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Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis.

Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, Cunningham CC, McGarry T, Canavan M, Kennedy BN, Veale DJ, Fearon U.

EBioMedicine. 2019 Sep;47:402-413. doi: 10.1016/j.ebiom.2019.08.043. Epub 2019 Aug 26.


1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours.

Butler CT, Kennedy SA, Buckley A, Doyle R, Conroy E, Gallagher WM, O'Sullivan J, Kennedy BN.

Oncotarget. 2019 Jun 4;10(38):3725-3744. doi: 10.18632/oncotarget.26966. eCollection 2019 Jun 4.


Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae.

Ohnesorge N, Sasore T, Hillary D, Alvarez Y, Carey M, Kennedy BN.

Front Pharmacol. 2019 May 24;10:508. doi: 10.3389/fphar.2019.00508. eCollection 2019. Review.


Pharmacological restoration of visual function in a zebrafish model of von-Hippel Lindau disease.

Ward R, Ali Z, Slater K, Reynolds AL, Jensen LD, Kennedy BN.

Dev Biol. 2019 Feb 27. pii: S0012-1606(18)30731-0. doi: 10.1016/j.ydbio.2019.02.008. [Epub ahead of print]


Characterisation of an Isogenic Model of Cisplatin Resistance in Oesophageal Adenocarcinoma Cells.

Buckley AM, Bibby BA, Dunne MR, Kennedy SA, Davern MB, Kennedy BN, Maher SG, O'Sullivan J.

Pharmaceuticals (Basel). 2019 Feb 20;12(1). pii: E33. doi: 10.3390/ph12010033.


Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma.

Buckley AM, Dunne MR, Lynam-Lennon N, Kennedy SA, Cannon A, Reynolds AL, Maher SG, Reynolds JV, Kennedy BN, O'Sullivan J.

Cancer Lett. 2019 Apr 10;447:115-129. doi: 10.1016/j.canlet.2019.01.009. Epub 2019 Jan 19.


The potential of small molecule brain-derived neurotrophic factor: mimetics to treat inherited retinal degeneration.

Cerquone Perpetuini A, Mathoux J, Kennedy BN.

Neural Regen Res. 2019 Jan;14(1):85-86. doi: 10.4103/1673-5374.243711. No abstract available.


Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma.

Buckley AM, Lynam-Lennon N, Kennedy SA, Dunne MR, Aird JJ, Foley EK, Clarke N, Ravi N, O'Toole D, Reynolds JV, Kennedy BN, O'Sullivan J.

Oncotarget. 2018 Sep 14;9(72):33634-33647. doi: 10.18632/oncotarget.25950. eCollection 2018 Sep 14.


Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma.

Slater K, Hoo PS, Buckley AM, Piulats JM, Villanueva A, Portela A, Kennedy BN.

Cancer Metastasis Rev. 2018 Sep;37(2-3):335-345. doi: 10.1007/s10555-018-9751-z. Review.


Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration.

Daly C, Ward R, Reynolds AL, Galvin O, Collery RF, Kennedy BN.

Adv Exp Med Biol. 2018;1074:465-471. doi: 10.1007/978-3-319-75402-4_57. Review.


Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish.

Ward R, Sundaramurthi H, Di Giacomo V, Kennedy BN.

Front Cell Dev Biol. 2018 Apr 11;6:37. doi: 10.3389/fcell.2018.00037. eCollection 2018. Review.


Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish.

Raghupathy RK, Zhang X, Liu F, Alhasani RH, Biswas L, Akhtar S, Pan L, Moens CB, Li W, Liu M, Kennedy BN, Shu X.

Sci Rep. 2017 Dec 4;7(1):16881. doi: 10.1038/s41598-017-12838-x.


HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness.

Leyk J, Daly C, Janssen-Bienhold U, Kennedy BN, Richter-Landsberg C.

Cell Death Dis. 2017 Aug 31;8(8):e3028. doi: 10.1038/cddis.2017.415.


