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Items: 1 to 50 of 271

1.

Progress in the Molecular Characterization of Hepatobiliary Transporters.

Keppler D.

Dig Dis. 2017;35(3):197-202. doi: 10.1159/000450911. Epub 2017 Mar 1. Review.

PMID:
28249282
2.

Retroviral expression of human cystatin genes in HeLa cells.

Diep CM, Kaur G, Keppler D, Lin AW.

Methods Mol Biol. 2015;1249:121-31. doi: 10.1007/978-1-4939-2013-6_9.

PMID:
25348302
3.

The roles of MRP2, MRP3, OATP1B1, and OATP1B3 in conjugated hyperbilirubinemia.

Keppler D.

Drug Metab Dispos. 2014 Apr;42(4):561-5. doi: 10.1124/dmd.113.055772. Epub 2014 Jan 23. Review.

PMID:
24459177
4.

In vitro methods to support transporter evaluation in drug discovery and development.

Brouwer KL, Keppler D, Hoffmaster KA, Bow DA, Cheng Y, Lai Y, Palm JE, Stieger B, Evers R; International Transporter Consortium.

Clin Pharmacol Ther. 2013 Jul;94(1):95-112. doi: 10.1038/clpt.2013.81. Epub 2013 Apr 10. Review. Erratum in: Clin Pharmacol Ther. 2013 Sep;94(3):412.

5.

Emerging transporters of clinical importance: an update from the International Transporter Consortium.

Hillgren KM, Keppler D, Zur AA, Giacomini KM, Stieger B, Cass CE, Zhang L; International Transporter Consortium.

Clin Pharmacol Ther. 2013 Jul;94(1):52-63. doi: 10.1038/clpt.2013.74. Epub 2013 Apr 8. Review.

6.

Promoting drug discovery by collaborative innovation: a novel risk- and reward-sharing partnership between the German Cancer Research Center and Bayer HealthCare.

Wellenreuther R, Keppler D, Mumberg D, Ziegelbauer K, Lessl M.

Drug Discov Today. 2012 Nov;17(21-22):1242-8. doi: 10.1016/j.drudis.2012.04.004. Epub 2012 Apr 12. Review.

PMID:
22521665
7.

Cholestasis and the role of basolateral efflux pumps.

Keppler D.

Z Gastroenterol. 2011 Jul;49(12):1553-7. doi: 10.1055/s-0031-1281755. Epub 2011 Dec 2. Review.

PMID:
22139880
8.

Novel expression of CST1 as candidate senescence marker.

Keppler D, Zhang J, Bihani T, Lin AW.

J Gerontol A Biol Sci Med Sci. 2011 Jul;66(7):723-31. doi: 10.1093/gerona/glr033. Epub 2011 Jun 2.

PMID:
21636832
9.
10.

Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy.

Keppler D.

Handb Exp Pharmacol. 2011;(201):299-323. doi: 10.1007/978-3-642-14541-4_8. Review.

PMID:
21103974
11.

Vectorial transport of nucleoside analogs from the apical to the basolateral membrane in double-transfected cells expressing the human concentrative nucleoside transporter hCNT3 and the export pump ABCC4.

Rius M, Keller D, Brom M, Hummel-Eisenbeiss J, Lyko F, Keppler D.

Drug Metab Dispos. 2010 Jul;38(7):1054-63. doi: 10.1124/dmd.110.032664. Epub 2010 Apr 1.

PMID:
20360301
12.

Membrane transporters in drug development.

International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L.

Nat Rev Drug Discov. 2010 Mar;9(3):215-36. doi: 10.1038/nrd3028. Review.

13.

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E.

Hepatology. 2009 Oct;50(4):1227-40. doi: 10.1002/hep.23103.

PMID:
19591196
14.

Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation.

Rius M, Stresemann C, Keller D, Brom M, Schirrmacher E, Keppler D, Lyko F.

Mol Cancer Ther. 2009 Jan;8(1):225-31. doi: 10.1158/1535-7163.MCT-08-0743.

15.

