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Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction.

Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal J, Kensler TW, Dell'Italia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Namakkal Soorappan R.

Antioxid Redox Signal. 2020 Feb 16. doi: 10.1089/ars.2019.7808. [Epub ahead of print]


Nrf2 in liver toxicology.

Taguchi K, Kensler TW.

Arch Pharm Res. 2019 Nov 28. doi: 10.1007/s12272-019-01192-3. [Epub ahead of print] Review.


Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW.

Molecules. 2019 Oct 6;24(19). pii: E3593. doi: 10.3390/molecules24193593. Review.


Serum miR-182 is a predictive biomarker for dichotomization of risk of hepatocellular carcinoma in rats.

Livingstone MC, Johnson NM, Roebuck BD, Kensler TW, Groopman JD.

Mol Carcinog. 2019 Nov;58(11):2017-2025. doi: 10.1002/mc.23093. Epub 2019 Aug 2.


Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway.

Paunkov A, Chartoumpekis DV, Ziros PG, Chondrogianni N, Kensler TW, Sykiotis GP.

Curr Pharm Des. 2019;25(16):1828-1846. doi: 10.2174/1381612825666190701165821.


Qidong: a crucible for studies on liver cancer etiology and prevention.

Chen J, Zhu J, Wang G, Groopman JD, Kensler TW.

Cancer Biol Med. 2019 Feb;16(1):24-37. doi: 10.20892/j.issn.2095-3941.2018.0394.


Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

Fragoulis A, Schenkel J, Herzog M, Schellenberg T, Jahr H, Pufe T, Trautwein C, Kensler TW, Streetz KL, Wruck CJ.

Toxicol Sci. 2019 Jun 1;169(2):485-498. doi: 10.1093/toxsci/kfz055.


Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.

Chartoumpekis DV, Ziros PG, Chen JG, Groopman JD, Kensler TW, Sykiotis GP.

Food Chem Toxicol. 2019 Apr;126:1-6. doi: 10.1016/j.fct.2019.02.004. Epub 2019 Feb 5.


Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice.

Yagishita Y, Uruno A, Chartoumpekis DV, Kensler TW, Yamamoto M.

J Endocrinol. 2019 Jan 1. pii: JOE-18-0355.R2. doi: 10.1530/JOE-18-0355. [Epub ahead of print]


Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.

Cuadrado A, Rojo AI, Wells G, Hayes JD, Cousin SP, Rumsey WL, Attucks OC, Franklin S, Levonen AL, Kensler TW, Dinkova-Kostova AT.

Nat Rev Drug Discov. 2019 Apr;18(4):295-317. doi: 10.1038/s41573-018-0008-x. Review.


AACR White Paper: Shaping the Future of Cancer Prevention - A Roadmap for Advancing Science and Public Health.

Lippman SM, Abate-Shen C, Colbert Maresso KL, Colditz GA, Dannenberg AJ, Davidson NE, Disis ML, DuBois RN, Szabo E, Giuliano AR, Hait WN, Lee JJ, Kensler TW, Kramer BS, Limburg P, Maitra A, Martinez ME, Rebbeck TR, Schmitz KH, Vilar E, Hawk ET.

Cancer Prev Res (Phila). 2018 Dec;11(12):735-778. doi: 10.1158/1940-6207.CAPR-18-0421.


Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake.

Palliyaguru DL, Salvatore SR, Schopfer FJ, Cheng X, Zhou J, Kensler TW, Wendell SG.

Mol Nutr Food Res. 2019 Feb;63(3):e1801029. doi: 10.1002/mnfr.201801029. Epub 2018 Nov 22.


Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor.

Rooney J, Oshida K, Vasani N, Vallanat B, Ryan N, Chorley BN, Wang X, Bell DA, Wu KC, Aleksunes LM, Klaassen CD, Kensler TW, Corton JC.

PLoS One. 2018 Aug 16;13(8):e0200004. doi: 10.1371/journal.pone.0200004. eCollection 2018.


NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland.

Ziros PG, Habeos IG, Chartoumpekis DV, Ntalampyra E, Somm E, Renaud CO, Bongiovanni M, Trougakos IP, Yamamoto M, Kensler TW, Santisteban P, Carrasco N, Ris-Stalpers C, Amendola E, Liao XH, Rossich L, Thomasz L, Juvenal GJ, Refetoff S, Sykiotis GP.

Thyroid. 2018 Jun;28(6):780-798. doi: 10.1089/thy.2018.0018.


The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.

Yamamoto M, Kensler TW, Motohashi H.

Physiol Rev. 2018 Jul 1;98(3):1169-1203. doi: 10.1152/physrev.00023.2017. Review.


Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice.

Chartoumpekis DV, Yagishita Y, Fazzari M, Palliyaguru DL, Rao UN, Zaravinos A, Khoo NK, Schopfer FJ, Weiss KR, Michalopoulos GK, Sipula I, O'Doherty RM, Kensler TW, Wakabayashi N.

JCI Insight. 2018 Mar 8;3(5). pii: 97735. doi: 10.1172/jci.insight.97735.


Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice.

