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Items: 1 to 50 of 94

1.

Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.

Oellerich T, Schneider C, Thomas D, Knecht KM, Buzovetsky O, Kaderali L, Schliemann C, Bohnenberger H, Angenendt L, Hartmann W, Wardelmann E, Rothenburger T, Mohr S, Scheich S, Comoglio F, Wilke A, Ströbel P, Serve H, Michaelis M, Ferreirós N, Geisslinger G, Xiong Y, Keppler OT, Cinatl J Jr.

Nat Commun. 2019 Aug 2;10(1):3475. doi: 10.1038/s41467-019-11413-4.

2.

Author Correction: The wide utility of rabbits as models of human diseases.

Esteves PJ, Abrantes J, Baldauf HM, BenMohamed L, Chen Y, Christensen N, González-Gallego J, Giacani L, Hu J, Kaplan G, Keppler OT, Knight KL, Kong XP, Lanning DK, Le Pendu J, de Matos AL, Liu J, Liu S, Lopes AM, Lu S, Lukehart S, Manabe YC, Neves F, McFadden G, Pan R, Peng X, de Sousa-Pereira P, Pinheiro A, Rahman M, Ruvoën-Clouet N, Subbian S, Tuñón MJ, van der Loo W, Vaine M, Via LE, Wang S, Mage R.

Exp Mol Med. 2019 Jul 4;51(7):71. doi: 10.1038/s12276-019-0252-0.

3.

Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children.

Muenchhoff M, Adland E, Roider J, Kløverpris H, Leslie A, Boehm S, Keppler OT, Ndung'u T, Goulder PJR.

J Infect Dis. 2019 Apr 16;219(9):1407-1417. doi: 10.1093/infdis/jiy668.

4.

The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists.

de Sousa-Pereira P, Abrantes J, Bauernfried S, Pierini V, Esteves PJ, Keppler OT, Pizzato M, Hornung V, Fackler OT, Baldauf HM.

J Gen Virol. 2019 Feb;100(2):278-288. doi: 10.1099/jgv.0.001201. Epub 2018 Dec 19.

PMID:
30566072
5.

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.

Knecht KM, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Kaderali L, Tofoleanu F, Reiss K, Ferreirós N, Geisslinger G, Batista VS, Ji X, Cinatl J Jr, Keppler OT, Xiong Y.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10022-E10031. doi: 10.1073/pnas.1805593115. Epub 2018 Oct 10.

6.

Post-translational Modification-Based Regulation of HIV Replication.

Chen L, Keppler OT, Schölz C.

Front Microbiol. 2018 Sep 11;9:2131. doi: 10.3389/fmicb.2018.02131. eCollection 2018. Review.

7.

[The HIV reservoir in resting CD4 T-cells: Barrier on the road to an HIV cure].

Muenchhoff M, Keppler OT.

MMW Fortschr Med. 2018 Jun;160(Suppl 2):32-35. doi: 10.1007/s15006-018-0653-3. Review. German. No abstract available.

PMID:
29943331
8.

The wide utility of rabbits as models of human diseases.

Esteves PJ, Abrantes J, Baldauf HM, BenMohamed L, Chen Y, Christensen N, González-Gallego J, Giacani L, Hu J, Kaplan G, Keppler OT, Knight KL, Kong XP, Lanning DK, Le Pendu J, de Matos AL, Liu J, Liu S, Lopes AM, Lu S, Lukehart S, Manabe YC, Neves F, McFadden G, Pan R, Peng X, de Sousa-Pereira P, Pinheiro A, Rahman M, Ruvoën-Clouet N, Subbian S, Tuñón MJ, van der Loo W, Vaine M, Via LE, Wang S, Mage R.

Exp Mol Med. 2018 May 22;50(5):66. doi: 10.1038/s12276-018-0094-1. Review. Erratum in: Exp Mol Med. 2019 Jul 4;51(7):71.

9.

Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.

Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, Ströbel P, Ferreirós N, Serve H, Keppler OT, Cinatl J Jr.

Nat Med. 2017 Jun 6;23(6):788. doi: 10.1038/nm0617-788a. No abstract available.

PMID:
28586337
10.

Retrospective analysis of clinical and virological parameters of influenza cases at four university hospitals in Germany, 2015.

Heyd R, Eis-Hübinger AM, Berger A, Bierbaum S, Pietzonka S, Wenzel JJ, Huzly D, Keppler OT, Panning M.

Infection. 2017 Jun;45(3):349-354. doi: 10.1007/s15010-017-1008-1. Epub 2017 Mar 18.

PMID:
28316058
11.

Elevated prevalence of multidrug-resistant gram-negative organisms in HIV positive men.

