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Items: 1 to 50 of 61

1.

Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon.

Ramharter M, Schwab M, Mombo-Ngoma G, Zoleko Manego R, Akerey-Diop D, Basra A, Mackanga JR, Würbel H, Wojtyniak JG, Gonzalez R, Hofmann U, Geditz M, Matsiegui PB, Kremsner PG, Menendez C, Kerb R, Lehr T.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01113-18. doi: 10.1128/AAC.01113-18. Print 2019 Feb.

2.

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations.

Krauss M, Hofmann U, Schafmayer C, Igel S, Schlender J, Mueller C, Brosch M, von Schoenfels W, Erhart W, Schuppert A, Block M, Schaeffeler E, Boehmer G, Goerlitz L, Hoecker J, Lippert J, Kerb R, Hampe J, Kuepfer L, Schwab M.

NPJ Syst Biol Appl. 2017 Mar 28;3:11. doi: 10.1038/s41540-017-0012-5. eCollection 2017.

3.

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters.

Matthaei J, Tzvetkov MV, Gal V, Sachse-Seeboth C, Sehrt D, Hjelmborg JB, Hofmann U, Schwab M, Kerb R, Brockmöller J.

Genome Med. 2016 Nov 8;8(1):119.

4.

Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2.

Matthaei J, Tzvetkov MV, Strube J, Sehrt D, Sachse-Seeboth C, Hjelmborg JB, Möller S, Halekoh U, Hofmann U, Schwab M, Kerb R, Brockmöller J.

Clin Pharmacol Ther. 2016 Dec;100(6):606-616. doi: 10.1002/cpt.444. Epub 2016 Sep 23.

PMID:
27509179
5.

Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial.

Kremsner PG, Adegnika AA, Hounkpatin AB, Zinsou JF, Taylor TE, Chimalizeni Y, Liomba A, Kombila M, Bouyou-Akotet MK, Mawili Mboumba DP, Agbenyega T, Ansong D, Sylverken J, Ogutu BR, Otieno GA, Wangwe A, Bojang KA, Okomo U, Sanya-Isijola F, Newton CR, Njuguna P, Kazungu M, Kerb R, Geditz M, Schwab M, Velavan TP, Nguetse C, Köhler C, Issifou S, Bolte S, Engleitner T, Mordmüller B, Krishna S.

PLoS Med. 2016 Jan 12;13(1):e1001938. doi: 10.1371/journal.pmed.1001938. eCollection 2016 Jan.

6.

Heritability of metoprolol and torsemide pharmacokinetics.

Matthaei J, Brockmöller J, Tzvetkov MV, Sehrt D, Sachse-Seeboth C, Hjelmborg JB, Möller S, Halekoh U, Hofmann U, Schwab M, Kerb R.

Clin Pharmacol Ther. 2015 Dec;98(6):611-21. doi: 10.1002/cpt.258. Epub 2015 Oct 19.

PMID:
26344676
7.

A new [2H]-labelled α-trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates.

Heinkele G, Geditz MC, Ganchev B, Kerb R, Hofmann U, Mürdter TE.

J Labelled Comp Radiopharm. 2014 Oct;57(12):699-703. doi: 10.1002/jlcr.3243. Epub 2014 Oct 22.

PMID:
25339577
8.

Clinical translation in the virtual liver network.

Kuepfer L, Kerb R, Henney AM.

CPT Pharmacometrics Syst Pharmacol. 2014 Jul 30;3:e127. doi: 10.1038/psp.2014.25.

9.

LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma.

Geditz MC, Heinkele G, Ahmed A, Kremsner PG, Kerb R, Schwab M, Hofmann U.

Anal Bioanal Chem. 2014 Jul;406(17):4299-308. doi: 10.1007/s00216-014-7820-x. Epub 2014 Apr 24.

PMID:
24760398
10.

Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by liquid chromatography/tandem mass spectrometry.

Geditz MC, Lindner W, Lämmerhofer M, Heinkele G, Kerb R, Ramharter M, Schwab M, Hofmann U.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 1;968:32-9. doi: 10.1016/j.jchromb.2013.11.035. Epub 2013 Nov 25.

PMID:
24315337
11.

