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Items: 46

1.

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma.

Xu J, Reznik E, Lee HJ, Gundem G, Jonsson P, Sarungbam J, Bialik A, Sanchez-Vega F, Creighton CJ, Hoekstra J, Zhang L, Sajjakulnukit P, Kremer D, Tolstyka Z, Casuscelli J, Stirdivant S, Tang J, Schultz N, Jeng P, Dong Y, Su W, Cheng EH, Russo P, Coleman JA, Papaemmanuil E, Chen YB, Reuter VE, Sander C, Kennedy SR, Hsieh JJ, Lyssiotis CA, Tickoo SK, Hakimi AA.

Elife. 2019 Apr 1;8. pii: e38986. doi: 10.7554/eLife.38986.

2.

Nanopore sequencing of long ribosomal DNA amplicons enables portable and simple biodiversity assessments with high phylogenetic resolution across broad taxonomic scale.

Krehenwinkel H, Pomerantz A, Henderson JB, Kennedy SR, Lim JY, Swamy V, Shoobridge JD, Graham N, Patel NH, Gillespie RG, Prost S.

Gigascience. 2019 May 1;8(5). pii: giz006. doi: 10.1093/gigascience/giz006.

3.

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.

Lee MB, Dowsett IT, Carr DT, Wasko BM, Stanton SG, Chung MS, Ghodsian N, Bode A, Kiflezghi MG, Uppal PA, Grayden KA, Elala YC, Tang TT, Tran NHB, Tran THB, Diep AB, Hope M, Promislow DEL, Kennedy SR, Kaeberlein M, Herr AJ.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3062-3071. doi: 10.1073/pnas.1815966116. Epub 2019 Feb 4.

PMID:
30718408
4.

Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ.

Samstag CL, Hoekstra JG, Huang CH, Chaisson MJ, Youle RJ, Kennedy SR, Pallanck LJ.

PLoS Genet. 2018 Nov 19;14(11):e1007805. doi: 10.1371/journal.pgen.1007805. eCollection 2018 Nov.

5.

Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer.

Baker KT, Nachmanson D, Kumar S, Emond MJ, Ussakli C, Brentnall TA, Kennedy SR, Risques RA.

Mol Cancer Res. 2019 Feb;17(2):488-498. doi: 10.1158/1541-7786.MCR-18-0520. Epub 2018 Nov 16.

PMID:
30446624
6.

Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS).

Nachmanson D, Lian S, Schmidt EK, Hipp MJ, Baker KT, Zhang Y, Tretiakova M, Loubet-Senear K, Kohrn BF, Salk JJ, Kennedy SR, Risques RA.

Genome Res. 2018 Oct;28(10):1589-1599. doi: 10.1101/gr.235291.118. Epub 2018 Sep 19.

7.

Ball-free mechanochemistry: in situ real-time monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing.

Michalchuk AAL, Hope KS, Kennedy SR, Blanco MV, Boldyreva EV, Pulham CR.

Chem Commun (Camb). 2018 Apr 17;54(32):4033-4036. doi: 10.1039/c8cc02187b.

PMID:
29619475
8.

Stable isotopes of Hawaiian spiders reflect substrate properties along a chronosequence.

Kennedy SR, Dawson TE, Gillespie RG.

PeerJ. 2018 Mar 21;6:e4527. doi: 10.7717/peerj.4527. eCollection 2018.

9.

Aging and the rise of somatic cancer-associated mutations in normal tissues.

Risques RA, Kennedy SR.

PLoS Genet. 2018 Jan 4;14(1):e1007108. doi: 10.1371/journal.pgen.1007108. eCollection 2018 Jan. Review.

10.

Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant.

Dennis DG, McKay-Fleisch J, Eitzen K, Dowsett I, Kennedy SR, Herr AJ.

Sci Rep. 2017 Apr 18;7:46535. doi: 10.1038/srep46535.

11.

Trimeric cyclamers: solution aggregation and high Z' crystals based on guest structure and basicity.

Kennedy SR, Miquelot A, Aguilar JA, Steed JW.

Chem Commun (Camb). 2016 Sep 27;52(79):11846-11849.

PMID:
27722260
12.

Werner syndrome through the lens of tissue and tumour genomics.

Tokita M, Kennedy SR, Risques RA, Chun SG, Pritchard C, Oshima J, Liu Y, Bryant-Greenwood PK, Welcsh P, Monnat RJ.

Sci Rep. 2016 Aug 25;6:32038. doi: 10.1038/srep32038.

13.

Steady-State Spectroscopic Analysis of Proton-Dependent Electron Transfer on Pyrazine-Appended Metal Dithiolenes [Ni(pdt)2], [Pd(pdt)2], and [Pt(pdt)2] (pdt = 2,3-Pyrazinedithiol).

Kennedy SR, Kozar MN, Yennawar HP, Lear BJ.