Reinheimer C, Keppler OT, Stephan C, Wichelhaus TA, Friedrichs I, Kempf VA.

BMC Infect Dis. 2017 Mar 13;17(1):206. doi: 10.1186/s12879-017-2286-z.

12.

HCV RNA Testing of Plasma Samples from Cornea Donors: Suitability of Plasma Samples Stored at 4 °C for up to 8 Days.

Berger A, Salla S, Keppler OT, Rabenau HF.

Transfus Med Hemother. 2017 Jan;44(1):39-44. doi: 10.1159/000449207. Epub 2016 Nov 4.

13.

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. doi: 10.1073/pnas.1613635114. Epub 2017 Feb 22.

14.

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.

Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, Ströbel P, Ferreirós N, Serve H, Keppler OT, Cinatl J Jr.

Nat Med. 2017 Feb;23(2):250-255. doi: 10.1038/nm.4255. Epub 2016 Dec 19. Erratum in: Nat Med. 2017 Jun 6;23 (6):788.

PMID:
27991919
15.

Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors.

Bulli L, Apolonia L, Kutzner J, Pollpeter D, Goujon C, Herold N, Schwarz SM, Giernat Y, Keppler OT, Malim MH, Schaller T.

J Virol. 2016 Jul 27;90(16):7469-7480. doi: 10.1128/JVI.00458-16. Print 2016 Aug 15.

16.

HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites.

Pujol FM, Laketa V, Schmidt F, Mukenhirn M, Müller B, Boulant S, Grimm D, Keppler OT, Fackler OT.

J Virol. 2016 Jul 11;90(15):6709-6723. doi: 10.1128/JVI.00504-16. Print 2016 Aug 1.

17.

Evolutionary study of leporid CD4 reveals a hotspot of genetic variability within the D2 domain.

de Sousa-Pereira P, Abrantes J, Baldauf HM, Keppler OT, Esteves PJ.

Immunogenetics. 2016 Jul;68(6-7):477-482. doi: 10.1007/s00251-016-0909-y. Epub 2016 Mar 15.

PMID:
26979977
18.

Prevalence of K65R in patients treated with tenofovir disoproxil fumarate: recommendations based on the Frankfurt HIV Cohort Study Resistance Database (FHCS-RD).

Reinheimer C, Wesner A, Keppler OT, Doerr HW, Herrmann E, Stürmer M, Stephan C.

Med Microbiol Immunol. 2016 Aug;205(4):315-20. doi: 10.1007/s00430-015-0448-4. Epub 2016 Jan 8.

PMID:
26746222
19.

No SEVI-mediated enhancement of rectal HIV-1 transmission of HIV-1 in two humanized mouse cohorts.

Van Dis ES, Moore TC, Lavender KJ, Messer RJ, Keppler OT, Verheyen J, Dittmer U, Hasenkrug KJ.

Virology. 2016 Jan 15;488:88-95. doi: 10.1016/j.virol.2015.11.005. Epub 2015 Nov 21.

20.

Mouse Siglec-1 Mediates trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner.

Erikson E, Wratil PR, Frank M, Ambiel I, Pahnke K, Pino M, Azadi P, Izquierdo-Useros N, Martinez-Picado J, Meier C, Schnaar RL, Crocker PR, Reutter W, Keppler OT.

J Biol Chem. 2015 Nov 6;290(45):27345-59. doi: 10.1074/jbc.M115.681338. Epub 2015 Sep 14.

21.

Evaluation of two HIV antibody confirmatory assays: Geenius™ HIV1/2 Confirmatory Assay and the recomLine HIV-1 & HIV-2 IgG Line Immunoassay.

Friedrichs I, Buus C, Berger A, Keppler OT, Rabenau HF.

J Virol Methods. 2015 Nov;224:91-4. doi: 10.1016/j.jviromet.2015.08.015. Epub 2015 Aug 24.

PMID:
26315319
22.

Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs.

Li D, Schlaepfer E, Audigé A, Rochat MA, Ivic S, Knowlton CN, Kim B, Keppler OT, Speck RF.

Stem Cell Res. 2015 Sep;15(2):271-80. doi: 10.1016/j.scr.2015.06.012. Epub 2015 Jul 3.

23.

Incidence of CMV co-infection in HIV-positive women and their neonates in a tertiary referral centre: a cohort study.

Reitter A, Buxmann H, Haberl AE, Schlösser R, Kreibich M, Keppler OT, Berger A.

Med Microbiol Immunol. 2016 Feb;205(1):63-71. doi: 10.1007/s00430-015-0427-9. Epub 2015 Jul 9.

