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Methodological Considerations on the Use of Different Spectral Decomposition Algorithms to Study Hippocampal Rhythms.

Zhou Y, Sheremet A, Qin Y, Kennedy JP, DiCola NM, Burke SN, Maurer AP.

eNeuro. 2019 Aug 1;6(4). pii: ENEURO.0142-19.2019. doi: 10.1523/ENEURO.0142-19.2019. Print 2019 Jul/Aug.


Wave Turbulence and Energy Cascade in the Hippocampus.

Sheremet A, Qin Y, Kennedy JP, Zhou Y, Maurer AP.

Front Syst Neurosci. 2019 Jan 4;12:62. doi: 10.3389/fnsys.2018.00062. eCollection 2018.


Theta-gamma cascades and running speed.

Sheremet A, Kennedy JP, Qin Y, Zhou Y, Lovett SD, Burke SN, Maurer AP.

J Neurophysiol. 2019 Feb 1;121(2):444-458. doi: 10.1152/jn.00636.2018. Epub 2018 Dec 5.


Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.

Abbott JR, Patel PA, Howes JE, Akan DT, Kennedy JP, Burns MC, Browning CF, Sun Q, Rossanese OW, Phan J, Waterson AG, Fesik SW.

ACS Med Chem Lett. 2018 Aug 8;9(9):941-946. doi: 10.1021/acsmedchemlett.8b00296. eCollection 2018 Sep 13.


Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.

Abbott JR, Hodges TR, Daniels RN, Patel PA, Kennedy JP, Howes JE, Akan DT, Burns MC, Sai J, Sobolik T, Beesetty Y, Lee T, Rossanese OW, Phan J, Waterson AG, Fesik SW.

J Med Chem. 2018 Jul 26;61(14):6002-6017. doi: 10.1021/acs.jmedchem.8b00360. Epub 2018 Jul 11.


Real-Time Monitoring of Chemical and Topological Rearrangements in Solidifying Amphiphilic Polymer Co-Networks: Understanding Surface Demixing.

Guzman G, Nugay T, Kennedy JP, Cakmak M.

Langmuir. 2016 Apr 12;32(14):3445-51. doi: 10.1021/acs.langmuir.6b00587. Epub 2016 Mar 29.


Postglacial expansion pathways of red mangrove, Rhizophora mangle, in the Caribbean Basin and Florida.

Kennedy JP, Pil MW, Proffitt CE, Boeger WA, Stanford AM, Devlin DJ.

Am J Bot. 2016 Feb;103(2):260-76. doi: 10.3732/ajb.1500183. Epub 2016 Feb 2.


Diphenylpyrazoles as replication protein a inhibitors.

Waterson AG, Kennedy JP, Patrone JD, Pelz NF, Feldkamp MD, Frank AO, Vangamudi B, Souza-Fagundes EM, Rossanese OW, Chazin WJ, Fesik SW.

ACS Med Chem Lett. 2014 Nov 11;6(2):140-5. doi: 10.1021/ml5003629. eCollection 2015 Feb 12.


Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.

Burns MC, Sun Q, Daniels RN, Camper D, Kennedy JP, Phan J, Olejniczak ET, Lee T, Waterson AG, Rossanese OW, Fesik SW.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3401-6. doi: 10.1073/pnas.1315798111. Epub 2014 Feb 18.


Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.

Frank AO, Feldkamp MD, Kennedy JP, Waterson AG, Pelz NF, Patrone JD, Vangamudi B, Camper DV, Rossanese OW, Chazin WJ, Fesik SW.

J Med Chem. 2013 Nov 27;56(22):9242-50. doi: 10.1021/jm401333u. Epub 2013 Nov 11.


Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein A interaction motif of ATR interacting protein.

Feldkamp MD, Frank AO, Kennedy JP, Patrone JD, Vangamudi B, Waterson AG, Fesik SW, Chazin WJ.

Biochemistry. 2013 Sep 17;52(37):6515-24. doi: 10.1021/bi400542z. Epub 2013 Sep 6.


Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.

Patrone JD, Kennedy JP, Frank AO, Feldkamp MD, Vangamudi B, Pelz NF, Rossanese OW, Waterson AG, Chazin WJ, Fesik SW.

ACS Med Chem Lett. 2013 Jul 11;4(7):601-605.


Treatment Options to Manage Wound Biofilm.

Jones CE, Kennedy JP.

Adv Wound Care (New Rochelle). 2012 Jun;1(3):120-126. Review.


Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding.

Speed N, Saunders C, Davis AR, Owens WA, Matthies HJ, Saadat S, Kennedy JP, Vaughan RA, Neve RL, Lindsley CW, Russo SJ, Daws LC, Niswender KD, Galli A.

PLoS One. 2011;6(9):e25169. doi: 10.1371/journal.pone.0025169. Epub 2011 Sep 28.


Engineered channels enhance cellular density in perfused scaffolds.

Kennedy JP, McCandless SP, Rauf A, Williams LM, Hillam J, Hitchcock RW.

Acta Biomater. 2011 Nov;7(11):3896-904. doi: 10.1016/j.actbio.2011.06.037. Epub 2011 Jun 28.


Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.

Bridges TM, Kennedy JP, Hopkins CR, Conn PJ, Lindsley CW.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-22. doi: 10.1016/j.bmcl.2010.08.042. Epub 2010 Aug 12.


Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis.

Robertson SD, Matthies HJ, Owens WA, Sathananthan V, Christianson NS, Kennedy JP, Lindsley CW, Daws LC, Galli A.

J Neurosci. 2010 Aug 25;30(34):11305-16. doi: 10.1523/JNEUROSCI.0126-10.2010.


Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression.

Speed NK, Matthies HJ, Kennedy JP, Vaughan RA, Javitch JA, Russo SJ, Lindsley CW, Niswender K, Galli A.

ACS Chem Neurosci. 2010 Jul 21;1(7):476-81. doi: 10.1021/cn100031t. Epub 2010 May 25.


Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice.

Siuta MA, Robertson SD, Kocalis H, Saunders C, Gresch PJ, Khatri V, Shiota C, Kennedy JP, Lindsley CW, Daws LC, Polley DB, Veenstra-Vanderweele J, Stanwood GD, Magnuson MA, Niswender KD, Galli A.

PLoS Biol. 2010 Jun 8;8(6):e1000393. doi: 10.1371/journal.pbio.1000393.


Design and characterization of a modified T-flask bioreactor for continuous monitoring of engineered tissue stiffness.

Lasher RA, Wolchok JC, Parikh MK, Kennedy JP, Hitchcock RW.

Biotechnol Prog. 2010 May-Jun;26(3):857-64. doi: 10.1002/btpr.380.


Toward a bioartificial pancreas: diffusion of insulin and IgG across immunoprotective membranes with controlled hydrophilic channel diameters.

Kang J, Erdodi G, Kennedy JP, Chou H, Lu L, Grundfest-Broniatowski S.

Macromol Biosci. 2010 Apr 8;10(4):369-77. doi: 10.1002/mabi.200900386.


Effects of biofilm treatments on the multi-species Lubbock chronic wound biofilm model.

Dowd SE, Sun Y, Smith E, Kennedy JP, Jones CE, Wolcott R.

J Wound Care. 2009 Dec;18(12):508, 510-12.


Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.

Lebois EP, Bridges TM, Lewis LM, Dawson ES, Kane AS, Xiang Z, Jadhav SB, Yin H, Kennedy JP, Meiler J, Niswender CM, Jones CK, Conn PJ, Weaver CD, Lindsley CW.

ACS Chem Neurosci. 2010;1(2):104-121.


Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

Bridges TM, Kennedy JP, Cho HP, Breininger ML, Gentry PR, Hopkins CR, Conn PJ, Lindsley CW.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62. doi: 10.1016/j.bmcl.2009.11.089. Epub 2009 Nov 22.


Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells.

Miller TW, Forbes JT, Shah C, Wyatt SK, Manning HC, Olivares MG, Sanchez V, Dugger TC, de Matos Granja N, Narasanna A, Cook RS, Kennedy JP, Lindsley CW, Arteaga CL.

Clin Cancer Res. 2009 Dec 1;15(23):7266-76. doi: 10.1158/1078-0432.CCR-09-1665. Epub 2009 Nov 24.


A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.

Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Xiang Z, Watson ML, Christian EP, Doherty JJ, Quirk MC, Snyder DH, Lah JJ, Levey AI, Nicolle MM, Lindsley CW, Conn PJ.

J Neurosci. 2009 Nov 11;29(45):14271-86. doi: 10.1523/JNEUROSCI.3930-09.2009.


The mechanically enhanced phase separation of sprayed polyurethane scaffolds and their effect on the alignment of fibroblasts.

Kennedy JP, McCandless SP, Lasher RA, Hitchcock RW.

Biomaterials. 2010 Feb;31(6):1126-32. doi: 10.1016/j.biomaterials.2009.10.024. Epub 2009 Oct 30.


Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe.

Weaver CD, Sheffler DJ, Lewis LM, Bridges TM, Williams R, Nalywajko NT, Kennedy JP, Mulder MM, Jadhav S, Aldrich LA, Jones CK, Marlo JE, Niswender CM, Mock MM, Zheng F, Conn PJ, Lindsley CW.

Curr Top Med Chem. 2009;9(13):1217-26. Review.


Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor.

Kennedy JP, Bridges TM, Gentry PR, Brogan JT, Kane AS, Jones CK, Brady AE, Shirey JK, Conn PJ, Lindsley CW.

ChemMedChem. 2009 Oct;4(10):1600-7. doi: 10.1002/cmdc.200900231. No abstract available.


A new bioartificial pancreas utilizing amphiphilic membranes for the immunoisolation of porcine islets: a pilot study in the canine.

Grundfest-Broniatowski SF, Tellioglu G, Rosenthal KS, Kang J, Erdodi G, Yalcin B, Cakmak M, Drazba J, Bennett A, Lu L, Kennedy JP.

ASAIO J. 2009 Jul-Aug;55(4):400-5. doi: 10.1097/MAT.0b013e3181a8deba.


A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin.

