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Prostaglandin E2 receptor EP1 (PGE2/EP1) deletion promotes glomerular podocyte and endothelial cell injury in hypertensive TTRhRen mice.

Nasrallah R, Zimpelmann J, Robertson SJ, Ghossein J, Thibodeau JF, Kennedy CRJ, Gutsol A, Xiao F, Burger D, Burns KD, Hébert RL.

Lab Invest. 2019 Sep 16. doi: 10.1038/s41374-019-0317-7. [Epub ahead of print]


The underlying etiology of infantile spasms (West syndrome): Information from the International Collaborative Infantile Spasms Study (ICISS).

Osborne JP, Edwards SW, Dietrich Alber F, Hancock E, Johnson AL, Kennedy CR, Likeman M, Lux AL, Mackay M, Mallick A, Newton RW, Nolan M, Pressler R, Rating D, Schmitt B, Verity CM, O'Callaghan FJK; participating investigators.

Epilepsia. 2019 Sep;60(9):1861-1869. doi: 10.1111/epi.16305. Epub 2019 Aug 16.


PBI-4050 via GPR40 activation improves adenine-induced kidney injury in mice.

Thibodeau JF, Simard JC, Holterman CE, Blais A, Cloutier MP, Medeiros T, Leduc M, Grouix B, Leblond FA, Burger D, Hébert RL, Kennedy CRJ, Gagnon L.

Clin Sci (Lond). 2019 Jul 22;133(14):1587-1602. doi: 10.1042/CS20190479. Print 2019 Jul 31.


Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse.

Jha JC, Dai A, Holterman CE, Cooper ME, Touyz RM, Kennedy CR, Jandeleit-Dahm KAM.

Diabetologia. 2019 Sep;62(9):1712-1726. doi: 10.1007/s00125-019-4924-z. Epub 2019 Jun 20.


A novel method for comparison of arterial remodeling in hypertension: Quantification of arterial trees and recognition of remodeling patterns on histological sections.

Gutsol AA, Blanco P, Samokhina SI, Afanasiev SA, Kennedy CRJ, Popov SV, Burns KD.

PLoS One. 2019 May 21;14(5):e0216734. doi: 10.1371/journal.pone.0216734. eCollection 2019.


Regio- and Diastereoselective Iron-Catalyzed [4+4]-Cycloaddition of 1,3-Dienes.

Kennedy CR, Zhong H, Macaulay RL, Chirik PJ.

J Am Chem Soc. 2019 May 29;141(21):8557-8573. doi: 10.1021/jacs.9b02443. Epub 2019 May 16.


Carriage of the Toxic Shock Syndrome Toxin Gene by Contemporary Community-Associated Staphylococcus aureus Isolates.

Parrish KL, Wylie KM, Reich PJ, Hogan PG, Wylie TN, Kennedy CR, Lainhart W, Hunstad DA, Burnham CD, Fritz SA.

J Pediatric Infect Dis Soc. 2018 Oct 4. doi: 10.1093/jpids/piy098. [Epub ahead of print]


Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial.

O'Callaghan FJK, Edwards SW, Alber FD, Cortina Borja M, Hancock E, Johnson AL, Kennedy CR, Likeman M, Lux AL, Mackay MT, Mallick AA, Newton RW, Nolan M, Pressler R, Rating D, Schmitt B, Verity CM, Osborne JP; International Collaborative Infantile Spasms Study (ICISS) investigators.

Lancet Child Adolesc Health. 2018 Oct;2(10):715-725. doi: 10.1016/S2352-4642(18)30244-X. Epub 2018 Aug 29.


Podocyte NADPH Oxidase 5 Promotes Renal Inflammation Regulated by the Toll-Like Receptor Pathway.

Holterman CE, Boisvert NC, Thibodeau JF, Kamto E, Novakovic M, Abd-Elrahman KS, Ferguson SSG, Kennedy CRJ.

Antioxid Redox Signal. 2019 May 20;30(15):1817-1830. doi: 10.1089/ars.2017.7402. Epub 2018 Sep 8.


GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation.

Tutunea-Fatan E, Abd-Elrahman KS, Thibodeau JF, Holterman CE, Holleran BJ, Leduc R, Kennedy CRJ, Gros R, Ferguson SSG.

Sci Rep. 2018 Jul 30;8(1):11415. doi: 10.1038/s41598-018-29876-8.


A Strategy for Changing Adherence to National Guidelines for Decreasing Laboratory Testing for Early Breast Cancer Patients.

Hill LA, Vang CA, Kennedy CR, Linebarger JH, Dietrich LL, Parsons BM, Hennessy JL, Theede LM, VanderLei LK, Ramirez LD, Ernst AJ, Landercasper J.

WMJ. 2018 Jun;117(2):68-72.


