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Items: 1 to 50 of 62

1.

Role of the highly conserved threonine in cytochrome P450 2E1: prevention of H2O2-induced inactivation during electron transfer.

Yoshigae Y, Kent UM, Hollenberg PF.

Biochemistry. 2013 Jul 9;52(27):4636-47. doi: 10.1021/bi4004843. Epub 2013 Jun 28.

2.

The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation.

Yoshigae Y, Sridar C, Kent UM, Hollenberg PF.

Drug Metab Dispos. 2013 Apr;41(4):858-69. doi: 10.1124/dmd.112.050609. Epub 2013 Jan 31.

3.

Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling.

Shebley M, Kent UM, Ballou DP, Hollenberg PF.

Drug Metab Dispos. 2009 Apr;37(4):745-52. doi: 10.1124/dmd.108.024661. Epub 2009 Jan 14.

4.

Modification of serine 360 by a reactive intermediate of 17-alpha-ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6.

Kent UM, Sridar C, Spahlinger G, Hollenberg PF.

Chem Res Toxicol. 2008 Oct;21(10):1956-63. doi: 10.1021/tx800138v. Epub 2008 Aug 26.

5.

Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether.

Sridar C, Kent UM, Noon K, McCall A, Alworth B, Foroozesh M, Hollenberg PF.

Drug Metab Dispos. 2008 Nov;36(11):2234-43. doi: 10.1124/dmd.108.021493. Epub 2008 Jul 24.

6.

Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications.

Hollenberg PF, Kent UM, Bumpus NN.

Chem Res Toxicol. 2008 Jan;21(1):189-205. Epub 2007 Dec 4. Review.

PMID:
18052110
7.

Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides.

Snider NT, Kornilov AM, Kent UM, Hollenberg PF.

J Pharmacol Exp Ther. 2007 May;321(2):590-7. Epub 2007 Feb 1.

PMID:
17272674
8.

Structure-activity relationship and elucidation of the determinant factor(s) responsible for the mechanism-based inactivation of cytochrome P450 2B6 by substituted phenyl diaziridines.

Kobayashi Y, Sridar C, Kent UM, Puppali SG, Rimoldi JM, Zhang H, Waskell L, Hollenberg PF.

Drug Metab Dispos. 2006 Dec;34(12):2102-10. Epub 2006 Sep 22.

PMID:
16997911
9.

Synthesis of substituted phenyl diaziridines and characterization as mechanism-based inactivators of human cytochrome P450 2B6.

Sridar C, Kobayashi Y, Brevig H, Kent UM, Puppali SG, Rimoldi JM, Hollenberg PF.

Drug Metab Dispos. 2006 Nov;34(11):1849-55. Epub 2006 Aug 1.

PMID:
16882766
10.

Metabolism of bergamottin by cytochromes P450 2B6 and 3A5.

Kent UM, Lin HL, Noon KR, Harris DL, Hollenberg PF.

J Pharmacol Exp Ther. 2006 Sep;318(3):992-1005. Epub 2006 Jun 19.

PMID:
16785317
11.

Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms.

Bumpus NN, Kent UM, Hollenberg PF.

J Pharmacol Exp Ther. 2006 Jul;318(1):345-51. Epub 2006 Apr 12.

PMID:
16611850
13.

The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation.

Bumpus NN, Sridar C, Kent UM, Hollenberg PF.

Drug Metab Dispos. 2005 Jun;33(6):795-802. Epub 2005 Mar 15.

PMID:
15769884
15.

Formation of a novel reversible cytochrome P450 spectral intermediate: role of threonine 303 in P450 2E1 inactivation.

Blobaum AL, Lu Y, Kent UM, Wang S, Hollenberg PF.

Biochemistry. 2004 Sep 28;43(38):11942-52.

PMID:
15379534
16.

The functional role of threonine-205 in the mechanism-based inactivation of P450 2B1 by two ethynyl substrates: the importance of the F helix in catalysis.

