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Items: 1 to 50 of 182

1.

Mechanistic insights into the pH-dependent membrane peptide ATRAM.

Nguyen VP, Palanikumar L, Kennel SJ, Alves DS, Ye Y, Wall JS, Magzoub M, Barrera FN.

J Control Release. 2019 Mar 28;298:142-153. doi: 10.1016/j.jconrel.2019.02.010. Epub 2019 Feb 11.

PMID:
30763623
2.

Anticytomegalovirus Peptides Point to New Insights for CMV Entry Mechanisms and the Limitations of In Vitro Screenings.

Jackson JW, Hancock TJ, Dogra P, Patel R, Arav-Boger R, Williams AD, Kennel SJ, Wall JS, Sparer TE.

mSphere. 2019 Feb 13;4(1). pii: e00586-18. doi: 10.1128/mSphere.00586-18.

3.

Macrophage-Mediated Phagocytosis and Dissolution of Amyloid-Like Fibrils in Mice, Monitored by Optical Imaging.

Richey T, Foster JS, Williams AD, Williams AB, Stroh A, Macy S, Wooliver C, Heidel RE, Varanasi SK, Ergen EN, Trent DJ, Kania SA, Kennel SJ, Martin EB, Wall JS.

Am J Pathol. 2019 Feb 6. pii: S0002-9440(18)31094-0. doi: 10.1016/j.ajpath.2019.01.011. [Epub ahead of print]

PMID:
30735627
4.

Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy.

Wall JS, Williams AD, Foster JS, Richey T, Stuckey A, Macy S, Wooliver C, Campagna SR, Tague ED, Farmer AT, Lands RH, Martin EB, Heidel RE, Kennel SJ.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10839-E10848. doi: 10.1073/pnas.1805515115. Epub 2018 Oct 30.

PMID:
30377267
5.

Relative skeletal distribution of proliferating marrow in the adult dog determined using 3'-deoxy-3'-[18 F]fluorothymidine.

Rowe JA, Morandi F, Osborne DR, Wall JS, Kennel SJ, Reed RB, LeBlanc AK.

Anat Histol Embryol. 2019 Jan;48(1):46-52. doi: 10.1111/ahe.12410. Epub 2018 Oct 23.

PMID:
30353574
6.

A functional assay to identify amyloidogenic light chains.

Martin EB, Williams AD, Heidel RE, Foster JS, Lands RH, Kennel SJ, Wall JS.

Amyloid. 2018 Jun;25(2):93-100. doi: 10.1080/13506129.2018.1456425. Epub 2018 Mar 23.

PMID:
29571269
7.

Evaluation of the effect of D-amino acid incorporation into amyloid-reactive peptides.

Martin EB, Williams A, Richey T, Wooliver C, Stuckey A, Foster JS, Kennel SJ, Wall JS.

J Transl Med. 2017 Dec 11;15(1):247. doi: 10.1186/s12967-017-1351-0.

8.

A Peptide-Fc Opsonin with Pan-Amyloid Reactivity.

Foster JS, Williams AD, Macy S, Richey T, Stuckey A, Wooliver DC, Koul-Tiwari R, Martin EB, Kennel SJ, Wall JS.

Front Immunol. 2017 Sep 4;8:1082. doi: 10.3389/fimmu.2017.01082. eCollection 2017.

9.

Pretargeting immunotherapy: a novel treatment approach for systemic amyloidosis.

Wall JS, Foster JS, Martin EB, Kennel SJ.

Pharm Pat Anal. 2017 Sep;6(5):215-223. doi: 10.4155/ppa-2017-0022. Epub 2017 Aug 21.

10.

Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis.

Wall JS, Kennel SJ, Martin EB.

Mol Imaging. 2017 Jan 1;16:1536012117708705. doi: 10.1177/1536012117708705.

11.

A bifunctional peptide, "peptope", for pre-targeting antibody 7D8 to systemic amyloid deposits.

Wall JS, Williams A, Foster JS, Martin EB, Richey T, Stuckey A, Macy S, Zago W, Kinney GG, Kennel SJ.

Amyloid. 2017 Mar;24(sup1):22-23. doi: 10.1080/13506129.2017.1295372. No abstract available.

12.

Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity.

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia L, Kennel SJ, Wall JS.

Amyloid. 2017 Mar;24(sup1):24-25. doi: 10.1080/13506129.2017.1295374. No abstract available.

PMID:
28434355
13.

Preliminary characterization of a novel peptide-Fc-fusion construct for targeting amyloid deposits.

Foster JS, Koul-Tiwari R, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Kennel SJ, Wall JS.

