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Items: 1 to 50 of 207

1.

Novel protein science enabled by total chemical synthesis.

Kent SBH.

Protein Sci. 2019 Feb;28(2):313-328. doi: 10.1002/pro.3533. Epub 2018 Dec 18. Review.

PMID:
30345579
2.

Racemic & quasi-racemic protein crystallography enabled by chemical protein synthesis.

Kent SB.

Curr Opin Chem Biol. 2018 Oct;46:1-9. doi: 10.1016/j.cbpa.2018.03.012. Epub 2018 Apr 5. Review.

PMID:
29626784
3.

Reinvestigation of the biological activity of d-allo-ShK protein.

Dang B, Chhabra S, Pennington MW, Norton RS, Kent SBH.

J Biol Chem. 2017 Jul 28;292(30):12599-12605. doi: 10.1074/jbc.M117.793943. Epub 2017 Jun 8.

4.

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.

Kubota T, Durek T, Dang B, Finol-Urdaneta RK, Craik DJ, Kent SB, French RJ, Bezanilla F, Correa AM.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1857-E1865. doi: 10.1073/pnas.1700453114. Epub 2017 Feb 15.

5.

Inversion of the Side-Chain Stereochemistry of Indvidual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin.

Dang B, Shen R, Kubota T, Mandal K, Bezanilla F, Roux B, Kent SB.

Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3324-3328. doi: 10.1002/anie.201612398. Epub 2017 Feb 14.

6.

Perplexing cooperative folding and stability of a low-sequence complexity, polyproline 2 protein lacking a hydrophobic core.

Gates ZP, Baxa MC, Yu W, Riback JA, Li H, Roux B, Kent SB, Sosnick TR.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2241-2246. doi: 10.1073/pnas.1609579114. Epub 2017 Feb 13.

7.

Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin.

Dhayalan B, Mandal K, Rege N, Weiss MA, Eitel SH, Meier T, Schoenleber RO, Kent SB.

Chemistry. 2017 Jan 31;23(7):1709-1716. doi: 10.1002/chem.201605578. Epub 2017 Jan 10.

8.

Obviation of hydrogen fluoride in Boc chemistry solid phase peptide synthesis of peptide-αthioesters.

Gates ZP, Dhayalan B, Kent SB.

Chem Commun (Camb). 2016 Nov 29;52(97):13979-13982.

PMID:
27847960
9.

Chemical synthesis and enzymatic properties of RNase A analogues designed to enhance second-step catalytic activity.

Boerema DJ, Tereshko VA, Zhang J, Kent SB.

Org Biomol Chem. 2016 Sep 21;14(37):8804-8814.

PMID:
27714155
10.

Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin.

Dang B, Kubota T, Mandal K, Correa AM, Bezanilla F, Kent SB.

Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8639-42. doi: 10.1002/anie.201603420. Epub 2016 May 31.

11.

β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel.

Castillo JP, Sánchez-Rodríguez JE, Hyde HC, Zaelzer CA, Aguayo D, Sepúlveda RV, Luk LY, Kent SB, Gonzalez-Nilo FD, Bezanilla F, Latorre R.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3231-9. doi: 10.1073/pnas.1606381113. Epub 2016 May 23.

12.

A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.

Uppalapati M, Lee DJ, Mandal K, Li H, Miranda LP, Lowitz J, Kenney J, Adams JJ, Ault-Riché D, Kent SB, Sidhu SS.

ACS Chem Biol. 2016 Apr 15;11(4):1058-65. doi: 10.1021/acschembio.5b01006. Epub 2016 Feb 3.

PMID:
26745345
13.

Efficient Total Chemical Synthesis of (13) C=(18) O Isotopomers of Human Insulin for Isotope-Edited FTIR.

Dhayalan B, Fitzpatrick A, Mandal K, Whittaker J, Weiss MA, Tokmakoff A, Kent SB.

Chembiochem. 2016 Mar 2;17(5):415-20. doi: 10.1002/cbic.201500601. Epub 2016 Feb 16.

14.

Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin.

Mandal K, Dhayalan B, Avital-Shmilovici M, Tokmakoff A, Kent SB.

Chembiochem. 2016 Mar 2;17(5):421-5. doi: 10.1002/cbic.201500600. Epub 2016 Feb 10.

PMID:
26707939
15.

Enhanced Solvation of Peptides Attached to "Solid-Phase" Resins: Straightforward Syntheses of the Elastin Sequence Pro-Gly-Val-Gly-Val-Pro-Gly-Val-Gly-Val.

Dang B, Dhayalan B, Kent SB.

Org Lett. 2015 Jul 17;17(14):3521-3. doi: 10.1021/acs.orglett.5b01632. Epub 2015 Jun 25.

PMID:
26110966
16.

Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.

Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2979. doi: 10.1073/pnas.1507812112. Epub 2015 May 8. No abstract available.

17.

A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography.

Bunker RD, Mandal K, Bashiri G, Chaston JJ, Pentelute BL, Lott JS, Kent SB, Baker EN.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4310-5. doi: 10.1073/pnas.1422387112. Epub 2015 Mar 23.