Proteostasis as a therapeutic target in glomerular injury associated with mutant α-actinin-4.

Yee A, Papillon J, Guillemette J, Kaufman DR, Kennedy CRJ, Cybulsky AV.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F954-F966. doi: 10.1152/ajprenal.00082.2018. Epub 2018 Jun 6.


Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice.

Boisvert NC, Holterman CE, Thibodeau JF, Nasrallah R, Kamto E, Comin CH, Costa LDF, Carter A, Hébert RL, Gutsol A, Cron GO, Lacoste B, Gray DA, Kennedy CR.

Clin Sci (Lond). 2018 Jul 18;132(13):1453-1470. doi: 10.1042/CS20180085. Print 2018 Jul 18.


Ubiquitin COOH-terminal hydrolase L1 deletion is associated with urinary α-klotho deficiency and perturbed phosphate homeostasis.

Boisvert NC, Holterman CE, Gutsol A, Coulombe J, Pan W, Alexander RT, Gray DA, Kennedy CR.

Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F353-F363. doi: 10.1152/ajprenal.00411.2017. Epub 2018 Apr 18.


Societal costs of permanent childhood hearing loss at teen age: a cross-sectional cohort follow-up study of universal newborn hearing screening.

Chorozoglou M, Mahon M, Pimperton H, Worsfold S, Kennedy CR.

BMJ Paediatr Open. 2018 Feb 24;2(1):e000228. doi: 10.1136/bmjpo-2017-000228. eCollection 2018.


A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84.

Gagnon L, Leduc M, Thibodeau JF, Zhang MZ, Grouix B, Sarra-Bournet F, Gagnon W, Hince K, Tremblay M, Geerts L, Kennedy CRJ, Hébert RL, Gutsol A, Holterman CE, Kamto E, Gervais L, Ouboudinar J, Richard J, Felton A, Laverdure A, Simard JC, Létourneau S, Cloutier MP, Leblond FA, Abbott SD, Penney C, Duceppe JS, Zacharie B, Dupuis J, Calderone A, Nguyen QT, Harris RC, Laurin P.

Am J Pathol. 2018 May;188(5):1132-1148. doi: 10.1016/j.ajpath.2018.01.009. Epub 2018 Feb 16.


Podocyte-derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36.

Munkonda MN, Akbari S, Landry C, Sun S, Xiao F, Turner M, Holterman CE, Nasrallah R, Hébert RL, Kennedy CRJ, Burger D.

J Extracell Vesicles. 2018 Feb 2;7(1):1432206. doi: 10.1080/20013078.2018.1432206. eCollection 2018.


Selective [1,4]-Hydrovinylation of 1,3-Dienes with Unactivated Olefins Enabled by Iron Diimine Catalysts.

Schmidt VA, Kennedy CR, Bezdek MJ, Chirik PJ.

J Am Chem Soc. 2018 Mar 7;140(9):3443-3453. doi: 10.1021/jacs.8b00245. Epub 2018 Feb 21.


Phonological processing during silent reading in teenagers who are deaf/hard of hearing: an eye movement investigation.

Blythe HI, Dickins JH, Kennedy CR, Liversedge SP.

Dev Sci. 2018 Sep;21(5):e12643. doi: 10.1111/desc.12643. Epub 2018 Jan 22.


PGE2 EP1 receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct.

Nasrallah R, Zimpelmann J, Eckert D, Ghossein J, Geddes S, Beique JC, Thibodeau JF, Kennedy CRJ, Burns KD, Hébert RL.

Lab Invest. 2018 Mar;98(3):360-370. doi: 10.1038/labinvest.2017.133. Epub 2017 Dec 18.


Transforming growth factor-β1 and phosphatases modulate COX-2 protein expression and TAU phosphorylation in cultured immortalized podocytes.

Abdallah MS, Kennedy CRJ, Stephan JS, Khalil PA, Mroueh M, Eid AA, Faour WH.

Inflamm Res. 2018 Feb;67(2):191-201. doi: 10.1007/s00011-017-1110-y. Epub 2017 Oct 30.


Chiral Thioureas Promote Enantioselective Pictet-Spengler Cyclization by Stabilizing Every Intermediate and Transition State in the Carboxylic Acid-Catalyzed Reaction.

Klausen RS, Kennedy CR, Hyde AM, Jacobsen EN.

J Am Chem Soc. 2017 Sep 6;139(35):12299-12309. doi: 10.1021/jacs.7b06811. Epub 2017 Aug 22.


NADPH Oxidase Nox5 Accelerates Renal Injury in Diabetic Nephropathy.

Jha JC, Banal C, Okabe J, Gray SP, Hettige T, Chow BSM, Thallas-Bonke V, De Vos L, Holterman CE, Coughlan MT, Power DA, Skene A, Ekinci EI, Cooper ME, Touyz RM, Kennedy CR, Jandeleit-Dahm K.

