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Constrained peptides and biological targets.

Kennedy EJ.

Bioorg Med Chem. 2018 Mar 15;26(6):1117. doi: 10.1016/j.bmc.2018.02.046. No abstract available.


Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.

Burgess SG, Mukherjee M, Sabir S, Joseph N, Gutiérrez-Caballero C, Richards MW, Huguenin-Dezot N, Chin JW, Kennedy EJ, Pfuhl M, Royle SJ, Gergely F, Bayliss R.

EMBO J. 2018 Apr 13;37(8). pii: e97902. doi: 10.15252/embj.201797902. Epub 2018 Mar 6.


Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2.

Bendzunas NG, Dörfler S, Autenrieth K, Bertinetti D, Machal EMF, Kennedy EJ, Herberg FW.

Bioorg Med Chem. 2018 Mar 15;26(6):1174-1178. doi: 10.1016/j.bmc.2018.02.001. Epub 2018 Feb 12.


Cell penetrating peptides to dissect host-pathogen protein-protein interactions in Theileria-transformed leukocytes.

Haidar M, Latré de Laté P, Kennedy EJ, Langsley G.

Bioorg Med Chem. 2018 Mar 15;26(6):1127-1134. doi: 10.1016/j.bmc.2017.08.056. Epub 2017 Sep 7. Review.


Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation.

Fulton MD, Hanold LE, Ruan Z, Patel S, Beedle AM, Kannan N, Kennedy EJ.

Bioorg Med Chem. 2018 Mar 15;26(6):1167-1173. doi: 10.1016/j.bmc.2017.08.051. Epub 2017 Sep 5.


Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss.

Refaey ME, McGee-Lawrence ME, Fulzele S, Kennedy EJ, Bollag WB, Elsalanty M, Zhong Q, Ding KH, Bendzunas NG, Shi XM, Xu J, Hill WD, Johnson MH, Hunter M, Pierce JL, Yu K, Hamrick MW, Isales CM.

J Bone Miner Res. 2017 Nov;32(11):2182-2193. doi: 10.1002/jbmr.3224. Epub 2017 Aug 14.


Suppression of Breast Cancer Metastasis Using Stapled Peptides Targeting the WASF Regulatory Complex.

Cowell JK, Teng Y, Bendzunas NG, Ara R, Arbab AS, Kennedy EJ.

Cancer Growth Metastasis. 2017 Jun 19;10:1179064417713197. doi: 10.1177/1179064417713197. eCollection 2017.


Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution.

Mo GC, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, Jimenez R, Xiao J, Dedecker P, Zhang J.

Nat Methods. 2017 Apr;14(4):427-434. doi: 10.1038/nmeth.4221. Epub 2017 Mar 13.


Targeting kinase signaling pathways with constrained peptide scaffolds.

Hanold LE, Fulton MD, Kennedy EJ.

Pharmacol Ther. 2017 May;173:159-170. doi: 10.1016/j.pharmthera.2017.02.014. Epub 2017 Feb 7. Review.


HK2 Recruitment to Phospho-BAD Prevents Its Degradation, Promoting Warburg Glycolysis by Theileria-Transformed Leukocytes.

Haidar M, Lombès A, Bouillaud F, Kennedy EJ, Langsley G.

ACS Infect Dis. 2017 Mar 10;3(3):216-224. doi: 10.1021/acsinfecdis.6b00180. Epub 2017 Jan 24.


PKA and Apicomplexan Parasite Diseases.

Haidar M, Ramdani G, Kennedy EJ, Langsley G.

Horm Metab Res. 2017 Apr;49(4):e1. doi: 10.1055/s-0042-121366. Epub 2016 Nov 22. German. No abstract available.


PKA and Apicomplexan Parasite Diseases.

Haidar M, Ramdani G, Kennedy EJ, Langsley G.

Horm Metab Res. 2017 Apr;49(4):296-300. doi: 10.1055/s-0042-118459. Epub 2016 Nov 11. Review.


Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N.

PLoS Genet. 2016 Aug 11;12(8):e1006265. doi: 10.1371/journal.pgen.1006265. eCollection 2016 Aug.


The WASF3-NCKAP1-CYFIP1 Complex Is Essential for Breast Cancer Metastasis.

Teng Y, Qin H, Bahassan A, Bendzunas NG, Kennedy EJ, Cowell JK.