18.

Photosensitivity of neurons enabled by cell-targeted gold nanoparticles.

Carvalho-de-Souza JL, Treger JS, Dang B, Kent SB, Pepperberg DR, Bezanilla F.

Neuron. 2015 Apr 8;86(1):207-17. doi: 10.1016/j.neuron.2015.02.033. Epub 2015 Mar 12.

19.

The critical role of peptide chemistry in the life sciences.

Kent SB.

J Pept Sci. 2015 Mar;21(3):136-8. doi: 10.1002/psc.2754. Epub 2015 Feb 3.

PMID:
25643657
20.

Editorial overview: synthetic biomolecules.

Kent SB, Alewood PF.

Curr Opin Chem Biol. 2014 Oct;22:viii-xi. doi: 10.1016/j.cbpa.2014.09.037. Epub 2014 Oct 16. No abstract available.

PMID:
25438804
21.

Deciphering a molecular mechanism of neonatal diabetes mellitus by the chemical synthesis of a protein diastereomer, [D-AlaB8]human proinsulin.

Avital-Shmilovici M, Whittaker J, Weiss MA, Kent SB.

J Biol Chem. 2014 Aug 22;289(34):23683-92. doi: 10.1074/jbc.M114.572040. Epub 2014 Jul 7.

22.

Total chemical synthesis of biologically active fluorescent dye-labeled Ts1 toxin.

Dang B, Kubota T, Correa AM, Bezanilla F, Kent SB.

Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8970-4. doi: 10.1002/anie.201404438. Epub 2014 Jul 2.

23.

(Quasi-)racemic X-ray structures of glycosylated and non-glycosylated forms of the chemokine Ser-CCL1 prepared by total chemical synthesis.

Okamoto R, Mandal K, Sawaya MR, Kajihara Y, Yeates TO, Kent SB.

Angew Chem Int Ed Engl. 2014 May 12;53(20):5194-8. doi: 10.1002/anie.201400679. Epub 2014 Apr 1.

PMID:
24692304
24.

Total chemical synthesis of the enzyme sortase A(ΔN59) with full catalytic activity.

Deng FK, Zhang L, Wang YT, Schneewind O, Kent SB.

Angew Chem Int Ed Engl. 2014 Apr 25;53(18):4662-6. doi: 10.1002/anie.201310900. Epub 2014 Mar 25.

PMID:
24668498
25.

Total chemical synthesis and biological activities of glycosylated and non-glycosylated forms of the chemokines CCL1 and Ser-CCL1.

Okamoto R, Mandal K, Ling M, Luster AD, Kajihara Y, Kent SB.

Angew Chem Int Ed Engl. 2014 May 12;53(20):5188-93. doi: 10.1002/anie.201310574. Epub 2014 Mar 18.

PMID:
24644239
26.

Total Chemical Synthesis of an Orf Virus Protein, ORFV002, an Inhibitor of the Master Gene Regulator NF-κB.

Son SJ, Harris PW, Squire CJ, Baker EN, Kent SB, Brimble MA.

Biopolymers. 2014 Mar;102(2):137-44.

PMID:
26820014
27.

Bringing the science of proteins into the realm of organic chemistry: total chemical synthesis of SEP (synthetic erythropoiesis protein).

Kent SB.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):11988-96. doi: 10.1002/anie.201304116. Epub 2013 Oct 11.

PMID:
24127351
28.

Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high-resolution X-ray structure of ShK toxin by racemic protein crystallography.

Dang B, Kubota T, Mandal K, Bezanilla F, Kent SB.

J Am Chem Soc. 2013 Aug 14;135(32):11911-9. doi: 10.1021/ja4046795. Epub 2013 Aug 6.

29.

Total chemical synthesis of fully functional Photoactive Yellow Protein.

Gordon WR, Bang D, Hoff WD, Kent SB.

Bioorg Med Chem. 2013 Jun 15;21(12):3436-42. doi: 10.1016/j.bmc.2013.03.025. Epub 2013 Mar 27.

PMID:
23602622
30.

Fully convergent chemical synthesis of ester insulin: determination of the high resolution X-ray structure by racemic protein crystallography.

Avital-Shmilovici M, Mandal K, Gates ZP, Phillips NB, Weiss MA, Kent SB.

J Am Chem Soc. 2013 Feb 27;135(8):3173-85. doi: 10.1021/ja311408y. Epub 2013 Feb 8.

31.

Rapid formal hydrolysis of peptide-αthioesters.

Gates ZP, Stephan JR, Lee DJ, Kent SB.

Chem Commun (Camb). 2013 Jan 28;49(8):786-8. doi: 10.1039/c2cc38229f.

PMID:
23233036
32.

Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.

Mandal K, Uppalapati M, Ault-Riché D, Kenney J, Lowitz J, Sidhu SS, Kent SB.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14779-84. doi: 10.1073/pnas.1210483109. Epub 2012 Aug 27.

33.
34.

Racemic protein crystallography.

