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Items: 1 to 50 of 72

1.

Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development.

Henssen AG, Kentsis A.

JCI Insight. 2018 Oct 18;3(20). pii: 123172. doi: 10.1172/jci.insight.123172. [Epub ahead of print] Review.

2.

ProteomeGenerator: A Framework for Comprehensive Proteomics Based on de Novo Transcriptome Assembly and High-Accuracy Peptide Mass Spectral Matching.

Cifani P, Dhabaria A, Chen Z, Yoshimi A, Kawaler E, Abdel-Wahab O, Poirier JT, Kentsis A.

J Proteome Res. 2018 Nov 2;17(11):3681-3692. doi: 10.1021/acs.jproteome.8b00295. Epub 2018 Oct 19.

PMID:
30295032
3.

Disabling an oncogenic transcription factor by targeting of control kinases.

Vakoc CR, Kentsis A.

Oncotarget. 2018 Aug 17;9(64):32276-32277. doi: 10.18632/oncotarget.25971. eCollection 2018 Aug 17. No abstract available.

4.

Analytical Validation of Clinical Whole-Genome and Transcriptome Sequencing of Patient-Derived Tumors for Reporting Targetable Variants in Cancer.

Wrzeszczynski KO, Felice V, Abhyankar A, Kozon L, Geiger H, Manaa D, London F, Robinson D, Fang X, Lin D, Lamendola-Essel MF, Khaira D, Dikoglu E, Emde AK, Robine N, Shah M, Arora K, Basturk O, Bhanot U, Kentsis A, Mansukhani MM, Bhagat G, Jobanputra V.

J Mol Diagn. 2018 Nov;20(6):822-835. doi: 10.1016/j.jmoldx.2018.06.007. Epub 2018 Aug 21.

5.

Germline SDHA mutations in children and adults with cancer.

Dubard Gault M, Mandelker D, DeLair D, Stewart CR, Kemel Y, Sheehan MR, Siegel B, Kennedy J, Marcell V, Arnold A, Al-Ahmadie H, Modak S, Robson M, Shukla N, Roberts S, Vijai J, Topka S, Kentsis A, Cadoo K, Carlo M, Latham Schwark A, Reznik E, Dinatale R, Hechtman J, Borras Flores E, Jairam S, Yang C, Li Y, Bayraktar EC, Ceyhan-Birsoy O, Zhang L, Kohlman W, Schiffman J, Stadler Z, Birsoy K, Kung A, Offit K, Walsh MF.

Cold Spring Harb Mol Case Stud. 2018 Aug 1;4(4). pii: a002584. doi: 10.1101/mcs.a002584. Print 2018 Aug.

6.

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.

Johnson DC, Taabazuing CY, Okondo MC, Chui AJ, Rao SD, Brown FC, Reed C, Peguero E, de Stanchina E, Kentsis A, Bachovchin DA.

Nat Med. 2018 Aug;24(8):1151-1156. doi: 10.1038/s41591-018-0082-y. Epub 2018 Jul 2.

PMID:
29967349
7.

A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.

Hoshii T, Cifani P, Feng Z, Huang CH, Koche R, Chen CW, Delaney CD, Lowe SW, Kentsis A, Armstrong SA.

Cell. 2018 Feb 22;172(5):1007-1021.e17. doi: 10.1016/j.cell.2018.01.032.

PMID:
29474905
8.

Acute myeloid/T-lymphoblastic leukaemia (AMTL): a distinct category of acute leukaemias with common pathogenesis in need of improved therapy.

Gutierrez A, Kentsis A.

Br J Haematol. 2018 Mar;180(6):919-924. doi: 10.1111/bjh.15129. Epub 2018 Feb 14.

PMID:
29441563
9.

MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia.

Brown FC, Still E, Koche RP, Yim CY, Takao S, Cifani P, Reed C, Gunasekera S, Ficarro SB, Romanienko P, Mark W, McCarthy C, de Stanchina E, Gonen M, Seshan V, Bhola P, O'Donnell C, Spitzer B, Stutzke C, Lavallée VP, Hébert J, Krivtsov AV, Melnick A, Paietta EM, Tallman MS, Letai A, Sauvageau G, Pouliot G, Levine R, Marto JA, Armstrong SA, Kentsis A.

Cancer Discov. 2018 Apr;8(4):478-497. doi: 10.1158/2159-8290.CD-17-1271. Epub 2018 Feb 5.

PMID:
29431698
10.

Peptidomimetic blockade of MYB in acute myeloid leukemia.

Ramaswamy K, Forbes L, Minuesa G, Gindin T, Brown F, Kharas MG, Krivtsov AV, Armstrong SA, Still E, de Stanchina E, Knoechel B, Koche R, Kentsis A.

Nat Commun. 2018 Jan 9;9(1):110. doi: 10.1038/s41467-017-02618-6.

