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Fitness Restoration of a Genetically Tractable Enterococcus faecalis V583 Derivative To Study Decoration-Related Phenotypes of the Enterococcal Polysaccharide Antigen.

Furlan S, Matos RC, Kennedy SP, Doublet B, Serror P, Rigottier-Gois L.

mSphere. 2019 Jul 10;4(4). pii: e00310-19. doi: 10.1128/mSphere.00310-19.


RadD Contributes to R-Loop Avoidance in Sub-MIC Tobramycin.

Negro V, Krin E, Aguilar Pierlé S, Chaze T, Giai Gianetto Q, Kennedy SP, Matondo M, Mazel D, Baharoglu Z.

MBio. 2019 Jul 2;10(4). pii: e01173-19. doi: 10.1128/mBio.01173-19.


Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

Kennedy SP, Han JZR, Portman N, Nobis M, Hastings JF, Murphy KJ, Latham SL, Cadell AL, Miladinovic D, Marriott GR, O'Donnell YEI, Shearer RF, Williams JT, Munoz AG, Cox TR, Watkins DN, Saunders DN, Timpson P, Lim E, Kolch W, Croucher DR.

Breast Cancer Res. 2019 Mar 21;21(1):43. doi: 10.1186/s13058-019-1127-y.


Prediction of the intestinal resistome by a three-dimensional structure-based method.

Ruppé E, Ghozlane A, Tap J, Pons N, Alvarez AS, Maziers N, Cuesta T, Hernando-Amado S, Clares I, Martínez JL, Coque TM, Baquero F, Lanza VF, Máiz L, Goulenok T, de Lastours V, Amor N, Fantin B, Wieder I, Andremont A, van Schaik W, Rogers M, Zhang X, Willems RJL, de Brevern AG, Batto JM, Blottière HM, Léonard P, Léjard V, Letur A, Levenez F, Weiszer K, Haimet F, Doré J, Kennedy SP, Ehrlich SD.

Nat Microbiol. 2019 Jan;4(1):112-123. doi: 10.1038/s41564-018-0292-6. Epub 2018 Nov 26.


Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification (BiCAP).

Hastings JF, Han JZR, Shearer RF, Kennedy SP, Iconomou M, Saunders DN, Croucher DR.

J Vis Exp. 2018 Jun 15;(136). doi: 10.3791/57109.


Evaluation of the Impact of an Institution-Specific Dofetilide Initiation Protocol on Mean Hospital Length of Stay and Cost for Dofetilide Initiation.

Kennedy SP, Iaizzo H, Fayn E, Singh D.

Pharmacoecon Open. 2019 Mar;3(1):119-126. doi: 10.1007/s41669-018-0077-0.


Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells.

Vouri M, Croucher DR, Kennedy SP, An Q, Pilkington GJ, Hafizi S.

Oncogenesis. 2016 Oct 24;5(10):e266. doi: 10.1038/oncsis.2016.66.


The Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor Family.

Kennedy SP, Hastings JF, Han JZ, Croucher DR.

Front Cell Dev Biol. 2016 Aug 22;4:88. doi: 10.3389/fcell.2016.00088. eCollection 2016. Review.


Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers.

Croucher DR, Iconomou M, Hastings JF, Kennedy SP, Han JZ, Shearer RF, McKenna J, Wan A, Lau J, Aparicio S, Saunders DN.

Sci Signal. 2016 Jul 12;9(436):ra69. doi: 10.1126/scisignal.aaf0793.


A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae.

Val ME, Marbouty M, de Lemos Martins F, Kennedy SP, Kemble H, Bland MJ, Possoz C, Koszul R, Skovgaard O, Mazel D.

Sci Adv. 2016 Apr 22;2(4):e1501914. doi: 10.1126/sciadv.1501914. eCollection 2016 Apr.


Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients.

Fey D, Halasz M, Dreidax D, Kennedy SP, Hastings JF, Rauch N, Munoz AG, Pilkington R, Fischer M, Westermann F, Kolch W, Kholodenko BN, Croucher DR.

Sci Signal. 2015 Dec 22;8(408):ra130. doi: 10.1126/scisignal.aab0990.


Evaluation of the Food and Agriculture Sector Criticality Assessment Tool (FASCAT) and the Collected Data.