Yeates TO, Kent SB.

Annu Rev Biophys. 2012;41:41-61. doi: 10.1146/annurev-biophys-050511-102333. Epub 2012 Mar 14. Review.

PMID:
22443988
35.

Design, total chemical synthesis, and X-ray structure of a protein having a novel linear-loop polypeptide chain topology.

Mandal K, Pentelute BL, Bang D, Gates ZP, Torbeev VY, Kent SB.

Angew Chem Int Ed Engl. 2012 Feb 6;51(6):1481-6. doi: 10.1002/anie.201107846. Epub 2011 Dec 30. No abstract available.

PMID:
22213444
36.

Single-wavelength phasing strategy for quasi-racemic protein crystal diffraction data.

Sawaya MR, Pentelute BL, Kent SB, Yeates TO.

Acta Crystallogr D Biol Crystallogr. 2012 Jan;68(Pt 1):62-8. doi: 10.1107/S0907444911049985. Epub 2011 Dec 9.

PMID:
22194334
37.

Convergent chemical synthesis of [lysine(24,38,83)] human erythropoietin.

Liu S, Pentelute BL, Kent SB.

Angew Chem Int Ed Engl. 2012 Jan 23;51(4):993-9. doi: 10.1002/anie.201106060. Epub 2011 Dec 16. No abstract available.

38.

Protein conformational dynamics in the mechanism of HIV-1 protease catalysis.

Torbeev VY, Raghuraman H, Hamelberg D, Tonelli M, Westler WM, Perozo E, Kent SB.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20982-7. doi: 10.1073/pnas.1111202108. Epub 2011 Dec 8.

39.

Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds.

de Araujo AD, Christensen C, Buchardt J, Kent SB, Alewood PF.

Chemistry. 2011 Dec 9;17(50):13983-6. doi: 10.1002/chem.201102732. Epub 2011 Nov 14. No abstract available.

PMID:
22084036
40.

Total chemical synthesis of biologically active vascular endothelial growth factor.

Mandal K, Kent SB.

Angew Chem Int Ed Engl. 2011 Aug 22;50(35):8029-33. doi: 10.1002/anie.201103237. Epub 2011 Jul 8.

41.

An investigation into the origin of the dramatically reduced reactivity of peptide-prolyl-thioesters in native chemical ligation.

Pollock SB, Kent SB.

Chem Commun (Camb). 2011 Feb 28;47(8):2342-4. doi: 10.1039/c0cc04120c. Epub 2010 Dec 21.

PMID:
21173985
42.

Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography.

Pentelute BL, Mandal K, Gates ZP, Sawaya MR, Yeates TO, Kent SB.

Chem Commun (Camb). 2010 Nov 21;46(43):8174-6. doi: 10.1039/c0cc03148h. Epub 2010 Sep 28.

PMID:
20877851
43.

Total chemical synthesis of human proinsulin.

Luisier S, Avital-Shmilovici M, Weiss MA, Kent SB.

Chem Commun (Camb). 2010 Nov 21;46(43):8177-9. doi: 10.1039/c0cc03141k. Epub 2010 Sep 28.

44.

Chemical protein synthesis.

Alewood P, Engelhard M, Kent SB.

J Pept Sci. 2010 Oct;16(10):513. doi: 10.1002/psc.1291. No abstract available.

PMID:
20862718
45.

Synthesis and comparative properties of two amide-generating resin linkers for use in solid phase peptide synthesis.

Deng FK, Mandal K, Luisier S, Kent SB.

J Pept Sci. 2010 Oct;16(10):545-50. doi: 10.1002/psc.1279.

PMID:
20824627
46.

Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography.

Banigan JR, Mandal K, Sawaya MR, Thammavongsa V, Hendrickx AP, Schneewind O, Yeates TO, Kent SB.

Protein Sci. 2010 Oct;19(10):1840-9. doi: 10.1002/pro.468.

47.

Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulin.

Sohma Y, Hua QX, Whittaker J, Weiss MA, Kent SB.

Angew Chem Int Ed Engl. 2010 Jul 26;49(32):5489-93. doi: 10.1002/anie.201001151. No abstract available.

48.

A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor.

Pentelute BL, Barker AP, Janowiak BE, Kent SB, Collier RJ.

ACS Chem Biol. 2010 Apr 16;5(4):359-64. doi: 10.1021/cb100003r.

49.

Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.

Sohma Y, Hua QX, Liu M, Phillips NB, Hu SQ, Whittaker J, Whittaker LJ, Ng A, Roberts CT Jr, Arvan P, Kent SB, Weiss MA.

J Biol Chem. 2010 Feb 12;285(7):5040-55. doi: 10.1074/jbc.M109.062992. Epub 2009 Dec 3.

50.

A one-pot approach to neoglycopeptides using orthogonal native chemical ligation and click chemistry.

Lee DJ, Mandal K, Harris PW, Brimble MA, Kent SB.

Org Lett. 2009 Nov 19;11(22):5270-3. doi: 10.1021/ol902131n.

PMID:
19842689

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