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Items: 1 to 50 of 425

1.

Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib.

Bielec B, Schueffl H, Terenzi A, Berger W, Heffeter P, Keppler BK, Kowol CR.

Bioorg Chem. 2020 Mar 20;99:103778. doi: 10.1016/j.bioorg.2020.103778. [Epub ahead of print]

PMID:
32229347
2.

How versatile is the use of ultrafiltration to study biointeractions of therapeutic metallodrugs?

Foteeva LS, Kuznetsova OV, Keppler BK.

Anal Biochem. 2020 Mar 26:113697. doi: 10.1016/j.ab.2020.113697. [Epub ahead of print]

PMID:
32224145
3.

Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors.

Legina MS, Nogueira JJ, Kandioller W, Jakupec MA, González L, Keppler BK.

J Biol Inorg Chem. 2020 Mar 19. doi: 10.1007/s00775-020-01775-2. [Epub ahead of print]

PMID:
32193613
4.

Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib.

Bielec B, Poetsch I, Ahmed E, Heffeter P, Keppler BK, Kowol CR.

Molecules. 2020 Mar 4;25(5). pii: E1149. doi: 10.3390/molecules25051149.

5.

Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)SbIII}4(A-α-XW9O34)2]n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity.

Ma T, Yang P, Dammann I, Lin Z, Mougharbel AS, Li MX, Adǎscǎliţei F, Mitea R, Silvestru C, Thorstenson C, Ullrich MS, Cseh K, Jakupec MA, Keppler BK, Donalisio M, Cavalli R, Lembo D, Kortz U.

Inorg Chem. 2020 Mar 2;59(5):2978-2987. doi: 10.1021/acs.inorgchem.9b03322. Epub 2020 Feb 10.

PMID:
32037809
6.

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes, and Their Unexpected (Biological) Behavior.

Harringer S, Happl B, Ozenil M, Kast C, Hejl M, Wernitznig D, Legin A, Schweikert A, Gajic N, Roller A, Koellensperger G, Jakupec MA, Kandioller W, Keppler BK.

Chemistry. 2020 Jan 20. doi: 10.1002/chem.201905546. [Epub ahead of print]

PMID:
31958176
7.

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour.

Geisler H, Wernitznig D, Hejl M, Gajic N, Jakupec MA, Kandioller W, Keppler BK.

Dalton Trans. 2020 Feb 5;49(5):1393-1397. doi: 10.1039/c9dt04462k.

PMID:
31950944
8.

The Challenge of Classifying Metastatic Cell Properties by Molecular Profiling Exemplified with Cutaneous Melanoma Cells and Their Cerebral Metastasis from Patient Derived Mouse Xenografts.

Neuditschko B, Janker L, Niederstaetter L, Brunmair J, Krivanek K, Izraely S, Sagi-Assif O, Meshel T, Keppler BK, Del Favero G, Witz IP, Gerner C.

Mol Cell Proteomics. 2020 Mar;19(3):478-489. doi: 10.1074/mcp.RA119.001886. Epub 2019 Dec 31.

9.

Single Spheroid Metabolomics: Optimizing Sample Preparation of Three-Dimensional Multicellular Tumor Spheroids.

Rusz M, Rampler E, Keppler BK, Jakupec MA, Koellensperger G.

Metabolites. 2019 Dec 14;9(12). pii: E304. doi: 10.3390/metabo9120304.

10.

Targeting G-quadruplexes with Organic Dyes: Chelerythrine-DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy.

Terenzi A, Gattuso H, Spinello A, Keppler BK, Chipot C, Dehez F, Barone G, Monari A.

Antioxidants (Basel). 2019 Oct 10;8(10). pii: E472. doi: 10.3390/antiox8100472.

11.

Chemical imaging and assessment of cadmium distribution in the human body.

Egger AE, Grabmann G, Gollmann-Tepeköylü C, Pechriggl EJ, Artner C, Türkcan A, Hartinger CG, Fritsch H, Keppler BK, Brenner E, Grimm M, Messner B, Bernhard D.

Metallomics. 2019 Dec 11;11(12):2010-2019. doi: 10.1039/c9mt00178f.

PMID:
31593199
12.

The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo-A Comparison of O,O-, S,O-, and N,N-Chelate Effects.

Berasaluce I, Cseh K, Roller A, Hejl M, Heffeter P, Berger W, Jakupec MA, Kandioller W, Malarek MS, Keppler BK.

Chemistry. 2020 Feb 17;26(10):2211-2221. doi: 10.1002/chem.201903605. Epub 2019 Nov 19.

13.

Preclinical studies on metal based anticancer drugs as enabled by integrated metallomics and metabolomics.

Galvez L, Rusz M, Schwaiger-Haber M, El Abiead Y, Hermann G, Jungwirth U, Berger W, Keppler BK, Jakupec MA, Koellensperger G.