Huff AG, Hodges JS, Kennedy SP, Kircher A.

Risk Anal. 2015 Aug;35(8):1448-67. doi: 10.1111/risa.12377. Epub 2015 Apr 7.


Small-plasmid-mediated antibiotic resistance is enhanced by increases in plasmid copy number and bacterial fitness.

San Millan A, Santos-Lopez A, Ortega-Huedo R, Bernabe-Balas C, Kennedy SP, Gonzalez-Zorn B.

Antimicrob Agents Chemother. 2015;59(6):3335-41. doi: 10.1128/AAC.00235-15. Epub 2015 Mar 30.


Whole-genome mapping of 5' RNA ends in bacteria by tagged sequencing: a comprehensive view in Enterococcus faecalis.

Innocenti N, Golumbeanu M, Fouquier d'Hérouël A, Lacoux C, Bonnin RA, Kennedy SP, Wessner F, Serror P, Bouloc P, Repoila F, Aurell E.

RNA. 2015 May;21(5):1018-30. doi: 10.1261/rna.048470.114. Epub 2015 Mar 3.


Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects.

Kong LC, Holmes BA, Cotillard A, Habi-Rachedi F, Brazeilles R, Gougis S, Gausserès N, Cani PD, Fellahi S, Bastard JP, Kennedy SP, Doré J, Ehrlich SD, Zucker JD, Rizkalla SW, Clément K.

PLoS One. 2014 Oct 20;9(10):e109434. doi: 10.1371/journal.pone.0109434. eCollection 2014.


Next-generation sequencing identifies equine cartilage and subchondral bone miRNAs and suggests their involvement in osteochondrosis physiopathology.

Desjardin C, Vaiman A, Mata X, Legendre R, Laubier J, Kennedy SP, Laloe D, Barrey E, Jacques C, Cribiu EP, Schibler L.

BMC Genomics. 2014 Sep 17;15:798. doi: 10.1186/1471-2164-15-798.


Changes of the human gut microbiome induced by a fermented milk product.

Veiga P, Pons N, Agrawal A, Oozeer R, Guyonnet D, Brazeilles R, Faurie JM, van Hylckama Vlieg JE, Houghton LA, Whorwell PJ, Ehrlich SD, Kennedy SP.

Sci Rep. 2014 Sep 11;4:6328. doi: 10.1038/srep06328.


Alterations of the human gut microbiome in liver cirrhosis.

Qin N, Yang F, Li A, Prifti E, Chen Y, Shao L, Guo J, Le Chatelier E, Yao J, Wu L, Zhou J, Ni S, Liu L, Pons N, Batto JM, Kennedy SP, Leonard P, Yuan C, Ding W, Chen Y, Hu X, Zheng B, Qian G, Xu W, Ehrlich SD, Zheng S, Li L.

Nature. 2014 Sep 4;513(7516):59-64. doi: 10.1038/nature13568. Epub 2014 Jul 23.


Fuse or die: how to survive the loss of Dam in Vibrio cholerae.

Val ME, Kennedy SP, Soler-Bistué AJ, Barbe V, Bouchier C, Ducos-Galand M, Skovgaard O, Mazel D.

Mol Microbiol. 2014 Feb;91(4):665-78. doi: 10.1111/mmi.12483. Epub 2014 Jan 7.


Dietary intervention impact on gut microbial gene richness.

Cotillard A, Kennedy SP, Kong LC, Prifti E, Pons N, Le Chatelier E, Almeida M, Quinquis B, Levenez F, Galleron N, Gougis S, Rizkalla S, Batto JM, Renault P; ANR MicroObes consortium, Doré J, Zucker JD, Clément K, Ehrlich SD.

Nature. 2013 Aug 29;500(7464):585-8. doi: 10.1038/nature12480. Erratum in: Nature. 2013 Oct 24;502(7472)580.


Efficacy and tolerability of once-weekly rosuvastatin in patients with previous statin intolerance.

Kennedy SP, Barnas GP, Schmidt MJ, Glisczinski MS, Paniagua AC.

J Clin Lipidol. 2011 Jul-Aug;5(4):308-15. doi: 10.1016/j.jacl.2011.03.454. Epub 2011 May 13.