PMID:
26155982
24.

Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells.

Posch W, Steger M, Knackmuss U, Blatzer M, Baldauf HM, Doppler W, White TE, Hörtnagl P, Diaz-Griffero F, Lass-Flörl C, Hackl H, Moris A, Keppler OT, Wilflingseder D.

PLoS Pathog. 2015 Jun 29;11(6):e1005005. doi: 10.1371/journal.ppat.1005005. eCollection 2015 Jun.

25.

Management of Microbiological Samples in a Confirmed Case of Ebola Virus Disease: Constraints and Limitations.

Hogardt M, Wolf T, Kann G, Brodt HR, Brandt C, Keppler OT, Wicker S, Zacharowski K, Gottschalk R, Becker S, Kempf VA.

J Clin Microbiol. 2015 Nov;53(11):3396-400. doi: 10.1128/JCM.01142-15. Epub 2015 Jun 24.

26.

HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells.

Pino M, Erkizia I, Benet S, Erikson E, Fernández-Figueras MT, Guerrero D, Dalmau J, Ouchi D, Rausell A, Ciuffi A, Keppler OT, Telenti A, Kräusslich HG, Martinez-Picado J, Izquierdo-Useros N.

Retrovirology. 2015 May 7;12:37. doi: 10.1186/s12977-015-0160-x.

27.

Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry.

Thomas D, Herold N, Keppler OT, Geisslinger G, Ferreirós N.

Anal Bioanal Chem. 2015 May;407(13):3693-704. doi: 10.1007/s00216-015-8588-3. Epub 2015 Mar 8.

PMID:
25749797
28.

SAMHD1's protein expression profile in humans.

Schmidt S, Schenkova K, Adam T, Erikson E, Lehmann-Koch J, Sertel S, Verhasselt B, Fackler OT, Lasitschka F, Keppler OT.

J Leukoc Biol. 2015 Jul;98(1):5-14. doi: 10.1189/jlb.4HI0714-338RR. Epub 2015 Feb 2.

PMID:
25646359
29.

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care.

Wolf T, Kann G, Becker S, Stephan C, Brodt HR, de Leuw P, Grünewald T, Vogl T, Kempf VA, Keppler OT, Zacharowski K.

Lancet. 2015 Apr 11;385(9976):1428-35. doi: 10.1016/S0140-6736(14)62384-9. Epub 2014 Dec 19.

PMID:
25534190
30.

HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.

Haller C, Müller B, Fritz JV, Lamas-Murua M, Stolp B, Pujol FM, Keppler OT, Fackler OT.

J Virol. 2014 Dec;88(24):14241-57. doi: 10.1128/JVI.02333-14. Epub 2014 Oct 1.

31.

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.

Pauls E, Ruiz A, Badia R, Permanyer M, Gubern A, Riveira-Muñoz E, Torres-Torronteras J, Alvarez M, Mothe B, Brander C, Crespo M, Menéndez-Arias L, Clotet B, Keppler OT, Martí R, Posas F, Ballana E, Esté JA.

J Immunol. 2014 Aug 15;193(4):1988-97. doi: 10.4049/jimmunol.1400873. Epub 2014 Jul 11.

32.

Impact of raltegravir on HIV-1 RNA and DNA forms following initiation of antiretroviral therapy in treatment-naive patients.

Stephan C, Baldauf HM, Barry J, Giordano FA, Bartholomae CC, Haberl A, Bickel M, Schmidt M, Laufs S, Kaderali L, Keppler OT.

J Antimicrob Chemother. 2014 Oct;69(10):2809-18. doi: 10.1093/jac/dku213. Epub 2014 Jun 23.

PMID:
24962031
33.

Differential loss of humoral immunity against measles, mumps, rubella and varicella-zoster virus in children treated for cancer.

Bochennek K, Allwinn R, Langer R, Becker M, Keppler OT, Klingebiel T, Lehrnbecher T.

Vaccine. 2014 Jun 5;32(27):3357-61. doi: 10.1016/j.vaccine.2014.04.042. Epub 2014 Apr 29.

PMID:
24793952
34.

p21 regulates the HIV-1 restriction factor SAMHD1.

Pauls E, Ruiz A, Riveira-Muñoz E, Permanyer M, Badia R, Clotet B, Keppler OT, Ballana E, Este JA.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1322-4. doi: 10.1073/pnas.1322059111. Epub 2014 Mar 7. No abstract available.

35.

MxB/Mx2: the latest piece in HIV's interferon puzzle.

Fackler OT, Keppler OT.

EMBO Rep. 2013 Dec;14(12):1028-9. doi: 10.1038/embor.2013.172. Epub 2013 Nov 1. No abstract available.