A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model.

Daly C, Shine L, Heffernan T, Deeti S, Reynolds AL, O'Connor JJ, Dillon ET, Duffy DJ, Kolch W, Cagney G, Kennedy BN.

Sci Rep. 2017 Sep 12;7(1):11320. doi: 10.1038/s41598-017-11513-5.


Genome editing: the breakthrough technology for inherited retinal disease?

Smith AJ, Carter SP, Kennedy BN.

Expert Opin Biol Ther. 2017 Oct;17(10):1245-1254. doi: 10.1080/14712598.2017.1347629. Epub 2017 Jul 11. Review.


Vitamin D receptor agonists regulate ocular developmental angiogenesis and modulate expression of dre-miR-21 and VEGF.

Merrigan SL, Kennedy BN.

Br J Pharmacol. 2017 Aug;174(16):2636-2651. doi: 10.1111/bph.13875. Epub 2017 Jul 7.


A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab.

Butler CT, Reynolds AL, Tosetto M, Dillon ET, Guiry PJ, Cagney G, O'Sullivan J, Kennedy BN.

J Biol Chem. 2017 Mar 3;292(9):3552-3567. doi: 10.1074/jbc.M116.747766. Epub 2016 Dec 29.


Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.

Jensen VL, Carter S, Sanders AA, Li C, Kennedy J, Timbers TA, Cai J, Scheidel N, Kennedy BN, Morin RD, Leroux MR, Blacque OE.

PLoS Genet. 2016 Dec 8;12(12):e1006469. doi: 10.1371/journal.pgen.1006469. eCollection 2016 Dec.


A method for isolation of cone photoreceptors from adult zebrafish retinae.

Glaviano A, Smith AJ, Blanco A, McLoughlin S, Cederlund ML, Heffernan T, Sapetto-Rebow B, Alvarez Y, Yin J, Kennedy BN.

BMC Neurosci. 2016 Nov 7;17(1):71.


Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer.

Murphy AG, Casey R, Maguire A, Tosetto M, Butler CT, Conroy E, Reynolds AL, Sheahan K, O'Donoghue D, Gallagher WM, Fennelly D, Kennedy BN, O'Sullivan J.

Sci Rep. 2016 Oct 14;6:34523. doi: 10.1038/srep34523.


Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer.

Burke L, Butler CT, Murphy A, Moran B, Gallagher WM, O'Sullivan J, Kennedy BN.

Front Cell Dev Biol. 2016 Sep 21;4:103. eCollection 2016. Review.


A sustained release formulation of novel quininib-hyaluronan microneedles inhibits angiogenesis and retinal vascular permeability in vivo.

Galvin O, Srivastava A, Carroll O, Kulkarni R, Dykes S, Vickers S, Dickinson K, Reynolds AL, Kilty C, Redmond G, Jones R, Cheetham S, Pandit A, Kennedy BN.

J Control Release. 2016 Jul 10;233:198-207. doi: 10.1016/j.jconrel.2016.04.004. Epub 2016 Apr 13.


Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis.

Reynolds AL, Alvarez Y, Sasore T, Waghorne N, Butler CT, Kilty C, Smith AJ, McVicar C, Wong VH, Galvin O, Merrigan S, Osman J, Grebnev G, Sjölander A, Stitt AW, Kennedy BN.

J Biol Chem. 2016 Apr 1;291(14):7242-55. doi: 10.1074/jbc.M115.710665. Epub 2016 Feb 4.


Histone Deacetylase: Therapeutic Targets in Retinal Degeneration.

Daly C, Yin J, Kennedy BN.

Adv Exp Med Biol. 2016;854:455-61. doi: 10.1007/978-3-319-17121-0_61.


Genes and signaling networks regulated during zebrafish optic vesicle morphogenesis.

Yin J, Morrissey ME, Shine L, Kennedy C, Higgins DG, Kennedy BN.

BMC Genomics. 2014 Sep 30;15:825. doi: 10.1186/1471-2164-15-825.