Complete genome sequence of the clinical Streptococcus salivarius strain CCHSS3.

Delorme C, Guédon E, Pons N, Cruaud C, Couloux A, Loux V, Chiapello H, Poyart C, Gautier C, Sanchez N, Almeida M, Kennedy SP, Ehrlich SD, Gibrat JF, Wincker P, Renault P.

J Bacteriol. 2011 Sep;193(18):5041-2. doi: 10.1128/JB.05416-11. Epub 2011 Jul 8.


Complete genome sequence of the commensal Streptococcus salivarius strain JIM8777.

Guédon E, Delorme C, Pons N, Cruaud C, Loux V, Couloux A, Gautier C, Sanchez N, Layec S, Galleron N, Almeida M, van de Guchte M, Kennedy SP, Ehrlich SD, Gibrat JF, Wincker P, Renault P.

J Bacteriol. 2011 Sep;193(18):5024-5. doi: 10.1128/JB.05390-11. Epub 2011 Jul 8.


A simple and efficient method to search for selected primary transcripts: non-coding and antisense RNAs in the human pathogen Enterococcus faecalis.

Fouquier d'Hérouel A, Wessner F, Halpern D, Ly-Vu J, Kennedy SP, Serror P, Aurell E, Repoila F.

Nucleic Acids Res. 2011 Apr;39(7):e46. doi: 10.1093/nar/gkr012. Epub 2011 Jan 25.


FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae.

Val ME, Kennedy SP, El Karoui M, Bonné L, Chevalier F, Barre FX.

PLoS Genet. 2008 Sep 26;4(9):e1000201. doi: 10.1371/journal.pgen.1000201.


Delayed activation of Xer recombination at dif by FtsK during septum assembly in Escherichia coli.

Kennedy SP, Chevalier F, Barre FX.

Mol Microbiol. 2008 May;68(4):1018-28. doi: 10.1111/j.1365-2958.2008.06212.x. Epub 2008 Mar 19.


Effective partnering of academic and physician scientists with the pharmaceutical drug development industry.

Kennedy SP, Bormann BJ.

Exp Biol Med (Maywood). 2006 Dec;231(11):1690-4.


The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor.

DeNinno MP, Masamune H, Chenard LK, DiRico KJ, Eller C, Etienne JB, Tickner JE, Kennedy SP, Knight DR, Kong J, Oleynek JJ, Tracey WR, Hill RJ.

Bioorg Med Chem Lett. 2006 May 1;16(9):2525-7. Epub 2006 Feb 7.


Informed toxicity assessment in drug discovery: systems-based toxicology.

Mayne JT, Ku WW, Kennedy SP.

Curr Opin Drug Discov Devel. 2006 Jan;9(1):75-83. Review.


Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon.

Dassarma S, Kennedy SP, Berquist B, Victor Ng W, Baliga NS, Spudich JL, Krebs MP, Eisen JA, Johnson CH, Hood L.

Photosynth Res. 2001;70(1):3-17.


Arsenic resistance in Halobacterium sp. strain NRC-1 examined by using an improved gene knockout system.

Wang G, Kennedy SP, Fasiludeen S, Rensing C, DasSarma S.

J Bacteriol. 2004 May;186(10):3187-94.


Emergency department management of suicidal adolescents.

Kennedy SP, Baraff LJ, Suddath RL, Asarnow JR.

Ann Emerg Med. 2004 Apr;43(4):452-60. Review.


3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.

DeNinno MP, Masamune H, Chenard LK, DiRico KJ, Eller C, Etienne JB, Tickner JE, Kennedy SP, Knight DR, Kong J, Oleynek JJ, Tracey WR, Hill RJ.

J Med Chem. 2003 Jan 30;46(3):353-5.


Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.

Marala RB, Brown JA, Kong JX, Tracey WR, Knight DR, Wester RT, Sun D, Kennedy SP, Hamanaka ES, Ruggeri RB, Hill RJ.

Eur J Pharmacol. 2002 Sep 6;451(1):37-41.


Breeding soundness evaluations of 3,648 yearling beef bulls using the 1993 Society for Theriogenology guidelines.

Kennedy SP, Spitzer JC, Hopkins FM, Higdon HL, Bridges WC Jr.

