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Items: 1 to 50 of 81

1.

A synthetic glycosaminoglycan reduces sinonasal inflammation in a murine model of chronic rhinosinusitis.

Alt JA, Lee WY, Davis BM, Savage JR, Kennedy TP, Prestwich GD, Pulsipher A.

PLoS One. 2018 Sep 25;13(9):e0204709. doi: 10.1371/journal.pone.0204709. eCollection 2018.

2.

2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia.

Tkaczynski E, Arulselvan A, Tkaczynski J, Avery S, Xiao L, Torok-Storb B, Abrams K, Rao NV, Johnson G, Kennedy TP, Poncz M, Lambert MP.

Blood Adv. 2018 Apr 10;2(7):754-761. doi: 10.1182/bloodadvances.2017013672. Erratum in: Blood Adv. 2018 May 22;2(10 ):1129.

3.

Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia.

Kovacsovics TJ, Mims A, Salama ME, Pantin J, Rao N, Kosak KM, Ahorukomeye P, Glenn MJ, Deininger MWN, Boucher KM, Bavisotto LM, Gutierrez-Sanchez G, Kennedy TP, Marcus SG, Shami PJ.

Blood Adv. 2018 Feb 27;2(4):381-389. doi: 10.1182/bloodadvances.2017013391.

4.

A Modified Glycosaminoglycan, GM-0111, Inhibits Molecular Signaling Involved in Periodontitis.

Savage JR, Pulsipher A, Rao NV, Kennedy TP, Prestwich GD, Ryan ME, Lee WY.

PLoS One. 2016 Jun 16;11(6):e0157310. doi: 10.1371/journal.pone.0157310. eCollection 2016.

5.

Adrenergic Inhibition with Dexmedetomidine to Treat Stress Cardiomyopathy during Alcohol Withdrawal: A Case Report and Literature Review.

Harris ZM, Alonso A, Kennedy TP.

Case Rep Crit Care. 2016;2016:9693653. doi: 10.1155/2016/9693653. Epub 2016 Feb 24.

6.

Low anticoagulant heparin blocks thrombin-induced endothelial permeability in a PAR-dependent manner.

Gonzales JN, Kim KM, Zemskova MA, Rafikov R, Heeke B, Varn MN, Black S, Kennedy TP, Verin AD, Zemskov EA.

Vascul Pharmacol. 2014 Aug;62(2):63-71. doi: 10.1016/j.vph.2014.01.005. Epub 2014 Jan 25.

7.

2-O, 3-O-desulfated heparin inhibits neutrophil elastase-induced HMGB-1 secretion and airway inflammation.

Griffin KL, Fischer BM, Kummarapurugu AB, Zheng S, Kennedy TP, Rao NV, Foster WM, Voynow JA.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):684-9. doi: 10.1165/rcmb.2013-0338RC.

8.

Partially-desulfated heparin improves survival in Pseudomonas pneumonia by enhancing bacterial clearance and ameliorating lung injury.

Sharma L, Wu J, Patel V, Sitapara R, Rao NV, Kennedy TP, Mantell LL.

J Immunotoxicol. 2014 Jul-Sep;11(3):260-7. doi: 10.3109/1547691X.2013.839587. Epub 2013 Oct 7.

PMID:
24099632
9.

Hyperoxia, HMGB1, and ventilator-associated pneumonia: reducing risk by practicing what we teach.

Kennedy TP, Nelson S.

Am J Respir Cell Mol Biol. 2013 Mar;48(3):269-70. doi: 10.1165/rcmb.2013-0020ED. No abstract available.

10.

A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides.

Oottamasathien S, Jia W, McCoard L, Slack S, Zhang J, Skardal A, Job K, Kennedy TP, Dull RO, Prestwich GD.

J Urol. 2011 Oct;186(4 Suppl):1684-92. doi: 10.1016/j.juro.2011.03.099. Epub 2011 Aug 19. Erratum in: J Urol. 2012 Feb;187(2):768.