11.

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.

Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A.

Sci Transl Med. 2017 Nov 1;9(414). pii: eaam9078. doi: 10.1126/scitranslmed.aam9078.

12.

Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors.

Henssen AG, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, Still E, MacArthur IC, Rodríguez-Fos E, Gonzalez S, Puiggròs M, Blackford AN, Mason CE, de Stanchina E, Gönen M, Emde AK, Shah M, Arora K, Reeves C, Socci ND, Perlman E, Antonescu CR, Roberts CWM, Steen H, Mullen E, Jackson SP, Torrents D, Weng Z, Armstrong SA, Kentsis A.

Nat Genet. 2017 Sep 27;49(10):1558. doi: 10.1038/ng1017-1558b. No abstract available.

PMID:
28951624
13.
14.

Germline BRCA2 mutations detected in pediatric sequencing studies impact parents' evaluation and care.

Walsh MF, Kennedy J, Harlan M, Kentsis A, Shukla N, Musinsky J, Roberts S, Kung AL, Robson M, Kushner BH, Meyers P, Offit K.

Cold Spring Harb Mol Case Stud. 2017 Nov 21;3(6). pii: a001925. doi: 10.1101/mcs.a001925. Print 2017 Nov.

15.

PGBD5 promotes site-specific oncogenic mutations in human tumors.

Henssen AG, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, Still E, MacArthur IC, Rodríguez-Fos E, Gonzalez S, Puiggròs M, Blackford AN, Mason CE, de Stanchina E, Gönen M, Emde AK, Shah M, Arora K, Reeves C, Socci ND, Perlman E, Antonescu CR, Roberts CWM, Steen H, Mullen E, Jackson SP, Torrents D, Weng Z, Armstrong SA, Kentsis A.

Nat Genet. 2017 Jul;49(7):1005-1014. doi: 10.1038/ng.3866. Epub 2017 May 15. Erratum in: Nat Genet. 2017 Sep 27;49(10 ):1558.

16.

ProteoModlR for functional proteomic analysis.

Cifani P, Shakiba M, Chhangawala S, Kentsis A.

BMC Bioinformatics. 2017 Mar 4;18(1):153. doi: 10.1186/s12859-017-1563-6.

17.

A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition.

Mathias MD, Ortiz MV, Magnan H, Ambati SR, Slotkin EK, Chou AJ, Walsh MF, Offit K, Moskowitz C, Kentsis A, Wexler LH.

Biomark Res. 2017 Feb 8;5:7. doi: 10.1186/s40364-017-0086-7. eCollection 2017.

18.

Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma.

Ortiz MV, Magnan H, Slotkin EK, Ambati SR, Chou AJ, Wexler LH, Meyers PA, Walsh MF, Heaton T, Girardi LN, Wolden SL, Price AP, Kennedy JA, Zehir A, Hameed M, Berger MF, Kentsis A, Shukla N.

J Pediatr Hematol Oncol. 2017 Nov;39(8):e443-e445. doi: 10.1097/MPH.0000000000000754.

19.

Erratum to: High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.

Laszlo GS, Alonzo TA, Gudgeon CJ, Harrington KH, Kentsis A, Gerbing RB, Wang YC, Ries RE, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB.

J Hematol Oncol. 2016 Nov 30;9(1):133. No abstract available.

20.

Towards comprehensive and quantitative proteomics for diagnosis and therapy of human disease.

Cifani P, Kentsis A.

Proteomics. 2017 Jan;17(1-2). doi: 10.1002/pmic.201600079. Epub 2016 Dec 21. Review.

21.

Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia.

Brown FC, Cifani P, Drill E, He J, Still E, Zhong S, Balasubramanian S, Pavlick D, Yilmazel B, Knapp KM, Alonzo TA, Meshinchi S, Stone RM, Kornblau SM, Marcucci G, Gamis AS, Byrd JC, Gonen M, Levine RL, Kentsis A.

Br J Haematol. 2017 Jan;176(1):86-91. doi: 10.1111/bjh.14413. Epub 2016 Oct 21.

22.

Forward genetic screen of human transposase genomic rearrangements.

Henssen AG, Jiang E, Zhuang J, Pinello L, Socci ND, Koche R, Gonen M, Villasante CM, Armstrong SA, Bauer DE, Weng Z, Kentsis A.

BMC Genomics. 2016 Aug 4;17:548. doi: 10.1186/s12864-016-2877-x.

23.

Osteosarcoma With Apparent Ewing Sarcoma Gene Rearrangement.

Mathias MD, Chou AJ, Meyers P, Shukla N, Hameed M, Agaram N, Wang L, Berger MF, Walsh M, Kentsis A.

J Pediatr Hematol Oncol. 2016 Jul;38(5):e166-8. doi: 10.1097/MPH.0000000000000553.

