimicrob Agents Chemother. 2010 Jan;54(1):134-42. doi: 10.1128/AAC.00827-09. Epub 2009 Oct 5.

4.

Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes.

Payne RJ, Bulloch EM, Toscano MM, Jones MA, Kerbarh O, Abell C.

Org Biomol Chem. 2009 Jun 7;7(11):2421-9. doi: 10.1039/b901694e. Epub 2009 Apr 2.

PMID:
19462053
5.

Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases.

Payne RJ, Riboldi-Tunnicliffe A, Kerbarh O, Abell AD, Lapthorn AJ, Abell C.

ChemMedChem. 2007 Jul;2(7):1010-3. No abstract available.

PMID:
17487901
6.

Rational design, synthesis, and evaluation of nanomolar type II dehydroquinase inhibitors.

Payne RJ, Peyrot F, Kerbarh O, Abell AD, Abell C.

ChemMedChem. 2007 Jul;2(7):1015-29.

PMID:
17487900
7.

Nucleophile selectivity of chorismate-utilizing enzymes.

Kerbarh O, Ciulli A, Chirgadze DY, Blundell TL, Abell C.

Chembiochem. 2007 Apr 16;8(6):622-4. No abstract available.

PMID:
17335098
8.

Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism.

Toscano MD, Payne RJ, Chiba A, Kerbarh O, Abell C.

ChemMedChem. 2007 Jan;2(1):101-12.

PMID:
17068841
9.

Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine.

Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP.

Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1.

PMID:
16557306
10.

Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate.

Kerbarh O, Chirgadze DY, Blundell TL, Abell C.

J Mol Biol. 2006 Mar 24;357(2):524-34. Epub 2006 Jan 11.

PMID:
16434053
11.

Mechanism of alpha-oxoamine synthases: identification of the intermediate Claisen product in the 8-amino-7-oxononanoate synthase reaction.

Kerbarh O, Campopiano DJ, Baxter RL.

Chem Commun (Camb). 2006 Jan 7;(1):60-2. Epub 2005 Nov 14.

PMID:
16353092
12.

Mechanistic and inhibition studies of chorismate-utilizing enzymes.

Kerbarh O, Bulloch EM, Payne RJ, Sahr T, Rébeillé F, Abell C.

Biochem Soc Trans. 2005 Aug;33(Pt 4):763-6. Review.

PMID:
16042594
14.

Inhibition studies on salicylate synthase.

Payne RJ, Kerbarh O, Miguel RN, Abell AD, Abell C.

Org Biomol Chem. 2005 May 21;3(10):1825-7. Epub 2005 May 5.

PMID:
15889161

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