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Items: 1 to 50 of 225

1.

Immunological Effects of Epigenetic Modifiers.

Bezu L, Chuang AW, Liu P, Kroemer G, Kepp O.

Cancers (Basel). 2019 Dec 1;11(12). pii: E1911. doi: 10.3390/cancers11121911. Review.

2.

Immunosuppression by Mutated Calreticulin Released from Malignant Cells.

Liu P, Zhao L, Loos F, Marty C, Xie W, Martins I, Lachkar S, Qu B, Waeckel-Énée E, Plo I, Vainchenker W, Perez F, Rodriguez D, López-Otin C, van Endert P, Zitvogel L, Kepp O, Kroemer G.

Mol Cell. 2019 Nov 23. pii: S1097-2765(19)30833-0. doi: 10.1016/j.molcel.2019.11.004. [Epub ahead of print]

PMID:
31785928
3.

Quantification of eIF2alpha phosphorylation during immunogenic cell death.

Bezu L, Wu Chuang A, Humeau J, Kroemer G, Kepp O.

Methods Enzymol. 2019;629:53-69. doi: 10.1016/bs.mie.2019.04.010. Epub 2019 Apr 27.

PMID:
31727256
4.

Methods for measuring HMGB1 release during immunogenic cell death.

Zhao L, Liu P, Kepp O, Kroemer G.

Methods Enzymol. 2019;629:177-193. doi: 10.1016/bs.mie.2019.05.001. Epub 2019 May 27.

PMID:
31727240
5.

Quinacrine-mediated detection of intracellular ATP.

Forveille S, Humeau J, Sauvat A, Bezu L, Kroemer G, Kepp O.

Methods Enzymol. 2019;629:103-113. doi: 10.1016/bs.mie.2019.05.050. Epub 2019 Jun 17.

PMID:
31727236
6.

A discovery platform for the identification of caloric restriction mimetics with broad health-improving effects.

Kepp O, Chen G, Carmona-Gutierrez D, Madeo F, Kroemer G.

Autophagy. 2019 Nov 7:1-2. doi: 10.1080/15548627.2019.1688984. [Epub ahead of print]

PMID:
31690168
7.

BML-265 and Tyrphostin AG1478 Disperse the Golgi Apparatus and Abolish Protein Transport in Human Cells.

Boncompain G, Gareil N, Tessier S, Lescure A, Jones TR, Kepp O, Kroemer G, Del Nery E, Perez F.

Front Cell Dev Biol. 2019 Oct 11;7:232. doi: 10.3389/fcell.2019.00232. eCollection 2019.

8.

Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity.

Xie W, Forveille S, Iribarren K, Sauvat A, Senovilla L, Wang Y, Humeau J, Perez-Lanzon M, Zhou H, Martínez-Leal JF, Kroemer G, Kepp O.

Oncoimmunology. 2019 Sep 5;8(11):e1656502. doi: 10.1080/2162402X.2019.1656502. eCollection 2019.

PMID:
31646106
9.

Clinical evidence that immunogenic cell death sensitizes to PD-1/PD-L1 blockade.

Kepp O, Zitvogel L, Kroemer G.

Oncoimmunology. 2019 Jul 22;8(10):e1637188. doi: 10.1080/2162402X.2019.1637188. eCollection 2019.

PMID:
31646079
10.

3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB.

Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, Sica V, Carmona-Gutierrez D, Zimmermann A, Pendl T, Tadic J, Bergmann M, Hofer SJ, Domuz L, Lachkar S, Markaki M, Tavernarakis N, Sadoshima J, Madeo F, Kepp O, Kroemer G.

EMBO Mol Med. 2019 Nov 7;11(11):e10469. doi: 10.15252/emmm.201910469. Epub 2019 Oct 14.

11.

Artificial tethering of LC3 or p62 to organelles is not sufficient to trigger autophagy.

Loos F, Xie W, Sica V, Bravo-San Pedro JM, Souquère S, Pierron G, Lachkar S, Sauvat A, Petrazzuolo A, Jimenez AJ, Perez F, Maiuri MC, Kepp O, Kroemer G.

Cell Death Dis. 2019 Oct 10;10(10):771. doi: 10.1038/s41419-019-2011-5.

12.

Oncolysis without viruses - inducing systemic anticancer immune responses with local therapies.

Kepp O, Marabelle A, Zitvogel L, Kroemer G.

Nat Rev Clin Oncol. 2019 Oct 8. doi: 10.1038/s41571-019-0272-7. [Epub ahead of print] Review.

PMID:
31595049
13.

A fluorescent biosensor-based platform for the discovery of immunogenic cancer cell death inducers.