11.

Heparins with reduced anti-coagulant activity reduce myocardial reperfusion injury.

Barry WH, Kennedy TP.

Recent Pat Cardiovasc Drug Discov. 2011 May;6(2):148-57. Review.

PMID:
21453252
12.

Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea.

Zhang J, Xu X, Rao NV, Argyle B, McCoard L, Rusho WJ, Kennedy TP, Prestwich GD, Krueger G.

PLoS One. 2011 Feb 9;6(2):e16658. doi: 10.1371/journal.pone.0016658.

13.

Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands.

Rao NV, Argyle B, Xu X, Reynolds PR, Walenga JM, Prechel M, Prestwich GD, MacArthur RB, Walters BB, Hoidal JR, Kennedy TP.

Am J Physiol Cell Physiol. 2010 Jul;299(1):C97-110. doi: 10.1152/ajpcell.00009.2010. Epub 2010 Apr 7.

14.

Nonanticoagulant heparin reduces myocyte Na+ and Ca2+ loading during simulated ischemia and decreases reperfusion injury.

Barry WH, Zhang XQ, Halkos ME, Vinten-Johansen J, Saegusa N, Spitzer KW, Matsuoka N, Sheets M, Rao NV, Kennedy TP.

Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H102-11. doi: 10.1152/ajpheart.00316.2009. Epub 2009 Oct 23.

15.

Prevention of contrast-induced nephropathy with sodium bicarbonate: an evidence-based protocol.

Merten GJ, Burgess WP, Rittase RA, Kennedy TP.

Crit Pathw Cardiol. 2004 Sep;3(3):138-43. doi: 10.1097/01.hpc.0000137152.52554.76.

PMID:
18340155
16.

O-desulfated heparin improves outcome after rat cerebral ischemia/reperfusion injury.

Mocco J, Shelton CE, Sergot P, Ducruet AF, Komotar RJ, Otten ML, Sosunov SA, Macarthur RB, Kennedy TP, Connolly ES Jr.

Neurosurgery. 2007 Dec;61(6):1297-303; discussion 1303-4.

PMID:
18162910
17.

Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase.

Chitano P, Wang L, Mason SN, Auten RL, Potts EN, Foster WM, Sturrock A, Kennedy TP, Hoidal JR, Murphy TM.

Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L139-48. Epub 2007 Nov 9. Retraction in: Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L854.

18.

Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells.

Sturrock A, Huecksteadt TP, Norman K, Sanders K, Murphy TM, Chitano P, Wilson K, Hoidal JR, Kennedy TP.

Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1543-55. Epub 2007 Mar 16.

19.
20.

Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells.

Sturrock A, Cahill B, Norman K, Huecksteadt TP, Hill K, Sanders K, Karwande SV, Stringham JC, Bull DA, Gleich M, Kennedy TP, Hoidal JR.

Am J Physiol Lung Cell Mol Physiol. 2006 Apr;290(4):L661-L673. Epub 2005 Oct 14.

21.

Titrimetric method for determination of O-desulfated heparin in physiological samples using protamine-sensitive membrane electrode as endpoint detector.

Buchanan SA, Kennedy TP, MacArthur RB, Meyerhoff ME.

Anal Biochem. 2005 Nov 15;346(2):241-5. Epub 2005 Sep 15.

PMID:
16213460
22.

The association between serum ferritin and uric acid in humans.

Ghio AJ, Ford ES, Kennedy TP, Hoidal JR.

Free Radic Res. 2005 Mar;39(3):337-42. Erratum in: Free Radic Res. 2007 Dec;41(12):1385.

PMID:
15788238
23.

The role of oral microbial colonization in ventilator-associated pneumonia.

Brennan MT, Bahrani-Mougeot F, Fox PC, Kennedy TP, Hopkins S, Boucher RC, Lockhart PB.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Dec;98(6):665-72. Review.