24.

Integrating Genomics Into Clinical Pediatric Oncology Using the Molecular Tumor Board at the Memorial Sloan Kettering Cancer Center.

Ortiz MV, Kobos R, Walsh M, Slotkin EK, Roberts S, Berger MF, Hameed M, Solit D, Ladanyi M, Shukla N, Kentsis A.

Pediatr Blood Cancer. 2016 Aug;63(8):1368-74. doi: 10.1002/pbc.26002. Epub 2016 Apr 15.

25.

Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius.

Rosenfeld JA, Reeves D, Brugler MR, Narechania A, Simon S, Durrett R, Foox J, Shianna K, Schatz MC, Gandara J, Afshinnekoo E, Lam ET, Hastie AR, Chan S, Cao H, Saghbini M, Kentsis A, Planet PJ, Kholodovych V, Tessler M, Baker R, DeSalle R, Sorkin LN, Kolokotronis SO, Siddall ME, Amato G, Mason CE.

Nat Commun. 2016 Feb 2;7:10164. doi: 10.1038/ncomms10164.

26.

Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization.

Sabath DE, Bender MA, Sankaran VG, Vamos E, Kentsis A, Yi HS, Greisman HA.

J Mol Diagn. 2016 Jan;18(1):92-9. doi: 10.1016/j.jmoldx.2015.07.011. Epub 2015 Nov 21.

27.

High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.

Laszlo GS, Alonzo TA, Gudgeon CJ, Harrington KH, Kentsis A, Gerbing RB, Wang YC, Ries RE, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB.

J Hematol Oncol. 2015 Oct 20;8:115. doi: 10.1186/s13045-015-0215-4. Erratum in: J Hematol Oncol. 2016 Nov 30;9(1):133.

28.

Advancing Urinary Protein Biomarker Discovery by Data-Independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer.

Muntel J, Xuan Y, Berger ST, Reiter L, Bachur R, Kentsis A, Steen H.

J Proteome Res. 2015 Nov 6;14(11):4752-62. doi: 10.1021/acs.jproteome.5b00826. Epub 2015 Oct 22.

29.

Genomic DNA transposition induced by human PGBD5.

Henssen AG, Henaff E, Jiang E, Eisenberg AR, Carson JR, Villasante CM, Ray M, Still E, Burns M, Gandara J, Feschotte C, Mason CE, Kentsis A.

Elife. 2015 Sep 25;4. pii: e10565. doi: 10.7554/eLife.10565.

30.

MStern Blotting-High Throughput Polyvinylidene Fluoride (PVDF) Membrane-Based Proteomic Sample Preparation for 96-Well Plates.

Berger ST, Ahmed S, Muntel J, Cuevas Polo N, Bachur R, Kentsis A, Steen J, Steen H.

Mol Cell Proteomics. 2015 Oct;14(10):2814-23. doi: 10.1074/mcp.O115.049650. Epub 2015 Jul 29.

31.

Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice.

Etchin J, Montero J, Berezovskaya A, Le BT, Kentsis A, Christie AL, Conway AS, Chen WC, Reed C, Mansour MR, Ng CE, Adamia S, Rodig SJ, Galinsky IA, Stone RM, Klebanov B, Landesman Y, Kauffman M, Shacham S, Kung AL, Wang JC, Letai A, Look AT.

Leukemia. 2016 Jan;30(1):190-9. doi: 10.1038/leu.2015.194. Epub 2015 Jul 23.

32.

A High-Efficiency Cellular Extraction System for Biological Proteomics.

Dhabaria A, Cifani P, Reed C, Steen H, Kentsis A.

J Proteome Res. 2015 Aug 7;14(8):3403-8. doi: 10.1021/acs.jproteome.5b00547. Epub 2015 Jul 14.

33.

Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia.

Ramaswamy K, Spitzer B, Kentsis A.

Front Oncol. 2015 Feb 2;5:16. doi: 10.3389/fonc.2015.00016. eCollection 2015. Review.

34.

Biological properties of ligand-dependent activation of the MET receptor kinase in acute myeloid leukemia.

McGee SF, Kornblau SM, Qiu Y, Look AT, Zhang N, Yoo SY, Coombes KR, Kentsis A.

Leukemia. 2015 May;29(5):1218-21. doi: 10.1038/leu.2014.348. Epub 2014 Dec 26. No abstract available.

35.

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.

Mansour MR, Reed C, Eisenberg AR, Tseng JC, Twizere JC, Daakour S, Yoda A, Rodig SJ, Tal N, Shochat C, Berezovskaya A, DeAngelo DJ, Sallan SE, Weinstock DM, Izraeli S, Kung AL, Kentsis A, Look AT.

Br J Haematol. 2015 Jan;168(2):230-8. doi: 10.1111/bjh.13115. Epub 2014 Sep 26.