Inorg Chem. 2016 Sep 6;55(17):8459-67. doi: 10.1021/acs.inorgchem.6b01065. Epub 2016 Aug 8.

PMID:
27500686
14.

A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster.

Patel MR, Miriyala GK, Littleton AJ, Yang H, Trinh K, Young JM, Kennedy SR, Yamashita YM, Pallanck LJ, Malik HS.

Elife. 2016 Aug 2;5. pii: e16923. doi: 10.7554/eLife.16923.

15.

Cavity-containing supramolecular gels as a crystallization tool for hydrophobic pharmaceuticals.

Kaufmann L, Kennedy SR, Jones CD, Steed JW.

Chem Commun (Camb). 2016 Aug 9;52(66):10113-6. doi: 10.1039/c6cc04037c.

PMID:
27373468
16.

Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage.

Hoekstra JG, Hipp MJ, Montine TJ, Kennedy SR.

Ann Neurol. 2016 Aug;80(2):301-6. doi: 10.1002/ana.24709. Epub 2016 Jul 13.

17.

Pharmaceutical crystallization with nanocellulose organogels.

Ruiz-Palomero C, Kennedy SR, Soriano ML, Jones CD, Valcárcel M, Steed JW.

Chem Commun (Camb). 2016 Jun 14;52(50):7782-5. doi: 10.1039/c6cc03088b.

PMID:
27168091
18.

Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues.

Krimmel JD, Schmitt MW, Harrell MI, Agnew KJ, Kennedy SR, Emond MJ, Loeb LA, Swisher EM, Risques RA.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6005-10. doi: 10.1073/pnas.1601311113. Epub 2016 May 5.

19.

Fluorescent carbon quantum dot hydrogels for direct determination of silver ions.

Cayuela A, Soriano ML, Kennedy SR, Steed JW, Valcárcel M.

Talanta. 2016 May 1;151:100-105. doi: 10.1016/j.talanta.2016.01.029. Epub 2016 Jan 15.

PMID:
26946015
20.

Manipulating three-dimensional gel network entanglement by thin film shearing.

Kumari H, Kline SR, Kennedy SR, Garvey C, Raston CL, Atwood JL, Steed JW.

Chem Commun (Camb). 2016 Mar 25;52(24):4513-6. doi: 10.1039/c6cc00171h.

PMID:
26934983
21.

Effect of Protonation upon Electronic Coupling in the Mixed Valence and Mixed Protonated Complex, [Ni(2,3-pyrazinedithiol)2].

Kennedy SR, Goyal P, Kozar MN, Yennawar HP, Hammes-Schiffer S, Lear BJ.

Inorg Chem. 2016 Feb 15;55(4):1433-45. doi: 10.1021/acs.inorgchem.5b02035. Epub 2016 Jan 26.

PMID:
26812117
22.

Gelation by supramolecular dimerization of mono(urea)s.

Hooper AE, Kennedy SR, Jones CD, Steed JW.

Chem Commun (Camb). 2016 Jan 4;52(1):198-201. doi: 10.1039/c5cc06995e.

PMID:
26540132
23.

Fluorescent carbon dot-molecular salt hydrogels.

Cayuela A, Kennedy SR, Soriano ML, Jones CD, Valcárcel M, Steed JW.

Chem Sci. 2015 Nov 1;6(11):6139-6146. doi: 10.1039/c5sc01859e. Epub 2015 Jul 29. Erratum in: Chem Sci. 2015 Oct 1;6(10):6020.

24.

Correction: Fluorescent carbon dot-molecular salt hydrogels.

Cayuela A, Kennedy SR, Soriano ML, Jones CD, Valcárcel M, Steed JW.

Chem Sci. 2015 Oct 1;6(10):6020. doi: 10.1039/c5sc90052b. Epub 2015 Sep 7.

25.

Fluorous 'ponytails' lead to strong gelators showing thermally induced structure evolution.

Kumari H, Armitage SE, Kline SR, Damodaran KK, Kennedy SR, Atwood JL, Steed JW.

Soft Matter. 2015 Nov 21;11(43):8471-8. doi: 10.1039/c5sm01865j.

PMID:
26364926
26.

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress.

Pickrell AM, Huang CH, Kennedy SR, Ordureau A, Sideris DP, Hoekstra JG, Harper JW, Youle RJ.

Neuron. 2015 Jul 15;87(2):371-81. doi: 10.1016/j.neuron.2015.06.034.

27.

Volatility of Mutator Phenotypes at Single Cell Resolution.

Kennedy SR, Schultz EM, Chappell TM, Kohrn B, Knowels GM, Herr AJ.

PLoS Genet. 2015 Apr 13;11(4):e1005151. doi: 10.1371/journal.pgen.1005151. eCollection 2015 Apr.

28.

Detecting ultralow-frequency mutations by Duplex Sequencing.

Kennedy SR, Schmitt MW, Fox EJ, Kohrn BF, Salk JJ, Ahn EH, Prindle MJ, Kuong KJ, Shen JC, Risques RA, Loeb LA.