Amyloid. 2017 Mar;24(sup1):26-27. doi: 10.1080/13506129.2017.1295375. No abstract available.

14.

A novel murine system for validating the specific targeting of peptides to light chain associated (AL) amyloid.

Beierle SP, Foster JS, Richey T, Stuckey A, Macy S, Kennel SJ, Wall JS.

Amyloid. 2017 Mar;24(sup1):74-75. doi: 10.1080/13506129.2017.1295377. No abstract available.

15.

Probing the structural requirements of polybasic peptides for effective and specific amyloid reactivity.

Wall JS, Williams A, Stuckey A, Martin EB, Richey T, Wooliver C, Heidel RE, Cheng X, Kennel SJ.

Amyloid. 2017 Mar;24(sup1):30-31. doi: 10.1080/13506129.2017.1295946. No abstract available.

16.

Serendipitous inhibition of Aβ and rVλ6Wil amyloid fibril growth by bi-functional peptides.

Wall JS, Williams A, Martin EB, Cheng X, Kennel SJ.

Amyloid. 2017 Mar;24(sup1):32-33. doi: 10.1080/13506129.2017.1295947. No abstract available.

17.

Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity.

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia LM, Lands RH, Kennel SJ, Wall JS.

PLoS One. 2017 Mar 28;12(3):e0174152. doi: 10.1371/journal.pone.0174152. eCollection 2017.

18.

Secondary structure propensity and chirality of the amyloidophilic peptide p5 and its analogues impacts ligand binding - In vitro characterization.

Wall JS, Williams A, Wooliver C, Martin EB, Cheng X, Heidel RE, Kennel SJ.

Biochem Biophys Rep. 2016 Dec;8:89-99. doi: 10.1016/j.bbrep.2016.08.007. Epub 2016 Aug 11.

19.

Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini.

Piehl DW, Blancas-Mejía LM, Wall JS, Kennel SJ, Ramirez-Alvarado M, Rienstra CM.

ACS Omega. 2017 Feb 28;2(2):712-720. doi: 10.1021/acsomega.6b00494. Epub 2017 Feb 27.

20.

Specific Amyloid Binding of Polybasic Peptides In Vivo Is Retained by β-Sheet Conformers but Lost in the Disrupted Coil and All D-Amino Acid Variants.

Wall JS, Williams A, Richey T, Stuckey A, Wooliver C, Christopher Scott J, Donnell R, Martin EB, Kennel SJ.

Mol Imaging Biol. 2017 Oct;19(5):714-722. doi: 10.1007/s11307-017-1063-0.

21.

Comparative evaluation of p5+14 with SAP and peptide p5 by dual-energy SPECT imaging of mice with AA amyloidosis.

Martin EB, Williams A, Richey T, Stuckey A, Heidel RE, Kennel SJ, Wall JS.

Sci Rep. 2016 Mar 3;6:22695. doi: 10.1038/srep22695.

22.

The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice.

Kennel SJ, Williams A, Stuckey A, Richey T, Wooliver C, Chazin W, Stern DA, Martin EB, Wall JS.

Amyloid. 2016;23(1):8-16. doi: 10.3109/13506129.2015.1112782. Epub 2015 Dec 24.

23.

Tc-99m Radiolabeled Peptide p5 + 14 is an Effective Probe for SPECT Imaging of Systemic Amyloidosis.

Kennel SJ, Stuckey A, McWilliams-Koeppen HP, Richey T, Wall JS.

Mol Imaging Biol. 2016 Aug;18(4):483-9. doi: 10.1007/s11307-015-0914-9.

24.

Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes.

McWilliams-Koeppen HP, Foster JS, Hackenbrack N, Ramirez-Alvarado M, Donohoe D, Williams A, Macy S, Wooliver C, Wortham D, Morrell-Falvey J, Foster CM, Kennel SJ, Wall JS.

PLoS One. 2015 Sep 22;10(9):e0137716. doi: 10.1371/journal.pone.0137716. eCollection 2015.

25.

Novel heparan sulfate-binding peptides for blocking herpesvirus entry.

Dogra P, Martin EB, Williams A, Richardson RL, Foster JS, Hackenback N, Kennel SJ, Sparer TE, Wall JS.

PLoS One. 2015 May 18;10(5):e0126239. doi: 10.1371/journal.pone.0126239. eCollection 2015.

26.

Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis.

Wall JS, Martin EB, Richey T, Stuckey AC, Macy S, Wooliver C, Williams A, Foster JS, McWilliams-Koeppen P, Uberbacher E, Cheng X, Kennel SJ.