36.

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

Gutierrez A, Pan L, Groen RW, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, Burbank J, Norton S, Tolliday N, Steen H, Weng AP, Yuan H, Bradner JE, Mitsiades C, Look AT, Aster JC.

J Clin Invest. 2014 Feb;124(2):644-55. doi: 10.1172/JCI65093. Epub 2014 Jan 9.

37.

Colorimetric and longitudinal analysis of leukocoria in recreational photographs of children with retinoblastoma.

Abdolvahabi A, Taylor BW, Holden RL, Shaw EV, Kentsis A, Rodriguez-Galindo C, Mukai S, Shaw BF.

PLoS One. 2013 Oct 30;8(10):e76677. doi: 10.1371/journal.pone.0076677. eCollection 2013.

38.

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

Etchin J, Sanda T, Mansour MR, Kentsis A, Montero J, Le BT, Christie AL, McCauley D, Rodig SJ, Kauffman M, Shacham S, Stone R, Letai A, Kung AL, Thomas Look A.

Br J Haematol. 2013 Apr;161(1):117-27. doi: 10.1111/bjh.12231. Epub 2013 Feb 4.

39.

Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease.

Kentsis A, Shulman A, Ahmed S, Brennan E, Monuteaux MC, Lee YH, Lipsett S, Paulo JA, Dedeoglu F, Fuhlbrigge R, Bachur R, Bradwin G, Arditi M, Sundel RP, Newburger JW, Steen H, Kim S.

EMBO Mol Med. 2013 Feb;5(2):210-20. doi: 10.1002/emmm.201201494. Epub 2012 Dec 20.

40.

Distinct and dynamic requirements for mTOR signaling in hematopoiesis and leukemogenesis.

Kentsis A, Look AT.

Cell Stem Cell. 2012 Sep 7;11(3):281-2. doi: 10.1016/j.stem.2012.08.007.

41.

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.

Etchin J, Sun Q, Kentsis A, Farmer A, Zhang ZC, Sanda T, Mansour MR, Barcelo C, McCauley D, Kauffman M, Shacham S, Christie AL, Kung AL, Rodig SJ, Chook YM, Look AT.

Leukemia. 2013 Jan;27(1):66-74. doi: 10.1038/leu.2012.219. Epub 2012 Jul 31.

42.

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.

Kentsis A, Reed C, Rice KL, Sanda T, Rodig SJ, Tholouli E, Christie A, Valk PJ, Delwel R, Ngo V, Kutok JL, Dahlberg SE, Moreau LA, Byers RJ, Christensen JG, Vande Woude G, Licht JD, Kung AL, Staudt LM, Look AT.

Nat Med. 2012 Jul;18(7):1118-22. doi: 10.1038/nm.2819.

43.

Detection and diagnostic value of urine leucine-rich α-2-glycoprotein in children with suspected acute appendicitis.

Kentsis A, Ahmed S, Kurek K, Brennan E, Bradwin G, Steen H, Bachur R.

Ann Emerg Med. 2012 Jul;60(1):78-83.e1. doi: 10.1016/j.annemergmed.2011.12.015. Epub 2012 Feb 2.

44.

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.

Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT.

Blood. 2011 Oct 13;118(15):4169-73. doi: 10.1182/blood-2010-11-318873. Epub 2011 Aug 30.

45.

Challenges and opportunities for discovery of disease biomarkers using urine proteomics.

Kentsis A.

Pediatr Int. 2011 Feb;53(1):1-6. doi: 10.1111/j.1442-200X.2010.03253.x.

46.

Venous thrombosis associated with gene deletion of tissue factor pathway inhibitor.

Kentsis A, Bradwin G, Miller DT, Trenor CC 3rd.

Am J Hematol. 2009 Nov;84(11):775-6. doi: 10.1002/ajh.21542. No abstract available.

47.

Urine proteomics for profiling of human disease using high accuracy mass spectrometry.

Kentsis A, Monigatti F, Dorff K, Campagne F, Bachur R, Steen H.

Proteomics Clin Appl. 2009 Sep 1;3(9):1052-1061.

48.

Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry.

Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur R.

Ann Emerg Med. 2010 Jan;55(1):62-70.e4. doi: 10.1016/j.annemergmed.2009.04.020. Epub 2009 Jun 25.

49.

Discordant haemophilia A in male siblings due to a de novo mutation on a familial missense mutant allele.

Kentsis A, Anewalt R, Ganguly A, Allen JB, Neufeld EJ.

Haemophilia. 2009 Jul;15(4):971-2. doi: 10.1111/j.1365-2516.2009.02035.x. Epub 2009 Apr 27. No abstract available.

50.

Calculation of the free energy and cooperativity of protein folding.

Kentsis A, Gindin T, Mezei M, Osman R.

PLoS One. 2007 May 16;2(5):e446.

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