Nat Protoc. 2014 Nov;9(11):2586-606. doi: 10.1038/nprot.2014.170. Epub 2014 Oct 9. Erratum in: Nat Protoc. 2014 Dec;9(12):2903.

29.

Imaging and target volume delineation in glioma.

Whitfield GA, Kennedy SR, Djoukhadar IK, Jackson A.

Clin Oncol (R Coll Radiol). 2014 Jul;26(7):364-76. doi: 10.1016/j.clon.2014.04.026. Epub 2014 May 11. Review.

PMID:
24824451
30.

Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations.

Itsara LS, Kennedy SR, Fox EJ, Yu S, Hewitt JJ, Sanchez-Contreras M, Cardozo-Pelaez F, Pallanck LJ.

PLoS Genet. 2014 Feb 6;10(2):e1003974. doi: 10.1371/journal.pgen.1003974. eCollection 2014 Feb.

31.

DNA replication error-induced extinction of diploid yeast.

Herr AJ, Kennedy SR, Knowels GM, Schultz EM, Preston BD.

Genetics. 2014 Mar;196(3):677-91. doi: 10.1534/genetics.113.160960. Epub 2014 Jan 3.

32.

From evidence to practice: using the RE-AIM framework to adapt the REACHII caregiver intervention to the community.

Altpeter M, Gwyther LP, Kennedy SR, Patterson TR, Derence K.

Dementia (London). 2015 Jan;14(1):104-13. doi: 10.1177/1471301213494499. Epub 2013 Jul 19.

PMID:
24339092
33.

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage.

Kennedy SR, Salk JJ, Schmitt MW, Loeb LA.

PLoS Genet. 2013;9(9):e1003794. doi: 10.1371/journal.pgen.1003794. Epub 2013 Sep 26.

34.

Detection of ultra-rare mutations by next-generation sequencing.

Schmitt MW, Kennedy SR, Salk JJ, Fox EJ, Hiatt JB, Loeb LA.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14508-13. doi: 10.1073/pnas.1208715109. Epub 2012 Aug 1.

35.

Somatic mutations in aging, cancer and neurodegeneration.

Kennedy SR, Loeb LA, Herr AJ.

Mech Ageing Dev. 2012 Apr;133(4):118-26. doi: 10.1016/j.mad.2011.10.009. Epub 2011 Nov 3. Review.

36.

The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparum.

Kennedy SR, Chen CY, Schmitt MW, Bower CN, Loeb LA.

J Mol Biol. 2011 Jul 1;410(1):27-38. doi: 10.1016/j.jmb.2011.04.071. Epub 2011 May 5.

37.

Templated nucleoside triphosphate binding to a noncatalytic site on RNA polymerase regulates transcription.

Kennedy SR, Erie DA.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6079-84. doi: 10.1073/pnas.1011274108. Epub 2011 Mar 29.

38.

Forks, pincers, and triggers: the tools for nucleotide incorporation and translocation in multi-subunit RNA polymerases.

Erie DA, Kennedy SR.

Curr Opin Struct Biol. 2009 Dec;19(6):708-14. doi: 10.1016/j.sbi.2009.10.008. Epub 2009 Nov 11. Review.

39.
40.

Influence of dietary conjugated linoleic acid (CLA) on lipid and fatty acid composition in liver and flesh of Atlantic salmon (Salmo salar).

Kennedy SR, Campbell PJ, Porter A, Tocher DR.

Comp Biochem Physiol B Biochem Mol Biol. 2005 Jun;141(2):168-78. Epub 2005 Apr 12.

PMID:
15939320
41.

Porous broadband antireflection coating by glancing angle deposition.

Kennedy SR, Brett MJ.

Appl Opt. 2003 Aug 1;42(22):4573-9.

PMID:
12916623
42.
43.

Tissue distribution, subcellular localization and covalent binding of 2-chloroaniline and 4-chloroaniline in Fischer 344 rats.

Dial LD, Anestis DK, Kennedy SR, Rankin GO.

Toxicology. 1998 Nov 16;131(2-3):109-19.

PMID:
9928626
44.

Are mouse strains differentially susceptible to the reproductive toxicity of ethylene glycol monomethyl ether? A study of three strains.

Chapin RE, Morrissey RE, Gulati DK, Hope E, Barnes LH, Russell SA, Kennedy SR.

Fundam Appl Toxicol. 1993 Jul;21(1):8-14.

PMID:
8365589
45.

Sharing, caring, living, dying.

Kennedy SR.

Geriatr Nurs. 1985 Jan-Feb;6(1):12-7. No abstract available.

PMID:
3843820
46.

The action of intravenous histamine on the blood of the hemophiliac.

SANFORD HN, BUTLER S, KENNEDY SR.

Proc Inst Med Chic. 1949 May;17(14):329. No abstract available.

PMID:
18129997

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