Kepp O, Sauvat A, Leduc M, Forveille S, Liu P, Zhao L, Bezu L, Xie W, Zitvogel L, Kroemer G.

Oncoimmunology. 2019 Apr 26;8(8):1606665. doi: 10.1080/2162402X.2019.1606665. eCollection 2019. Review.

PMID:
31413915
14.

4,4'Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects.

Zimmermann A, Kainz K, Hofer SJ, Bauer MA, Schroeder S, Dengjel J, Pietrocola F, Kepp O, Ruckenstuhl C, Eisenberg T, Sigrist SJ, Madeo F, Carmona-Gutierrez D, Kroemer G.

Autophagy. 2019 Sep;15(9):1662-1664. doi: 10.1080/15548627.2019.1632623. Epub 2019 Jun 28.

15.

Crizotinib - a tyrosine kinase inhibitor that stimulates immunogenic cell death.

Liu P, Zhao L, Kepp O, Kroemer G.

Oncoimmunology. 2019 Apr 13;8(7):1596652. doi: 10.1080/2162402X.2019.1596652. eCollection 2019.

PMID:
31143519
16.

Tumor lysis with LTX-401 creates anticancer immunity.

Xie W, Mondragón L, Mauseth B, Wang Y, Pol J, Lévesque S, Zhou H, Yamazaki T, Eksteen JJ, Zitvogel L, Sveinbjørnsson B, Rekdal Ø, Kepp O, Kroemer G.

Oncoimmunology. 2019 Apr 13;8(7):1594555. doi: 10.1080/2162402X.2019.1594555. eCollection 2019.

PMID:
31143516
17.

AIF-regulated oxidative phosphorylation supports lung cancer development.

Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Köcher T, Zhang P, Jais A, Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N, Pai TP, Onji M, Uribesalgo I, Hanada R, Kozieradzki I, Koglgruber R, Cronin SJ, She Z, Quehenberger F, Popper H, Kenner L, Haigh JJ, Kepp O, Rak M, Cai K, Kroemer G, Penninger JM.

Cell Res. 2019 Jul;29(7):579-591. doi: 10.1038/s41422-019-0181-4. Epub 2019 May 27.

18.

Targeting GATA transcription factors - a novel strategy for anti-aging interventions?

Zimmermann A, Kainz K, Hofer SJ, Bauer MA, Schroeder S, Dengjel J, Pietrocola F, Kepp O, Ruckenstuhl C, Eisenberg T, Sigrist SJ, Madeo F, Kroemer G, Carmona-Gutierrez D.

Microb Cell. 2019 May 6;6(5):212-216. doi: 10.15698/mic2019.05.676.

19.

Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C, Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E, Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S, Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V, Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.

Nat Commun. 2019 Apr 17;10(1):1883. doi: 10.1038/s41467-019-09838-y.

20.

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.

Sica V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S, Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N, Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC, Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.

Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.

21.

Author Correction: Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux.

Zhang S, Wang Y, Xie W, Howe ENW, Busschaert N, Sauvat A, Leduc M, Gomes-da-Silva LC, Chen G, Martins I, Deng X, Maiuri L, Kepp O, Soussi T, Gale PA, Zamzami N, Kroemer G.

Cell Death Dis. 2019 Apr 3;10(4):301. doi: 10.1038/s41419-019-1536-y.

22.

Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C, Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E, Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S, Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V, Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.

Nat Commun. 2019 Apr 2;10(1):1486. doi: 10.1038/s41467-019-09415-3. Erratum in: Nat Commun. 2019 Apr 17;10(1):1883.

23.

Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux.

Zhang S, Wang Y, Xie W, Howe ENW, Busschaert N, Sauvat A, Leduc M, Gomes-da-Silva LC, Chen G, Martins I, Deng X, Maiuri L, Kepp O, Soussi T, Gale PA, Zamzami N, Kroemer G.

Cell Death Dis. 2019 Mar 11;10(3):242. doi: 10.1038/s41419-019-1474-8. Erratum in: Cell Death Dis. 2019 Apr 3;10(4):301.

24.

ColocalizR: An open-source application for cell-based high-throughput colocalization analysis.

Sauvat A, Leduc M, Müller K, Kepp O, Kroemer G.

Comput Biol Med. 2019 Apr;107:227-234. doi: 10.1016/j.compbiomed.2019.02.024. Epub 2019 Mar 2.

PMID:
30852249
25.

The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.

Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F.

Nat Commun. 2019 Feb 19;10(1):651. doi: 10.1038/s41467-019-08555-w.

26.

Anticancer effects of anti-CD47 immunotherapy in vivo.

Iribarren K, Buque A, Mondragon L, Xie W, Lévesque S, Pol J, Zitvogel L, Kepp O, Kroemer G.

