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Items: 1 to 50 of 91

1.

Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel.

O'Reilly M, Kirkwood NK, Kenyon EJ, Huckvale R, Cantillon DM, Waddell SJ, Ward SE, Richardson GP, Kros CJ, Derudas M.

J Med Chem. 2019 Jun 13;62(11):5312-5329. doi: 10.1021/acs.jmedchem.8b01325. Epub 2019 May 24.

PMID:
31083995
2.

Impacts of a Web-Based Course on Mental Health Clinicians' Attitudes and Communication Behaviors Related to Use of OpenNotes.

Dobscha SK, Kenyon EA, Pisciotta MK, Niederhausen M, Woods S, Denneson LM.

Psychiatr Serv. 2019 Jun 1;70(6):474-479. doi: 10.1176/appi.ps.201800416. Epub 2019 Mar 20.

PMID:
30890047
3.

The Impact of Scaling Factor Variability on Risk-Relevant Pharmacokinetic Outcomes in Children: A Case Study Using Bromodichloromethane (BDCM).

Kenyon EM, Lipscomb JC, Pegram RA, George BJ, Hines RN.

Toxicol Sci. 2019 Feb 1;167(2):347-359. doi: 10.1093/toxsci/kfy236.

PMID:
30252107
4.

Health Coaching to Enhance Psychological Well-being Among Veterans with Suicidal Ideation: a Pilot Study.

Denneson LM, Trevino AY, Kenyon EA, Ono SS, Pfeiffer PN, Dobscha SK.

J Gen Intern Med. 2019 Feb;34(2):192-194. doi: 10.1007/s11606-018-4677-2. No abstract available.

PMID:
30251215
5.

BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection.

Urata S, Kenyon E, Nayak D, Cubitt B, Kurosaki Y, Yasuda J, de la Torre JC, McGavern DB.

PLoS Pathog. 2018 Jul 20;14(7):e1007172. doi: 10.1371/journal.ppat.1007172. eCollection 2018 Jul.

6.

Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death.

Kenyon EJ, Kirkwood NK, Kitcher SR, O'Reilly M, Derudas M, Cantillon DM, Goodyear RJ, Secker A, Baxendale S, Bull JC, Waddell SJ, Whitfield TT, Ward SE, Kros CJ, Richardson GP.

JCI Insight. 2017 Dec 21;2(24). pii: 96773. doi: 10.1172/jci.insight.96773.

7.

From the Cover: Genomic Effects of Androstenedione and Sex-Specific Liver Cancer Susceptibility in Mice.

Rooney JP, Ryan N, Chorley BN, Hester SD, Kenyon EM, Schmid JE, George BJ, Hughes MF, Sey YM, Tennant A, MacMillan DK, Simmons JE, McQueen CA, Pandiri A, Wood CE, Corton JC.

Toxicol Sci. 2017 Nov 1;160(1):15-29. doi: 10.1093/toxsci/kfx153.

8.

d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity.

Kirkwood NK, O'Reilly M, Derudas M, Kenyon EJ, Huckvale R, van Netten SM, Ward SE, Richardson GP, Kros CJ.

Front Cell Neurosci. 2017 Sep 5;11:262. doi: 10.3389/fncel.2017.00262. eCollection 2017.

9.

The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.

Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL.

Sci Immunol. 2016 Dec 23;1(6). pii: eaai8593. doi: 10.1126/sciimmunol.aai8593. Epub 2016 Dec 9.

10.

The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM).

Kenyon EM, Eklund C, Lipscomb JC, Pegram RA.

Toxicol Mech Methods. 2016 Oct;26(8):620-626. Epub 2016 Oct 27.

PMID:
27595344
11.

Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis.

Kenyon EJ, Luijten MN, Gill H, Li N, Rawlings M, Bull JC, Hadzhiev Y, van Steensel MA, Maher E, Mueller F.

BMC Dev Biol. 2016 Jul 8;16(1):23. doi: 10.1186/s12861-016-0119-8.

12.

Fractal measures of spatial pattern as a heuristic for return rate in vegetative systems.