PMID:
15583538
24.

Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease.

Brar SS, Grigg C, Wilson KS, Holder WD Jr, Dreau D, Austin C, Foster M, Ghio AJ, Whorton AR, Stowell GW, Whittall LB, Whittle RR, White DP, Kennedy TP.

Mol Cancer Ther. 2004 Sep;3(9):1049-60.

25.

Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.

Merten GJ, Burgess WP, Gray LV, Holleman JH, Roush TS, Kowalchuk GJ, Bersin RM, Van Moore A, Simonton CA 3rd, Rittase RA, Norton HJ, Kennedy TP.

JAMA. 2004 May 19;291(19):2328-34.

PMID:
15150204
26.

The role of endogenous NADPH oxidases in airway and pulmonary vascular smooth muscle function.

Hoidal JR, Brar SS, Sturrock AB, Sanders KA, Dinger B, Fidone S, Kennedy TP.

Antioxid Redox Signal. 2003 Dec;5(6):751-8. Review.

PMID:
14588148
27.

Redox signaling of NF-kappaB by membrane NAD(P)H oxidases in normal and malignant cells.

Brar SS, Kennedy TP, Quinn M, Hoidal JR.

Protoplasma. 2003 May;221(1-2):117-27. Review.

PMID:
12768349
28.

NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.

Brar SS, Corbin Z, Kennedy TP, Hemendinger R, Thornton L, Bommarius B, Arnold RS, Whorton AR, Sturrock AB, Huecksteadt TP, Quinn MT, Krenitsky K, Ardie KG, Lambeth JD, Hoidal JR.

Am J Physiol Cell Physiol. 2003 Aug;285(2):C353-69. Epub 2003 Apr 9.

29.

Iron regulates xanthine oxidase activity in the lung.

Ghio AJ, Kennedy TP, Stonehuerner J, Carter JD, Skinner KA, Parks DA, Hoidal JR.

Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L563-72.

30.

An NAD(P)H oxidase regulates growth and transcription in melanoma cells.

Brar SS, Kennedy TP, Sturrock AB, Huecksteadt TP, Quinn MT, Whorton AR, Hoidal JR.

Am J Physiol Cell Physiol. 2002 Jun;282(6):C1212-24.

31.

NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle.

Brar SS, Kennedy TP, Sturrock AB, Huecksteadt TP, Quinn MT, Murphy TM, Chitano P, Hoidal JR.

Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L782-95.

32.

Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignant melanoma cells.

Brar SS, Kennedy TP, Whorton AR, Sturrock AB, Huecksteadt TP, Ghio AJ, Hoidal JR.

Am J Physiol Cell Physiol. 2001 Mar;280(3):C659-76.

33.

Calcium oxalate and iron accumulation in sarcoidosis.

Ghio AJ, Roggli VL, Kennedy TP, Piantadosi CA.

Sarcoidosis Vasc Diffuse Lung Dis. 2000 Jun;17(2):140-50.

PMID:
10957762
34.

Nonanticoagulant heparin inhibits NF-kappaB activation and attenuates myocardial reperfusion injury.

Thourani VH, Brar SS, Kennedy TP, Thornton LR, Watts JA, Ronson RS, Zhao ZQ, Sturrock AL, Hoidal JR, Vinten-Johansen J.

Am J Physiol Heart Circ Physiol. 2000 Jun;278(6):H2084-93.

35.

Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle.

Brar SS, Kennedy TP, Whorton AR, Murphy TM, Chitano P, Hoidal JR.

J Biol Chem. 1999 Jul 9;274(28):20017-26.

36.

Dehydroepiandrosterone and analogs inhibit DNA binding of AP-1 and airway smooth muscle proliferation.

Dashtaki R, Whorton AR, Murphy TM, Chitano P, Reed W, Kennedy TP.

J Pharmacol Exp Ther. 1998 May;285(2):876-83.

PMID:
9580639
37.