Cancer Res. 2016 Sep 1;76(17):5133-42. doi: 10.1158/0008-5472.CAN-16-0562. Epub 2016 Jul 18.


AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.

Götz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zühlke K, Kreuchwig A, Kennedy EJ, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E.

Biochem J. 2016 Jul 1;473(13):1881-94. doi: 10.1042/BCJ20160242. Epub 2016 Apr 21.


Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N.

PLoS Genet. 2016 Feb 29;12(2):e1005885. doi: 10.1371/journal.pgen.1005885. eCollection 2016 Feb. Erratum in: PLoS Genet. 2016 Aug;12(8):e1006265.


Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation.

Bavencoffe A, Li Y, Wu Z, Yang Q, Herrera J, Kennedy EJ, Walters ET, Dessauer CW.

J Neurosci. 2016 Feb 3;36(5):1660-8. doi: 10.1523/JNEUROSCI.0895-15.2016.


Targeting the WASF3-CYFIP1 Complex Using Stapled Peptides Suppresses Cancer Cell Invasion.

Teng Y, Bahassan A, Dong D, Hanold LE, Ren X, Kennedy EJ, Cowell JK.

Cancer Res. 2016 Feb 15;76(4):965-73. doi: 10.1158/0008-5472.CAN-15-1680. Epub 2015 Dec 16.


Lysophosphatidic Acid Mediates Activating Transcription Factor 3 Expression Which Is a Target for Post-Transcriptional Silencing by miR-30c-2-3p.

Nguyen HT, Jia W, Beedle AM, Kennedy EJ, Murph MM.

PLoS One. 2015 Sep 29;10(9):e0139489. doi: 10.1371/journal.pone.0139489. eCollection 2015.


Dialing in EGFR Signaling.

Kennedy EJ, Kannan N.

Chem Biol. 2015 Jun 18;22(6):687-8. doi: 10.1016/j.chembiol.2015.06.001.


The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism.

Flaherty BR, Wang Y, Trope EC, Ho TG, Muralidharan V, Kennedy EJ, Peterson DS.

PLoS One. 2015 May 26;10(5):e0129239. doi: 10.1371/journal.pone.0129239. eCollection 2015.


Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein.

Hermann JS, Skroblin P, Bertinetti D, Hanold LE, von der Heide EK, Wagener EM, Zenn HM, Klussmann E, Kennedy EJ, Herberg FW.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1667-75. doi: 10.1016/j.bbapap.2015.04.018. Epub 2015 Apr 23.


Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design.

Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan N.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1575-85. doi: 10.1016/j.bbapap.2015.03.012. Epub 2015 Apr 3.


Design of a selenylsulfide-bridged EGFR dimerization arm mimic.

Hanold LE, Watkins CP, Ton NT, Liaw P, Beedle AM, Kennedy EJ.

Bioorg Med Chem. 2015 Jun 15;23(12):2761-6. doi: 10.1016/j.bmc.2015.03.040. Epub 2015 Mar 20.


Inhibiting EGFR dimerization using triazolyl-bridged dimerization arm mimics.

Hanold LE, Oruganty K, Ton NT, Beedle AM, Kannan N, Kennedy EJ.

PLoS One. 2015 Mar 19;10(3):e0118796. doi: 10.1371/journal.pone.0118796. eCollection 2015.


Selective disruption of the AKAP signaling complexes.

Kennedy EJ, Scott JD.

Methods Mol Biol. 2015;1294:137-50. doi: 10.1007/978-1-4939-2537-7_11.


PKA-type I selective constrained peptide disruptors of AKAP complexes.

Wang Y, Ho TG, Franz E, Hermann JS, Smith FD, Hehnly H, Esseltine JL, Hanold LE, Murph MM, Bertinetti D, Scott JD, Herberg FW, Kennedy EJ.

ACS Chem Biol. 2015 Jun 19;10(6):1502-10. doi: 10.1021/acschembio.5b00009. Epub 2015 Mar 25.


Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells.

El Refaey M, Watkins CP, Kennedy EJ, Chang A, Zhong Q, Ding KH, Shi XM, Xu J, Bollag WB, Hill WD, Johnson M, Hunter M, Hamrick MW, Isales CM.

Mol Cell Endocrinol. 2015 Jul 15;410:87-96. doi: 10.1016/j.mce.2015.01.034. Epub 2015 Jan 28.


EMBO conference series: Chemical Biology 2014.

Kennedy EJ.