Irvine MA, Jackson EL, Kenyon EJ, Cook KJ, Keeling MJ, Bull JC.

R Soc Open Sci. 2016 Mar 30;3(3):150519. doi: 10.1098/rsos.150519. eCollection 2016 Mar.

13.

Development and application of a human PBPK model for bromodichloromethane to investigate the impacts of multi-route exposure.

Kenyon EM, Eklund C, Leavens T, Pegram RA.

J Appl Toxicol. 2016 Sep;36(9):1095-111. doi: 10.1002/jat.3269. Epub 2015 Dec 9.

PMID:
26649444
14.

Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action.

Lake AD, Wood CE, Bhat VS, Chorley BN, Carswell GK, Sey YM, Kenyon EM, Padnos B, Moore TM, Tennant AH, Schmid JE, George BJ, Ross DG, Hughes MF, Corton JC, Simmons JE, McQueen CA, Hester SD.

Toxicol Sci. 2016 Feb;149(2):312-25. doi: 10.1093/toxsci/kfv236. Epub 2015 Oct 31.

PMID:
26519955
15.

Identifiability of PBPK models with applications to dimethylarsinic acid exposure.

Garcia RI, Ibrahim JG, Wambaugh JF, Kenyon EM, Setzer RW.

J Pharmacokinet Pharmacodyn. 2015 Dec;42(6):591-609. doi: 10.1007/s10928-015-9424-2. Epub 2015 Jul 21.

PMID:
26194069
16.

Zebrafish Rab5 proteins and a role for Rab5ab in nodal signalling.

Kenyon EJ, Campos I, Bull JC, Williams PH, Stemple DL, Clark MD.

Dev Biol. 2015 Jan 15;397(2):212-24. doi: 10.1016/j.ydbio.2014.11.007. Epub 2014 Dec 3.

17.

Immunophenotype and gene expression profile of mesenchymal stem cells derived from canine adipose tissue and bone marrow.

Screven R, Kenyon E, Myers MJ, Yancy HF, Skasko M, Boxer L, Bigley EC 3rd, Borjesson DL, Zhu M.

Vet Immunol Immunopathol. 2014 Sep 15;161(1-2):21-31. doi: 10.1016/j.vetimm.2014.06.002. Epub 2014 Jul 1.

PMID:
25026887
18.

The roles of flowering, overwinter survival and sea surface temperature in the long-term population dynamics of Zostera marina around the Isles of Scilly, UK.

Potouroglou M, Kenyon EJ, Gall A, Cook KJ, Bull JC.

Mar Pollut Bull. 2014 Jun 30;83(2):500-7. doi: 10.1016/j.marpolbul.2014.03.035. Epub 2014 Apr 14.

PMID:
24731880
19.

Correlating in vitro data to in vivo findings for risk assessment.

Bale AS, Kenyon E, Flynn TJ, Lipscomb JC, Mendrick DL, Hartung T, Patton GW.

ALTEX. 2014;31(1):79-90. doi: 10.14573/altex.1310011. Epub 2013 Nov 14.

20.

The zebrafish reference genome sequence and its relationship to the human genome.

Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett JC, Koch R, Rauch GJ, White S, Chow W, Kilian B, Quintais LT, Guerra-Assunção JA, Zhou Y, Gu Y, Yen J, Vogel JH, Eyre T, Redmond S, Banerjee R, Chi J, Fu B, Langley E, Maguire SF, Laird GK, Lloyd D, Kenyon E, Donaldson S, Sehra H, Almeida-King J, Loveland J, Trevanion S, Jones M, Quail M, Willey D, Hunt A, Burton J, Sims S, McLay K, Plumb B, Davis J, Clee C, Oliver K, Clark R, Riddle C, Elliot D, Threadgold G, Harden G, Ware D, Begum S, Mortimore B, Kerry G, Heath P, Phillimore B, Tracey A, Corby N, Dunn M, Johnson C, Wood J, Clark S, Pelan S, Griffiths G, Smith M, Glithero R, Howden P, Barker N, Lloyd C, Stevens C, Harley J, Holt K, Panagiotidis G, Lovell J, Beasley H, Henderson C, Gordon D, Auger K, Wright D, Collins J, Raisen C, Dyer L, Leung K, Robertson L, Ambridge K, Leongamornlert D, McGuire S, Gilderthorp R, Griffiths C, Manthravadi D, Nichol S, Barker G, Whitehead S, Kay M, Brown J, Murnane C, Gray E, Humphries M, Sycamore N, Barker D, Saunders D, Wallis J, Babbage A, Hammond S, Mashreghi-Mohammadi M, Barr L, Martin S, Wray P, Ellington A, Matthews N, Ellwood M, Woodmansey R, Clark G, Cooper J, Tromans A, Grafham D, Skuce C, Pandian R, Andrews R, Harrison E, Kimberley A, Garnett J, Fosker N, Hall R, Garner P, Kelly D, Bird C, Palmer S, Gehring I, Berger A, Dooley CM, Ersan-Ürün Z, Eser C, Geiger H, Geisler M, Karotki L, Kirn A, Konantz J, Konantz M, Oberländer M, Rudolph-Geiger S, Teucke M, Lanz C, Raddatz G, Osoegawa K, Zhu B, Rapp A, Widaa S, Langford C, Yang F, Schuster SC, Carter NP, Harrow J, Ning Z, Herrero J, Searle SM, Enright A, Geisler R, Plasterk RH, Lee C, Westerfield M, de Jong PJ, Zon LI, Postlethwait JH, Nüsslein-Volhard C, Hubbard TJ, Roest Crollius H, Rogers J, Stemple DL.

Nature. 2013 Apr 25;496(7446):498-503. doi: 10.1038/nature12111. Epub 2013 Apr 17. Erratum in: Nature. 2014 Jan 9;505(7482):248. Cooper, James [corrected to Cooper, James D]; Eliott, David [corrected to Elliot, David]; Mortimer, Beverly [corrected to Mortimore, Beverley]; Begum, Sharmin [added]; Lloyd, Christine [added]; Lanz, Christa [added]; Raddatz, Günter [added]; Schuster, Ste.

21.

Local competition and metapopulation processes drive long-term seagrass-epiphyte population dynamics.

Lobelle D, Kenyon EJ, Cook KJ, Bull JC.

PLoS One. 2013;8(2):e57072. doi: 10.1371/journal.pone.0057072. Epub 2013 Feb 21.

22.

Interspecies extrapolation.

Kenyon EM.

Methods Mol Biol. 2012;929:501-20.

PMID:
23007441
23.

In vivo characterization of inflammatory biomarkers in swine and the impact of flunixin meglumine administration.

Peters SM, Yancy H, Deaver C, Jones YL, Kenyon E, Chiesa OA, Esparza J, Screven R, Lancaster V, Stubbs JT 3rd, Yang M, Wiesenfeld PL, Myers MJ.

Vet Immunol Immunopathol. 2012 Aug 15;148(3-4):236-42. doi: 10.1016/j.vetimm.2012.05.001. Epub 2012 May 4.

PMID:
22648045
24.

Wasting disease regulates long-term population dynamics in a threatened seagrass.

Bull JC, Kenyon EJ, Cook KJ.

Oecologia. 2012 May;169(1):135-42. doi: 10.1007/s00442-011-2187-6. Epub 2011 Nov 11.

PMID:
22076311
25.

Concentration- and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to 12 weeks.

Clewell HJ, Thomas RS, Kenyon EM, Hughes MF, Adair BM, Gentry PR, Yager JW.

Toxicol Sci. 2011 Oct;123(2):421-32. doi: 10.1093/toxsci/kfr199. Epub 2011 Jul 27.

PMID:
21795629
26.

Functional analysis of conserved non-coding regions around the short stature hox gene (shox) in whole zebrafish embryos.

Kenyon EJ, McEwen GK, Callaway H, Elgar G.

PLoS One. 2011;6(6):e21498. doi: 10.1371/journal.pone.0021498. Epub 2011 Jun 24.