Depletion of iron and ascorbate in rodents diminishes lung injury after silica.

Ghio AJ, Kennedy TP, Crissman KM, Richards JH, Hatch GE.

Exp Lung Res. 1998 Mar-Apr;24(2):219-32.

PMID:
9555578
38.

Alterations in the course of acid-induced lung injury in rats after general anesthesia: volatile anesthetics versus ketamine.

Nader-Djalal N, Knight PR, Bacon MF, Tait AR, Kennedy TP, Johnson KJ.

Anesth Analg. 1998 Jan;86(1):141-6.

PMID:
9428869
39.

Ferritin expression after in vitro exposures of human alveolar macrophages to silica is iron-dependent.

Ghio AJ, Carter JD, Samet JM, Quay J, Wortman IA, Richards JH, Kennedy TP, Devlin RB.

Am J Respir Cell Mol Biol. 1997 Nov;17(5):533-40.

PMID:
9374104
40.

Postexposure treatment with aminophylline protects against phosgene-induced acute lung injury.

Sciuto AM, Strickland PT, Kennedy TP, Gurtner GH.

Exp Lung Res. 1997 Jul-Aug;23(4):317-32.

PMID:
9202957
41.

Disruption of protein tyrosine phosphate homeostasis in bronchial epithelial cells exposed to oil fly ash.

Samet JM, Stonehuerner J, Reed W, Devlin RB, Dailey LA, Kennedy TP, Bromberg PA, Ghio AJ.

Am J Physiol. 1997 Mar;272(3 Pt 1):L426-32.

PMID:
9124599
42.

Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum.

Ghio AJ, Marshall BC, Diaz JL, Hasegawa T, Samuelson W, Povia D, Kennedy TP, Piantodosi CA.

Am J Respir Crit Care Med. 1996 Sep;154(3 Pt 1):783-8.

PMID:
8810619
43.

Intratracheal administration of DBcAMP attenuates edema formation in phosgene-induced acute lung injury.

Sciuto AM, Strickland PT, Kennedy TP, Guo YL, Gurtner GH.

J Appl Physiol (1985). 1996 Jan;80(1):149-57.

PMID:
8847296
44.

Protective effects of N-acetylcysteine treatment after phosgene exposure in rabbits.

Sciuto AM, Strickland PT, Kennedy TP, Gurtner GH.

Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):768-72.

PMID:
7881668
45.

Complexation of iron cation by sodium urate crystals and gouty inflammation.

Ghio AJ, Kennedy TP, Rao G, Cooke CL, Miller MJ, Hoidal JR.

Arch Biochem Biophys. 1994 Sep;313(2):215-21.

PMID:
8080265
46.

Nontuberculous mycobacteria. An underappreciated cause of geriatric lung disease.

Kennedy TP, Weber DJ.

Am J Respir Crit Care Med. 1994 Jun;149(6):1654-8.

PMID:
8004325
47.

DNA strand breaks following in vitro exposure to asbestos increase with surface-complexed [Fe3+].

Ghio AJ, Kennedy TP, Stonehuerner JG, Crumbliss AL, Hoidal JR.

Arch Biochem Biophys. 1994 May 15;311(1):13-8.

PMID:
8185309
48.

PO2-dependent hydroxyl radical production during ischemia-reperfusion lung injury.

Fisher PW, Huang YC, Kennedy TP, Piantadosi CA.

Am J Physiol. 1993 Sep;265(3 Pt 1):L279-85.

PMID:
8214088
49.

The camel, Camelus dromedarius, as a host of the cattle tick, Boophilus microplus.

Kennedy TP, Green PE.

Aust Vet J. 1993 Jul;70(7):267-8. No abstract available.

PMID:
8368973
50.

Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung.

Huang YC, Kennedy TP, Su YF, Watkins WD, Whorton AR, Piantadosi CA.

J Appl Physiol (1985). 1993 Jan;74(1):251-8.

PMID:
8444700

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