Metallomics. 2019 Oct 16;11(10):1716-1728. doi: 10.1039/c9mt00141g.

PMID:
31497817
14.

Ruthenium-arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition.

Hager LA, Mokesch S, Kieler C, Alonso-de Castro S, Baier D, Roller A, Kandioller W, Keppler BK, Berger W, Salassa L, Terenzi A.

Dalton Trans. 2019 Aug 28;48(32):12040-12049. doi: 10.1039/c9dt02078k. Epub 2019 Jul 11.

PMID:
31292575
15.

Fine-Tuning the Activation Mode of an 1,3-Indandione-Based Ruthenium(II)-Cymene Half-Sandwich Complex by Variation of Its Leaving Group.

Mokesch S, Schwarz D, Hejl M, Klose MHM, Roller A, Jakupec MA, Kandioller W, Keppler BK.

Molecules. 2019 Jun 27;24(13). pii: E2373. doi: 10.3390/molecules24132373.

16.

Interplay of Three G-Quadruplex Units in the KIT Promoter.

Ducani C, Bernardinelli G, Högberg B, Keppler BK, Terenzi A.

J Am Chem Soc. 2019 Jul 3;141(26):10205-10213. doi: 10.1021/jacs.8b12753. Epub 2019 Jun 20.

PMID:
31244182
17.

An improved protocol for ICP-MS-based assessment of the cellular uptake of metal-based nanoparticles.

Kruszewska J, Kur A, Kulpińska D, Grabowska-Jadach I, Matczuk M, Keppler BK, Timerbaev AR, Jarosz M.

J Pharm Biomed Anal. 2019 Sep 10;174:300-304. doi: 10.1016/j.jpba.2019.06.006. Epub 2019 Jun 5.

PMID:
31195318
18.

Mercury, silver, selenium and other trace elements in three cyprinid fish species from the Vaal Dam, South Africa, including implications for fish consumers.

Plessl C, Gilbert BM, Sigmund MF, Theiner S, Avenant-Oldewage A, Keppler BK, Jirsa F.

Sci Total Environ. 2019 Apr 1;659:1158-1167. doi: 10.1016/j.scitotenv.2018.12.442. Epub 2018 Dec 29.

PMID:
31096329
19.

Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle.

Domarco O, Kieler C, Pirker C, Dinhof C, Englinger B, Reisecker JM, Timelthaler G, García MD, Peinador C, Keppler BK, Berger W, Terenzi A.

Angew Chem Int Ed Engl. 2019 Jun 11;58(24):8007-8012. doi: 10.1002/anie.201900934. Epub 2019 May 8.

20.

First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro.

Wernitznig D, Kiakos K, Del Favero G, Harrer N, Machat H, Osswald A, Jakupec MA, Wernitznig A, Sommergruber W, Keppler BK.

Metallomics. 2019 Jun 19;11(6):1044-1048. doi: 10.1039/c9mt00051h.

PMID:
30942231
21.

A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum.

Kuznetsova OV, Reshetnikova IS, Shtykov SN, Karandashev VK, Keppler BK, Timerbaev AR.

Chem Commun (Camb). 2019 Apr 4;55(29):4270-4272. doi: 10.1039/c9cc01642b.

PMID:
30907914
22.

A Dogma in Doubt: Hydrolysis of Equatorial Ligands of PtIV Complexes under Physiological Conditions.

Kastner A, Poetsch I, Mayr J, Burda JV, Roller A, Heffeter P, Keppler BK, Kowol CR.

Angew Chem Int Ed Engl. 2019 May 27;58(22):7464-7469. doi: 10.1002/anie.201900682. Epub 2019 Apr 25.

23.

Analytical methodology for studying cellular uptake, processing and localization of gold nanoparticles.

Matczuk M, Ruzik L, Aleksenko SS, Keppler BK, Jarosz M, Timerbaev AR.

Anal Chim Acta. 2019 Apr 4;1052:1-9. doi: 10.1016/j.aca.2018.10.027. Epub 2018 Oct 16. Review.

PMID:
30685026
24.

Natural iron fertilization of the coastal ocean by "blackwater rivers".

Krachler R, Krachler R, Valda A, Keppler BK.

Sci Total Environ. 2019 Mar 15;656:952-958. doi: 10.1016/j.scitotenv.2018.11.423. Epub 2018 Nov 29.

PMID:
30625681
25.

3-Aminobenzamide Blocks MAMP-Induced Callose Deposition Independently of Its Poly(ADPribosyl)ation Inhibiting Activity.

Keppler BD, Song J, Nyman J, Voigt CA, Bent AF.

Front Plant Sci. 2018 Dec 19;9:1907. doi: 10.3389/fpls.2018.01907. eCollection 2018.