Oncoimmunology. 2018 Dec 11;8(3):1550619. doi: 10.1080/2162402X.2018.1550619. eCollection 2019.

PMID:
30723582
27.

Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells.

Dajon M, Iribarren K, Petitprez F, Marmier S, Lupo A, Gillard M, Ouakrim H, Victor N, Vincenzo DB, Joubert PE, Kepp O, Kroemer G, Alifano M, Damotte D, Cremer I.

Oncoimmunology. 2018 Oct 11;8(1):e1505174. doi: 10.1080/2162402X.2018.1505174. eCollection 2019.

28.

Trial watch: Peptide-based vaccines in anticancer therapy.

Bezu L, Kepp O, Cerrato G, Pol J, Fucikova J, Spisek R, Zitvogel L, Kroemer G, Galluzzi L.

Oncoimmunology. 2018 Sep 6;7(12):e1511506. doi: 10.1080/2162402X.2018.1511506. eCollection 2018. Review.

29.

Chlamydia trachomatis fails to protect its growth niche against pro-apoptotic insults.

Sixt BS, Núñez-Otero C, Kepp O, Valdivia RH, Kroemer G.

Cell Death Differ. 2019 Aug;26(8):1485-1500. doi: 10.1038/s41418-018-0224-2. Epub 2018 Oct 30.

30.

Spermidine reduces cancer-related mortality in humans.

Pietrocola F, Castoldi F, Kepp O, Carmona-Gutierrez D, Madeo F, Kroemer G.

Autophagy. 2019 Feb;15(2):362-365. doi: 10.1080/15548627.2018.1539592. Epub 2018 Oct 29.

31.

Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals.

Zhou H, Mondragón L, Xie W, Mauseth B, Leduc M, Sauvat A, Gomes-da-Silva LC, Forveille S, Iribarren K, Souquere S, Bezu L, Liu P, Zhao L, Zitvogel L, Sveinbjørnsson B, Eksteen JJ, Rekdal Ø, Kepp O, Kroemer G.

Cell Death Dis. 2018 Oct 23;9(11):1086. doi: 10.1038/s41419-018-1127-3.

32.

Recruitment of LC3 to damaged Golgi apparatus.

Gomes-da-Silva LC, Jimenez AJ, Sauvat A, Xie W, Souquere S, Divoux S, Storch M, Sveinbjørnsson B, Rekdal Ø, Arnaut LG, Kepp O, Kroemer G, Perez F.

Cell Death Differ. 2019 Aug;26(8):1467-1484. doi: 10.1038/s41418-018-0221-5. Epub 2018 Oct 22.

PMID:
30349077
33.

Identification of pharmacological inhibitors of conventional protein secretion.

Zhao L, Liu P, Boncompain G, Loos F, Lachkar S, Bezu L, Chen G, Zhou H, Perez F, Kepp O, Kroemer G.

Sci Rep. 2018 Oct 8;8(1):14966. doi: 10.1038/s41598-018-33378-y.

34.

Redaporfin induces immunogenic cell death by selective destruction of the endoplasmic reticulum and the Golgi apparatus.

Gomes-da-Silva LC, Zhao L, Arnaut LG, Kroemer G, Kepp O.

Oncotarget. 2018 Jul 27;9(58):31169-31170. doi: 10.18632/oncotarget.25798. eCollection 2018 Jul 27. No abstract available.

35.

Spermidine delays aging in humans.

Madeo F, Carmona-Gutierrez D, Kepp O, Kroemer G.

Aging (Albany NY). 2018 Aug 6;10(8):2209-2211. doi: 10.18632/aging.101517. No abstract available.

36.

Epigenetic anticancer agents cause HMGB1 release in vivo.

Liu P, Zhao L, Loos F, Iribarren K, Kepp O, Kroemer G.

Oncoimmunology. 2018 Feb 14;7(6):e1431090. doi: 10.1080/2162402X.2018.1431090. eCollection 2018.

37.

eIF2α phosphorylation: A hallmark of immunogenic cell death.

Bezu L, Sauvat A, Humeau J, Leduc M, Kepp O, Kroemer G.

Oncoimmunology. 2018 Feb 14;7(6):e1431089. doi: 10.1080/2162402X.2018.1431089. eCollection 2018.

38.

Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus.

Gomes-da-Silva LC, Zhao L, Bezu L, Zhou H, Sauvat A, Liu P, Durand S, Leduc M, Souquere S, Loos F, Mondragón L, Sveinbjørnsson B, Rekdal Ø, Boncompain G, Perez F, Arnaut LG, Kepp O, Kroemer G.

EMBO J. 2018 Jul 2;37(13). pii: e98354. doi: 10.15252/embj.201798354. Epub 2018 May 28.

39.

Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids.