Intraperitoneal chemotherapy of peritoneal carcinomatosis using pressurized aerosol as an alternative to liquid solution: first evidence for efficacy.

Solass W, Kerb R, Mürdter T, Giger-Pabst U, Strumberg D, Tempfer C, Zieren J, Schwab M, Reymond MA.

Ann Surg Oncol. 2014 Feb;21(2):553-9. doi: 10.1245/s10434-013-3213-1. Epub 2013 Sep 5.

12.

Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells.

Arlanov R, Porter A, Strand D, Brough R, Karpova D, Kerb R, Wojnowski L, Schwab M, Lang T.

Hum Mutat. 2012 Apr;33(4):750-62. doi: 10.1002/humu.22041. Epub 2012 Feb 28.

PMID:
22290738
13.

Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites.

Mürdter TE, Kerb R, Turpeinen M, Schroth W, Ganchev B, Böhmer GM, Igel S, Schaeffeler E, Zanger U, Brauch H, Schwab M.

Hum Mol Genet. 2012 Mar 1;21(5):1145-54. doi: 10.1093/hmg/ddr543. Epub 2011 Nov 22.

PMID:
22108178
14.

Quantification of clomiphene metabolite isomers in human plasma by rapid-resolution liquid chromatography-electrospray ionization-tandem mass spectrometry.

Ganchev B, Heinkele G, Kerb R, Schwab M, Mürdter TE.

Anal Bioanal Chem. 2011 Jul;400(10):3429-41. doi: 10.1007/s00216-011-5045-9. Epub 2011 May 1.

PMID:
21533795
15.

Pharmacogenetics of antimalarial drugs: effect on metabolism and transport.

Kerb R, Fux R, Mörike K, Kremsner PG, Gil JP, Gleiter CH, Schwab M.

Lancet Infect Dis. 2009 Dec;9(12):760-74. doi: 10.1016/S1473-3099(09)70320-2. Review.

PMID:
19926036
16.

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E.

Hepatology. 2009 Oct;50(4):1227-40. doi: 10.1002/hep.23103.

PMID:
19591196
17.

Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group.

Schwab M, Zanger UM, Marx C, Schaeffeler E, Klein K, Dippon J, Kerb R, Blievernicht J, Fischer J, Hofmann U, Bokemeyer C, Eichelbaum M; German 5-FU Toxicity Study Group.

J Clin Oncol. 2008 May 1;26(13):2131-8. doi: 10.1200/JCO.2006.10.4182. Epub 2008 Feb 25.

PMID:
18299612
18.

Variability in human hepatic MRP4 expression: influence of cholestasis and genotype.

Gradhand U, Lang T, Schaeffeler E, Glaeser H, Tegude H, Klein K, Fritz P, Jedlitschky G, Kroemer HK, Bachmakov I, Anwald B, Kerb R, Zanger UM, Eichelbaum M, Schwab M, Fromm MF.

Pharmacogenomics J. 2008 Feb;8(1):42-52. Epub 2007 Apr 3.

PMID:
17404579
19.

Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury.

Lang C, Meier Y, Stieger B, Beuers U, Lang T, Kerb R, Kullak-Ublick GA, Meier PJ, Pauli-Magnus C.

Pharmacogenet Genomics. 2007 Jan;17(1):47-60.

PMID:
17264802
20.

Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11).

Lang T, Haberl M, Jung D, Drescher A, Schlagenhaufer R, Keil A, Mornhinweg E, Stieger B, Kullak-Ublick GA, Kerb R.

Drug Metab Dispos. 2006 Sep;34(9):1582-99. Epub 2006 Jun 8.

PMID:
16763017
21.

Neonatal jaundice and bilirubin UDP-glucuronosyl transferase 1A1 gene polymorphism in Turkish patients.

Babaoglu MO, Yigit S, Aynacioglu AS, Kerb R, Yurdakok M, Bozkurt A.

Basic Clin Pharmacol Toxicol. 2006 Apr;98(4):377-80.

22.

Implications of genetic polymorphisms in drug transporters for pharmacotherapy.

Kerb R.

Cancer Lett. 2006 Mar 8;234(1):4-33. Epub 2006 Feb 28. Review.

PMID:
16504381
23.

Association of the ABCB1 3435C>T polymorphism with antiemetic efficacy of 5-hydroxytryptamine type 3 antagonists.