27.

Extrapolating the acute behavioral effects of toluene from 1- to 24-h exposures in rats: roles of dose metric and metabolic and behavioral tolerance.

Oshiro WM, Kenyon EM, Gordon CJ, Bishop B, Krantz QT, Ford J, Bushnell PJ.

Toxicol Sci. 2011 Sep;123(1):180-92. doi: 10.1093/toxsci/kfr162. Epub 2011 Jun 24.

PMID:
21705712
28.

Hearing sensitivity in older adults: associations with cardiovascular risk factors in the health, aging and body composition study.

Helzner EP, Patel AS, Pratt S, Sutton-Tyrrell K, Cauley JA, Talbott E, Kenyon E, Harris TB, Satterfield S, Ding J, Newman AB.

J Am Geriatr Soc. 2011 Jun;59(6):972-9. doi: 10.1111/j.1532-5415.2011.03444.x. Epub 2011 Jun 7.

29.

Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure.

Boellmann F, Zhang L, Clewell HJ, Schroth GP, Kenyon EM, Andersen ME, Thomas RS.

Toxicol Sci. 2010 Oct;117(2):404-17. doi: 10.1093/toxsci/kfq225. Epub 2010 Jul 28.

PMID:
20667999
30.

Aging and susceptibility to toluene in rats: a pharmacokinetic, biomarker, and physiological approach.

Gordon CJ, Gottipolu RR, Kenyon EM, Thomas R, Schladweiler MC, Mack CM, Shannahan JH, Wallenborn JG, Nyska A, MacPhail RC, Richards JE, Devito M, Kodavanti UP.

J Toxicol Environ Health A. 2010;73(4):301-18. doi: 10.1080/15287390903421144.

PMID:
20077299
31.

Neurobehavioral effects of acute exposure to four solvents: meta-analyses.

Benignus VA, Bushnell PJ, Boyes WK, Eklund C, Kenyon EM.

Toxicol Sci. 2009 Jun;109(2):296-305. doi: 10.1093/toxsci/kfp063. Epub 2009 Apr 1.

PMID:
19339666
32.

Acute perchloroethylene exposure alters rat visual-evoked potentials in relation to brain concentrations.

Boyes WK, Bercegeay M, Oshiro WM, Krantz QT, Kenyon EM, Bushnell PJ, Benignus VA.

Toxicol Sci. 2009 Mar;108(1):159-72. doi: 10.1093/toxsci/kfn265. Epub 2008 Dec 19.

PMID:
19098276
33.

Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water.

Kenyon EM, Hughes MF, Adair BM, Highfill JH, Crecelius EA, Clewell HJ, Yager JW.

Toxicol Appl Pharmacol. 2008 Nov 1;232(3):448-55. doi: 10.1016/j.taap.2008.07.018. Epub 2008 Jul 28.

PMID:
18706920
34.

How can biologically-based modeling of arsenic kinetics and dynamics inform the risk assessment process? - A workshop review.

Kenyon EM, Klimecki WT, El-Masri H, Conolly RB, Clewell HJ, Beck BD.

Toxicol Appl Pharmacol. 2008 Nov 1;232(3):359-68. doi: 10.1016/j.taap.2008.06.023. Epub 2008 Jul 15. Review.

PMID:
18687352
35.

A physiologically based pharmacokinetic model for intravenous and ingested dimethylarsinic acid in mice.

Evans MV, Dowd SM, Kenyon EM, Hughes MF, El-Masri HA.

Toxicol Sci. 2008 Aug;104(2):250-60. doi: 10.1093/toxsci/kfn080. Epub 2008 Apr 21.

PMID:
18430741
36.

Modeling the toxicokinetics of inhaled toluene in rats: influence of physical activity and feeding status.

Kenyon EM, Benignus V, Eklund C, Highfill JW, Oshiro WM, Samsam TE, Bushnell PJ.

J Toxicol Environ Health A. 2008;71(4):249-65. doi: 10.1080/15287390701528363.

PMID:
18253891
37.