Molecules. 2015 Apr 27;20(5):7657-82. doi: 10.3390/molecules20057657.

27.

GATE validation of standard dual energy corrections in small animal SPECT-CT.

Lee S, Gregor J, Kennel SJ, Osborne DR, Wall J.

PLoS One. 2015 Apr 7;10(4):e0122780. doi: 10.1371/journal.pone.0122780. eCollection 2015.

28.

Dynamic PET and SPECT imaging with radioiodinated, amyloid-reactive peptide p5 in mice: a positive role for peptide dehalogenation.

Martin EB, Kennel SJ, Richey T, Wooliver C, Osborne D, Williams A, Stuckey A, Wall JS.

Peptides. 2014 Oct;60:63-70. doi: 10.1016/j.peptides.2014.07.024. Epub 2014 Aug 4.

29.

Phagocyte depletion inhibits AA amyloid accumulation in AEF-induced huIL-6 transgenic mice.

Kennel SJ, Macy S, Wooliver C, Huang Y, Richey T, Heidel E, Wall JS.

Amyloid. 2014 Mar;21(1):45-53. doi: 10.3109/13506129.2013.876400. Epub 2014 Jan 22.

30.

LnPO4 nanoparticles doped with Ac-225 and sequestered daughters for targeted alpha therapy.

McLaughlin MF, Robertson D, Pevsner PH, Wall JS, Mirzadeh S, Kennel SJ.

Cancer Biother Radiopharm. 2014 Feb;29(1):34-41. doi: 10.1089/cbr.2013.1546. Epub 2013 Oct 8.

PMID:
24102173
31.

Enteroaggregative Escherichia coli: surface protein dispersin increases bacterial uptake of ciprofloxacin.

Mortensen NP, Boisen N, Carey S, Kennel SJ, Fowlkes JD, Doktycz MJ, Nataro JP, Allison DP.

Int J Antimicrob Agents. 2013 Nov;42(5):462-5. doi: 10.1016/j.ijantimicag.2013.07.007. Epub 2013 Aug 15.

PMID:
24011504
32.

A binding-site barrier affects imaging efficiency of high affinity amyloid-reactive peptide radiotracers in vivo.

Wall JS, Williams A, Richey T, Stuckey A, Huang Y, Wooliver C, Macy S, Heidel E, Gupta N, Lee A, Rader B, Martin EB, Kennel SJ.

PLoS One. 2013 Jun 4;8(6):e66181. doi: 10.1371/journal.pone.0066181. Print 2013.

33.

Peptide p5 binds both heparinase-sensitive glycosaminoglycans and fibrils in patient-derived AL amyloid extracts.

Martin EB, Williams A, Heidel E, Macy S, Kennel SJ, Wall JS.

Biochem Biophys Res Commun. 2013 Jun 21;436(1):85-9. doi: 10.1016/j.bbrc.2013.05.063. Epub 2013 May 23.

34.

Whole-body biodistribution of 3'-deoxy-3'-[(18) f]fluorothymidine ((18) FLT) in healthy adult cats.

Rowe JA, Morandi F, Wall JS, Akula M, Kennel SJ, Osborne D, Martin EB, Galyon GD, Long MJ, Stuckey AC, LeBlanc AK.

Vet Radiol Ultrasound. 2013 May-Jun;54(3):299-306. doi: 10.1111/vru.12024. Epub 2013 Mar 7.

PMID:
23464567
35.

Gold coated lanthanide phosphate nanoparticles for targeted alpha generator radiotherapy.

McLaughlin MF, Woodward J, Boll RA, Wall JS, Rondinone AJ, Kennel SJ, Mirzadeh S, Robertson JD.

PLoS One. 2013;8(1):e54531. doi: 10.1371/journal.pone.0054531. Epub 2013 Jan 18.

36.

A novel method for quantifying peripheral tissue amyloid load by using the radiolabeled amyloidophilic peptide, p5.

Wall JS, Richey T, Macy S, Heidel E, Wooliver C, Kennel SJ.

Amyloid. 2013 Mar;20(1):21-6. doi: 10.3109/13506129.2012.757216. Epub 2013 Jan 17.

37.

AL amyloid imaging and therapy with a monoclonal antibody to a cryptic epitope on amyloid fibrils.

Wall JS, Kennel SJ, Williams A, Richey T, Stuckey A, Huang Y, Macy S, Donnell R, Barbour R, Seubert P, Schenk D.

PLoS One. 2012;7(12):e52686. doi: 10.1371/journal.pone.0052686. Epub 2012 Dec 26.