Babaoglu MO, Bayar B, Aynacioglu AS, Kerb R, Abali H, Celik I, Bozkurt A.

Clin Pharmacol Ther. 2005 Dec;78(6):619-26.

PMID:
16338277
24.

Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis.

Noe J, Kullak-Ublick GA, Jochum W, Stieger B, Kerb R, Haberl M, Müllhaupt B, Meier PJ, Pauli-Magnus C.

J Hepatol. 2005 Sep;43(3):536-43.

PMID:
16039748
25.

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).

Niemi M, Schaeffeler E, Lang T, Fromm MF, Neuvonen M, Kyrklund C, Backman JT, Kerb R, Schwab M, Neuvonen PJ, Eichelbaum M, Kivistö KT.

Pharmacogenetics. 2004 Jul;14(7):429-40.

PMID:
15226675
26.

Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles.

Lang T, Klein K, Richter T, Zibat A, Kerb R, Eichelbaum M, Schwab M, Zanger UM.

J Pharmacol Exp Ther. 2004 Oct;311(1):34-43. Epub 2004 Jun 9.

PMID:
15190123
27.

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver.

Lang T, Hitzl M, Burk O, Mornhinweg E, Keil A, Kerb R, Klein K, Zanger UM, Eichelbaum M, Fromm MF.

Pharmacogenetics. 2004 Mar;14(3):155-64.

PMID:
15167703
28.

Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects.

Eap CB, Buclin T, Hustert E, Bleiber G, Golay KP, Aubert AC, Baumann P, Telenti A, Kerb R.

Eur J Clin Pharmacol. 2004 Jun;60(4):231-6. Epub 2004 Apr 28.

PMID:
15114431
29.

Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity.

Eap CB, Buclin T, Cucchia G, Zullino D, Hustert E, Bleiber G, Golay KP, Aubert AC, Baumann P, Telenti A, Kerb R.

Eur J Clin Pharmacol. 2004 Jun;60(4):237-46. Epub 2004 Apr 28.

PMID:
15114429
30.

Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy.

Pauli-Magnus C, Lang T, Meier Y, Zodan-Marin T, Jung D, Breymann C, Zimmermann R, Kenngott S, Beuers U, Reichel C, Kerb R, Penger A, Meier PJ, Kullak-Ublick GA.

Pharmacogenetics. 2004 Feb;14(2):91-102.

PMID:
15077010
31.

BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis.

Pauli-Magnus C, Kerb R, Fattinger K, Lang T, Anwald B, Kullak-Ublick GA, Beuers U, Meier PJ.

Hepatology. 2004 Mar;39(3):779-91.

PMID:
14999697
32.

Identification of twelve polymorphisms in the endothelin-1 gene by use of fluorescently labeled oligonucleotides and PCR with restriction fragment polymorphism analysis.

Diefenbach K, Arjomand Nahad F, Meisel C, Fietze I, Cascorbi I, Stangl K, Landt O, Kerb R, Brinkmann U, Roots I.

Clin Chem. 2004 Feb;50(2):448-51. No abstract available.

33.

Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart.

Dazert P, Meissner K, Vogelgesang S, Heydrich B, Eckel L, Böhm M, Warzok R, Kerb R, Brinkmann U, Schaeffeler E, Schwab M, Cascorbi I, Jedlitschky G, Kroemer HK.

Am J Pathol. 2003 Oct;163(4):1567-77.

34.

[A new, rapid and robust genotyping method for CYP2C9 and MDR1].

Verstuyft C, Morin S, Yang J, Loriot MA, Barbu V, Kerb R, Brinkmann U, Beaune P, Jaillon P, Becquemont L.

Ann Biol Clin (Paris). 2003 May-Jun;61(3):305-9. French.

35.

Digoxin pharmacokinetics and MDR1 genetic polymorphisms.

Verstuyft C, Schwab M, Schaeffeler E, Kerb R, Brinkmann U, Jaillon P, Funck-Brentano C, Becquemont L.

Eur J Clin Pharmacol. 2003 Apr;58(12):809-12. Epub 2003 Mar 1.

PMID:
12698307
36.

Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.