36.

Detection of herpesvirus EBV DNA in the lower respiratory tract of ICU patients: a marker of infection of the lower respiratory tract?

Friedrichs I, Bingold T, Keppler OT, Pullmann B, Reinheimer C, Berger A.

Med Microbiol Immunol. 2013 Dec;202(6):431-6. doi: 10.1007/s00430-013-0306-1. Epub 2013 Jul 31.

PMID:
23900401
37.

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes.

Pan X, Baldauf HM, Keppler OT, Fackler OT.

Cell Res. 2013 Jul;23(7):876-85. doi: 10.1038/cr.2013.74. Epub 2013 Jun 4. Review.

38.

Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients.

Farnik H, Bojunga J, Berger A, Allwinn R, Waidmann O, Kronenberger B, Keppler OT, Zeuzem S, Sarrazin C, Lange CM.

Hepatology. 2013 Oct;58(4):1270-6. doi: 10.1002/hep.26488. Epub 2013 Aug 7.

PMID:
23703797
39.

Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides.

Izquierdo-Useros N, Lorizate M, Puertas MC, Rodriguez-Plata MT, Zangger N, Erikson E, Pino M, Erkizia I, Glass B, Clotet B, Keppler OT, Telenti A, Kräusslich HG, Martinez-Picado J.

PLoS Biol. 2012;10(12):e1001448. doi: 10.1371/journal.pbio.1001448. Epub 2012 Dec 18.

40.

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT, Keppler OT.

Nat Med. 2012 Nov;18(11):1682-7. doi: 10.1038/nm.2964.

41.

Conformation-specific display of 4E10 and 2F5 epitopes on self-assembling protein nanoparticles as a potential HIV vaccine.

Wahome N, Pfeiffer T, Ambiel I, Yang Y, Keppler OT, Bosch V, Burkhard P.

Chem Biol Drug Des. 2012 Sep;80(3):349-57. doi: 10.1111/j.1747-0285.2012.01423.x. Epub 2012 Jul 3.

PMID:
22650354
42.

A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes.

Haid S, Novodomská A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, Chhatwal P, Jannack B, Hennebelle T, Bailleul F, Keppler OT, Poenisch M, Bartenschlager R, Hernandez C, Lemasson M, Rosenberg AR, Wong-Staal F, Davioud-Charvet E, Pietschmann T.

Gastroenterology. 2012 Jul;143(1):213-22.e5. doi: 10.1053/j.gastro.2012.03.036. Epub 2012 Mar 27.

PMID:
22465429
43.

HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin.

Fritz JV, Tibroni N, Keppler OT, Fackler OT.

Virology. 2012 Mar 1;424(1):33-44. doi: 10.1016/j.virol.2011.12.008. Epub 2012 Jan 4.

44.

The cellular antiviral restriction factor tetherin does not inhibit poxviral replication.

Sliva K, Resch T, Kraus B, Goffinet C, Keppler OT, Schnierle BS.

J Virol. 2012 Feb;86(3):1893-6. doi: 10.1128/JVI.05198-11. Epub 2011 Nov 16.

45.

In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans.

Erikson E, Adam T, Schmidt S, Lehmann-Koch J, Over B, Goffinet C, Harter C, Bekeredjian-Ding I, Sertel S, Lasitschka F, Keppler OT.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13688-93. doi: 10.1073/pnas.1101684108. Epub 2011 Aug 1.

46.

Architecture and regulation of the HIV-1 assembly and holding compartment in macrophages.

Welsch S, Groot F, Kräusslich HG, Keppler OT, Sattentau QJ.

J Virol. 2011 Aug;85(15):7922-7. doi: 10.1128/JVI.00834-11. Epub 2011 May 25.

47.

HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction.

Schmidt S, Fritz JV, Bitzegeio J, Fackler OT, Keppler OT.

MBio. 2011 May 24;2(3):e00036-11. doi: 10.1128/mBio.00036-11. Print 2011.

48.

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release.

Tervo HM, Homann S, Ambiel I, Fritz JV, Fackler OT, Keppler OT.

Retrovirology. 2011 Feb 10;8:9. doi: 10.1186/1742-4690-8-9.

49.

High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.

Tervo HM, Keppler OT.

J Virol. 2010 Dec;84(23):12300-14. doi: 10.1128/JVI.01607-10. Epub 2010 Sep 22.

50.

Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.

Goffinet C, Schmidt S, Kern C, Oberbremer L, Keppler OT.

J Virol. 2010 Nov;84(21):11374-84. doi: 10.1128/JVI.01067-10. Epub 2010 Aug 11.

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