Lin HL, Kent UM, Zhang H, Waskell L, Hollenberg PF.

J Pharmacol Exp Ther. 2004 Dec;311(3):855-63. Epub 2004 Aug 9.

PMID:
15302894
17.

Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.

Sridar C, Goosen TC, Kent UM, Williams JA, Hollenberg PF.

Drug Metab Dispos. 2004 Jun;32(6):587-94.

PMID:
15155549
18.

Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms.

Harleton E, Webster M, Bumpus NN, Kent UM, Rae JM, Hollenberg PF.

J Pharmacol Exp Ther. 2004 Sep;310(3):1011-9. Epub 2004 Apr 30.

PMID:
15121764
19.
20.

Novel reversible inactivation of cytochrome P450 2E1 T303A by tert-butyl acetylene: the role of threonine 303 in proton delivery to the active site of cytochrome P450 2E1.

Blobaum AL, Kent UM, Alworth WL, Hollenberg PF.

J Pharmacol Exp Ther. 2004 Jul;310(1):281-90. Epub 2004 Feb 26.

PMID:
14988423
21.

Mutation of tyrosine 190 to alanine eliminates the inactivation of cytochrome P450 2B1 by peroxynitrite.

Lin HL, Kent UM, Zhang H, Waskell L, Hollenberg PF.

Chem Res Toxicol. 2003 Feb;16(2):129-36.

PMID:
12588183
22.

The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine.

Jushchyshyn MI, Kent UM, Hollenberg PF.

Drug Metab Dispos. 2003 Jan;31(1):46-52.

PMID:
12485952
23.
24.

Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo.

Vuletich JL, Lowe ER, Jianmongkol S, Kamada Y, Kent UM, Bender AT, Demady DR, Hollenberg PF, Osawa Y.

Mol Pharmacol. 2002 Jul;62(1):110-8.

PMID:
12065761
25.

Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6.

Sridar C, Kent UM, Notley LM, Gillam EM, Hollenberg PF.

J Pharmacol Exp Ther. 2002 Jun;301(3):945-52.

PMID:
12023523
26.

The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9.

Kent UM, Aviram M, Rosenblat M, Hollenberg PF.

Drug Metab Dispos. 2002 Jun;30(6):709-15.

PMID:
12019199
27.
28.
29.

Mechanism-based inactivators as probes of cytochrome P450 structure and function.

Kent UM, Juschyshyn MI, Hollenberg PF.

Curr Drug Metab. 2001 Sep;2(3):215-43. Review.

PMID:
11513328
30.

Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A.

Moreno RL, Goosen T, Kent UM, Chung FL, Hollenberg PF.

Arch Biochem Biophys. 2001 Jul 1;391(1):99-110.

PMID:
11414690
31.

Spectral studies of tert-butyl isothiocyanate-inactivated P450 2E1.

Kent UM, Roberts-Kirchhoff ES, Moon N, Dunham WR, Hollenberg PF.

Biochemistry. 2001 Jun 19;40(24):7253-61.

PMID:
11401573
32.

Inactivation of cytochrome P450 2B1 by benzyl isothiocyanate, a chemopreventative agent from cruciferous vegetables.

Goosen TC, Kent UM, Brand L, Hollenberg PF.

Chem Res Toxicol. 2000 Dec;13(12):1349-59.

PMID:
11123978
33.

Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane.

Chun J, Kent UM, Moss RM, Sayre LM, Hollenberg PF.

Drug Metab Dispos. 2000 Aug;28(8):905-11.

PMID:
10901699
34.

Mechanistic studies of cytochrome P450 2B1 inactivation by xanthates.

Yanev SG, Kent UM, Roberts ES, Ballou DP, Hollenberg PF.

Arch Biochem Biophys. 2000 Jun 1;378(1):157-66.

PMID:
10871056
35.

Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynylcoumarin: verification of apo-P450 adduction by electrospray ion trap mass spectrometry.

Regal KA, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF.