Tissue dosimetry, metabolism and excretion of pentavalent and trivalent dimethylated arsenic in mice after oral administration.

Hughes MF, Devesa V, Adair BM, Conklin SD, Creed JT, Styblo M, Kenyon EM, Thomas DJ.

Toxicol Appl Pharmacol. 2008 Feb 15;227(1):26-35. Epub 2007 Oct 22.

38.

Development of a human physiologically based pharmacokinetic (PBPK) model for inorganic arsenic and its mono- and di-methylated metabolites.

El-Masri HA, Kenyon EM.

J Pharmacokinet Pharmacodyn. 2008 Feb;35(1):31-68. Epub 2007 Oct 18.

PMID:
17943421
39.

Quantitative comparisons of the acute neurotoxicity of toluene in rats and humans.

Benignus VA, Boyes WK, Kenyon EM, Bushnell PJ.

Toxicol Sci. 2007 Nov;100(1):146-55. Epub 2007 Aug 13.

PMID:
17698514
40.

Acute toluene exposure and rat visual function in proportion to momentary brain concentration.

Boyes WK, Bercegeay M, Krantz QT, Kenyon EM, Bale AS, Shafer TJ, Bushnell PJ, Benignus VA.

Toxicol Sci. 2007 Oct;99(2):572-81. Epub 2007 Jul 10.

PMID:
17623699
41.

A dosimetric analysis of the acute behavioral effects of inhaled toluene in rats.

Bushnell PJ, Oshiro WM, Samsam TE, Benignus VA, Krantz QT, Kenyon EM.

Toxicol Sci. 2007 Sep;99(1):181-9. Epub 2007 Jun 4.

PMID:
17548890
42.

Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report.

Clewell HJ, Thomas RS, Gentry PR, Crump KS, Kenyon EM, El-Masri HA, Yager JW.

Toxicol Appl Pharmacol. 2007 Aug 1;222(3):388-98. Epub 2007 Mar 30.

PMID:
17499324
43.

Macular pigment optical density in the elderly: findings in a large biracial Midsouth population sample.

Iannaccone A, Mura M, Gallaher KT, Johnson EJ, Todd WA, Kenyon E, Harris TL, Harris T, Satterfield S, Johnson KC, Kritchevsky SB.

Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1458-65.

44.

Research approaches to address uncertainties in the risk assessment of arsenic in drinking water.

Hughes MF, Kenyon EM, Kitchin KT.

Toxicol Appl Pharmacol. 2007 Aug 1;222(3):399-404. Epub 2007 Feb 9. Review.

PMID:
17379267
45.

Estimation of macular pigment optical density in the elderly: test-retest variability and effect of optical blur in pseudophakic subjects.

Gallaher KT, Mura M, Todd WA, Harris TL, Kenyon E, Harris T, Johnson KC, Satterfield S, Kritchevsky SB, Iannaccone A; Health ABC Study.

Vision Res. 2007 Apr;47(9):1253-9. Epub 2007 Mar 21.

46.

A General Physiological and Toxicokinetic (GPAT) Model for Simulating Complex Toluene Exposure Scenarios in Humans.

Benignus VA, Coleman T, Eklund CR, Kenyon EM.

Toxicol Mech Methods. 2006;16(1):27-36. doi: 10.1080/15376520500191862.

PMID:
20021038
47.

Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration.

Hughes MF, Devesa V, Adair BM, Styblo M, Kenyon EM, Thomas DJ.

Toxicol Appl Pharmacol. 2005 Oct 15;208(2):186-97.

48.
49.

An integrated pharmacokinetic and pharmacodynamic study of arsenite action 2. Heme oxygenase induction in mice.

Kenyon EM, Del Razo LM, Hughes MF, Kitchin KT.

Toxicology. 2005 Jan 31;206(3):389-401.

PMID:
15588929
50.

Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis.

Himmelstein MW, Carpenter SC, Evans MV, Hinderliter PM, Kenyon EM.

Toxicol Sci. 2004 May;79(1):28-37. Epub 2004 Feb 19.

PMID:
14976335

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