Diabetes. 2017 Oct;66(10):2691-2703. doi: 10.2337/db16-1585. Epub 2017 Jul 26.


Hearing loss mediates executive function impairment in sleep-disordered breathing.

Hill CM, Bucks RS, Kennedy CR, Harrison D, Carroll A, Upton N, Hogan AM.

Sleep Med. 2017 Jun;34:18-23. doi: 10.1016/j.sleep.2017.02.008. Epub 2017 Mar 7.


Language Outcomes in Deaf or Hard of Hearing Teenagers Who Are Spoken Language Users: Effects of Universal Newborn Hearing Screening and Early Confirmation.

Pimperton H, Kreppner J, Mahon M, Stevenson J, Terlektsi E, Worsfold S, Yuen HM, Kennedy CR.

Ear Hear. 2017 Sep/Oct;38(5):598-610. doi: 10.1097/AUD.0000000000000434.


Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study.

Matthews YY, Dean F, Lim MJ, Mclachlan K, Rigby AS, Solanki GA, White CP, Whitehouse WP, Kennedy CR.

Arch Dis Child. 2017 Aug;102(8):715-721. doi: 10.1136/archdischild-2016-312238. Epub 2017 Mar 29.


Assessment of urinary microparticles in normotensive patients with type 1 diabetes.

Lytvyn Y, Xiao F, Kennedy CR, Perkins BA, Reich HN, Scholey JW, Cherney DZ, Burger D.

Diabetologia. 2017 Mar;60(3):581-584. doi: 10.1007/s00125-016-4190-2. Epub 2016 Dec 21.


Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial.

O'Callaghan FJ, Edwards SW, Alber FD, Hancock E, Johnson AL, Kennedy CR, Likeman M, Lux AL, Mackay M, Mallick AA, Newton RW, Nolan M, Pressler R, Rating D, Schmitt B, Verity CM, Osborne JP; participating investigators.

Lancet Neurol. 2017 Jan;16(1):33-42. doi: 10.1016/S1474-4422(16)30294-0. Epub 2016 Nov 10.


Mechanism-Guided Development of a Highly Active Bis-thiourea Catalyst for Anion-Abstraction Catalysis.

Kennedy CR, Lehnherr D, Rajapaksa NS, Ford DD, Park Y, Jacobsen EN.

J Am Chem Soc. 2016 Oct 19;138(41):13525-13528. doi: 10.1021/jacs.6b09205. Epub 2016 Oct 11.


Synergistic Ion-Binding Catalysis Demonstrated via an Enantioselective, Catalytic [2,3]-Wittig Rearrangement.

Kennedy CR, Guidera JA, Jacobsen EN.

ACS Cent Sci. 2016 Jun 22;2(6):416-23. doi: 10.1021/acscentsci.6b00125. Epub 2016 Jun 14.


The Cation-π Interaction in Small-Molecule Catalysis.

Kennedy CR, Lin S, Jacobsen EN.

Angew Chem Int Ed Engl. 2016 Oct 4;55(41):12596-624. doi: 10.1002/anie.201600547. Epub 2016 Jun 22. Review.


Conformational Control of Chiral Amido-Thiourea Catalysts Enables Improved Activity and Enantioselectivity.

Lehnherr D, Ford DD, Bendelsmith AJ, Kennedy CR, Jacobsen EN.

Org Lett. 2016 Jul 1;18(13):3214-7. doi: 10.1021/acs.orglett.6b01435. Epub 2016 Jun 13.


On- and Off-Cycle Catalyst Cooperativity in Anion-Binding Catalysis.

Ford DD, Lehnherr D, Kennedy CR, Jacobsen EN.

J Am Chem Soc. 2016 Jun 29;138(25):7860-7863. doi: 10.1021/jacs.6b04686. Epub 2016 Jun 15.


Vascular Smooth Muscle-Specific EP4 Receptor Deletion in Mice Exacerbates Angiotensin II-Induced Renal Injury.

Thibodeau JF, Holterman CE, He Y, Carter A, Cron GO, Boisvert NC, Abd-Elrahman KS, Hsu KJ, Ferguson SS, Kennedy CR.

Antioxid Redox Signal. 2016 Oct 20;25(12):642-656. Epub 2016 Aug 5.


Prevalence of qacA/B Genes and Mupirocin Resistance Among Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates in the Setting of Chlorhexidine Bathing Without Mupirocin.

Warren DK, Prager M, Munigala S, Wallace MA, Kennedy CR, Bommarito KM, Mazuski JE, Burnham CA.

Infect Control Hosp Epidemiol. 2016 May;37(5):590-7. doi: 10.1017/ice.2016.1. Epub 2016 Feb 2.