26.

Synthesis, Characterization and in vitro Studies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib.

Karnthaler-Benbakka C, Koblmüller B, Mathuber M, Holste K, Berger W, Heffeter P, Kowol CR, Keppler BK.

Chem Biodivers. 2019 Jan;16(1):e1800520. doi: 10.1002/cbdv.201800520. Epub 2018 Dec 19.

27.

Metal Drugs and the Anticancer Immune Response.

Englinger B, Pirker C, Heffeter P, Terenzi A, Kowol CR, Keppler BK, Berger W.

Chem Rev. 2019 Jan 23;119(2):1519-1624. doi: 10.1021/acs.chemrev.8b00396. Epub 2018 Nov 29. Review.

PMID:
30489072
28.

Biological activity of PtIV prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis.

Alonso-de Castro S, Terenzi A, Hager S, Englinger B, Faraone A, Martínez JC, Galanski M, Keppler BK, Berger W, Salassa L.

Sci Rep. 2018 Nov 21;8(1):17198. doi: 10.1038/s41598-018-35655-2.

29.

New Variations on the Theme of Gold(III) CNN Cyclometalated Complexes as Anticancer Agents: Synthesis and Biological Characterization.

Carboni S, Zucca A, Stoccoro S, Maiore L, Arca M, Ortu F, Artner C, Keppler BK, Meier-Menches SM, Casini A, Cinellu MA.

Inorg Chem. 2018 Dec 3;57(23):14852-14865. doi: 10.1021/acs.inorgchem.8b02604. Epub 2018 Nov 20.

PMID:
30457328
30.

Solvent Bar Micro-Extraction of Heavy Metals from Natural Water Samples Using 3-Hydroxy-2-Naphthoate-Based Ionic Liquids.

Pirkwieser P, López-López JA, Kandioller W, Keppler BK, Moreno C, Jirsa F.

Molecules. 2018 Nov 17;23(11). pii: E3011. doi: 10.3390/molecules23113011.

31.

Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes.

Kallus S, Uhlik L, van Schoonhoven S, Pelivan K, Berger W, Enyedy ÉA, Hofmann T, Heffeter P, Kowol CR, Keppler BK.

J Inorg Biochem. 2019 Jan;190:85-97. doi: 10.1016/j.jinorgbio.2018.10.006. Epub 2018 Oct 19.

PMID:
30384010
32.

The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition.

Hager S, Korbula K, Bielec B, Grusch M, Pirker C, Schosserer M, Liendl L, Lang M, Grillari J, Nowikovsky K, Pape VFS, Mohr T, Szakács G, Keppler BK, Berger W, Kowol CR, Heffeter P.

Cell Death Dis. 2018 Oct 15;9(11):1052. doi: 10.1038/s41419-018-1102-z.

33.

Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC-ICP-MS.

Klose MHM, Schöberl A, Heffeter P, Berger W, Hartinger CG, Koellensperger G, Meier-Menches SM, Keppler BK.

Monatsh Chem. 2018;149(10):1719-1726. doi: 10.1007/s00706-018-2280-1. Epub 2018 Aug 25.

34.

Critical assessment of different methods for quantitative measurement of metallodrug-protein associations.

Galvez L, Theiner S, Grabarics M, Kowol CR, Keppler BK, Hann S, Koellensperger G.

Anal Bioanal Chem. 2018 Nov;410(27):7211-7220. doi: 10.1007/s00216-018-1328-8. Epub 2018 Aug 29.

35.

Nanoformulations of anticancer FGFR inhibitors with improved therapeutic index.

Kallus S, Englinger B, Senkiv J, Laemmerer A, Heffeter P, Berger W, Kowol CR, Keppler BK.

Nanomedicine. 2018 Nov;14(8):2632-2643. doi: 10.1016/j.nano.2018.08.001. Epub 2018 Aug 16.

PMID:
30121385
36.

Understanding the interactions of diruthenium anticancer agents with amino acids.

Nazarov AA, Mendoza-Ferri MG, Hanif M, Keppler BK, Dyson PJ, Hartinger CG.

J Biol Inorg Chem. 2018 Oct;23(7):1159-1164. doi: 10.1007/s00775-018-1597-x. Epub 2018 Jul 25.

PMID:
30046902
37.

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction.

Streciwilk W, Terenzi A, Cheng X, Hager L, Dabiri Y, Prochnow P, Bandow JE, Wölfl S, Keppler BK, Ott I.

Eur J Med Chem. 2018 Aug 5;156:148-161. doi: 10.1016/j.ejmech.2018.06.056. Epub 2018 Jun 25.

PMID:
30006161
38.

Novel 3-Hydroxy-2-Naphthoate-Based Task-Specific Ionic Liquids for an Efficient Extraction of Heavy Metals.