Chartoumpekis DV, Palliyaguru DL, Wakabayashi N, Fazzari M, Khoo NKH, Schopfer FJ, Sipula I, Yagishita Y, Michalopoulos GK, O'Doherty RM, Kensler TW.

Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E180-E195. doi: 10.1152/ajpendo.00311.2017. Epub 2018 Feb 27.


NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus.

Wible RS, Ramanathan C, Sutter CH, Olesen KM, Kensler TW, Liu AC, Sutter TR.

Elife. 2018 Feb 26;7. pii: e31656. doi: 10.7554/eLife.31656.


Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.

Chen T, Qian G, Fan C, Sun Y, Wang J, Lu P, Xue X, Wu Y, Zhang Q, Jin Y, Wu Y, Gan Y, Lu J, Kensler TW, Groopman JD, Tu H.

Hepatoma Res. 2018;4. pii: 4. doi: 10.20517/2394-5079.2017.50. Epub 2018 Jan 26.


Isothiocyanates: Translating the Power of Plants to People.

Palliyaguru DL, Yuan JM, Kensler TW, Fahey JW.

Mol Nutr Food Res. 2018 Sep;62(18):e1700965. doi: 10.1002/mnfr.201700965. Epub 2018 Mar 26. Review.


Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo.

Wible RS, Tran QT, Fathima S, Sutter CH, Kensler TW, Sutter TR.

Mol Pharmacol. 2018 Apr;93(4):297-308. doi: 10.1124/mol.117.110262. Epub 2018 Jan 24.


KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane.

Dinkova-Kostova AT, Fahey JW, Kostov RV, Kensler TW.

Trends Food Sci Technol. 2017 Nov;69(Pt B):257-269. doi: 10.1016/j.tifs.2017.02.002. Epub 2017 Feb 16.


Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States.

Yu Z, Samavat H, Dostal AM, Wang R, Torkelson CJ, Yang CS, Butler LM, Kensler TW, Wu AH, Kurzer MS, Yuan JM.

Cancer Prev Res (Phila). 2017 Oct;10(10):571-579. doi: 10.1158/1940-6207.CAPR-17-0160. Epub 2017 Aug 1.


Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH.

Ramadori P, Drescher H, Erschfeld S, Fragoulis A, Kensler TW, Wruck CJ, Cubero FJ, Trautwein C, Streetz KL, Kroy DC.

Oxid Med Cell Longev. 2017;2017:3420286. doi: 10.1155/2017/3420286. Epub 2017 Jun 6.


Correction: Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice.

Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP.

J Immunol. 2017 May 1;198(9):3755. doi: 10.4049/jimmunol.1700291. No abstract available.


NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.

Lu K, Alcivar AL, Ma J, Foo TK, Zywea S, Mahdi A, Huo Y, Kensler TW, Gatza ML, Xia B.

Cancer Res. 2017 Jun 1;77(11):2881-2892. doi: 10.1158/0008-5472.CAN-16-2204. Epub 2017 Apr 17.


NRF2 as an Emerging Therapeutic Target.

Copple IM, Dinkova-Kostova AT, Kensler TW, Liby KT, Wigley WC.

Oxid Med Cell Longev. 2017;2017:8165458. doi: 10.1155/2017/8165458. Epub 2017 Jan 31. No abstract available.


Profound changes in miRNA expression during cancer initiation by aflatoxin B1 and their abrogation by the chemopreventive triterpenoid CDDO-Im.

Livingstone MC, Johnson NM, Roebuck BD, Kensler TW, Groopman JD.

Mol Carcinog. 2017 Nov;56(11):2382-2390. doi: 10.1002/mc.22635. Epub 2017 Sep 2.


Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms.

Palliyaguru DL, Chartoumpekis DV, Wakabayashi N, Skoko JJ, Yagishita Y, Singh SV, Kensler TW.

Free Radic Biol Med. 2016 Dec;101:116-128. doi: 10.1016/j.freeradbiomed.2016.10.003. Epub 2016 Oct 4.


Keap1 hypomorphism protects against ischemic and obstructive kidney disease.

Tan RJ, Chartoumpekis DV, Rush BM, Zhou D, Fu H, Kensler TW, Liu Y.

Sci Rep. 2016 Nov 2;6:36185. doi: 10.1038/srep36185.


Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model.

Draheim T, Liessem A, Scheld M, Wilms F, Weißflog M, Denecke B, Kensler TW, Zendedel A, Beyer C, Kipp M, Wruck CJ, Fragoulis A, Clarner T.

Glia. 2016 Dec;64(12):2219-2230. doi: 10.1002/glia.23058. Epub 2016 Sep 19.


AACR Cancer Progress Report 2016.

Davidson NE, Armstrong SA, Coussens LM, Cruz-Correa MR, DeBerardinis RJ, Doroshow JH, Foti M, Hwu P, Kensler TW, Morrow M, Mulligan CG, Pao W, Platz EA, Smith TJ, Willman CL.

Clin Cancer Res. 2016 Oct 1;22 Suppl 19:S1-S137. No abstract available.


Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane.

Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE.

Cancer Prev Res (Phila). 2016 Jul;9(7):547-57. doi: 10.1158/1940-6207.CAPR-15-0290. Epub 2016 Jun 23.


Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.

Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M.

Toxicol Sci. 2016 Jul;152(1):40-52. doi: 10.1093/toxsci/kfw065. Epub 2016 Apr 12.


Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane.

Yang L, Palliyaguru DL, Kensler TW.

Semin Oncol. 2016 Feb;43(1):146-153. doi: 10.1053/j.seminoncol.2015.09.013. Epub 2015 Sep 8. Review.


Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle.

Shelar SB, Narasimhan M, Shanmugam G, Litovsky SH, Gounder SS, Karan G, Arulvasu C, Kensler TW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS.

FASEB J. 2016 May;30(5):1865-79. doi: 10.1096/fj.201500153. Epub 2016 Feb 2.


Transforming Cancer Prevention through Precision Medicine and Immune-oncology.

Kensler TW, Spira A, Garber JE, Szabo E, Lee JJ, Dong Z, Dannenberg AJ, Hait WN, Blackburn E, Davidson NE, Foti M, Lippman SM.

Cancer Prev Res (Phila). 2016 Jan;9(1):2-10. doi: 10.1158/1940-6207.CAPR-15-0406.


Withania somnifera: From prevention to treatment of cancer.

Palliyaguru DL, Singh SV, Kensler TW.

Mol Nutr Food Res. 2016 Jun;60(6):1342-53. doi: 10.1002/mnfr.201500756. Epub 2016 Jan 29. Review.


Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet.

Slocum SL, Skoko JJ, Wakabayashi N, Aja S, Yamamoto M, Kensler TW, Chartoumpekis DV.

Arch Biochem Biophys. 2016 Feb 1;591:57-65. doi: 10.1016/ Epub 2015 Dec 14.


Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development.

Ramadori P, Drescher H, Erschfeld S, Schumacher F, Berger C, Fragoulis A, Schenkel J, Kensler TW, Wruck CJ, Trautwein C, Kroy DC, Streetz KL.

Free Radic Biol Med. 2016 Feb;91:114-26. doi: 10.1016/j.freeradbiomed.2015.12.014. Epub 2015 Dec 15.


Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism.

Chartoumpekis DV, Wakabayashi N, Kensler TW.

Biochem Soc Trans. 2015 Aug;43(4):639-44. doi: 10.1042/BST20150049. Epub 2015 Aug 3. Review.


Cancer Prevention: Obstacles, Challenges and the Road Ahead.

Meyskens FL Jr, Mukhtar H, Rock CL, Cuzick J, Kensler TW, Yang CS, Ramsey SD, Lippman SM, Alberts DS.

J Natl Cancer Inst. 2015 Nov 7;108(2). pii: djv309. doi: 10.1093/jnci/djv309. Print 2016 Feb. Review.


Lung Cancer in a Rural Area of China: Rapid Rise in Incidence and Poor Improvement in Survival.

Yang J, Zhu J, Zhang YH, Chen YS, Ding LL, Kensler TW, Chen JG.

Asian Pac J Cancer Prev. 2015;16(16):7295-302.


Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice.

Chartoumpekis DV, Palliyaguru DL, Wakabayashi N, Khoo NK, Schoiswohl G, O'Doherty RM, Kensler TW.

Mol Metab. 2015 May 2;4(7):543-50. doi: 10.1016/j.molmet.2015.04.004. eCollection 2015 Jul.


Crosstalk between Nrf2 and Notch signaling.

Wakabayashi N, Chartoumpekis DV, Kensler TW.

Free Radic Biol Med. 2015 Nov;88(Pt B):158-167. doi: 10.1016/j.freeradbiomed.2015.05.017. Epub 2015 May 21. Review.


Chemoprevention targets for tobacco-related head and neck cancer: past lessons and future directions.

Sheth SH, Johnson DE, Kensler TW, Bauman JE.

Oral Oncol. 2015 Jun;51(6):557-64. doi: 10.1016/j.oraloncology.2015.02.101. Epub 2015 Apr 11. Review.


NRF2/long noncoding RNA ROR signaling regulates mammary stem cell expansion and protects against estrogen genotoxicity.

Zhang Y, Xia J, Li Q, Yao Y, Eades G, Gernapudi R, Duru N, Kensler TW, Zhou Q.

J Biol Chem. 2014 Nov 7;289(45):31310-8. doi: 10.1074/jbc.M114.604868. Epub 2014 Sep 17.


Reduced foodborne toxin exposure is a benefit of improving dietary diversity.

Wu F, Mitchell NJ, Male D, Kensler TW.

Toxicol Sci. 2014 Oct;141(2):329-34. doi: 10.1093/toxsci/kfu137. Epub 2014 Jul 11. Review.


Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity.

Skoko JJ, Wakabayashi N, Noda K, Kimura S, Tobita K, Shigemura N, Tsujita T, Yamamoto M, Kensler TW.

Toxicol Sci. 2014 Sep;141(1):112-9. doi: 10.1093/toxsci/kfu109. Epub 2014 Jun 12.


Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China.

Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW.

Cancer Prev Res (Phila). 2014 Aug;7(8):813-823. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.

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