Modified Constraint-Induced Movement Therapy as a Home-Based Intervention for Children With Cerebral Palsy.

Psychouli P, Kennedy CR.

Pediatr Phys Ther. 2016 Summer;28(2):154-60. doi: 10.1097/PEP.0000000000000227.


Perspectives of Decisional Surrogates and Patients Regarding Critical Illness Genetic Research.

Freeman BD, Bolcic-Jankovic D, Kennedy CR, LeBlanc J, Eastman A, Barillas J, Wittgen CM, Indsey K, Mahmood RS, Clarridge BR.

AJOB Empir Bioeth. 2016 Jan 1;7(1):39-47. Epub 2015 May 1.


Changing and challenging times for Canadian kidney health and disease research.

Kennedy CR.

Can J Kidney Health Dis. 2015 Dec 1;2:49. doi: 10.1186/s40697-015-0085-2. eCollection 2015. No abstract available.


Screening for cognitive deficits in 8 to 14-year old children with cerebellar tumors using self-report measures of executive and behavioral functioning and health-related quality of life.

Bull KS, Liossi C, Peacock JL, Yuen HM, Kennedy CR; Children's Cancer and Leukaemia Group (CCLG).

Neuro Oncol. 2015 Dec;17(12):1628-36. doi: 10.1093/neuonc/nov129. Epub 2015 Jul 22.


Prostaglandin E2 increases proximal tubule fluid reabsorption, and modulates cultured proximal tubule cell responses via EP1 and EP4 receptors.

Nasrallah R, Hassouneh R, Zimpelmann J, Karam AJ, Thibodeau JF, Burger D, Burns KD, Kennedy CR, Hébert RL.

Lab Invest. 2015 Sep;95(9):1044-55. doi: 10.1038/labinvest.2015.79. Epub 2015 Jun 29.


Child-related characteristics predicting subsequent health-related quality of life in 8- to 14-year-old children with and without cerebellar tumors: a prospective longitudinal study.

Bull KS, Liossi C, Culliford D, Peacock JL, Kennedy CR; Children's Cancer and Leukaemia Group (CCLG).

Neurooncol Pract. 2014 Sep;1(3):114-122. Epub 2014 Aug 11.


Nox and renal disease.

Holterman CE, Read NC, Kennedy CR.

Clin Sci (Lond). 2015 Apr;128(8):465-81. doi: 10.1042/CS20140361. Review.


Quality of survival assessment in European childhood brain tumour trials, for children aged 5 years and over.

Limond JA, Bull KS, Calaminus G, Kennedy CR, Spoudeas HA, Chevignard MP; Brain Tumour Quality of Survival Group, International Society of Paediatric Oncology (Europe) (SIOP-E).

Eur J Paediatr Neurol. 2015 Mar;19(2):202-10. doi: 10.1016/j.ejpn.2014.12.003. Epub 2014 Dec 17.


A novel mouse model of advanced diabetic kidney disease.

Thibodeau JF, Holterman CE, Burger D, Read NC, Reudelhuber TL, Kennedy CR.

PLoS One. 2014 Dec 16;9(12):e113459. doi: 10.1371/journal.pone.0113459. eCollection 2014.


The impact of universal newborn hearing screening on long-term literacy outcomes: a prospective cohort study.

Pimperton H, Blythe H, Kreppner J, Mahon M, Peacock JL, Stevenson J, Terlektsi E, Worsfold S, Yuen HM, Kennedy CR.

Arch Dis Child. 2016 Jan;101(1):9-15. doi: 10.1136/archdischild-2014-307516. Epub 2014 Nov 25.


NADPH oxidase 5 and renal disease.

Holterman CE, Thibodeau JF, Kennedy CR.

Curr Opin Nephrol Hypertens. 2015 Jan;24(1):81-7. doi: 10.1097/MNH.0000000000000081. Review.


Surrogate receptivity to participation in critical illness genetic research: aligning research oversight and stakeholder concerns.

Freeman BD, Butler K, Bolcic-Jankovic D, Clarridge BR, Kennedy CR, LeBlanc J, Chandros Hull S.

Chest. 2015 Apr;147(4):979-988. doi: 10.1378/chest.14-0797.


Nitrate, nitrite, and nitric oxide find a home in the kidney by offsetting angiotensin II-mediated hypertension.

Kennedy CR.

Hypertension. 2015 Jan;65(1):31-3. doi: 10.1161/HYPERTENSIONAHA.114.04349. Epub 2014 Oct 13. No abstract available.


Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors.

Bull KS, Kennedy CR, Bailey S, Ellison DW, Clifford SC.

Acta Neuropathol. 2014 Jul;128(1):151-3. doi: 10.1007/s00401-014-1300-4. Epub 2014 May 31. No abstract available.

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