Theriogenology. 2002 Sep;58(5):947-61.


Coherent control of optical emission from a conjugated polymer.

Kennedy SP, Garro N, Phillips RT.

Phys Rev Lett. 2001 Apr 30;86(18):4148-51.


Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.

Guzman-Perez A, Wester RT, Allen MC, Brown JA, Buchholz AR, Cook ER, Day WW, Hamanaka ES, Kennedy SP, Knight DR, Kowalczyk PJ, Marala RB, Mularski CJ, Novomisle WA, Ruggeri RB, Tracey WR, Hill RJ.

Bioorg Med Chem Lett. 2001 Mar 26;11(6):803-7.


Genomic and genetic dissection of an archaeal regulon.

Baliga NS, Kennedy SP, Ng WV, Hood L, DasSarma S.

Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2521-5. Epub 2001 Feb 20.


brp and blh are required for synthesis of the retinal cofactor of bacteriorhodopsin in Halobacterium salinarum.

Peck RF, Echavarri-Erasun C, Johnson EA, Ng WV, Kennedy SP, Hood L, DasSarma S, Krebs MP.

J Biol Chem. 2001 Feb 23;276(8):5739-44. Epub 2000 Nov 22.


Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation.

Haley KJ, Lilly CM, Yang JH, Feng Y, Kennedy SP, Turi TG, Thompson JF, Sukhova GH, Libby P, Lee RT.

Circulation. 2000 Oct 31;102(18):2185-9.


Genome sequence of Halobacterium species NRC-1.

Ng WV, Kennedy SP, Mahairas GG, Berquist B, Pan M, Shukla HD, Lasky SR, Baliga NS, Thorsson V, Sbrogna J, Swartzell S, Weir D, Hall J, Dahl TA, Welti R, Goo YA, Leithauser B, Keller K, Cruz R, Danson MJ, Hough DW, Maddocks DG, Jablonski PE, Krebs MP, Angevine CM, Dale H, Isenbarger TA, Peck RF, Pohlschroder M, Spudich JL, Jung KW, Alam M, Freitas T, Hou S, Daniels CJ, Dennis PP, Omer AD, Ebhardt H, Lowe TM, Liang P, Riley M, Hood L, DasSarma S.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12176-81.


Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.

Carman CV, Barak LS, Chen C, Liu-Chen LY, Onorato JJ, Kennedy SP, Caron MG, Benovic JL.

J Biol Chem. 2000 Apr 7;275(14):10443-52.


Transcriptional profile of mechanically induced genes in human vascular smooth muscle cells.

Feng Y, Yang JH, Huang H, Kennedy SP, Turi TG, Thompson JF, Libby P, Lee RT.

Circ Res. 1999 Dec 3-17;85(12):1118-23.


Induction of tenascin-C in cardiac myocytes by mechanical deformation. Role of reactive oxygen species.

Yamamoto K, Dang QN, Kennedy SP, Osathanondh R, Kelly RA, Lee RT.

J Biol Chem. 1999 Jul 30;274(31):21840-6.


Human ventricular myocytes in vitro exhibit both early and delayed preconditioning responses to simulated ischemia.

Arstall MA, Zhao YZ, Hornberger L, Kennedy SP, Buchholz RA, Osathanondh R, Kelly RA.

J Mol Cell Cardiol. 1998 May;30(5):1019-25.


Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response.

Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ.

Biochem Biophys Res Commun. 1998 Mar 27;244(3):832-7.


Evidence for a role for both the adenosine A1 and A3 receptors in protection of isolated human atrial muscle against simulated ischaemia.

Carr CS, Hill RJ, Masamune H, Kennedy SP, Knight DR, Tracey WR, Yellon DM.

Cardiovasc Res. 1997 Oct;36(1):52-9.


Delivery of tumor suppressor genes to reverse the malignant phenotype.

Kennedy SP, Gibson NW.

Adv Drug Deliv Rev. 1997 Jul 7;26(2-3):119-133.


Selective adenosine A3 receptor stimulation reduces ischemic myocardial injury in the rabbit heart.

Tracey WR, Magee W, Masamune H, Kennedy SP, Knight DR, Buchholz RA, Hill RJ.

Cardiovasc Res. 1997 Feb;33(2):410-5.


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