Unexpected genetic heterogeneity for primary ciliary dyskinesia in the Irish Traveller population.

Casey JP, McGettigan PA, Healy F, Hogg C, Reynolds A, Kennedy BN, Ennis S, Slattery D, Lynch SA.

Eur J Hum Genet. 2015 Feb;23(2):210-7. doi: 10.1038/ejhg.2014.79. Epub 2014 May 14.


Targeting the PI3K/Akt/mTOR pathway in ocular neovascularization.

Sasore T, Reynolds AL, Kennedy BN.

Adv Exp Med Biol. 2014;801:805-11. doi: 10.1007/978-1-4614-3209-8_101. Review.


Current and emerging therapies for ocular neovascularisation.

Reynolds AL, Kent D, Kennedy BN.

Adv Exp Med Biol. 2014;801:797-804. doi: 10.1007/978-1-4614-3209-8_100. Review.


Early safety assessment of human oculotoxic drugs using the zebrafish visualmotor response.

Deeti S, O'Farrell S, Kennedy BN.

J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):1-8. doi: 10.1016/j.vascn.2013.09.002. Epub 2013 Sep 30.


Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology.

Collery RF, Cederlund ML, Kennedy BN.

Exp Eye Res. 2013 Mar;108:120-8. doi: 10.1016/j.exer.2013.01.003. Epub 2013 Jan 15.


Inhibition of the Pim1 oncogene results in diminished visual function.

Yin J, Shine L, Raycroft F, Deeti S, Reynolds A, Ackerman KM, Glaviano A, O'Farrell S, O'Leary O, Kilty C, Kennedy C, McLoughlin S, Rice M, Russell E, Higgins DG, Hyde DR, Kennedy BN.

PLoS One. 2012;7(12):e52177. doi: 10.1371/journal.pone.0052177. Epub 2012 Dec 26.


The genetics of outer segment morphogenesis in zebrafish.

Reynolds AL, Blacque OE, Kennedy BN.

Adv Exp Med Biol. 2012;723:431-41. doi: 10.1007/978-1-4614-0631-0_55. Review. No abstract available.


Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.

Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y, Collery R, O'Sullivan J, Van Eeden F, Hensey C, Kennedy BN.

BMC Dev Biol. 2011 Nov 23;11:71. doi: 10.1186/1471-213X-11-71.


First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype.

Casey J, Kawaguchi R, Morrissey M, Sun H, McGettigan P, Nielsen JE, Conroy J, Regan R, Kenny E, Cormican P, Morris DW, Tormey P, Chróinín MN, Kennedy BN, Lynch S, Green A, Ennis S.

Hum Mutat. 2011 Dec;32(12):1417-26. doi: 10.1002/humu.21590. Epub 2011 Sep 29.


mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation.

Cederlund ML, Vendrell V, Morrissey ME, Yin J, Gaora PÓ, Smyth VA, Higgins DG, Kennedy BN.

Dev Dyn. 2011 Apr;240(4):745-54. doi: 10.1002/dvdy.22573. Epub 2011 Feb 28.


PRE-1, a cis element sufficient to enhance cone- and rod- specific expression in differentiating zebrafish photoreceptors.

Morrissey ME, Shelton S, Brockerhoff SE, Hurley JB, Kennedy BN.

BMC Dev Biol. 2011 Jan 24;11:3. doi: 10.1186/1471-213X-11-3.


Zebrafish Tg(7.2mab21l2:EGFP)ucd2 transgenics reveal a unique population of retinal amacrine cells.

Cederlund ML, Morrissey ME, Baden T, Scholz D, Vendrell V, Lagnado L, Connaughton VP, Kennedy BN.

Invest Ophthalmol Vis Sci. 2011 Mar 1;52(3):1613-21. doi: 10.1167/iovs.10-5376.


Characterisation of expression patterns and functional role of Cactin in early zebrafish development.

Atzei P, Yang F, Collery R, Kennedy BN, Moynagh PN.