Chem Res Toxicol. 2000 Apr;13(4):262-70.

PMID:
10775326
36.

Inactivation of cytochrome P450 2E1 by benzyl isothiocyanate.

Moreno RL, Kent UM, Hodge K, Hollenberg PF.

Chem Res Toxicol. 1999 Jul;12(7):582-7.

PMID:
10409397
37.

Selective mechanism-based inactivation of cytochromes P-450 2B1 and P-450 2B6 by a series of xanthates.

Yanev S, Kent UM, Pandova B, Hollenberg PF.

Drug Metab Dispos. 1999 May;27(5):600-4.

PMID:
10220489
38.

Microsomal cytochromes P450 catalyze the oxidation of low density lipoprotein.

Aviram M, Kent UM, Hollenberg PF.

Atherosclerosis. 1999 Apr;143(2):253-60.

PMID:
10217353
39.

Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by n-propylxanthate.

Kent UM, Yanev S, Hollenberg PF.

Chem Res Toxicol. 1999 Apr;12(4):317-22.

PMID:
10207119
40.

Purification of antibodies using protein A-sepharose and FPLC.

Kent UM.

Methods Mol Biol. 1999;115:29-33. Review. No abstract available.

PMID:
10098162
41.

Purification of antibodies using affinity chromatography.

Kent UM.

Methods Mol Biol. 1999;115:23-8. Review. No abstract available.

PMID:
10098161
42.

Purification of antibodies using ion-exchange chromatography.

Kent UM.

Methods Mol Biol. 1999;115:19-22. Review. No abstract available.

PMID:
10098160
43.

Purification of antibodies using ammonium sulfate fractionation or gel filtration.

Kent UM.

Methods Mol Biol. 1999;115:11-8. Review. No abstract available.

PMID:
10098159
44.

Overview of antibody use in immunocytochemistry.

Mao SY, Javois LC, Kent UM.

Methods Mol Biol. 1999;115:3-10. No abstract available.

PMID:
10098158
45.

Inactivation of cytochrome P450 2E1 by tert-butylisothiocyanate.

Kent UM, Roberts ES, Chun J, Hodge K, Juncaj J, Hollenberg PF.

Chem Res Toxicol. 1998 Oct;11(10):1154-61.

PMID:
9778311
46.

Exploiting the difference between intrinsic and extrinsic kinases: implications for regulation of signaling by immunoreceptors.

Wofsy C, Torigoe C, Kent UM, Metzger H, Goldstein B.

J Immunol. 1997 Dec 15;159(12):5984-92.

PMID:
9550396
47.

Significance of glycine 478 in the metabolism of N-benzyl-1-aminobenzotriazole to reactive intermediates by cytochrome P450 2B1.

Kent UM, Hanna IH, Szklarz GD, Vaz AD, Halpert JR, Bend JR, Hollenberg PF.

Biochemistry. 1997 Sep 30;36(39):11707-16.

PMID:
9305960
48.

Mechanism-based inactivation of cytochrome P450 2B1 by N-benzyl-1-aminobenzotriazole.

Kent UM, Bend JR, Chamberlin BA, Gage DA, Hollenberg PF.

Chem Res Toxicol. 1997 May;10(5):600-8.

PMID:
9168259
49.

Metabolic inactivation of cytochrome P4502B1 by phencyclidine: immunochemical and radiochemical analyses of the protective effects of glutathione.

Sharma U, Roberts ES, Kent UM, Owens SM, Hollenberg PF.

Drug Metab Dispos. 1997 Feb;25(2):243-50.

PMID:
9029055
50.

Kinetics of tyrosine phosphorylation when IgE dimers bind to FC epsilon receptors on rat basophilic leukemia cells.

Wofsy C, Kent UM, Mao SY, Metzger H, Goldstein B.

J Biol Chem. 1995 Sep 1;270(35):20264-72. Erratum in: J Biol Chem 1995 Dec 29;270(52):31414.

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