Sauvat A, Chen G, Müller K, Tong M, Aprahamian F, Durand S, Cerrato G, Bezu L, Leduc M, Franz J, Rockenfeller P, Sadoshima J, Madeo F, Kepp O, Kroemer G.

EBioMedicine. 2018 Apr;30:261-272. doi: 10.1016/j.ebiom.2018.03.028. Epub 2018 Mar 27.

40.

Evaluation of autophagy inducers in epithelial cells carrying the ΔF508 mutation of the cystic fibrosis transmembrane conductance regulator CFTR.

Zhang S, Stoll G, Pedro JMBS, Sica V, Sauvat A, Obrist F, Kepp O, Li Y, Maiuri L, Zamzami N, Kroemer G.

Cell Death Dis. 2018 Feb 7;9(2):191. doi: 10.1038/s41419-017-0235-9.

41.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

42.

eIF2α phosphorylation is pathognomonic for immunogenic cell death.

Bezu L, Sauvat A, Humeau J, Gomes-da-Silva LC, Iribarren K, Forveille S, Garcia P, Zhao L, Liu P, Zitvogel L, Senovilla L, Kepp O, Kroemer G.

Cell Death Differ. 2018 Aug;25(8):1375-1393. doi: 10.1038/s41418-017-0044-9. Epub 2018 Jan 22.

43.

Erratum: The oncolytic compound LTX-401 targets the Golgi apparatus.

Zhou H, Sauvat A, Gomes-da-Silva LC, Durand S, Forveille S, Iribarren K, Yamazaki T, Souquere S, Bezu L, Müller K, Leduc M, Liu P, Zhao L, Marabelle A, Zitvogel L, Rekdal Ø, Kepp O, Kroemer G.

Cell Death Differ. 2018 Jan;25(1):227-228. doi: 10.1038/cdd.2017.148.

44.

Trial watch: Immune checkpoint blockers for cancer therapy.

Vanpouille-Box C, Lhuillier C, Bezu L, Aranda F, Yamazaki T, Kepp O, Fucikova J, Spisek R, Demaria S, Formenti SC, Zitvogel L, Kroemer G, Galluzzi L.

Oncoimmunology. 2017 Aug 31;6(11):e1373237. doi: 10.1080/2162402X.2017.1373237. eCollection 2017. Review.

45.

The oncolytic compound LTX-401 targets the Golgi apparatus.

Zhou H, Sauvat A, Gomes-da-Silva LC, Durand S, Forveille S, Iribarren K, Yamazaki T, Souquere S, Bezu L, Müller K, Leduc M, Liu P, Zhao L, Marabelle A, Zitvogel L, Rekdal Ø, Kepp O, Kroemer G.

Cell Death Differ. 2018 Jan;25(1):227-228. doi: 10.1038/cdd.2017.148. Epub 2017 Nov 10.

46.

Identification of pharmacological agents that induce HMGB1 release.

Liu P, Zhao L, Loos F, Iribarren K, Lachkar S, Zhou H, Gomes-da-Silva LC, Chen G, Bezu L, Boncompain G, Perez F, Zitvogel L, Kepp O, Kroemer G.

Sci Rep. 2017 Nov 2;7(1):14915. doi: 10.1038/s41598-017-14848-1.

47.

Extracellular nucleosides and nucleotides as immunomodulators.

Kepp O, Loos F, Liu P, Kroemer G.

Immunol Rev. 2017 Nov;280(1):83-92. doi: 10.1111/imr.12571. Review.

PMID:
29027229
48.

Immune Checkpoint Blockade, Immunogenic Chemotherapy or IFN-α Blockade Boost the Local and Abscopal Effects of Oncolytic Virotherapy.

Fend L, Yamazaki T, Remy C, Fahrner C, Gantzer M, Nourtier V, Préville X, Quéméneur E, Kepp O, Adam J, Marabelle A, Pitt JM, Kroemer G, Zitvogel L.

Cancer Res. 2017 Aug 1;77(15):4146-4157. doi: 10.1158/0008-5472.CAN-16-2165. Epub 2017 May 23.

49.

Pro-necrotic molecules impact local immunosurveillance in human breast cancer.

Stoll G, Ma Y, Yang H, Kepp O, Zitvogel L, Kroemer G.

Oncoimmunology. 2017 Apr 17;6(4):e1299302. doi: 10.1080/2162402X.2017.1299302. eCollection 2017.

50.

Reply: Immunosuppressive cell death in cancer.

Galluzzi L, Buqué A, Kepp O, Zitvogel L, Kroemer G.

Nat Rev Immunol. 2017 Jun;17(6):402. doi: 10.1038/nri.2017.48. Epub 2017 May 8. No abstract available.

PMID:
28480896

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