Gene Expr Patterns. 2010 Jun;10(4-5):199-206. doi: 10.1016/j.gep.2010.03.003. Epub 2010 Mar 27.


Photoreceptor guanylate cyclases and cGMP phosphodiesterases in zebrafish.

Collery RF, Kennedy BN.

Adv Exp Med Biol. 2010;664:55-61. doi: 10.1007/978-1-4419-1399-9_7. Review.


Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy.

Alvarez Y, Chen K, Reynolds AL, Waghorne N, O'Connor JJ, Kennedy BN.

Dis Model Mech. 2010 Mar-Apr;3(3-4):236-45. doi: 10.1242/dmm.003772. Epub 2010 Feb 8.


Selective inhibition of retinal angiogenesis by targeting PI3 kinase.

Alvarez Y, Astudillo O, Jensen L, Reynolds AL, Waghorne N, Brazil DP, Cao Y, O'Connor JJ, Kennedy BN.

PLoS One. 2009 Nov 17;4(11):e7867. doi: 10.1371/journal.pone.0007867.


Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis.

Coss A, Tosetto M, Fox EJ, Sapetto-Rebow B, Gorman S, Kennedy BN, Lloyd AT, Hyland JM, O'Donoghue DP, Sheahan K, Leahy DT, Mulcahy HE, O'Sullivan JN.

Cancer Lett. 2009 Apr 18;276(2):228-38. doi: 10.1016/j.canlet.2008.11.018. Epub 2008 Dec 25.


Duplication and divergence of zebrafish CRALBP genes uncovers novel role for RPE- and Muller-CRALBP in cone vision.

Collery R, McLoughlin S, Vendrell V, Finnegan J, Crabb JW, Saari JC, Kennedy BN.

Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3812-20. doi: 10.1167/iovs.08-1957. Epub 2008 May 23.


A novel, evolutionarily conserved enhancer of cone photoreceptor-specific expression.

Smyth VA, Di Lorenzo D, Kennedy BN.

J Biol Chem. 2008 Apr 18;283(16):10881-91. doi: 10.1074/jbc.M710454200. Epub 2008 Feb 13.


Genetic determinants of hyaloid and retinal vasculature in zebrafish.

Alvarez Y, Cederlund ML, Cottell DC, Bill BR, Ekker SC, Torres-Vazquez J, Weinstein BM, Hyde DR, Vihtelic TS, Kennedy BN.

BMC Dev Biol. 2007 Oct 15;7:114.


Identification of a zebrafish cone photoreceptor-specific promoter and genetic rescue of achromatopsia in the nof mutant.

Kennedy BN, Alvarez Y, Brockerhoff SE, Stearns GW, Sapetto-Rebow B, Taylor MR, Hurley JB.

Invest Ophthalmol Vis Sci. 2007 Feb;48(2):522-9.


Applying transgenic zebrafish technology to study the retina.

Collery RF, Cederlund ML, Smyth VA, Kennedy BN.

Adv Exp Med Biol. 2006;572:201-7. Review. No abstract available.


Zebrafish rx3 and mab21l2 are required during eye morphogenesis.

Kennedy BN, Stearns GW, Smyth VA, Ramamurthy V, van Eeden F, Ankoudinova I, Raible D, Hurley JB, Brockerhoff SE.

Dev Biol. 2004 Jun 15;270(2):336-49.


CRALBP transcriptional regulation in ciliary epithelial, retinal Müller and retinal pigment epithelial cells.

Kennedy BN, Li C, Ortego J, Coca-Prados M, Sarthy VP, Crabb JW.

Exp Eye Res. 2003 Feb;76(2):257-60.


Visual cycle impairment in cellular retinaldehyde binding protein (CRALBP) knockout mice results in delayed dark adaptation.

Saari JC, Nawrot M, Kennedy BN, Garwin GG, Hurley JB, Huang J, Possin DE, Crabb JW.

Neuron. 2001 Mar;29(3):739-48.

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