Siddiqui A, Kerb R, Weale ME, Brinkmann U, Smith A, Goldstein DB, Wood NW, Sisodiya SM.

N Engl J Med. 2003 Apr 10;348(15):1442-8.

37.

Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition.

Verstuyft C, Strabach S, El-Morabet H, Kerb R, Brinkmann U, Dubert L, Jaillon P, Funck-Brentano C, Trugnan G, Becquemont L.

Clin Pharmacol Ther. 2003 Jan;73(1):51-60.

PMID:
12545143
38.

Differential effects of Saint John's Wort (hypericum perforatum) on the urinary excretion of D-glucaric acid and 6beta-hydroxycortisol in healthy volunteers.

Bauer S, Störmer E, Kerb R, Johne A, Brockmöller J, Roots I.

Eur J Clin Pharmacol. 2002 Dec;58(9):581-5. Epub 2002 Nov 12.

PMID:
12483450
39.

Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences.

Kerb R, Brinkmann U, Chatskaia N, Gorbunov D, Gorboulev V, Mornhinweg E, Keil A, Eichelbaum M, Koepsell H.

Pharmacogenetics. 2002 Nov;12(8):591-5.

PMID:
12439218
40.

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.

Johne A, Köpke K, Gerloff T, Mai I, Rietbrock S, Meisel C, Hoffmeyer S, Kerb R, Fromm MF, Brinkmann U, Eichelbaum M, Brockmöller J, Cascorbi I, Roots I.

Clin Pharmacol Ther. 2002 Nov;72(5):584-94.

PMID:
12426522
41.

Angiotensin II increases expression of cyclooxygenase-2: implications for the function of vascular smooth muscle cells.

Hu ZW, Kerb R, Shi XY, Wei-Lavery T, Hoffman BB.

J Pharmacol Exp Ther. 2002 Nov;303(2):563-73.

PMID:
12388637
42.

Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors.

Siegsmund M, Brinkmann U, Scháffeler E, Weirich G, Schwab M, Eichelbaum M, Fritz P, Burk O, Decker J, Alken P, Rothenpieler U, Kerb R, Hoffmeyer S, Brauch H.

J Am Soc Nephrol. 2002 Jul;13(7):1847-54.

43.

Influence of GSTT1 and GSTM1 genotypes on sunburn sensitivity.

Kerb R, Brockmoller J, Schlagenhaufer R, Sprenger R, Roots I, Brinkmann U.

Am J Pharmacogenomics. 2002;2(2):147-54.

PMID:
12083949
44.
45.

The predictive value of MDR1, CYP2C9, and CYP2C19 polymorphisms for phenytoin plasma levels.

Kerb R, Aynacioglu AS, Brockmöller J, Schlagenhaufer R, Bauer S, Szekeres T, Hamwi A, Fritzer-Szekeres M, Baumgartner C, Ongen HZ, Güzelbey P, Roots I, Brinkmann U.

Pharmacogenomics J. 2001;1(3):204-10.

46.

Effect of grapefruit juice on digoxin pharmacokinetics in humans.

Becquemont L, Verstuyft C, Kerb R, Brinkmann U, Lebot M, Jaillon P, Funck-Brentano C.

Clin Pharmacol Ther. 2001 Oct;70(4):311-6.

PMID:
11673746
47.

ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.

Kerb R, Hoffmeyer S, Brinkmann U.

Pharmacogenomics. 2001 Feb;2(1):51-64. Review.

PMID:
11258197
48.

Analysis of drug pharmacology towards predicting drug behavior by expression profiling using high-density oligonucleotide arrays.

Hu JS, Durst M, Kerb R, Truong V, Ma JT, Khurgin E, Balaban D, Gingeras TR, Hoffman BB.

Ann N Y Acad Sci. 2000;919:9-15.

PMID:
11083092
49.

Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation.

Sprenger R, Schlagenhaufer R, Kerb R, Bruhn C, Brockmöller J, Roots I, Brinkmann U.

Pharmacogenetics. 2000 Aug;10(6):557-65.

PMID:
10975610
50.

Detection of the GSTM1*0 allele by long polymerase chain reaction.

Kerb R, Brockmöller J, Sachse C, Roots I.

Pharmacogenetics. 1999 Feb;9(1):89-94.

PMID:
10208647

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