Inactivation of the cystatin E/M tumor suppressor gene in cervical cancer.

Veena MS, Lee G, Keppler D, Mendonca MS, Redpath JL, Stanbridge EJ, Wilczynski SP, Srivatsan ES.

Genes Chromosomes Cancer. 2008 Sep;47(9):740-54. doi: 10.1002/gcc.20576.

16.

Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs.

Nies AT, Schwab M, Keppler D.

Expert Opin Drug Metab Toxicol. 2008 May;4(5):545-68. doi: 10.1517/17425255.4.5.545 . Review.

PMID:
18484914
17.
18.

ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4).

Rius M, Hummel-Eisenbeiss J, Keppler D.

J Pharmacol Exp Ther. 2008 Jan;324(1):86-94. Epub 2007 Oct 24.

PMID:
17959747
19.

Data-based mathematical modeling of vectorial transport across double-transfected polarized cells.

Bartholomé K, Rius M, Letschert K, Keller D, Timmer J, Keppler D.

Drug Metab Dispos. 2007 Sep;35(9):1476-81. Epub 2007 Jun 4.

PMID:
17548463
20.

Methylation-dependent silencing of CST6 in primary human breast tumors and metastatic lesions.

Rivenbark AG, Livasy CA, Boyd CE, Keppler D, Coleman WB.

Exp Mol Pathol. 2007 Oct;83(2):188-97. Epub 2007 Apr 18.

21.

Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis.

Lü J, Qian J, Keppler D, Cardoso WV.

J Biol Chem. 2007 Jul 27;282(30):22176-84. Epub 2007 May 11.

22.

Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3.

Komatsu M, Furukawa T, Ikeda R, Takumi S, Nong Q, Aoyama K, Akiyama S, Keppler D, Takeuchi T.

Toxicol Sci. 2007 Jun;97(2):407-16. Epub 2007 Mar 16.

PMID:
17369605
23.

The apical conjugate efflux pump ABCC2 (MRP2).

Nies AT, Keppler D.

Pflugers Arch. 2007 Feb;453(5):643-59. Epub 2006 Jul 18. Review.

PMID:
16847695
24.

Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers.

Liu L, Cui Y, Chung AY, Shitara Y, Sugiyama Y, Keppler D, Pang KS.

J Pharmacol Exp Ther. 2006 Jul;318(1):395-402. Epub 2006 Apr 20.

PMID:
16627748
25.

Role of cystatins in tumor neovascularization.

Keppler D, Sierra F.

Future Oncol. 2005 Oct;1(5):661-72. Review.

PMID:
16556043
26.

Molecular characterization and inhibition of amanitin uptake into human hepatocytes.

Letschert K, Faulstich H, Keller D, Keppler D.

Toxicol Sci. 2006 May;91(1):140-9. Epub 2006 Feb 22.

PMID:
16495352
27.

Uptake and efflux transporters for conjugates in human hepatocytes.

Keppler D.

Methods Enzymol. 2005;400:531-42.

PMID:
16399368
28.

Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system.

Bortfeld M, Rius M, König J, Herold-Mende C, Nies AT, Keppler D.

Neuroscience. 2006;137(4):1247-57. Epub 2005 Dec 15.

PMID:
16359813
29.

ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.

Bronger H, König J, Kopplow K, Steiner HH, Ahmadi R, Herold-Mende C, Keppler D, Nies AT.

Cancer Res. 2005 Dec 15;65(24):11419-28.

30.

The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin.

Song J, Jie C, Polk P, Shridhar R, Clair T, Zhang J, Yin L, Keppler D.

Biochem Biophys Res Commun. 2006 Feb 3;340(1):175-82. Epub 2005 Dec 9.

PMID:
16356477
31.

Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione.

Rius M, Hummel-Eisenbeiss J, Hofmann AF, Keppler D.

Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G640-9. Epub 2005 Nov 10.

32.
33.

Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts.

Mason DX, Keppler D, Zhang J, Jackson TJ, Seger YR, Matsui S, Abreo F, Cowell JK, Hannon GJ, Lowe SW, Lin AW.