38.

Development and evaluation of agents for targeting visceral amyloid.

Wall JS, Solomon A, Kennel SJ.

Tijdschr Nucl Geneeskd. 2011 Dec;33(4):807-814.

39.

Comparative analysis of peptide p5 and serum amyloid P component for imaging AA amyloid in mice using dual-isotope SPECT.

Wall JS, Richey T, Williams A, Stuckey A, Osborne D, Martin E, Kennel SJ.

Mol Imaging Biol. 2012 Aug;14(4):402-7. doi: 10.1007/s11307-011-0524-0.

40.

SPECT imaging of peripheral amyloid in mice by targeting hyper-sulfated heparan sulfate proteoglycans with specific scFv antibodies.

Wall JS, Richey T, Stuckey A, Donnell R, Oosterhof A, van Kuppevelt TH, Smits NC, Kennel SJ.

Nucl Med Biol. 2012 Jan;39(1):65-75. doi: 10.1016/j.nucmedbio.2011.06.007. Epub 2011 Sep 29.

41.

In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides.

Wall JS, Richey T, Stuckey A, Donnell R, Macy S, Martin EB, Williams A, Higuchi K, Kennel SJ.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E586-94. doi: 10.1073/pnas.1103247108. Epub 2011 Aug 1.

42.

ODAM Expression Inhibits Human Breast Cancer Tumorigenesis.

Kestler DP, Foster JS, Bruker CT, Prenshaw JW, Kennel SJ, Wall JS, Weiss DT, Solomon A.

Breast Cancer (Auckl). 2011;5:73-85. doi: 10.4137/BCBCR.S6859. Epub 2011 Apr 28.

43.

LaPO4 nanoparticles doped with actinium-225 that partially sequester daughter radionuclides.

Woodward J, Kennel SJ, Stuckey A, Osborne D, Wall J, Rondinone AJ, Standaert RF, Mirzadeh S.

Bioconjug Chem. 2011 Apr 20;22(4):766-76. doi: 10.1021/bc100574f. Epub 2011 Mar 24.

PMID:
21434681
44.

Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake.

Stuart CA, Ross IR, Howell ME, McCurry MP, Wood TG, Ceci JD, Kennel SJ, Wall J.

Brain Res. 2011 Apr 12;1384:15-22. doi: 10.1016/j.brainres.2011.02.014.

45.

Generation and characterization of anti-AA amyloid-specific monoclonal antibodies.

Wall JS, Kennel SJ, Richey T, Allen A, Stuckey A, Weiss DT, Macy SD, Barbour R, Seubert P, Solomon A, Schenk D.

Front Immunol. 2011 Aug 8;2:32. doi: 10.3389/fimmu.2011.00032. eCollection 2011.

46.

Kinetics of vascular targeted monoclonal antibody.

Kennel SJ, Huang Y, Zeng WB, Stuckey A, Wall J.

Curr Drug Deliv. 2010 Dec;7(5):428-35.

PMID:
20950267
47.

The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.

Smits NC, Kurup S, Rops AL, ten Dam GB, Massuger LF, Hafmans T, Turnbull JE, Spillmann D, Li JP, Kennel SJ, Wall JS, Shworak NW, Dekhuijzen PN, van der Vlag J, van Kuppevelt TH.

J Biol Chem. 2010 Dec 24;285(52):41143-51. doi: 10.1074/jbc.M110.153791. Epub 2010 Sep 13.

48.

Inhibition of pathologic immunoglobulin-free light chain production by small interfering RNA molecules.

Phipps JE, Kestler DP, Foster JS, Kennel SJ, Donnell R, Weiss DT, Solomon A, Wall JS.

Exp Hematol. 2010 Nov;38(11):1006-13. doi: 10.1016/j.exphem.2010.07.001. Epub 2010 Jul 14.

49.

Radioimmunodetection of amyloid deposits in patients with AL amyloidosis.

Wall JS, Kennel SJ, Stuckey AC, Long MJ, Townsend DW, Smith GT, Wells KJ, Fu Y, Stabin MG, Weiss DT, Solomon A.

Blood. 2010 Sep 30;116(13):2241-4. doi: 10.1182/blood-2010-03-273797. Epub 2010 Jun 3.

50.

Normal thoracic and abdominal distribution of 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) in adult cats.

LeBlanc AK, Wall JS, Morandi F, Kennel SJ, Stuckey A, Jakoby B, Townsend DW, Daniel GB.

Vet Radiol Ultrasound. 2009 Jul-Aug;50(4):436-41.

PMID:
19697611

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