Kennedy JP, Conn PJ, Lindsley CW.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3204-8. doi: 10.1016/j.bmcl.2009.04.106. Epub 2009 May 3.


Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer.

Miller TW, Pérez-Torres M, Narasanna A, Guix M, Stål O, Pérez-Tenorio G, Gonzalez-Angulo AM, Hennessy BT, Mills GB, Kennedy JP, Lindsley CW, Arteaga CL.

Cancer Res. 2009 May 15;69(10):4192-201. doi: 10.1158/0008-5472.CAN-09-0042. Epub 2009 May 12.


Regular debridement is the main tool for maintaining a healthy wound bed in most chronic wounds.

Wolcott RD, Kennedy JP, Dowd SE.

J Wound Care. 2009 Feb;18(2):54-6. Review.


A novel macroencapsulating immunoisolatory device: the preparation and properties of nanomat-reinforced amphiphilic co-networks deposited on perforated metal scaffold.

Erdodi G, Kang J, Yalcin B, Cakmak M, Rosenthal KS, Grundfest-Broniatowski S, Kennedy JP.

Biomed Microdevices. 2009 Feb;11(1):297-312. doi: 10.1007/s10544-008-9236-x.


Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ.

J Neurosci. 2008 Oct 8;28(41):10422-33. doi: 10.1523/JNEUROSCI.1850-08.2008.


Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties.

Bridges TM, Brady AE, Kennedy JP, Daniels RN, Miller NR, Kim K, Breininger ML, Gentry PR, Brogan JT, Jones CK, Conn PJ, Lindsley CW.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5439-42. doi: 10.1016/j.bmcl.2008.09.023. Epub 2008 Sep 10.


Direct probe-atmospheric pressure chemical ionization mass spectrometry of cross-linked copolymers and copolymer blends.

Whitson SE, Erdodi G, Kennedy JP, Lattimer RP, Wesdemiotis C.

Anal Chem. 2008 Oct 15;80(20):7778-85. doi: 10.1021/ac801198g. Epub 2008 Sep 12.


Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats.

Brady AE, Jones CK, Bridges TM, Kennedy JP, Thompson AD, Heiman JU, Breininger ML, Gentry PR, Yin H, Jadhav SB, Shirey JK, Conn PJ, Lindsley CW.

J Pharmacol Exp Ther. 2008 Dec;327(3):941-53. doi: 10.1124/jpet.108.140350. Epub 2008 Sep 4.


Application of combinatorial chemistry science on modern drug discovery.

Kennedy JP, Williams L, Bridges TM, Daniels RN, Weaver D, Lindsley CW.

J Comb Chem. 2008 May-Jun;10(3):345-54. doi: 10.1021/cc700187t. Epub 2008 Jan 26. Review. No abstract available.


Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists.

Lewis LM, Sheffler D, Williams R, Bridges TM, Kennedy JP, Brogan JT, Mulder MJ, Williams L, Nalywajko NT, Niswender CM, Weaver CD, Conn PJ, Lindsley CW.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):885-90. doi: 10.1016/j.bmcl.2007.12.051. Epub 2008 Jan 4.


Novel biostable and biocompatible amphiphilic membranes.

Jewrajka SK, Erdodi G, Kennedy JP, Ely D, Dunphy G, Boehme S, Popescu F.

J Biomed Mater Res A. 2008 Oct;87(1):69-77.


Medical applications of poly(styrene-block-isobutylene-block-styrene) ("SIBS").

Pinchuk L, Wilson GJ, Barry JJ, Schoephoerster RT, Parel JM, Kennedy JP.

Biomaterials. 2008 Feb;29(4):448-60. Epub 2007 Nov 5. Review.


Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility.

Silvaggi NR, Boldt GE, Hixon MS, Kennedy JP, Tzipori S, Janda KD, Allen KN.

Chem Biol. 2007 May;14(5):533-42.


Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation.

Xu Y, Lu H, Kennedy JP, Yan X, McAllister LA, Yamamoto N, Moss JA, Boldt GE, Jiang S, Janda KD.

J Comb Chem. 2006 Jul-Aug;8(4):531-9.


Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors.

Boldt GE, Kennedy JP, Hixon MS, McAllister LA, Barbieri JT, Tzipori S, Janda KD.

J Comb Chem. 2006 Jul-Aug;8(4):513-21.


Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: a new wrinkle in botulinum neurotoxin.

McAllister LA, Hixon MS, Kennedy JP, Dickerson TJ, Janda KD.

J Am Chem Soc. 2006 Apr 5;128(13):4176-7.


Intellectual ability in adolescents with conduct disorder.

Kennedy JP, Richardson GR, Dixon L, Kelly TP.

Percept Mot Skills. 2003 Dec;97(3 Pt 2):1089-90.


Synthesis, permeability and biocompatibility of tricomponent membranes containing polyethylene glycol, polydimethylsiloxane and polypentamethylcyclopentasiloxane domains.

Kurian P, Kasibhatla B, Daum J, Burns CA, Moosa M, Rosenthal KS, Kennedy JP.

Biomaterials. 2003 Sep;24(20):3493-503.


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