Carcinogenesis. 2006 Feb;27(2):350-9. Epub 2005 Nov 9. Erratum in: Carcinogenesis. 2006 Apr;27(4):882.

34.

The Tetratricopeptide repeat domain 7 gene is mutated in flaky skin mice: a model for psoriasis, autoimmunity, and anemia.

Helms C, Pelsue S, Cao L, Lamb E, Loffredo B, Taillon-Miller P, Herrin B, Burzenski LM, Gott B, Lyons BL, Keppler D, Shultz LD, Bowcock AM.

Exp Biol Med (Maywood). 2005 Oct;230(9):659-67.

PMID:
16179734
35.

Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells.

Kopplow K, Letschert K, König J, Walter B, Keppler D.

Mol Pharmacol. 2005 Oct;68(4):1031-8. Epub 2005 Jul 26.

PMID:
16046661
36.

Towards novel anti-cancer strategies based on cystatin function.

Keppler D.

Cancer Lett. 2006 Apr 28;235(2):159-76. Review.

PMID:
15893421
37.

Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis.

Keitel V, Burdelski M, Warskulat U, Kühlkamp T, Keppler D, Häussinger D, Kubitz R.

Hepatology. 2005 May;41(5):1160-72. Erratum in: Hepatology. 2005 Jul;42(1):242.

PMID:
15841457
38.

Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma.

König J, Hartel M, Nies AT, Martignoni ME, Guo J, Büchler MW, Friess H, Keppler D.

Int J Cancer. 2005 Jun 20;115(3):359-67.

39.

Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2.

Letschert K, Komatsu M, Hummel-Eisenbeiss J, Keppler D.

J Pharmacol Exp Ther. 2005 May;313(2):549-56. Epub 2005 Jan 21.

PMID:
15665139
40.

Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain.

Nies AT, Jedlitschky G, König J, Herold-Mende C, Steiner HH, Schmitt HP, Keppler D.

Neuroscience. 2004;129(2):349-60.

PMID:
15501592
41.

Cystatin m: a novel candidate tumor suppressor gene for breast cancer.

Zhang J, Shridhar R, Dai Q, Song J, Barlow SC, Yin L, Sloane BF, Miller FR, Meschonat C, Li BD, Abreo F, Keppler D.

Cancer Res. 2004 Oct 1;64(19):6957-64.

42.
43.

Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3).

Lee YM, Cui Y, König J, Risch A, Jäger B, Drings P, Bartsch H, Keppler D, Nies AT.

Pharmacogenetics. 2004 Apr;14(4):213-23.

PMID:
15083066
44.

Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells.

Shridhar R, Zhang J, Song J, Booth BA, Kevil CG, Sotiropoulou G, Sloane BF, Keppler D.

Oncogene. 2004 Mar 18;23(12):2206-15.

PMID:
14676833
45.

Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis.

Kojima H, Nies AT, König J, Hagmann W, Spring H, Uemura M, Fukui H, Keppler D.

J Hepatol. 2003 Nov;39(5):693-702.

PMID:
14568249
46.

Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins.

Fehrenbach T, Cui Y, Faulstich H, Keppler D.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):415-20. Epub 2003 Oct 3.

PMID:
14530907
47.

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.

Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D.

Hepatology. 2003 Aug;38(2):374-84.

PMID:
12883481
48.

Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma.

Cui Y, König J, Nies AT, Pfannschmidt M, Hergt M, Franke WW, Alt W, Moll R, Keppler D.

Lab Invest. 2003 Apr;83(4):527-38.

49.

Cysteinyl leukotrienes in the bile of patients with obstructive jaundice.

Uemura M, Kojima H, Buchholz U, Kikuchi E, Matsumoto M, Kikukawa M, Imazu H, Fukui H, Tsujii T, Keppler D.

J Gastroenterol. 2002;37(10):821-30.

PMID:
12424566
50.

A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2).

Keitel V, Nies AT, Brom M, Hummel-Eisenbeiss J, Spring H, Keppler D.

Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G165-74. Epub 2002 Oct 2.

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