Pirkwieser P, López-López JA, Kandioller W, Keppler BK, Moreno C, Jirsa F.

Front Chem. 2018 May 23;6:172. doi: 10.3389/fchem.2018.00172. eCollection 2018.

39.

Uranium concentrations in sediment pore waters of Lake Neusiedl, Austria.

Krachler R, Krachler R, Gülce F, Keppler BK, Wallner G.

Sci Total Environ. 2018 Aug 15;633:981-988. doi: 10.1016/j.scitotenv.2018.03.259. Epub 2018 Mar 28.

PMID:
29758919
40.

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis.

Groza D, Gehrig S, Kudela P, Holcmann M, Pirker C, Dinhof C, Schueffl HH, Sramko M, Hoebart J, Alioglu F, Grusch M, Ogris M, Lubitz W, Keppler BK, Pashkunova-Martic I, Kowol CR, Sibilia M, Berger W, Heffeter P.

Oncoimmunology. 2018 Feb 16;7(5):e1424676. doi: 10.1080/2162402X.2018.1424676. eCollection 2018.

41.

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS).

Frensemeier LM, Mayr J, Koellensperger G, Keppler BK, Kowol CR, Karst U.

Analyst. 2018 Apr 30;143(9):1997-2001. doi: 10.1039/c8an00258d.

42.

Comparative studies on the human serum albumin binding of the clinically approved EGFR inhibitors gefitinib, erlotinib, afatinib, osimertinib and the investigational inhibitor KP2187.

Dömötör O, Pelivan K, Borics A, Keppler BK, Kowol CR, Enyedy ÉA.

J Pharm Biomed Anal. 2018 May 30;154:321-331. doi: 10.1016/j.jpba.2018.03.011. Epub 2018 Mar 11.

PMID:
29567575
43.

The impact of whole human blood on the kinetic inertness of platinum(iv) prodrugs - an HPLC-ICP-MS study.

Theiner S, Grabarics M, Galvez L, Varbanov HP, Sommerfeld NS, Galanski M, Keppler BK, Koellensperger G.

Dalton Trans. 2018 Apr 17;47(15):5252-5258. doi: 10.1039/C7DT04537A.

44.

Design, synthesis, nuclear localization, and biological activity of a fluorescent duocarmycin analog, HxTfA.

Kiakos K, Englinger B, Yanow SK, Wernitznig D, Jakupec MA, Berger W, Keppler BK, Hartley JA, Lee M, Patil PC.

Bioorg Med Chem Lett. 2018 May 1;28(8):1342-1347. doi: 10.1016/j.bmcl.2018.03.016. Epub 2018 Mar 5.

PMID:
29548574
45.

N- and S-donor leaving groups in triazole-based ruthena(ii)cycles: potent anticancer activity, selective activation, and mode of action studies.

Riedl CA, Hejl M, Klose MHM, Roller A, Jakupec MA, Kandioller W, Keppler BK.

Dalton Trans. 2018 Mar 26;47(13):4625-4638. doi: 10.1039/c8dt00449h.

PMID:
29520401
46.

Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS.

Klose MHM, Theiner S, Kornauth C, Meier-Menches SM, Heffeter P, Berger W, Koellensperger G, Keppler BK.

Metallomics. 2018 Mar 1;10(3):388-396. doi: 10.1039/c8mt00012c. Epub 2018 Mar 7.

PMID:
29513313
47.

Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones.

Pelivan K, Frensemeier LM, Karst U, Koellensperger G, Heffeter P, Keppler BK, Kowol CR.

Anal Bioanal Chem. 2018 Mar;410(9):2343-2361. doi: 10.1007/s00216-018-0889-x. Epub 2018 Feb 23.

48.

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action.

Babak MV, Pfaffeneder-Kmen M, Meier-Menches SM, Legina MS, Theiner S, Licona C, Orvain C, Hejl M, Hanif M, Jakupec MA, Keppler BK, Gaiddon C, Hartinger CG.

Inorg Chem. 2018 Mar 5;57(5):2851-2864. doi: 10.1021/acs.inorgchem.7b03210. Epub 2018 Feb 14.

PMID:
29442506
49.

Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1.

Chakravarthy D, Muñoz AR, Su A, Hwang RF, Keppler BR, Chan DE, Halff G, Ghosh R, Kumar AP.

Cancer Lett. 2018 Apr 10;419:103-115. doi: 10.1016/j.canlet.2018.01.057.

50.

Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development.

Heffeter P, Pape VFS, Enyedy ÉA, Keppler BK, Szakacs G, Kowol CR.

Antioxid Redox Signal. 2019 Mar 10;30(8):1062-1082. doi: 10.1089/ars.2017.7487. Epub 2018 Feb 26.

PMID:
29334758

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