Chembiochem. 2014 Dec 15;15(18):2783-7. doi: 10.1002/cbic.201402527. Epub 2014 Oct 16.


Development of rabbit monoclonal antibodies for detection of alpha-dystroglycan in normal and dystrophic tissue.

Fortunato MJ, Ball CE, Hollinger K, Patel NB, Modi JN, Rajasekaran V, Nonneman DJ, Ross JW, Kennedy EJ, Selsby JT, Beedle AM.

PLoS One. 2014 May 13;9(5):e97567. doi: 10.1371/journal.pone.0097567. eCollection 2014.


Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides.

Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GC, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ.

ACS Chem Biol. 2014 Mar 21;9(3):635-42. doi: 10.1021/cb400900r. Epub 2014 Jan 21. Erratum in: ACS Chem Biol. 2014 Jun 20;9(6):1386.


Identifying critical non-catalytic residues that modulate protein kinase A activity.

Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G.

PLoS One. 2009;4(3):e4746. doi: 10.1371/journal.pone.0004746. Epub 2009 Mar 9.


Contribution of non-catalytic core residues to activity and regulation in protein kinase A.

Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor SS.

J Biol Chem. 2009 Mar 6;284(10):6241-8. doi: 10.1074/jbc.M805862200. Epub 2009 Jan 2.


Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2.

Kennedy EJ, Ghosh G, Pillus L.

J Biol Chem. 2008 Jan 11;283(2):1084-93. Epub 2007 Oct 30.


Hospital readmission for bronchiolitis.

Kemper AR, Kennedy EJ, Dechert RE, Saint S.

Clin Pediatr (Phila). 2005 Jul-Aug;44(6):509-13.


Hospital decision-making regarding the smallpox pre-event vaccination program.

Kemper AR, Cowan AE, Ching PL, Davis MM, Kennedy EJ, Clark SJ, Freed GL.

Biosecur Bioterror. 2005;3(1):23-30.


Early phonological awareness and reading skills in children with Down syndrome.

Kennedy EJ, Flynn MC.

Downs Syndr Res Pract. 2003 Aug;8(3):100-9.


Training phonological awareness skills in children with Down syndrome.

Kennedy EJ, Flynn MC.

Res Dev Disabil. 2003 Jan-Feb;24(1):44-57.


Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells.

Bourke E, Kennedy EJ, Moynagh PN.

J Biol Chem. 2000 Dec 22;275(51):39996-40002.


Over-the-counter emergency contraception: a feasible option.

Matheson CI, Smith BH, Flett G, Bond CM, Kennedy EJ, Michie C, Duthie I.

Fam Pract. 1998 Feb;15(1):38-43.


Prospective study of bone, indium-111-labeled white blood cell, and gallium-67 scanning for the evaluation of osteomyelitis in the diabetic foot.

Johnson JE, Kennedy EJ, Shereff MJ, Patel NC, Collier BD.

Foot Ankle Int. 1996 Jan;17(1):10-6.


Performance of a rapid, on-site human immunodeficiency virus antibody assay in a public health setting.

Kassler WJ, Haley C, Jones WK, Gerber AR, Kennedy EJ, George JR.

J Clin Microbiol. 1995 Nov;33(11):2899-902.


Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia.

Frischer H, Kennedy EJ, Chigurupati R, Sivarajan M.

J Clin Invest. 1993 Dec;92(6):2761-7.


Tricyclic antidepressants in red cells and plasma: correlation with impaired intraventricular conduction in acute overdose.

Amitai Y, Erickson T, Kennedy EJ, Leikin JB, Hryhorczuk DO, Noble J, Hanashiro PK, Frischer H.

Clin Pharmacol Ther. 1993 Aug;54(2):219-27.


Distribution of amitriptyline and nortriptyline in blood: role of alpha-1-glycoprotein.

Amitai Y, Kennedy EJ, DeSandre P, Frischer H.

Ther Drug Monit. 1993 Aug;15(4):267-73.


Fluorescent treponemal antibody absorption double-staining test evaluation.

Farshy CE, Kennedy EJ, Hunter EF, Larsen SA.

J Clin Microbiol. 1983 Feb;17(2):245-8.


Fluorescent treponemal antibody-absorption double-staining procedure.

Hunter EF, Pender BJ, Kennedy EJ, Pettit DE, Schubert CM, Feeley JC, Larsen SA, McGrew BE.

J Clin Microbiol. 1981 Aug;14(2):184-8.

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