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Items: 13


A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse.

Carlin LM, Evans R, Milewicz H, Fernandes L, Matthews DR, Perani M, Levitt J, Keppler MD, Monypenny J, Coolen T, Barber PR, Vojnovic B, Suhling K, Fraternali F, Ameer-Beg S, Parker PJ, Thomas NS, Ng T.

Sci Signal. 2011 Nov 29;4(201):ra81. doi: 10.1126/scisignal.2001729.


Integrating receptor signal inputs that influence small Rho GTPase activation dynamics at the immunological synapse.

Makrogianneli K, Carlin LM, Keppler MD, Matthews DR, Ofo E, Coolen A, Ameer-Beg SM, Barber PR, Vojnovic B, Ng T.

Mol Cell Biol. 2009 Jun;29(11):2997-3006. doi: 10.1128/MCB.01008-08. Epub 2009 Mar 23.


HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6.

Ramsay AG, Keppler MD, Jazayeri M, Thomas GJ, Parsons M, Violette S, Weinreb P, Hart IR, Marshall JF.

Cancer Res. 2007 Jun 1;67(11):5275-84.


Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.

Prag S, Parsons M, Keppler MD, Ameer-Beg SM, Barber P, Hunt J, Beavil AJ, Calvert R, Arpin M, Vojnovic B, Ng T.

Mol Biol Cell. 2007 Aug;18(8):2935-48. Epub 2007 May 30.


Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells.

Parsons M, Monypenny J, Ameer-Beg SM, Millard TH, Machesky LM, Peter M, Keppler MD, Schiavo G, Watson R, Chernoff J, Zicha D, Vojnovic B, Ng T.

Mol Cell Biol. 2005 Mar;25(5):1680-95.


Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions.

Peter M, Ameer-Beg SM, Hughes MK, Keppler MD, Prag S, Marsh M, Vojnovic B, Ng T.

Biophys J. 2005 Feb;88(2):1224-37. Epub 2004 Nov 5.


DNA sequence specificity of triplex-binding ligands.

Keppler MD, James PL, Neidle S, Brown T, Fox KR.

Eur J Biochem. 2003 Dec;270(24):4982-92.


Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.

Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T.

Mol Cell Biol. 2002 Aug;22(16):5897-911.


Stabilisation of TG- and AG-containing antiparallel DNA triplexes by triplex-binding ligands.

Keppler MD, Neidle S, Fox KR.

Nucleic Acids Res. 2001 May 1;29(9):1935-42.


DNA triple helix stabilisation by covalent attachment of a triplex-specific ligand.

Keppler MD, McKeen CM, Zegrocka O, Strekowski L, Brown T, Fox KR.

Biochim Biophys Acta. 1999 Oct 28;1447(2-3):137-45.


Stabilization of DNA triple helices by a series of mono- and disubstituted amidoanthraquinones.

Keppler MD, Read MA, Perry PJ, Trent JO, Jenkins TC, Reszka AP, Neidle S, Fox KR.

Eur J Biochem. 1999 Aug;263(3):817-25.


5-(1-propargylamino)-2'-deoxyuridine (UP): a novel thymidine analogue for generating DNA triplexes with increased stability.

Bijapur J, Keppler MD, Bergqvist S, Brown T, Fox KR.

Nucleic Acids Res. 1999 Apr 15;27(8):1802-9.


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